Projects per year
Personal profile
Biography
Prof Turner studies factors that regulate virus-specific T cell recruitment and differentiation after infection. His lab utilizes a multidisplinary approach to examine how differences in T cell receptor recognition of peptide-MHC antigens impacts development and differentiation of virus-specific T cell responses. He is also interested in factors that shape the transcriptional and epigenetic signatures that define virus-specific T cell differentiation from the naive state into both the effector and memory populations. He utilizes a combination of ChIP-Seq, RNA-Seq, bioinformatics and systems biology, inducible shRNA knockdown, retroviral bone-marrow transduction, gene-deficient mouse models and 3C approaches for determining promoter-enhancer interactions. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- T-cell
- Influenza
- Viral Immunity
- Systems Immunology
- Epigenetics
- Host-pathogen interaction
- Adaptive Immunity
- immunological memory
Network
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Achieving benefit without harm: a next-generation glucocorticoid replacement
Jones, S., Morand, E., Nicholson, S. E., Russ, B., Vincent, F., Harris, J., Moore, G., Goldberg, R., Turner, S. & Rosenbluh, S.
1/01/22 → 31/12/25
Project: Research
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Understanding the immunological and clinical sequelae of COVID-19 in affected Health Care Workers
Ojaimi, S., Rogers, B. & Turner, S.
28/08/20 → 28/08/21
Project: Research
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The T cell genome in 3D: understanding chromatin dynamics during T cell responses to virus infection
Turner, S., Collas, P. & Bell, T.
1/01/20 → 31/12/22
Project: Research
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The 3D genome: how changes in gene spatial organisation impacts effective T cell immunity
Turner, S. & Goldrath, A. W.
Monash University – Internal University Contribution
1/08/19 → 31/07/20
Project: Other
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Single cell transcriptional profiling of effective flu-specific T cell immunity
Turner, S. & Webby, R. J.
30/08/17 → 31/03/21
Project: Research
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Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function
Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., Purcell, D. F. J., Hertzog, P. J., Rao, S. & Turner, S. J., 19 Dec 2017, In: Cell Reports. 21, 12, p. 3624-3636 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile38 Citations (Scopus) -
Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8+ T cells
Nguyen, M. L. T., Hatton, L., Li, J., Olshansky, M., Kelso, A., Russ, B. E. & Turner, S. J., 1 Feb 2016, In: European Journal of Immunology. 46, 2, p. 307-318 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile12 Citations (Scopus) -
Inactivated influenza vaccine that provides rapid, innate-immune- system-mediated protection and subsequent long-term adaptive immunity
Chua, B. Y., Wong, C. Y., Mifsud, E. J., Edenborough, K. M., Sekiya, T., Tan, A. C. L., Mercuri, F., Rockman, S., Chen, W., Turner, S. J., Doherty, P. C., Kelso, A., Brown, L. E. & Jackson, D. C., 27 Oct 2015, In: mBio. 6, 6, 11 p., e01024-15.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile26 Citations (Scopus) -
3D Single Molecule Super-Resolution Microscopy of Whole Nuclear Lamina
Rozario, A. M., Morey, A., Elliott, C., Russ, B., Whelan, D. R., Turner, S. J. & Bell, T. D. M., 28 Apr 2022, In: Frontiers in Chemistry. 10, 11 p., 863610.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A subset of immune-system T cells branded as seeds for type 1 diabetes
Turner, S. J. & La Gruta, N. L., Jan 2022, In: Nature. 602, 7895, p. 35-36 2 p.Research output: Contribution to journal › Comment / Debate › Other › peer-review
2 Citations (Scopus)