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Research Output 1993 2019

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2010

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by tcrβ clonotype

Moffat, J. M., Handel, A., Doherty, P. C., Turner, S. J., Thomas, P. G. & La Gruta, N. L., 1 Dec 2010, In : Journal of Immunology. 185, 11, p. 6850-6856 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Multiplexed combinatorial tetramer staining in a mouse model of virus infection

Cukalac, T., Valkenburg, S. A., La Gruta, N. L., Turner, S. J., Doherty, P. C. & Kedzierska, K., Aug 2010, In : Journal of Immunological Methods. 360, 1-2, p. 157-161 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

La Gruta, N. L., Rothwell, W. T., Cukalac, T., Swan, N. G., Valkenburg, S. A., Kedzierska, K., Thomas, P. G., Doherty, P. C. & Turner, S. J., 1 Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 1885-1894 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Chimeric virus-like particles for the delivery of an inserted conserved influenza A-specific CTL epitope

Cheong, W. S., Reiseger, J. J., Turner, S. J., Boyd, R. L. & Netter, H. J., 2009, In : Antiviral Research. 81, p. 113 - 122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

Guillonneau, C., Mintern, J. D., Hubert, F. X., Hurt, A. C., Besra, G. S., Porcelli, S. A., Barr, I. G., Doherty, P. C., Godfrey, D. I. & Turner, S. J., 3 Mar 2009, In : Proceedings of the National Academy of Sciences. 106, 9, p. 3330-3335 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Division-linked differentiation can account for CD8+ T-cell phenotype in vivo

Schlub, T. E., Venturi, V., Kedzierska, K., Wellard, C., Doherty, P. C., Turner, S. J., Ribeiro, R. M., Hodgkin, P. D. & Davenport, M. P., 2009, In : European Journal of Immunology. 39, 1, p. 67-77 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques

Sexton, A., De Rose, R., Reece, J. C., Alcantara, S., Loh, L., Moffat, J. M., Laurie, K., Hurt, A., Doherty, P. C., Turner, S. J., Kent, S. J. & Stambas, J., Aug 2009, In : Journal of Virology. 83, 15, p. 7619-7628 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Granzyme a expression reveals distinct cytolytic CTL subsets following influenza A virus infection

Moffat, J. M., Gebhardt, T., Doherty, P. C., Turner, S. J. & Mintern, J. D., May 2009, In : European Journal of Immunology. 39, 5, p. 1203-1210 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression

Juelich, T., Sutcliffe, E. L., Denton, A. E., He, Y., Doherty, P. C., Parish, C. R., Turner, S. J., Tremethick, D. & Rao, S., 1 Dec 2009, In : Journal of Immunology. 183, 11, p. 7063-7072 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env311-320 virus

Cukalac, T., Moffat, J. M., Venturi, V., Davenport, M. P., Doherty, P. C., Turner, S. J. & Stambas, J., 12 Nov 2009, In : Vaccine. 27, 48, p. 6755-6761 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Transience of MHC Class I-restricted antigen presentation after influenza A virus infection

Mintern, J. D., Bedoui, S., Davey, G. M., Moffat, J. M., Doherty, P. C. & Turner, S. J., 21 Apr 2009, In : Proceedings of the National Academy of Sciences. 106, 16, p. 6724-6729 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

Jenkins, M. R., La Gruta, N. L., Doherty, P. C., Trapani, J. A., Turner, S. J. & Waterhouse, N. J., 2009, In : Cell Death and Differentiation. 16, 4, p. 537-542 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Anti-SIV cytolytic molecules in pigtail macaques

Rollman, E., Turner, S. J., Kedzierska, K. & Kent, S. J., 1 Aug 2008, In : AIDS Research and Human Retroviruses. 24, 8, p. 1127-1131 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8 + T cells

Jenkins, M. R., Mintern, J., La Gruta, N. L., Kedzierska, K., Doherty, P. C. & Turner, S. J., 15 Sep 2008, In : Journal of Immunology. 181, 6, p. 3818-3822 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice

Gualano, R. C., Hansen, M. J., Vlahos, R., Jones, J., Park-Jones, R. A., Deliyannis, G., Turner, S. J., Duca, K. A. & Anderson, G., 2008, In : Respiratory Research. 9, aRT. id: 53, p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice

Jenkins, M. R., Trapani, J. A., Doherty, P. C. & Turner, S. J., 1 Sep 2008, In : Viral Immunology. 21, 3, p. 341-346 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Homogenization of TCR repertoires within secondary CD62L high and CD62L low virus-specific CD8 + T cell populations

Kedzierska, K., Ventur, V., Valkenburg, S. A., Davenport, M. P., Turner, S. J. & Doherty, P. C., 2008, In : Journal of Immunology. 180, 12, p. 7938-7947 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Method for assessing the similarity between subsets of the T cell receptor repertoire

Venturi, V., Kedzierska, K., Tanaka, M. M., Turner, S. J., Doherty, P. C. & Davenport, M. P., 1 Jan 2008, In : Journal of Immunological Methods. 329, 1-2, p. 67-80 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield

Halasz, P., Holloway, G., Turner, S. J. & Coulson, B. S., 1 Jan 2008, In : Journal of Virology. 82, 1, p. 148-160 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination

Miller, A., Center, R. J., Stambas, J., Deliyannis, G., Doherty, P. C., Howard, J. L., Turner, S. J. & Purcell, D. F. J., 16 Oct 2008, In : Vaccine. 26, 44, p. 5641-5648 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8 + TCR repertoires and facilitates optimal CTL responses

Kedzierska, K., Thomas, P. G., Venturi, V., Davenport, M. P., Doherty, P. C., Turner, S. J. & La Gruta, N. L., 15 Aug 2008, In : Journal of Immunology. 181, 4, p. 2556-2562 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Kedzierska, K., La Gruta, N. L., Stambas, J., Turner, S. J. & Doherty, P. C., 1 Feb 2008, In : Molecular Immunology. 45, 3, p. 607-618 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8 + T cells

Stambas, J., Doherty, P. C. & Turner, S. J., 1 Feb 2007, In : Journal of Immunology. 178, 3, p. 1285-1292 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance

Mintern, J. D., Guillonneau, C., Carbone, F. R., Doherty, P. C. & Turner, S. J., 1 Dec 2007, In : Journal of Immunology. 179, 11, p. 7220-7224 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Disregulated influenza A virus-specific CD8 + T cell homeostasis in the absence of IFN-γ signaling

Turner, S. J., Olivas, E., Gutierrez, A., Diaz, G. & Doherty, P. C., 15 Jun 2007, In : Journal of Immunology. 178, 12, p. 7616-7622 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL

Jenkins, M. R., Kedzierska, K., Doherty, P. C. & Turner, S. J., 1 Jul 2007, In : Journal of Immunology. 179, 1, p. 64-70 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8 + T cells

Denton, A. E., Doherty, P. C., Turner, S. J. & La Gruta, N. L., 1 Feb 2007, In : European Journal of Immunology. 37, 2, p. 368-375 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8 + T cell memory

Kedzierska, K., Stambas, J., Jenkins, M. R., Keating, R., Turner, S. J. & Doherty, P. C., 5 Jun 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 23, p. 9782-9787 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Methods for comparing the diversity of samples of the T cell receptor repertoire

Venturi, V., Kedzierska, K., Turner, S. J., Doherty, P. C. & Davenport, M. P., 10 Apr 2007, In : Journal of Immunological Methods. 321, 1-2, p. 182-195 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8 + T cells with regime-dependent cytokine/granzyme B profiles

Ranasinghe, C., Turner, S. J., McArthur, C., Sutherland, D. B., Kim, J. H., Doherty, P. C. & Ramshaw, I. A., 15 Feb 2007, In : Journal of Immunology. 178, 4, p. 2370-2379 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The context of epitope presentation can influence functional quality of recalled influenza A virus-specific memory CD8 + T cells

Day, E. B., Zeng, W., Doherty, P. C., Jackson, D. C., Kedzierska, K. & Turner, S. J., 15 Aug 2007, In : Journal of Immunology. 179, 4, p. 2187-2194 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2006

A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8 + T cell responses

La Gruta, N. L., Doherty, P. C. & Turner, S. J., 1 Nov 2006, In : European Journal of Immunology. 36, 11, p. 2951-2959 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Addition of a prominent epitope affects influenza A virus-specific CD8 + T cell immunodominance hierarchies when antigen is limiting

Jenkins, M. R., Webby, R., Doherty, P. C. & Turner, S. J., 1 Sep 2006, In : Journal of Immunology. 177, 5, p. 2917-2925 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A virus-specific CD8 + T cell immunodominance hierarchy determined by antigen dose and precursor frequencies

La Gruta, N. L., Kedzierska, K., Pang, K. C., Webby, R., Davenport, M., Chen, W., Turner, S. J. & Doherty, P. C., 24 Jan 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 4, p. 994-999 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

Waterhouse, N. J., Sutton, V. R., Sedelies, K. A., Ciccone, A., Jenkins, M., Turner, S. J., Bird, P. I. & Trapani, J. A., 2006, In : Journal of Cell Biology. 173, 1, p. 133 - 144 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Early establishment of diverse T cell receptor profiles for influenza-specific CD8 + CD62L hi memory T cells

Kedzierska, K., Venturi, V., Field, K., Davenport, M. P., Turner, S. J. & Doherty, P. C., 13 Jun 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 24, p. 9184-9189 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Immunoproteasome subunit deficiencies impact differentially on two immunodominant influenza virus-specific CD8 + T cell responses

Pang, K. C., Sanders, M. T., Monaco, J. J., Doherty, P. C., Turner, S. J. & Chen, W., 1 Dec 2006, In : Journal of Immunology. 177, 11, p. 7680-7688 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Intranasal lipopeptide primes lung-resident memory CD8 + T cells for long-term pulmonary protection against influenza

Deliyannis, G., Kedzierska, K., Lau, Y. F., Zeng, W., Turner, S. J., Jackson, D. C. & Brown, L. E., 1 Mar 2006, In : European Journal of Immunology. 36, 3, p. 770-778 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage

Kedzierska, K., Day, E. B., Pi, J., Heard, S. B., Doherty, P. C., Turner, S. J. & Perlman, S., 15 Nov 2006, In : Journal of Immunology. 177, 10, p. 6705-6712 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination

Venturi, V., Kedzierska, K., Price, D. A., Doherty, P. C., Douek, D. C., Turner, S. J. & Davenport, M. P., 5 Dec 2006, In : Proceedings of the National Academy of Sciences of the United States of America. 103, 49, p. 18691-18696 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural determinants of T-cell receptor bias in immunity

Turner, S. J., Doherty, P., McCluskey, J. & Rossjohn, J., 2006, In : Nature Reviews Immunology. 6, 12, p. 883 - 894 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Contribution of T cell receptor affinity to overall avidity for virus-specific CD8 + T cell responses

Kedzierska, K., La Gruta, N. L., Davenport, M. P., Turner, S. J. & Doherty, P. C., 9 Aug 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 32, p. 11432-11437 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells

Pellicci, D. G., Hammond, K. J. L., Coquet, J., Kyparissoudis, K., Brooks, A. G., Kedzierska, K., Keating, R., Turner, S., Berzins, S., Smyth, M. J. & Godfrey, D. I., 1 Oct 2005, In : Journal of Immunology. 175, 7, p. 4416-4425 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Effector CD8 + T cell recovered from an influenza pneumonia to differentiate to a state of focused gene expression

Marshall, D. R., Olivas, E., Andreansky, S., La Gruta, N. L., Neale, G. A., Gutierrez, A., Wichlan, D. G., Wingo, S., Cheng, C., Doherty, P. C. & Turner, S. J., 26 Apr 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 17, p. 6074-6079 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

WASP - mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG

Andreansky, S., Liu, H., Turner, S., McCullers, J. A., Lang, R., Rutschman, R., Doherty, P. C., Murray, P. J., Nienhuis, A. W. & Strom, T. S., 1 Jan 2005, In : Experimental Hematology. 33, 4, p. 443-451 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Absence of an Essential Role for Thymic Stromal Lymphopoietin Receptor in Murine B-Cell Development

Carpino, N., Thierfelder, W. E., Chang, M. S., Saris, C., Turner, S. J., Ziegler, S. F. & Ihle, J. N., 1 Mar 2004, In : Molecular and Cellular Biology. 24, 6, p. 2584-2592 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access