Projects per year
Personal profile
Biography
Head of the Immune and Cancer Cell Signalling Laboratory
The Nuclear Factor of kappa B (NF-KB) signal transduction pathway plays a key role in the immune system and features prominently in disease-associated pathology. Our group focuses on the use of genetically modified mice to understand how NF-KB regulates normal development, differentiation and cellular functions particularly in the immune system, as well as its roles in autoimmune disease and cancer. The long-term goal of our research is to identify ways of manipulating NF-KB transcription factor activities for therapeutic purposes.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- NF-kappaB
- transcription
- signal transduction
- immunity
- inflammation
- autoimmunity
- cancer
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 5 Finished
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Apoptosis and stem cells in cancer development and therapy
Gerondakis, S., Adams, J. M., Bouillet, P., Colman, P. G., Cory, S., Huang, D., Kluck, R., Lindeman, G., Strasser, A., Vaux, D. & Visvader, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 31/12/16
Project: Research
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NHMRC Research Fellowship
National Health and Medical Research Council (NHMRC) (Australia)
1/01/11 → 31/12/15
Project: Research
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c-Rel employs multiple mechanisms to promote the thymic development and peripheral function of regulatory T cells in mice
Fulford, T. S., Grumont, R., Wirasinha, R. C., Ellis, D., Barugahare, A., Turner, S. J., Naeem, H., Powell, D., Lyons, P. A., Smith, K. G. C., Scheer, S., Zaph, C., Klein, U., Daley, S. R. & Gerondakis, S., Aug 2021, In: European Journal of Immunology. 51, 8, p. 2006-2026 21 p.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
c-Rel Is Required for IL-33-Dependent Activation of ILC2s
Zaini, A., Fulford, T. S., Grumont, R. J., Runting, J., Rodrigues, G., Ng, J., Gerondakis, S., Zaph, C. & Scheer, S., 14 Jun 2021, In: Frontiers in Immunology. 12, 11 p., 667922.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism
Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J., & 1 others, 1 May 2018, In: Cell Metabolism. 27, 5, p. 1096-1110 16 p.Research output: Contribution to journal › Article › Research › peer-review
321 Citations (Scopus) -
Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner
O'Reilly, L. A., Putoczki, T. L., Mielke, L. A., Low, J. T., Lin, A., Preaudet, A., Herold, M. J., Yaprianto, K., Tai, L., Kueh, A., Pacini, G., Ferrero, R. L., Gugasyan, R., Hu, Y., Christie, M., Wilcox, S., Grumont, R., Griffin, M. D. W., O'Connor, L., Smyth, G. K., & 4 others, 20 Mar 2018, In: Immunity. 48, 3, p. 570-583 14 p.Research output: Contribution to journal › Article › Research › peer-review
62 Citations (Scopus) -
Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis
Deliyanti, D., Talia, D. M., Zhu, T., Maxwell, M. J., Agrotis, A., Jerome, J. R., Hargreaves, E. M., Gerondakis, S., Hibbs, M. L., Mackay, F. & Wilkinson-Berka, J. L., 1 Dec 2017, In: Nature Communications. 8, 1, 12 p., 748.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile67 Citations (Scopus)