Personal profile


Prof Turner studies factors that regulate virus-specific T cell recruitment and differentiation after infection.  His lab utilizes a multidisplinary approach to examine how differences in T cell receptor recognition of peptide-MHC antigens impacts development and differentiation of virus-specific T cell responses. He is also interested in factors that shape the transcriptional and epigenetic signatures that define virus-specific T cell differentiation from the naive state into both the effector and memory populations. He utilizes a combination of ChIP-Seq, RNA-Seq, bioinformatics and systems biology, inducible shRNA knockdown, retroviral bone-marrow transduction, gene-deficient mouse models and 3C approaches for determining promoter-enhancer interactions. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.

Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being
  • SDG 10 - Reduced Inequalities

Research area keywords

  • T-cell
  • Influenza
  • Viral Immunity
  • Systems Immunology
  • Epigenetics
  • Host-pathogen interaction
  • Adaptive Immunity
  • immunological memory

Collaborations and top research areas from the last five years

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