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Research Output 1993 2019

2019

CD4 + T help promotes influenza virus-specific CD8 + T cell memory by limiting metabolic dysfunction

Cullen, J. G., McQuilten, H. A., Quinn, K. M., Olshansky, M., Russ, B. E., Morey, A., Wei, S., Prier, J. E., La Gruta, N. L., Doherty, P. C. & Turner, S. J., 5 Mar 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 10, p. 4481-4488 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Divergent SATB1 expression across human life span and tissue compartments

Nüssing, S., Koay, H. F., Sant, S., Loudovaris, T., Mannering, S. I., Lappas, M., d′Udekem, Y., Konstantinov, I. E., Berzins, S. P., Rimmelzwaan, G. F., Turner, S. J., Clemens, E. B., Godfrey, D. I., Nguyen, T. H. O. & Kedzierska, K., May 2019, In : Immunology and Cell Biology. 97, 5, p. 498-511 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Unique transcriptional architecture in airway epithelial cells and macrophages shapes distinct responses following influenza virus infection Ex vivo

Ma, J. Z., Ng, W. C., Zappia, L., Gearing, L. J., Olshansky, M., Pham, K., Cheong, K., Hsu, A., Turner, S. J., Wijburg, O., Londrigan, S. L., Brooks, A. G. & Reading, P. C., 1 Mar 2019, In : Journal of Virology. 93, 6, 22 p., e01986-18.

Research output: Contribution to journalArticleResearchpeer-review

2018

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L., 19 Jun 2018, In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Wang, Z., Zhu, L., Nguyen, T. H. O., Wan, Y., Sant, S., Quiñones-Parra, S. M., Crawford, J. C., Eltahla, A. A., Rizzetto, S., Bull, R. A., Qiu, C., Koutsakos, M., Clemens, E. B., Loh, L., Chen, T., Liu, L., Cao, P., Ren, Y., Kedzierski, L., Kotsimbos, T. & 10 othersMcCaw, J. M., La Gruta, N. L., Turner, S. J., Cheng, A. C., Luciani, F., Zhang, X., Doherty, P. C., Thomas, P. G., Xu, J. & Kedzierska, K., 26 Feb 2018, In : Nature Communications. 9, 1, 12 p., 824.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article

Achuthan, A., Aslam, A. S. M., Nguyen, Q., Lam, P-Y., Fleetwood, A. J., Frye, A. T., Louis, C., Lee, M-C., Smith, J. E., Cook, A. D., Olshansky, M., Turner, S. J. & Hamilton, J. A., 15 Feb 2018, In : Cell Death and Disease. 9, 3, 13 p., 267.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment

Harland, K. L., Fox, A., Nüssing, S., Hensen, L., Kedzierska, K., Turner, S. J. & Kelso, A., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3282-3293 12 p.

Research output: Contribution to journalArticleResearchpeer-review

T Cell LEGO: Identifying the Master Builders and What They Do

Li, J. & Turner, S. J., 20 Feb 2018, In : Immunity. 48, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

2017

Augmenting Influenza-Specific T Cell Memory Generation with a Natural Killer T Cell-Dependent Glycolipid-Peptide Vaccine

Anderson, R. J., Li, J., Kedzierski, L., Compton, B. J., Hayman, C. M., Osmond, T. L., Tang, C. W., Farrand, K. J., Koay, H. F., Almeida, C. F. D. S. S. E., Holz, L. R., Williams, G. M., Brimble, M. A., Wang, Z., Koutsakos, M., Kedzierska, K., Godfrey, D. I., Hermans, I. F., Turner, S. J. & Painter, G. F., 17 Nov 2017, In : ACS Chemical Biology. 12, 11, p. 2898-2905 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Extrinsically derived TNF is primarily responsible for limiting antiviral CD8+ T cell response magnitude

Quinn, K. M., Kan, W-T., Watson, K. A., Liddicoat, B. J., Swan, N. G., McQuilten, H., Denton, A. E., Li, J., Chen, W., Brown, L. E., Jackson, D. C., Reading, P. C., Doherty, P. C., Kedzierska, K., Kedzierski, L., Turner, S. J. & La Gruta, N. L., 8 Sep 2017, In : PLoS ONE. 12, 9, 13 p., e0184732.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Priming of transcriptional memory responses via the chromatin accessibility landscape in T cells

Tu, W. J., Hardy, K., Sutton, C. R., McCuaig, R., Li, J., Dunn, J., Tan, A., Brezar, V., Morris, M., Denyer, G., Lee, S. K., Turner, S. J., Seddiki, N., Smith, C., Khanna, R. & Rao, S., 20 Mar 2017, In : Scientific Reports. 7, 20 p., 44825.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., Purcell, D. F. J., Hertzog, P. J., Rao, S. & Turner, S. J., 19 Dec 2017, In : Cell Reports. 21, 12, p. 3624-3636 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Can T cells be too exhausted to fight back?

Turner, S. J. & Russ, B. E., 2 Dec 2016, In : Science. 354, 6316, p. 1104-1105 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Competition within the virus-specific CD4 T-cell pool limits the T follicular helper response after influenza infection

Olson, M. R., Chua, B. Y., Good-Jacobson, K. L., Doherty, P. C., Jackson, D. C. & Turner, S. J., 19 Jul 2016, In : Immunology and Cell Biology. 94, p. 729–740 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8+ T cells

Nguyen, M. L. T., Hatton, L., Li, J., Olshansky, M., Kelso, A., Russ, B. E. & Turner, S. J., 1 Feb 2016, In : European Journal of Immunology. 46, 2, p. 307-318 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation

Achuthan, A., Cook, A. D., Lee, M. C., Saleh, R., Khiew, H. W., Chang, M. W. N., Louis, C., Fleetwood, A. J., Lacey, D. C., Christensen, A. D., Frye, A. T., Lam, P. Y., Kusano, H., Nomura, K., Steiner, N., Förster, I., Nutt, S. L., Olshansky, M., Turner, S. J. & Hamilton, J. A., 1 Sep 2016, In : Journal of Clinical Investigation. 126, 9, p. 3453-3466 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nuclear PKC-θ facilitates rapid transcriptional responses in human memory CD4+T cells through p65 and H2B phosphorylation

Li, J., Hardy, K., Phetsouphanh, C., Tu, W. J., Sutcliffe, E. L., McCuaig, R., Sutton, C. R., Zafar, A., Mee Ling Munier, C., Zaunders, J., Xu, Y., Theodoratos, A., Tan, A., SiewLim, P., Knaute, T., Masch, A., Zerweck, J., Brezar, V., Milburn, P. J., Dunn, J. & 5 othersCasarotto, M. G., Turner, S. J., Seddiki, N., Kelleher, A. D. & Rao, S., 15 Jun 2016, In : Journal of Cell Science. 129, 12, p. 2448-2461 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming

Greyer, M., Whitney, P. G., Stock, A. T., Davey, G. M., Tebartz, C., Bachem, A., Mintern, J. D., Strugnell, R. A., Turner, S. J., Gebhardt, T., O'Keeffe, M., Heath, W. R. & Bedoui, S., 26 Jan 2016, In : Cell Reports. 14, 3, p. 586-597 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Epitope-specific CD4+, but not CD8+, T-cell responses induced by recombinant influenza A viruses protect against Mycobacterium tuberculosis infection

Flórido, M., Pillay, R., Gillis, C. M., Xia, Y., Turner, S. J., Triccas, J. A., Stambas, J. & Britton, W. J., 1 Mar 2015, In : European Journal of Immunology. 45, 3, p. 780-793 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Fixed expression of single influenza virus-specific TCR chains demonstrates the capacity for TCR α- and β-chain diversity in the face of peptide-MHC class I specificity

Clemens, E. B., Doherty, P. C., La Gruta, N. L. & Turner, S. J., 1 Feb 2015, In : Journal of Immunology. 194, 3, p. 898-910 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Inactivated influenza vaccine that provides rapid, innate-immune- system-mediated protection and subsequent long-term adaptive immunity

Chua, B. Y., Wong, C. Y., Mifsud, E. J., Edenborough, K. M., Sekiya, T., Tan, A. C. L., Mercuri, F., Rockman, S., Chen, W., Turner, S. J., Doherty, P. C., Kelso, A., Brown, L. E. & Jackson, D. C., 27 Oct 2015, In : mBio. 6, 6, 11 p., e01024-15.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oseltamivir prophylaxis reduces inflammation and facilitates establishment of cross-strain protective T cell memory to influenza viruses

Bird, N. L., Olson, M. R., Hurt, A. C., Oshansky, C. M., Oh, D. Y., Reading, P. C., Chua, B. Y., Sun, Y., Tang, L. Y., Handel, A., Jackson, D. C., Turner, S. J., Thomas, P. G. & Kedzierska, K., 18 Jun 2015, In : PLoS ONE. 10, 6, 21 p., e0129768.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T cell antigen receptor recognition of antigen-presenting molecules

Rossjohn, J., Gras, S., Miles, J. J., Turner, S. J., Godfrey, D. I. & McCluskey, J., 2015, In : Annual Review of Immunology. 33, p. 169 - 200 32 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses

Olson, M. R., Seah, S. G. K., Edenborough, K. M., Doherty, P. C., Lew, A. M. & Turner, S. J., Aug 2014, In : Immunology and Cell Biology. 92, 7, p. 605-611 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8+ T cell differentiation

Russ, B. E., Olshanksy, M., Smallwood, H. S., Li, J., Denton, A. E., Prier, J. E., Stock, A. T., Croom, H. A., Cullen, J. G., Nguyen, M. L. T., Rowe, S., Olson, M. R., Finkelstein, D. B., Kelso, A., Thomas, P. G., Speed, T. P., Rao, S. & Turner, S. J., 20 Nov 2014, In : Immunity. 41, 5, p. 853-865 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8+ T cell differentiation

Russ, B. E., Olshanksy, M., Smallwood, H. S., Li, J., Denton, A. E., Prier, J. E., Stock, A. T., Croom, H. A., Cullen, J. G., Nguyen, M. L. T., Rowe, S., Olson, M. R., Finkelstein, D. B., Kelso, A., Thomas, P. G., Speed, T. P., Rao, S. & Turner, S. J., 1 Jan 2014, In : Immunity. 41, 6, p. 1064-1064 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Epigenetic plasticity of Cd8a locus during CD8 + T-cell development and effector differentiation and reprogramming

Harland, K. L., Day, E. B., Apte, S. H., Russ, B. E., Doherty, P. C., Turner, S. J. & Kelso, A., 28 Mar 2014, In : Nature Communications. 5, 13 p., 3547.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Granzyme B promotes cytotoxic lymphocyte transmigration via basement membrane remodeling

Prakash, M. D., Munoz, M., Jain, R., Tong, P. L., Koskinen, A. M. L., Regner, M., Kleifeld, O., Ho, B. K-C., Olson, M. R., Turner, S. J., Mrass, P., Weninger, W. & Bird, P. I., 2014, In : Immunity. 41, 6, p. 960 - 972 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Helping themselves: Optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells

Olson, M. R., Seah, S. G. K., Cullen, J. G., Greyer, M., Edenborough, K. M., Doherty, P. C., Bedoui, S., Lew, A. M. & Turner, S. J., 1 Dec 2014, In : Journal of Immunology. 193, 11, p. 5420-5433 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Reproducible selection of high avidity CD8+ T-cell clones following secondary acute virus infection

Cukalac, T., Chadderton, J., Handel, A., Doherty, P. C., Turner, S. J., Thomas, P. G. & La Gruta, N. L., 28 Jan 2014, In : Proceedings of the National Academy of Sciences. 111, 4, p. 1485-1490 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T cell mediated immunity to influenza: Mechanisms of viral control

La Gruta, N. L. & Turner, S. J., Aug 2014, In : Trends in Immunology. 35, 8, p. 396-402 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The influenza virus-specific CTL immunodominance hierarchy in mice is determined by the relative frequency of high-avidity T cells

Cukalac, T., Chadderton, J., Zeng, W., Cullen, J. G., Kan, W. T., Doherty, P. C., Jackson, D. C., Turner, S. J. & La Gruta, N. L., 1 May 2014, In : Journal of Immunology. 192, 9, p. 4061-4068 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The use of a TLR2 agonist-based adjuvant for enhancing effector and memory CD8 T-cell responses

Chua, B. Y., Olson, M. R., Bedoui, S., Sekiya, T., Wong, C. Y., Turner, S. J. & Jackson, D. C., Apr 2014, In : Immunology and Cell Biology. 92, 4, p. 377-383 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides

Valkenburg, S. A., Quinones-Parra, S., Gras, S., Komadina, N., McVernon, J., Wang, Z. F., Abd Halim, N. H., Iannello, P., Cole, C., Laurie, K. L., Kelso, A., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2013, In : Nature Communications. 4, 10 p., 3663.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Influenza A virus infection impairs mycobacteria-specific T cell responses and mycobacterial clearance in the lung during pulmonary coinfection

Flórido, M., Grima, M. A., Gillis, C. M., Xia, Y., Turner, S. J., Triccas, J. A., Stambas, J. & Britto, W. J., 1 Jul 2013, In : Journal of Immunology. 191, 1, p. 302-311 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response

Seah, S. G. K., Brady, J. L., Carrington, E. M., Ng, W. C., Sutherland, R. M., Hancock, M. S., La Gruta, N. L., Brown, L. E., Turner, S. J., Lew, A. M. & Zhan, Y., Jan 2013, In : Journal of leukocyte biology. 93, 1, p. 145-154 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Predisposed αβ T cell antigen receptor recognition of MHC and MHC-I like molecules?

Eckle, S. BG., Turner, S. J., Rossjohn, J. & McCluskey, J., Oct 2013, In : Current Opinion in Immunology. 25, 5, p. 653-659 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Preemptive priming readily overcomes structure-based mechanisms of virus escape

Valkenburg, S. A., Gras, S., Guillonneau, C., Hatten, L. A., Bird, N. L., Twist, K-A., Abd Halim, N. H., Jackson, D. C., Purcell, A. W., Turner, S. J., Doherty, P. C., Rossjohn, J. & Kedzierska, K., 2013, In : Proceedings of the National Academy of Sciences. 110, 14, p. 5570 - 5575 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

T cell immunity as a tool for studying epigenetic regulation of cellular differentiation

Russ, B. E., Prier, J. E., Rao, S. & Turner, S. J., 2013, In : Frontiers in Genetics. 4, NOV, Article 218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Takiguchi, M., Dow, L. E., Prier, J. E., Carmichael, C., Kile, B., Turner, S. J., Lowe, S. W., Huang, D. C. S. & Dickins, R. A., Jan 2013, In : PLoS ONE. 8, 1, 10 p., e54009.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2012

A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned

Gras, S., Burrows, S. R., Turner, S. J., Sewell, A. K., McCluskey, J. & Rossjohn, J., 2012, In : Immunological Reviews. 250, 1, p. 61 - 81 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Defining the molecular blueprint that drives CD8+T cell differentiation in response to infection

Russ, B. E., Denton, A. E., Hatton, L. A., Croom, H. A., Olson, M. R. & Turner, S. J., 2012, In : Frontiers in Immunology. 3, DEC, Article 371.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access

Early priming minimizes the age-related immune compromise of CD8+ T cell diversity and function

Valkenburg, S. A., Venturi, V., Dang, T. H. Y., Bird, N. L., Doherty, P. C., Turner, S. J., Davenport, M. P. & Kedzierska, K., Feb 2012, In : PLoS Pathogens. 8, 2, e1002544.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Electrostatic-mediated enhancement of protein antigen immunogenicity using charged TLR2-targeting lipopeptides

Chua, B. Y., Pejoski, D., Turner, S. J., Zeng, W. & Jackson, D. C., 2012, In : Procedia in Vaccinology. 6, p. 80-84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of sex steroid ablation on viral, tumour and vaccine responses in aged mice

Heng, T. SP., Reiseger, J. J., Fletcher, A. L., Leggatt, G. R., White, O. J., Vlahos, K., Frazer, I. H., Turner, S. J. & Boyd, R. L., 2012, In : PLoS ONE. 7, 8, 11 p., e42677.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity

Seah, S. G. K., Carrington, E. M., Ng, W. C., Belz, G. T., Brady, J. L., Sutherland, R. M., Hancock, M. S., La Gruta, N. L., Brown, L. E., Turner, S. J., Zhan, Y. & Lew, A. M., Jul 2012, In : European Journal of Immunology. 42, 7, p. 1744-1754 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Affinity thresholds for naive CD8+ CTL activation by peptides and engineered influenza A viruses

Denton, A., Wesselingh, R., Gras, S., Guillonneau, C., Olson, M. R., Mintern, J. D., Zeng, W., Jackson, D. C., Rossjohn, J., Hodgkin, P. D., Doherty, P. C. & Turner, S. J., 2011, In : Journal of Immunology. 187, 11, p. 5733-5744 12 p.

Research output: Contribution to journalArticleResearchpeer-review

alphabeta T cell receptors come out swinging

Turner, S. & Rossjohn, J., 2011, In : Immunity. 35, 5, p. 660 - 662 3 p.

Research output: Contribution to journalLetterOther

A semi-invariant V{alpha}10{+} T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

Uldrich, A., Patel, O., Cameron, G., Pellicci, D., Day, E. B., Sullivan, L., Kyparissoudis, K., Kjer-Nielsen, L., Vivian, J., Cao, B., Brooks, A., Williams, S., Illarionov, P., Besra, G., Turner, S., Porcelli, S., McCluskey, J., Smyth, M., Rossjohn, J. & Godfrey, D., 2011, In : Nature Immunology. 12, 7, p. 616 - 623 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Differentiation-dependent functional and epigenetic landscapes for cytokine genes in virus-specific CD8 + T cells

Denton, A. E., Russ, B. E., Doherty, P. C., Rao, S. & Turner, S. J., 13 Sep 2011, In : Proceedings of the National Academy of Sciences. 108, 37, p. 15306-15311 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access