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Personal profile

Biography

Prof Turner studies factors that regulate virus-specific T cell recruitment and differentiation after infection.  His lab utilizes a multidisplinary approach to examine how differences in T cell receptor recognition of peptide-MHC antigens impacts development and differentiation of virus-specific T cell responses. He is also interested in factors that shape the transcriptional and epigenetic signatures that define virus-specific T cell differentiation from the naive state into both the effector and memory populations. He utilizes a combination of ChIP-Seq, RNA-Seq, bioinformatics and systems biology, inducible shRNA knockdown, retroviral bone-marrow transduction, gene-deficient mouse models and 3C approaches for determining promoter-enhancer interactions. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.

Keywords

  • T-cell
  • Influenza
  • Viral Immunity
  • Systems Immunology
  • Epigenetics
  • Host-pathogen interaction
  • Adaptive Immunity
  • immunological memory

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Projects 2007 2023

Research Output 1997 2018

Age-Related Decline in Primary CD8+ T Cell Responses Is Associated with the Development of Senescence in Virtual Memory CD8+ T Cells

Quinn, K. M., Fox, A., Harland, K. L., Russ, B. E., Li, J., Nguyen, T. H. O., Loh, L., Olshanksy, M., Naeem, H., Tsyganov, K., Wiede, F., Webster, R., Blyth, C., Sng, X. Y. X., Tiganis, T., Powell, D., Doherty, P. C., Turner, S. J., Kedzierska, K. & La Gruta, N. L., 19 Jun 2018, In : Cell Reports. 23, 12, p. 3512-3524 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Clonally diverse CD38+HLA-DR+CD8+ T cells persist during fatal H7N9 disease

Wang, Z., Zhu, L., Nguyen, T. H. O., Wan, Y., Sant, S., Quiñones-Parra, S. M., Crawford, J. C., Eltahla, A. A., Rizzetto, S., Bull, R. A., Qiu, C., Koutsakos, M., Clemens, E. B., Loh, L., Chen, T., Liu, L., Cao, P., Ren, Y., Kedzierski, L., Kotsimbos, T. & 10 othersMcCaw, J. M., La Gruta, N. L., Turner, S. J., Cheng, A. C., Luciani, F., Zhang, X., Doherty, P. C., Thomas, P. G., Xu, J. & Kedzierska, K., 26 Feb 2018, In : Nature Communications. 9, 1, 12 p., 824.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article

Achuthan, A., Aslam, A. S. M., Nguyen, Q., Lam, P-Y., Fleetwood, A. J., Frye, A. T., Louis, C., Lee, M-C., Smith, J. E., Cook, A. D., Olshansky, M., Turner, S. J. & Hamilton, J. A., 15 Feb 2018, In : Cell Death and Disease. 9, 3, 13 p., 267.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Limited Phenotypic and Functional Plasticity of Influenza Virus-Specific Memory CD8+ T Cells during Activation in an Alternative Cytokine Environment

Harland, K. L., Fox, A., Nüssing, S., Hensen, L., Kedzierska, K., Turner, S. J. & Kelso, A., 1 Dec 2018, In : Journal of Immunology. 201, 11, p. 3282-3293 12 p.

Research output: Contribution to journalArticleResearchpeer-review

T Cell LEGO: Identifying the Master Builders and What They Do

Li, J. & Turner, S. J., 20 Feb 2018, In : Immunity. 48, 2, p. 185-187 3 p.

Research output: Contribution to journalEditorialOtherpeer-review