Projects per year
Personal profile
Biography
Stephen Ting is a Haematology clinician-scientist based at Alfred Health-Monash University. He is an active practising haematologist and a principal investigator studying self-renewal pathways of haematopoeitic and leukemia stem cells.
Stephen Ting is a Haematology clinician scientist. He completed his medical training in clinical and laboratory haematology at Monash University and affiliated hospitals in 1998. He was awarded postgraduate scholarships by the HSANZ to study Polycythemia in Hopital Cochin, Paris (1999) and Cancer Council of Victoria to undertake PhD studies with Professor Stephen Jane at the Bone Marrow Research Laboratories (2000-2005) where his discoveries of the Grhl3 gene earned him numerous awards, including the Victorian Premier's Award in Medical Research (2005). Stephen obtained NHMRC CJ Martin, Canadian Post-Doctoral and RACP Bushell Travelling Fellowships to pursue further studies with Professor Guy Sauvageau in Montreal, Canada (2006-2009) investigating self-renewal mechanisms in hematopoietic stem cells. In 2010, he returned to Peter MacCallum Cancer Centre, as a senior Research Fellow and in mid-2011, was appointed as a group leader in the Division of Blood Cancers, ACBD to continue his independent research that identifies the importance of asymmetric cell division within both haematopoietic and leukemia stem cells.
Dr Ting's research has thus far received $1.5 million from funding bodies that include, the NHMRC, Cancer Council of Victoria, Leukaemia Foundation and RACP. His work has been published in high impact journals including Science, Nature Medicine, Cell, Cell Stem Cell, Developmental Cell, and Blood.
Research interests
The research focus of Dr Ting aims to understand the molecular mechanisms governing haematopoietic and leukemia stem cell self-renewal. Using a functional screen he has identified novel endocytosis and cytoskeleton genes that enhance HSC activity. And via live cell videomicroscopy established Ap2a2 as an asymmetrically segregating protein in HSCs, thereby linking asymmetric cell division (ACD) to HSC self-renewal. He will utilise these discoveries to interrogate the fate and gene expression of daughter cells from ACD of HSCs. These genes shall also be studied for ex-vivo HSC expansion properties and whether their perturbation alters leukemia outcome in mouse models.
- Investigating asymmetric cell division in HSCs
- The mitotic spindle during haematopoietic and leukemia stem cell self-renewal
- The role of the cytoskeleton gene, Kif3 in ACD and T-ALL
- Ex vivo expansion of HSCs for transplantation
Monash teaching commitment
Lecturer in Human Pathology and Clinical Science courses
Community service
1994
6 months studying Mandarin in China at the Beijing Language and Cultural University.
2 months on Thailand-Myanmar border as a volunteer doctor
2013 - present
Leukemia Foundation: speaker at annual patient information symposiums
Clinical activities
Consultant haematologist at Alfred Hospital, Melbourne, Victoria with inpatient and outpatient duties.
VMO consultant haematologist at Cabrini Hospital, Malvern, Victoria.
Research area keywords
- Ap2a2
- HSC
- Asymmetric Cell Division
- HSC self-renewal
- Biomedical Research, Multidisciplinary
- Blood Diseases
- Cancer
- Grhl3
- curly tail
- grainy head
- neural tube closure
- wound closure
- epithelial morphogenesis
- Hematology
- Stem Cell
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2012 2022
DIAAMOND: Diagnosis of aplastic anaemia, management, and outcomes from a national dataset
Wood, E., Ting, S., McQuilten, Z., Szer, J., Hiwase, D. K., McNeil, J., Lacaze, P., Blombery, P. A., Mills, A., Heritier, S., Fox, L., Firkin, F. & Higgins, L.
13/06/18 → 31/12/22
Project: Research
Establishing a Monash Partners national reference centre for molecular monitoring of residual disease (MRD) in acute myeloid leukaemia
Wei, A., Ivey, A., Fleming, S. A., Tiong, I. S., McManus, J. & Ting, S.
1/01/17 → 31/12/19
Project: Research
NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)
Tarlinton, D., Curtis, D., Guthridge, M. A., Jane, S., Medcalf, R., O'Hehir, R., Plebanski, M., Ting, S. & van Zelm, M.
National Health & Medical Research Council (NHMRC)
1/12/15 → 31/12/15
Project: Research
Restoration of immune competency in CLL
National Health & Medical Research Council (NHMRC)
1/01/14 → 31/12/16
Project: Research
Research Output 1998 2019
Correction: High expression of HMGA2 independently predicts poor clinical outcomes in acute myeloid leukemia (Blood Cancer Journal, (2018), 8, 8, (68), 10.1038/s41408-018-0103-6)
Marquis, M., Beaubois, C., Lavallée, V. P., Abrahamowicz, M., Danieli, C., Lemieux, S., Ahmad, I., Wei, A., Ting, S. B., Fleming, S., Schwarer, A., Grimwade, D., Grey, W., Hills, R. K., Vyas, P., Russell, N., Sauvageau, G. & Hébert, J., 1 Mar 2019, In : Blood Cancer Journal. 9, 3, 1 p., 28.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Molecular Patterns of Response and Outcome in the Chemotherapy and Venetoclax in Elderly AML Trial (CAVEAT) study. Blood 2018 132:333
Wei, A., Chua, C. C., Tiong, I. S., Fong, C. Y., Ting, S. B. N., Macraild, S., Salmon, J. M., Ivey, A., Nguyen, J., Yuen, F., Fleming, S. A., Bohlander, S., Reynolds, J. & Roberts, A. W., Dec 2018.Research output: Contribution to conference › Abstract › Other › peer-review
Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells
Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.Research output: Contribution to journal › Article › Research › peer-review
Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice
Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.Research output: Contribution to journal › Article › Research › peer-review
Up-Regulation of the Vitamin D Pathway in Acute Myeloid Leukemia: A Novel Cause of Hypercalcemia
Casan, J. M. L., Ghoth, S., Wei, A. H., Ting, S. B. & Morgan, S., 2017, In : Annals of Hematology and Oncology. 4, 3, 1141.Research output: Contribution to journal › Article › Other › peer-review
Prizes
Annual Symposium : Travel Award - International Society of Stem Cell Research
Stephen Ting (Recipient), 2012
Prize: Prize (including medals and awards)
Annual Symposium : Travel Award - International Society of Stem Cell Research
Stephen Ting (Recipient), 2010
Prize: Prize (including medals and awards)
Cleveland Young Investigator Award - Royal Melbourne Hospital
Stephen Ting (Recipient), 2003
Prize: Prize (including medals and awards)
Early-Mid Career Researcher Bursary Showcasing Excellence in Biomedical Research, Australia-France - NHMRC
Stephen Ting (Recipient), 2011
Prize: Prize (including medals and awards)
Medishield Prize in Obstetrics and Gynaecology Exam - Monash University
Stephen Ting (Recipient), 1986
Prize: Prize (including medals and awards)
Activities 2000 2016
National Health & Medical Research Council (NHMRC) (External organisation)
Stephen Ting (Member)Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
National Health & Medical Research Council (NHMRC) (External organisation)
Stephen Ting (Member)Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
Royal Australasian College of Pathologists (External organisation)
Stephen Ting (Member)Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
The Royal Australasian College of Physicians (External organisation)
Stephen Ting (Member)Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
International Journal for Hematology Research (Journal)
Stephen Ting (Editor in chief)Activity: Publication peer-review and editorial work types › Editorial responsibility