If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Head of the Immune and Cancer Cell Signalling Laboratory

The Nuclear Factor of kappa B (NF-KB) signal transduction pathway plays a key role in the immune system and features prominently in disease-associated pathology. Our group focuses on the use of genetically modified mice to understand how NF-KB regulates normal development, differentiation and cellular functions particularly in the immune system, as well as its roles in autoimmune disease and cancer. The long-term goal of our research is to identify ways of manipulating NF-KB transcription factor activities for therapeutic purposes.

Keywords

  • NF-kappaB
  • transcription
  • signal transduction
  • immunity
  • inflammation
  • autoimmunity
  • cancer

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2009 2016

Research Output 1980 2018

Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism

Lancaster, G. I., Langley, K. G., Berglund, N. A., Kammoun, H. L., Reibe, S., Estevez, E., Weir, J., Mellett, N. A., Pernes, G., Conway, J. R. W., Lee, M. K. S., Timpson, P., Murphy, A. J., Masters, S. L., Gerondakis, S., Bartonicek, N., Kaczorowski, D. C., Dinger, M. E., Meikle, P. J., Bond, P. J. & 1 othersFebbraio, M. A., 1 May 2018, In : Cell Metabolism. 27, 5, p. 1096-1110 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Loss of NF-κB1 Causes Gastric Cancer with Aberrant Inflammation and Expression of Immune Checkpoint Regulators in a STAT-1-Dependent Manner

O'Reilly, L. A., Putoczki, T. L., Mielke, L. A., Low, J. T., Lin, A., Preaudet, A., Herold, M. J., Yaprianto, K., Tai, L., Kueh, A., Pacini, G., Ferrero, R. L., Gugasyan, R., Hu, Y., Christie, M., Wilcox, S., Grumont, R., Griffin, M. D. W., O'Connor, L., Smyth, G. K. & 4 othersErnst, M., Waring, P., Gerondakis, S. & Strasser, A., 20 Mar 2018, In : Immunity. 48, 3, p. 570-583 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Foxp3+ Tregs are recruited to the retina to repair pathological angiogenesis

Deliyanti, D., Talia, D. M., Zhu, T., Maxwell, M. J., Agrotis, A., Jerome, J. R., Hargreaves, E. M., Gerondakis, S., Hibbs, M. L., Mackay, F. & Wilkinson-Berka, J. L., 1 Dec 2017, In : Nature Communications. 8, 1, 12 p., 748.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The bacterial peptidoglycan-sensing molecules NOD1 and NOD2 promote CD8+ thymocyte selection

Martinic, M. M., Caminschi, I., O'Keeffe, M., Thinnes, T. C., Grumont, R., Gerondakis, S., McKay, D. B., Nemazee, D. & Gavin, A. L., 1 Apr 2017, In : Journal of Immunology. 198, 7, p. 2649-2660 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Faslpr/lpr mutant mice

Low, JT., Hughes, P., Lin, A., Siebenlist, U., Jain, R., Yaprianto, K., Gray, DHD., Gerondakis, S., Strasser, A. & O'Reilly, LA., 2016, In : Immunology and Cell Biology. 94, 1, p. 66-78 13 p.

Research output: Contribution to journalArticleResearchpeer-review