Projects per year
Personal profile
Biography
Prof Turner studies factors that regulate virus-specific T cell recruitment and differentiation after infection. His lab utilizes a multidisplinary approach to examine how differences in T cell receptor recognition of peptide-MHC antigens impacts development and differentiation of virus-specific T cell responses. He is also interested in factors that shape the transcriptional and epigenetic signatures that define virus-specific T cell differentiation from the naive state into both the effector and memory populations. He utilizes a combination of ChIP-Seq, RNA-Seq, bioinformatics and systems biology, inducible shRNA knockdown, retroviral bone-marrow transduction, gene-deficient mouse models and 3C approaches for determining promoter-enhancer interactions. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- T-cell
- Influenza
- Viral Immunity
- Systems Immunology
- Epigenetics
- Host-pathogen interaction
- Adaptive Immunity
- immunological memory
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Visualising chromatin changes in 3 dimensions: super to ultra resolution
Turner, S. (Primary Chief Investigator (PCI)), Bell, T. (Chief Investigator (CI)), Sauer, M. (Partner Investigator (PI)) & Zaph, C. (Chief Investigator (CI))
21/09/23 → 20/09/26
Project: Research
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PROPHECY: Profiling immune RespOnses in Paediatric and High risk populations to SARS-CoV-2
McMahon, J. (Primary Chief Investigator (PCI)), van Zelm, M. (Chief Investigator (CI)), Khoury, G. (Chief Investigator (CI)), Drummer, H. (Chief Investigator (CI)), Mulley, W. (Chief Investigator (CI)), Holland, A. (Chief Investigator (CI)), Woolley, I. (Chief Investigator (CI)), Ojaimi, S. (Chief Investigator (CI)), Rogers, B. (Chief Investigator (CI)), Hoi, A. (Chief Investigator (CI)), Trauer, J. (Chief Investigator (CI)), Sparrow, M. (Chief Investigator (CI)), Licciardi, P. V. (Chief Investigator (CI)), Giles, E. (Chief Investigator (CI)), Curtis, D. (Chief Investigator (CI)), Crawford, N. (Associate Investigator (AI)), Leech, M. (Associate Investigator (AI)), Westall, G. (Associate Investigator (AI)), O'Hehir, R. (Associate Investigator (AI)), Jones, A. (Associate Investigator (AI)), Morand, E. (Associate Investigator (AI)), Bosco, J. J. (Associate Investigator (AI)) & Turner, S. (Associate Investigator (AI))
Monash University, Alfred Health, Monash Health, Murdoch Children's Research Institute, Burnet Institute (Australia), Spleen Australia, National Association of People with HIV Australia (NAPWHA) Incorporated, Musculoskeletal Australia , Safer Care Victoria (SCV)
1/06/22 → 30/05/26
Project: Research
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Achieving benefit without harm: a next-generation glucocorticoid replacement
Jones, S. (Primary Chief Investigator (PCI)), Morand, E. (Associate Investigator (AI)), Nicholson, S. E. (Associate Investigator (AI)), Russ, B. (Associate Investigator (AI)), Vincent, F. (Associate Investigator (AI)), Harris, J. (Associate Investigator (AI)), Moore, G. (Associate Investigator (AI)), Goldberg, R. (Associate Investigator (AI)), Turner, S. (Associate Investigator (AI)) & Rosenbluh, S. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
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Understanding the immunological and clinical sequelae of COVID-19 in affected Health Care Workers
Ojaimi, S. (Primary Chief Investigator (PCI)), Rogers, B. (Chief Investigator (CI)) & Turner, S. (Chief Investigator (CI))
28/08/20 → 28/08/21
Project: Research
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The T cell genome in 3D: understanding chromatin dynamics during T cell responses to virus infection
Turner, S. (Primary Chief Investigator (PCI)), Collas, P. (Chief Investigator (CI)) & Bell, T. (Chief Investigator (CI))
1/01/20 → 31/12/22
Project: Research
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Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function
Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., Purcell, D. F. J., Hertzog, P. J., Rao, S. & Turner, S. J., 19 Dec 2017, In: Cell Reports. 21, 12, p. 3624-3636 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile47 Citations (Scopus) -
Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8+ T cells
Nguyen, M. L. T., Hatton, L., Li, J., Olshansky, M., Kelso, A., Russ, B. E. & Turner, S. J., 1 Feb 2016, In: European Journal of Immunology. 46, 2, p. 307-318 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile16 Citations (Scopus) -
Inactivated influenza vaccine that provides rapid, innate-immune- system-mediated protection and subsequent long-term adaptive immunity
Chua, B. Y., Wong, C. Y., Mifsud, E. J., Edenborough, K. M., Sekiya, T., Tan, A. C. L., Mercuri, F., Rockman, S., Chen, W., Turner, S. J., Doherty, P. C., Kelso, A., Brown, L. E. & Jackson, D. C., 27 Oct 2015, In: mBio. 6, 6, 11 p., e01024-15.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile28 Citations (Scopus) -
Active maintenance of CD8+ T cell naivety through regulation of global genome architecture
Russ, B. E., Barugahare, A., Dakle, P., Tsyganov, K., Quon, S., Yu, B., Li, J., Lee, J. K. C., Olshansky, M., He, Z., Harrison, P. F., See, M., Nussing, S., Morey, A. E., Udupa, V. A., Bennett, T. J., Kallies, A., Murre, C., Collas, P. & Powell, D. & 2 others, , 31 Oct 2023, In: Cell Reports. 42, 10, 19 p., 113301.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells
Quon, S., Yu, B., Russ, B. E., Tsyganov, K., Nguyen, H., Toma, C., Heeg, M., Hocker, J. D., Milner, J. J., Crotty, S., Pipkin, M. E., Turner, S. J. & Goldrath, A. W., 9 May 2023, In: Immunity. 56, 5, p. 959-978.e10 31 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)