Projects per year
Personal profile
Biography
Stephen Ting is a Haematology clinician-scientist based at Alfred Health-Monash University. He is an active practising haematologist and a principal investigator studying self-renewal pathways of haematopoeitic and leukemia stem cells.
Stephen Ting is a Haematology clinician scientist. He completed his medical training in clinical and laboratory haematology at Monash University and affiliated hospitals in 1998. He was awarded postgraduate scholarships by the HSANZ to study Polycythemia in Hopital Cochin, Paris (1999) and Cancer Council of Victoria to undertake PhD studies with Professor Stephen Jane at the Bone Marrow Research Laboratories (2000-2005) where his discoveries of the Grhl3 gene earned him numerous awards, including the Victorian Premier's Award in Medical Research (2005). Stephen obtained NHMRC CJ Martin, Canadian Post-Doctoral and RACP Bushell Travelling Fellowships to pursue further studies with Professor Guy Sauvageau in Montreal, Canada (2006-2009) investigating self-renewal mechanisms in hematopoietic stem cells. In 2010, he returned to Peter MacCallum Cancer Centre, as a senior Research Fellow and in mid-2011, was appointed as a group leader in the Division of Blood Cancers, ACBD to continue his independent research that identifies the importance of asymmetric cell division within both haematopoietic and leukemia stem cells.
Dr Ting's research has thus far received $1.5 million from funding bodies that include, the NHMRC, Cancer Council of Victoria, Leukaemia Foundation and RACP. His work has been published in high impact journals including Science, Nature Medicine, Cell, Cell Stem Cell, Developmental Cell, and Blood.
Research interests
The research focus of Dr Ting aims to understand the molecular mechanisms governing haematopoietic and leukemia stem cell self-renewal. Using a functional screen he has identified novel endocytosis and cytoskeleton genes that enhance HSC activity. And via live cell videomicroscopy established Ap2a2 as an asymmetrically segregating protein in HSCs, thereby linking asymmetric cell division (ACD) to HSC self-renewal. He will utilise these discoveries to interrogate the fate and gene expression of daughter cells from ACD of HSCs. These genes shall also be studied for ex-vivo HSC expansion properties and whether their perturbation alters leukemia outcome in mouse models.
- Investigating asymmetric cell division in HSCs
- The mitotic spindle during haematopoietic and leukemia stem cell self-renewal
- The role of the cytoskeleton gene, Kif3 in ACD and T-ALL
- Ex vivo expansion of HSCs for transplantation
Monash teaching commitment
Lecturer in Human Pathology and Clinical Science courses
Community service
1994
6 months studying Mandarin in China at the Beijing Language and Cultural University.
2 months on Thailand-Myanmar border as a volunteer doctor
2013 - present
Leukemia Foundation: speaker at annual patient information symposiums
Clinical activities
Consultant haematologist at Alfred Hospital, Melbourne, Victoria with inpatient and outpatient duties.
VMO consultant haematologist at Cabrini Hospital, Malvern, Victoria.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Ap2a2
- HSC
- Asymmetric Cell Division
- HSC self-renewal
- Biomedical Research, Multidisciplinary
- Blood Diseases
- Cancer
- Grhl3
- curly tail
- grainy head
- neural tube closure
- wound closure
- epithelial morphogenesis
- Hematology
- Stem Cell
Collaborations and top research areas from the last five years
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DIAAMOND: Diagnosis of aplastic anaemia, management, and outcomes from a national dataset
Wood, E., Ting, S., McQuilten, Z., Szer, J., Hiwase, D. K., McNeil, J., Lacaze, P., Blombery, P. A., Mills, A. K., Heritier, S., Fox, L., Firkin, F. & Higgins, L.
13/06/18 → 15/02/24
Project: Research
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Getting the timing right: Prehabilitation to Improve outcomes afteR Autologous sTem cEll tra nsplantation (PIRATE)
Dennett, A. M., Taylor, N. F., Ting, S. & Porter, J.
1/01/20 → 31/12/20
Project: Research
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Establishing a Monash Partners national reference centre for molecular monitoring of residual disease (MRD) in acute myeloid leukaemia
Wei, A., Ivey, A., Fleming, S. A., Tiong, I. S., McManus, J. & Ting, S.
1/01/17 → 31/12/19
Project: Research
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NHMRC Equipment Grant - Amnis ImageStreamX Mark II Imaging Flow Cytometer (Mark II)
Tarlinton, D., Curtis, D., Guthridge, M. A., Jane, S., Medcalf, R., O'Hehir, R., Plebanski, M., Ting, S. & van Zelm, M.
National Health and Medical Research Council (NHMRC) (Australia)
1/12/15 → 31/12/15
Project: Research
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Increased STAT expression in Reed–Sternberg cells as a potential positive prognostication biomarker in Hodgkin lymphoma
Zargari, A., Cummins, K. D., Hosking, P., Pham, A., Hawkes, E. & Ting, S. B., Aug 2023, In: Pathology. 55, 5, p. 650-655 6 p.Research output: Contribution to journal › Article › Research › peer-review
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Diflunisal Significantly Improves Survival of Patients With Transthyretin (TTR) Amyloidosis Cardiomyopathy (ATTR-CM); A Retrospective Analysis
Choi, B., Lasica, M., Huynh, N., Sirdesai, S., Nagarethinam, M., Ting, S., Cooke, J., Hare, J. & Gibbs, S., 2022, In: Heart Lung and Circulation. 31, S3, p. S79-S80 2 p., 078.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access -
High Deliverability of a Midostaurin Triplet Regimen Incorporating Venetoclax and Low Dose Cytarabine in Non-Adverse Cytogenetic Risk Acute Myeloid Leukaemia: A Sub-Analysis of the Australasian Leukaemia Lymphoma Group (ALLG) Intervene Study
Chua, C. C., Anstee, N. S., Enjeti, A. K., Hiwase, D., Marlton, P., Bajel, A., Tan, S. Y., Morris, E. S., Ma, C-K-K., Grove, C., Cooney, J., Beligaswatte, A., Koldej, R. M., Ting, S. B., Perera, T., Johnston, A., Reynolds, J., Ritchie, D. & Wei, A. H., 15 Nov 2022, In: Blood. 140, Supplement 1, p. 3362-3364 3 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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High Response and Prolonged Treatment-Free Remission after a Short-Course of Modified Intensive Chemotherapy and Venetoclax in Elderly AML: An Updated Analysis of the Caveat Trial
Chua, C. C., Loo, S., Reynolds, J., Tiong, I. S., Fong, C. Y., Ting, S. B., Fleming, S., Roberts, A. W. & Wei, A. H., 1 Nov 2022, In: Blood. 140, Supplement 1, p. 1708-1710 3 p.Research output: Contribution to journal › Meeting Abstract › peer-review
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The Increasing Recognition of Transthyretin Cardiac Amyloidosis (ATTR-CA): Patient Characteristics and Survival in the Australian Context
Choi, B., Lasica, M., Huynh, N., Sirdesai, S., Nagarethinam, M., Ting, S., Cooke, J., Hare, J. & Gibbs, S., Jan 2022, In: Heart Lung and Circulation. 31, S3, p. S103 1 p., 131.Research output: Contribution to journal › Meeting Abstract › peer-review
Open Access
Prizes
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Annual Symposium : Travel Award - International Society of Stem Cell Research
Ting, Stephen (Recipient), 2010
Prize: Prize (including medals and awards)
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Annual Symposium : Travel Award - International Society of Stem Cell Research
Ting, Stephen (Recipient), 2012
Prize: Prize (including medals and awards)
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Cleveland Young Investigator Award - Royal Melbourne Hospital
Ting, Stephen (Recipient), 2003
Prize: Prize (including medals and awards)
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Early-Mid Career Researcher Bursary Showcasing Excellence in Biomedical Research, Australia-France - NHMRC
Ting, Stephen (Recipient), 2011
Prize: Prize (including medals and awards)
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Medishield Prize in Obstetrics and Gynaecology Exam - Monash University
Ting, Stephen (Recipient), 1986
Prize: Prize (including medals and awards)
Activities
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National Health & Medical Research Council (NHMRC) (External organisation)
Stephen Ting (Member)
1 Jan 2016Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Alfred Hospital (External organisation)
Stephen Ting (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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National Health & Medical Research Council (NHMRC) (External organisation)
Stephen Ting (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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Royal College of Pathologists of Australasia (External organisation)
Stephen Ting (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board
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The Royal Australasian College of Physicians (External organisation)
Stephen Ting (Member)
1 Jan 2014Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of an advisory panel/policy group/ board