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Prof Turner studies factors that regulate virus-specific T cell recruitment and differentiation after infection.  His lab utilizes a multidisplinary approach to examine how differences in T cell receptor recognition of peptide-MHC antigens impacts development and differentiation of virus-specific T cell responses. He is also interested in factors that shape the transcriptional and epigenetic signatures that define virus-specific T cell differentiation from the naive state into both the effector and memory populations. He utilizes a combination of ChIP-Seq, RNA-Seq, bioinformatics and systems biology, inducible shRNA knockdown, retroviral bone-marrow transduction, gene-deficient mouse models and 3C approaches for determining promoter-enhancer interactions. Such analysis will tell us if the molecular mechanisms regulating transcriptional control of T cell effector function are unique and/or shared among key effector genes. This will lead to identification of key immune correlates of protective immunity and will contribute to improvement of immunotherapies for both infectious and autoimmune disease.

Research area keywords

  • T-cell
  • Influenza
  • Viral Immunity
  • Systems Immunology
  • Epigenetics
  • Host-pathogen interaction
  • Adaptive Immunity
  • immunological memory

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Research Output

Regulation of H3K4me3 at Transcriptional Enhancers Characterizes Acquisition of Virus-Specific CD8+ T Cell-Lineage-Specific Function

Russ, B. E., Olshansky, M., Li, J., Nguyen, M. L. T., Gearing, L. J., Nguyen, T. H. O., Olson, M. R., McQuilton, H. A., Nüssing, S., Khoury, G., Purcell, D. F. J., Hertzog, P. J., Rao, S. & Turner, S. J., 19 Dec 2017, In : Cell Reports. 21, 12, p. 3624-3636 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Dynamic regulation of permissive histone modifications and GATA3 binding underpin acquisition of granzyme A expression by virus-specific CD8+ T cells

Nguyen, M. L. T., Hatton, L., Li, J., Olshansky, M., Kelso, A., Russ, B. E. & Turner, S. J., 1 Feb 2016, In : European Journal of Immunology. 46, 2, p. 307-318 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Inactivated influenza vaccine that provides rapid, innate-immune- system-mediated protection and subsequent long-term adaptive immunity

Chua, B. Y., Wong, C. Y., Mifsud, E. J., Edenborough, K. M., Sekiya, T., Tan, A. C. L., Mercuri, F., Rockman, S., Chen, W., Turner, S. J., Doherty, P. C., Kelso, A., Brown, L. E. & Jackson, D. C., 27 Oct 2015, In : mBio. 6, 6, 11 p., e01024-15.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

The impact of MHC class I dose on development and maintenance of the polyclonal naive CD8+ T cell repertoire

Sng, X. Y. X., Li, J., Zareie, P., Assmus, L. M., Lee, J. K. C., Jones, C. M., Turner, S. J., Daley, S. R., Quinn, K. M. & La Gruta, N. L., 15 Jun 2020, In : Journal of Immunology. 204, 12, p. 3108-3116 9 p.

Research output: Contribution to journalArticleResearchpeer-review