Stephen Ting

Personal profile

Biography

Stephen Ting is a Haematology clinician-scientist based at Alfred Health-Monash University. He is an active practising haematologist and a principal investigator studying self-renewal pathways of haematopoeitic and leukemia stem cells.

Stephen Ting is a Haematology clinician scientist. He completed his medical training in clinical and laboratory haematology at Monash University and affiliated hospitals in 1998. He was awarded postgraduate scholarships by the HSANZ to study Polycythemia in Hopital Cochin, Paris (1999) and Cancer Council of Victoria to undertake PhD studies with Professor Stephen Jane at the Bone Marrow Research Laboratories (2000-2005) where his discoveries of the Grhl3 gene earned him numerous awards, including the Victorian Premier's Award in Medical Research (2005). Stephen obtained NHMRC CJ Martin, Canadian Post-Doctoral and RACP Bushell Travelling Fellowships to pursue further studies with Professor Guy Sauvageau in Montreal, Canada (2006-2009) investigating self-renewal mechanisms in hematopoietic stem cells. In 2010, he returned to Peter MacCallum Cancer Centre, as a senior Research Fellow and in mid-2011, was appointed as a group leader in the Division of Blood Cancers, ACBD to continue his independent research that identifies the importance of asymmetric cell division within both haematopoietic and leukemia stem cells.

Dr Ting's research has thus far received $1.5 million from funding bodies that include, the NHMRC, Cancer Council of Victoria, Leukaemia Foundation and RACP. His work has been published in high impact journals including Science, Nature Medicine, Cell, Cell Stem Cell, Developmental Cell, and Blood.

Research interests

The research focus of Dr Ting aims to understand the molecular mechanisms governing haematopoietic and leukemia stem cell self-renewal. Using a functional screen he has identified novel endocytosis and cytoskeleton genes that enhance HSC activity. And via live cell videomicroscopy established Ap2a2 as an asymmetrically segregating protein in HSCs, thereby linking asymmetric cell division (ACD) to HSC self-renewal. He will utilise these discoveries to interrogate the fate and gene expression of daughter cells from ACD of HSCs. These genes shall also be studied for ex-vivo HSC expansion properties and whether their perturbation alters leukemia outcome in mouse models.

Investigating asymmetric cell division in HSCs
The mitotic spindle during haematopoietic and leukemia stem cell self-renewal
The role of the cytoskeleton gene, Kif3 in ACD and T-ALL
Ex vivo expansion of HSCs for transplantation

Monash teaching commitment

Lecturer in Human Pathology and Clinical Science courses

Community service

1994
6 months studying Mandarin in China at the Beijing Language and Cultural University.
2 months on Thailand-Myanmar border as a volunteer doctor

2013 - present

Leukemia Foundation: speaker at annual patient information symposiums

Clinical activities

Consultant haematologist at Alfred Hospital, Melbourne, Victoria with inpatient and outpatient duties.

VMO consultant haematologist at Cabrini Hospital, Malvern, Victoria.

Keywords

Ap2a2
HSC
Asymmetric Cell Division
HSC self-renewal
Biomedical Research, Multidisciplinary
Blood Diseases
Cancer
Grhl3
curly tail
grainy head
neural tube closure
wound closure
epithelial morphogenesis
Hematology
Stem Cell

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Projects 2012 2022

2 Active
6 Finished

DIAAMOND: Diagnosis of aplastic anaemia, management, and outcomes from a national dataset

Wood, E., Ting, S., McQuilten, Z., Szer, J., Hiwase, D. K., McNeil, J., Lacaze, P., Blombery, P. A., Mills, A., Heritier, S., Fox, L., Firkin, F. & Higgins, L.

13/06/18 → 31/12/22

Project: Research

Establishing a Monash Partners national reference centre for molecular monitoring of residual disease (MRD) in acute myeloid leukaemia

Wei, A., Ivey, A., Fleming, S. A., Tiong, I. S., McManus, J. & Ting, S.

1/01/17 → 31/12/19

Project: Research

Epigenetics in myelodysplastic syndromes

Ling, Y. V. & Ting, S.

5/09/16 → 4/10/18

Project: Research

NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)

Tarlinton, D., Curtis, D., Guthridge, M. A., Jane, S., Medcalf, R., O'Hehir, R., Plebanski, M., Ting, S. & van Zelm, M.

National Health & Medical Research Council (NHMRC)

1/12/15 → 31/12/15

Project: Research

Restoration of immune competency in CLL

Mackay-Fisson, F. & Ting, S.

National Health & Medical Research Council (NHMRC)

1/01/14 → 31/12/16

Project: Research

Research Output 1998 2018

26 Article
2 Letter
1 Abstract
1 Comment / Debate

Molecular Patterns of Response and Outcome in the Chemotherapy and Venetoclax in Elderly AML Trial (CAVEAT) study. Blood 2018 132:333

Wei, A., Chua, C. C., Tiong, I. S., Fong, C. Y., Ting, S. B. N., Macraild, S., Salmon, J. M., Ivey, A., Nguyen, J., Yuen, F., Fleming, S. A., Bohlander, S., Reynolds, J. & Roberts, A. W., Dec 2018.

Research output: Contribution to conference › Abstract › Other › peer-review

Open Access

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia

Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B. & Morgan, S., 2017, In : Annals of Hematology and Oncology. 4, 3, 1141.

Research output: Contribution to journal › Article › Other › peer-review

Open Access

File

The BAFF receptor TACI controls IL-10 production by regulatory B cells and CLL B cells

Saulep-Easton, D., Vincent, F. B., Quah, P. S., Wei, A., Ting, S. B., Croce, C. M., Tam, C. & Mackay, F., 2016, In : Leukemia. 30, 1, p. 163 - 172 10 p.

Research output: Contribution to journal › Article › Research › peer-review