Projects per year
Personal profile
Biography
Stephen Ting is a Haematology clinician-scientist based at Alfred Health-Monash University. He is an active practising haematologist and a principal investigator studying self-renewal pathways of haematopoeitic and leukemia stem cells.
Stephen Ting is a Haematology clinician scientist. He completed his medical training in clinical and laboratory haematology at Monash University and affiliated hospitals in 1998. He was awarded postgraduate scholarships by the HSANZ to study Polycythemia in Hopital Cochin, Paris (1999) and Cancer Council of Victoria to undertake PhD studies with Professor Stephen Jane at the Bone Marrow Research Laboratories (2000-2005) where his discoveries of the Grhl3 gene earned him numerous awards, including the Victorian Premier's Award in Medical Research (2005). Stephen obtained NHMRC CJ Martin, Canadian Post-Doctoral and RACP Bushell Travelling Fellowships to pursue further studies with Professor Guy Sauvageau in Montreal, Canada (2006-2009) investigating self-renewal mechanisms in hematopoietic stem cells. In 2010, he returned to Peter MacCallum Cancer Centre, as a senior Research Fellow and in mid-2011, was appointed as a group leader in the Division of Blood Cancers, ACBD to continue his independent research that identifies the importance of asymmetric cell division within both haematopoietic and leukemia stem cells.
Dr Ting's research has thus far received $1.5 million from funding bodies that include, the NHMRC, Cancer Council of Victoria, Leukaemia Foundation and RACP. His work has been published in high impact journals including Science, Nature Medicine, Cell, Cell Stem Cell, Developmental Cell, and Blood.
Research interests
The research focus of Dr Ting aims to understand the molecular mechanisms governing haematopoietic and leukemia stem cell self-renewal. Using a functional screen he has identified novel endocytosis and cytoskeleton genes that enhance HSC activity. And via live cell videomicroscopy established Ap2a2 as an asymmetrically segregating protein in HSCs, thereby linking asymmetric cell division (ACD) to HSC self-renewal. He will utilise these discoveries to interrogate the fate and gene expression of daughter cells from ACD of HSCs. These genes shall also be studied for ex-vivo HSC expansion properties and whether their perturbation alters leukemia outcome in mouse models.
- Investigating asymmetric cell division in HSCs
- The mitotic spindle during haematopoietic and leukemia stem cell self-renewal
- The role of the cytoskeleton gene, Kif3 in ACD and T-ALL
- Ex vivo expansion of HSCs for transplantation
Monash teaching commitment
Lecturer in Human Pathology and Clinical Science courses
Community service
1994
6 months studying Mandarin in China at the Beijing Language and Cultural University.
2 months on Thailand-Myanmar border as a volunteer doctor
2013 - present
Leukemia Foundation: speaker at annual patient information symposiums
Clinical activities
Consultant haematologist at Alfred Hospital, Melbourne, Victoria with inpatient and outpatient duties.
VMO consultant haematologist at Cabrini Hospital, Malvern, Victoria.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Ap2a2
- HSC
- Asymmetric Cell Division
- HSC self-renewal
- Biomedical Research, Multidisciplinary
- Blood Diseases
- Cancer
- Grhl3
- curly tail
- grainy head
- neural tube closure
- wound closure
- epithelial morphogenesis
- Hematology
- Stem Cell
Collaborations and top research areas from the last five years
Projects
- 11 Finished
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Getting the timing right: Prehabilitation to Improve outcomes afteR Autologous sTem cEll tra nsplantation (PIRATE)
Dennett, A. M. (Chief Investigator (CI)), Taylor, N. F. (Chief Investigator (CI)), Ting, S. (Chief Investigator (CI)) & Porter, J. (Chief Investigator (CI))
1/01/20 → 31/12/20
Project: Research
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DIAAMOND: Diagnosis of aplastic anaemia, management, and outcomes from a national dataset
Wood, E. (Primary Chief Investigator (PCI)), Ting, S. (Chief Investigator (CI)), McQuilten, Z. (Chief Investigator (CI)), Szer, J. (Chief Investigator (CI)), Hiwase, D. K. (Chief Investigator (CI)), McNeil, J. (Chief Investigator (CI)), Lacaze, P. (Chief Investigator (CI)), Blombery, P. (Chief Investigator (CI)), Mills, A. K. (Chief Investigator (CI)), Heritier, S. (Associate Investigator (AI)), Fox, L. (Associate Investigator (AI)), Firkin, F. (Associate Investigator (AI)) & Higgins, L. (Associate Investigator (AI))
13/06/18 → 15/02/24
Project: Research
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Establishing a Monash Partners national reference centre for molecular monitoring of residual disease (MRD) in acute myeloid leukaemia
Wei, A. (Primary Chief Investigator (PCI)), Ivey, A. (Chief Investigator (CI)), Fleming, S. (Chief Investigator (CI)), Tiong, I. S. (Chief Investigator (CI)), McManus, J. (Chief Investigator (CI)) & Ting, S. (Chief Investigator (CI))
1/01/17 → 31/12/19
Project: Research
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Epigenetics in myelodysplastic syndromes
Ling, Y.-M. V. (Primary Chief Investigator (PCI)) & Ting, S. (Chief Investigator (CI))
5/09/16 → 4/10/18
Project: Research
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NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)
Tarlinton, D. (Primary Chief Investigator (PCI)), Curtis, D. (Chief Investigator (CI)), Guthridge, M. A. (Chief Investigator (CI)), Jane, S. (Chief Investigator (CI)), Medcalf, R. (Chief Investigator (CI)), O'Hehir, R. (Chief Investigator (CI)), Plebanski, M. (Chief Investigator (CI)), Ting, S. (Chief Investigator (CI)) & van Zelm, M. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/12/15 → 31/12/15
Project: Research
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Final analysis of the phase 1b Chemotherapy and Venetoclax in Elderly Acute Myeloid Leukemia Trial (CAVEAT)
Chua, C. C., Loo, S., Fong, C. Y., Ting, S. B., Tiong, I. S., Fleming, S., Anstee, N. S., Ivey, A., Ashby, M., Teh, T. C., Reynolds, J., Roberts, A. W. & Wei, A. H., 22 Apr 2025, In: Blood Advances. 9, 8, p. 1827-1835 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Efficacy and safety of avatrombopag in combination with immunosuppressive therapy in treatment-naïve and relapsed/refractory severe aplastic anaemia: Protocol for the DIAAMOND-Ava-FIRST and DIAAMOND-Ava-NEXT Bayesian Optimal Phase II trials
McQuilten, Z., Heritier, S., Fox, L., Fox, V., Young, L., Blombery, P., Cunningham, I., Curnow, J., Higgins, A., Hiwase, D. K., Filshie, R., Firkin, F., Lacaze, P., Mason, K., Mills, A. K., Pepperell, D., Patil, S., Stevenson, W., Szer, J. & Waters, N. & 3 others, , 18 Jan 2024, In: BMJ Open. 14, 1, 11 p., e076246.Research output: Contribution to journal › Article › Other › peer-review
Open Access4 Citations (Scopus) -
Increased STAT expression in Reed–Sternberg cells as a potential positive prognostication biomarker in Hodgkin lymphoma
Zargari, A., Cummins, K. D., Hosking, P., Pham, A., Hawkes, E. & Ting, S. B., Aug 2023, In: Pathology. 55, 5, p. 650-655 6 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG
Loo, S., Roberts, A. W., Anstee, N. S., Kennedy, G. A., He, S., Schwarer, A. P., Enjeti, A. K., D'Rozario, J., Marlton, P., Bilmon, I. A., Taper, J., Cull, G., Tiley, C., Verner, E., Hahn, U., Hiwase, D. K., Iland, H. J., Murphy, N., Ramanathan, S. & Reynolds, J. & 17 others, , 7 Dec 2023, In: Blood. 142, 23, p. 1960-1971 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access20 Citations (Scopus) -
The Australian Aplastic Anaemia and other Bone Marrow Failure Syndromes Registry
Fox, L. C., McQuilten, Z. K., Firkin, F., Fox, V., Badoux, X., Bajel, A., Barbaro, P., Cole-Sinclair, M. F., Forsyth, C., Gibson, J., Hiwase, D. K., Johnston, A., Mills, A., Roncolato, F., Sutherland, R., Szer, J., Ting, S. B., Vilcassim, S., Young, L. & Waters, N. A. & 2 others, , Dec 2023, In: Best Practice & Research: Clinical Haematology. 36, 4, 10 p., 101516.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus)
Prizes
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Annual Symposium : Travel Award - International Society of Stem Cell Research
Ting, S. (Recipient), 2010
Prize: Prize (including medals and awards)
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Annual Symposium : Travel Award - International Society of Stem Cell Research
Ting, S. (Recipient), 2012
Prize: Prize (including medals and awards)
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Cleveland Young Investigator Award - Royal Melbourne Hospital
Ting, S. (Recipient), 2003
Prize: Prize (including medals and awards)
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Early-Mid Career Researcher Bursary Showcasing Excellence in Biomedical Research, Australia-France - NHMRC
Ting, S. (Recipient), 2011
Prize: Prize (including medals and awards)
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Medishield Prize in Obstetrics and Gynaecology Exam - Monash University
Ting, S. (Recipient), 1986
Prize: Prize (including medals and awards)
Activities
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NHMRC - National Health and Medical Research Council (Australia) (External organisation)
Ting, S. (Member)
1 Jan 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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The Royal Australasian College of Physicians (External organisation)
Ting, S. (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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NHMRC - National Health and Medical Research Council (Australia) (External organisation)
Ting, S. (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Alfred Hospital (External organisation)
Ting, S. (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Royal College of Pathologists of Australasia (External organisation)
Ting, S. (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board