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Research Output 1993 2019

2011

A semi-invariant V{alpha}10{+} T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Uldrich, A., Patel, O., Cameron, G., Pellicci, D., Day, E. B., Sullivan, L., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J., Cao, B., Brooks, A., Williams, S., Illarionov, P., Besra, G., Turner, S., Porcelli, S., McCluskey, J., Smyth, M., Rossjohn, J. & Godfrey, D., 2011, In : Nature Immunology. 12, 7, p. 616 - 623 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8 + T cells

Denton, A. E., Russ, B. E., Doherty, P. C., Rao, S. & Turner, S. J., 13 Sep 2011, In : Proceedings of the National Academy of Sciences. 108, 37, p. 15306-15311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Effect of MHC class I diversification on influenza epitope-specific CD8+ T cell precursor frequency and subsequent effector function

Day, E. B., Charlton, K. L., La Gruta, N. L., Doherty, P. C. & Turner, S. J., 1 Jun 2011, In : Journal of Immunology. 186, 11, p. 6319-6328 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Memory precursor phenotype of CD8+ T cells reflects early antigenic experience rather than memory numbers in a model of localized acute influenza infection

Croom, H. A., Denton, A. E., Valkenburg, S. A., Swan, N. G., Olson, M. R., Turner, S. J., Doherty, P. C. & Kedzierska, K., Mar 2011, In : European Journal of Immunology. 41, 3, p. 682-693 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Shaping the T-cell repertoire in the periphery

Allen, S., Turner, S. J., Bourges, D., Gleeson, P. A. & Van Driel, I. R., Jan 2011, In : Immunology and Cell Biology. 89, 1, p. 60-69 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Soluble proteins induce strong CD8 + T cell and antibody responses through electrostatic association with simple cationic or anionic lipopeptides that target TLR2

Chua, B. Y., Pejoski, D., Turner, S. J., Zeng, W. & Jackson, D. C., 15 Aug 2011, In : Journal of Immunology. 187, 4, p. 1692-1701 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Day, E. B., Guillonneau, C., Gras, S., La Gruta, N. L., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J. & Turner, S., 2011, In : Proceedings of the National Academy of Sciences. 108, 23, p. 9536 - 9541 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The immune response to influenza a viruses

Mintern, J. D., Guillonneau, C., Turner, S. J. & Doherty, P. C., 2011, Influenza Vaccines for the Future. Rappuoli, R. & Del Giudice, G. (eds.). 2nd ed. Basel Switzerland: Springer, p. 173-197 25 p. (Birkhauser Advances in Infectious Diseases).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

The linear range for accurately quantifying antigen-specific T-cell frequencies by tetramer staining during natural immune responses

Seah, S. G. K., Sutherland, R. M., La Gruta, N. L., Brown, L. E., Carrington, E. M., Belz, G. T., Brady, J. L., Turner, S. J., Zhan, Y. & Lew, A. M., May 2011, In : European Journal of Immunology. 41, 5, p. 1499-1500 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2010

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses

Gras, S., Kedzierski, L., Valkenburg, S. A., Laurie, K. L., Liu, Y. C., Denholm, J. T., Richards, M. J., Rimmelzwaan, G. F., Kelso, A., Doherty, P. C., Turner, S. J., Rossjohn, J. & Kedzierska, K., 2010, In : Proceedings of the National Academy of Sciences. 107, 28, p. 12599 - 12604 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Fixing an irrelevant TCRα chain reveals the importance of TCRβ diversity for optimal TCRαβ pairing and function of virus-specific CD8+ T cells

Valkenburg, S. A., Day, E. B., Swan, N. G., Croom, H. A., Carbone, F. R., Doherty, P. C., Turner, S. J. & Kedzierska, K., Sep 2010, In : European Journal of Immunology. 40, 9, p. 2470-2481 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Forewarned is forearmed

La Gruta, N. & Turner, S. J., Jul 2010, In : Immunity. 33, 1, p. 5-6 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Influenza a virus-specific CD8+ T-cell responses: From induction to function

Olson, M. R., Russ, B. E., Doherty, P. C., Turner, S. J. & Stambas, J., Mar 2010, In : Future Virology. 5, 2, p. 175-183 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Influenza epitope-specific CD8+ T cell avidity, but not cytokine polyfunctionality, can be determined by tcrβ clonotype

Moffat, J. M., Handel, A., Doherty, P. C., Turner, S. J., Thomas, P. G. & La Gruta, N. L., 1 Dec 2010, In : Journal of Immunology. 185, 11, p. 6850-6856 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression (Journal of Immunology (2009) 183, (7063-7072))

Juelich, T., Sutcliffe, E. L., Denton, A. E., He, Y., Doherty, P. C., Parish, C. R., Turner, S. J., Tremethick, D. J. & Rao, S., 1 Feb 2010, In : Journal of Immunology. 184, 3, p. 1653 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Multiplexed combinatorial tetramer staining in a mouse model of virus infection

Cukalac, T., Valkenburg, S. A., La Gruta, N. L., Turner, S. J., Doherty, P. C. & Kedzierska, K., Aug 2010, In : Journal of Immunological Methods. 360, 1-2, p. 157-161 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Primary CTL response magnitude in mice is determined by the extent of naive T cell recruitment and subsequent clonal expansion

La Gruta, N. L., Rothwell, W. T., Cukalac, T., Swan, N. G., Valkenburg, S. A., Kedzierska, K., Thomas, P. G., Doherty, P. C. & Turner, S. J., 1 Jun 2010, In : Journal of Clinical Investigation. 120, 6, p. 1885-1894 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Q&A: H1N1 pandemic influenza - what's new?

Turner, S. J., Doherty, P. C. & Kelso, A., 11 Oct 2010, In : BMC Biology. 8, 130.

Research output: Contribution to journalComment / DebateOtherpeer-review

The role of epigenetics in the acquisition and maintenance of effector function in virus-specific CD8 T cells

Olson, M. R., Russ, B. E., Doherty, P. C. & Turner, S. J., 2010, In : IUBMB Life. 62, 7, p. 519-526 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2009

Chimeric virus-like particles for the delivery of an inserted conserved influenza A-specific CTL epitope

Cheong, W. S., Reiseger, J. J., Turner, S. J., Boyd, R. L. & Netter, H. J., 2009, In : Antiviral Research. 81, p. 113 - 122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity

Guillonneau, C., Mintern, J. D., Hubert, F. X., Hurt, A. C., Besra, G. S., Porcelli, S. A., Barr, I. G., Doherty, P. C., Godfrey, D. I. & Turner, S. J., 3 Mar 2009, In : Proceedings of the National Academy of Sciences. 106, 9, p. 3330-3335 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Division-linked differentiation can account for CD8+ T-cell phenotype in vivo

Schlub, T. E., Venturi, V., Kedzierska, K., Wellard, C., Doherty, P. C., Turner, S. J., Ribeiro, R. M., Hodgkin, P. D. & Davenport, M. P., 2009, In : European Journal of Immunology. 39, 1, p. 67-77 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of recombinant influenza virus-simian immunodeficiency virus vaccines in macaques

Sexton, A., De Rose, R., Reece, J. C., Alcantara, S., Loh, L., Moffat, J. M., Laurie, K., Hurt, A., Doherty, P. C., Turner, S. J., Kent, S. J. & Stambas, J., Aug 2009, In : Journal of Virology. 83, 15, p. 7619-7628 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional implications of T cell receptor diversity

Turner, S. J., La Gruta, N. L., Kedzierska, K., Thomas, P. G. & Doherty, P. C., Jun 2009, In : Current Opinion in Immunology. 21, 3, p. 286-290 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Granzyme a expression reveals distinct cytolytic CTL subsets following influenza A virus infection

Moffat, J. M., Gebhardt, T., Doherty, P. C., Turner, S. J. & Mintern, J. D., May 2009, In : European Journal of Immunology. 39, 5, p. 1203-1210 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay between chromatin remodeling and epigenetic changes during lineage-specific commitment to granzyme B expression

Juelich, T., Sutcliffe, E. L., Denton, A. E., He, Y., Doherty, P. C., Parish, C. R., Turner, S. J., Tremethick, D. & Rao, S., 1 Dec 2009, In : Journal of Immunology. 183, 11, p. 7063-7072 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Narrowed TCR diversity for immunised mice challenged with recombinant influenza A-HIV Env311-320 virus

Cukalac, T., Moffat, J. M., Venturi, V., Davenport, M. P., Doherty, P. C., Turner, S. J. & Stambas, J., 12 Nov 2009, In : Vaccine. 27, 48, p. 6755-6761 7 p.

Research output: Contribution to journalArticleResearchpeer-review

P19-24. Evaluation of recombinant influenza-SIV vaccines in macaques

Stambas, J., Sexton, A., De Rose, R., Reece, J. C., Alcantara, S., Loh, L., Moffat, J. M., Laurie, K., Hurt, A., Doherty, P. C., Turner, S. J. & Kent, S. J., 22 Oct 2009, In : Retrovirology. 6, SUPPL. 3, 1742.

Research output: Contribution to journalComment / DebateOtherpeer-review

Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?

Turner, S. J., Brown, L. E., Doherty, P. C. & Kelso, A., 2009, In : Journal of Cell Biology. 8, 8, 69.

Research output: Contribution to journalComment / DebateOtherpeer-review

Q & A: What do we know about influenza and what can we do about it?

Doherty, P. C. & Turner, S. J., 2009, In : Journal of Cell Biology. 8, 5, 46.

Research output: Contribution to journalComment / DebateOtherpeer-review

Role of CD8+ T-cell immunity in influenza infection: Potential use in future vaccine development

La Gruta, N., Kelso, A., Brown, L. E., Chen, W., Jackson, D. C. & Turner, S. J., 2009, In : Expert Review of Respiratory Medicine. 3, 5, p. 523-537 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Thinking about broadly cross-reactive vaccines

Doherty, P. C. & Turner, S. J., Jun 2009, In : Clinical Pharmacology and Therapeutics. 85, 6, p. 665-668 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Transience of MHC Class I-restricted antigen presentation after influenza A virus infection

Mintern, J. D., Bedoui, S., Davey, G. M., Moffat, J. M., Doherty, P. C. & Turner, S. J., 21 Apr 2009, In : Proceedings of the National Academy of Sciences. 106, 16, p. 6724-6729 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing

Jenkins, M. R., La Gruta, N. L., Doherty, P. C., Trapani, J. A., Turner, S. J. & Waterhouse, N. J., 2009, In : Cell Death and Differentiation. 16, 4, p. 537-542 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Anti-SIV cytolytic molecules in pigtail macaques

Rollman, E., Turner, S. J., Kedzierska, K. & Kent, S. J., 1 Aug 2008, In : AIDS Research and Human Retroviruses. 24, 8, p. 1127-1131 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8 + T cells

Jenkins, M. R., Mintern, J., La Gruta, N. L., Kedzierska, K., Doherty, P. C. & Turner, S. J., 15 Sep 2008, In : Journal of Immunology. 181, 6, p. 3818-3822 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Cigarette smoke worsens lung inflammation and impairs resolution of influenza infection in mice

Gualano, R. C., Hansen, M. J., Vlahos, R., Jones, J., Park-Jones, R. A., Deliyannis, G., Turner, S. J., Duca, K. A. & Anderson, G., 2008, In : Respiratory Research. 9, aRT. id: 53, p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice

Jenkins, M. R., Trapani, J. A., Doherty, P. C. & Turner, S. J., 1 Sep 2008, In : Viral Immunology. 21, 3, p. 341-346 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Homogenization of TCR repertoires within secondary CD62L high and CD62L low virus-specific CD8 + T cell populations

Kedzierska, K., Ventur, V., Valkenburg, S. A., Davenport, M. P., Turner, S. J. & Doherty, P. C., 2008, In : Journal of Immunology. 180, 12, p. 7938-7947 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Method for assessing the similarity between subsets of the T cell receptor repertoire

Venturi, V., Kedzierska, K., Tanaka, M. M., Turner, S. J., Doherty, P. C. & Davenport, M. P., 1 Jan 2008, In : Journal of Immunological Methods. 329, 1-2, p. 67-80 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Rotavirus replication in intestinal cells differentially regulates integrin expression by a phosphatidylinositol 3-kinase-dependent pathway, resulting in increased cell adhesion and virus yield

Halasz, P., Holloway, G., Turner, S. J. & Coulson, B. S., 1 Jan 2008, In : Journal of Virology. 82, 1, p. 148-160 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination

Miller, A., Center, R. J., Stambas, J., Deliyannis, G., Doherty, P. C., Howard, J. L., Turner, S. J. & Purcell, D. F. J., 16 Oct 2008, In : Vaccine. 26, 44, p. 5641-5648 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8 + TCR repertoires and facilitates optimal CTL responses

Kedzierska, K., Thomas, P. G., Venturi, V., Davenport, M. P., Doherty, P. C., Turner, S. J. & La Gruta, N. L., 15 Aug 2008, In : Journal of Immunology. 181, 4, p. 2556-2562 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity

Kedzierska, K., La Gruta, N. L., Stambas, J., Turner, S. J. & Doherty, P. C., 1 Feb 2008, In : Molecular Immunology. 45, 3, p. 607-618 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8 + T cells

Stambas, J., Doherty, P. C. & Turner, S. J., 1 Feb 2007, In : Journal of Immunology. 178, 3, p. 1285-1292 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance

Mintern, J. D., Guillonneau, C., Carbone, F. R., Doherty, P. C. & Turner, S. J., 1 Dec 2007, In : Journal of Immunology. 179, 11, p. 7220-7224 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access