Stephen Nicholls

Projects

Projects per year 2018 2019 2020 2021 2022 2023 2029

• 2 Not started
• 30 Finished
• 33 Active

Projects per year

Search results

• Active

  Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy and Safety of Plozasiran in Adults with Severe Hypertriglyceridemia (SHASTA-3 Study)

  Nicholls, S.

  15/01/25 → 21/07/25

  Project: Research

• Precision prevention of cardiovascular disease using genomic risk stratification

  Yu, C., Lacaze, P., Nicholls, S. & McNeil, J.

  1/01/25 → 31/12/26

  Project: Research

• A Phase 3, Open-label Extension Study to Evaluate the Safety and Efficacy of MK-0616 in Adults With Hypercholesterolemia

  Nicholls, S.

  12/11/24 → 8/07/25

  Project: Research

• CORE - Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients with Severe Hypertriglyceridemia (SHTG)

  Nicholls, S.

  1/11/24 → 1/03/25

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults with Elevated Lipoprotein(a) who have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular Event – ACCLAIM-Lp(a)

  Nicholls, S.

  24/05/24 → 23/05/29

  Project: Research

• A Phase 1 Open-label, Multicenter, First-in-human, Ascending Single Dose Study Evaluating the Safety and Tolerability of a Lipid Nanoparticle Formulation of CRISPR–Guide RNA–Cas9 Nuclease (CTX320) for In Vivo Editing of the Apolipoprotein(a) Gene (LPA) in Subjects with Elevated Lipoprotein(a) and a History of Atherosclerotic Cardiovascular Disease or Calcific Aortic Valve Stenosis

  Nicholls, S.

  10/04/24 → 9/04/29

  Project: Research

• A Phase 3, randomised, double-blind, parallel-group, event-driven, cardiovascular safety study with BI 456906 administered subcutaneously compared with placebo in participants with overweight or obesity with established cardiovascular disease (CVD) or chronic kidney disease, and/or at least two weight-related complications or risk factors for CVD.

  Nicholls, S.

  21/03/24 → 20/03/29

  Project: Research

• Characteristics and treatment patterns of heart failure patients with Reduced ejection fraction in Australia (CHEERS-HF)

  Nicholls, S. & Nelson, A.

  Boehringer Ingelheim (Australia)

  9/11/23 → 9/03/25

  Project: Research

• A Phase 1 Open-label, Multicenter, First-in-human, Ascending Single-dose Study Evaluating the Safety and Tolerability of a Lipid Nanoparticle Formulation of CRISPR-Guide RNA–Cas9 Nuclease (CTX310) for In Vivo Editing of the Angiopoietin-like 3 (ANGPTL3) Gene in Subjects With Refractory Dyslipidemias

  Nicholls, S.

  1/11/23 → 2/11/28

  Project: Research

• A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-0616 in Adults With Heterozygous Familial Hypercholesterolemia.

  Nicholls, S.

  2/10/23 → 1/10/28

  Project: Research

• Intervene Medical Pty Ltd - QFR corelab

  Nicholls, S. & Wong, D.

  Intervene Medical Pty Ltd

  15/08/23 → 30/09/25

  Project: Research

• A randomized, double-blind, placebo-controlled multicenter study to evaluate the effect of inclisiran on preventing major adverse cardiovascular events in high-risk primary prevention patients (VICTORION-1 PREVENT)

  Nicholls, S.

  22/05/23 → 21/05/28

  Project: Research

• ASCERTAIN: AtheroSclerotic Cardiovascular disEase Risk assessmenT and treAtment In AustraliaN primary care

  Nicholls, S.

  1/02/23 → 31/01/25

  Project: Research

• Advancing Preclinical Development of Novel GPCR-targeted Therapeutics for Heart Failure

  Ritchie, R., Figtree, G., Qin, C. H., May, L., Nicholls, S., Taylor, A., Yang, J. Y. H., Shackleford, D., Schiattarella, G., Pinto, A., Drummond, G., Horowitz, J. D., Bubb, K., Ng, H. H., Vecchio, L., Nelson, A., Kirkpatrick, C., McDonald, C., Febbraio, M., Vinh, A., Odiba, J., Brown, H. & Stupple, P.

  1/02/23 → 31/01/26

  Project: Research

• A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)

  Nicholls, S.

  12/12/22 → 11/12/27

  Project: Research

• A Phase 3, Randomized, Double-blind, Placebo-Controlled Study to Investigate the Effect of Tirzepatide on the Reduction of Morbidity and Mortality in Adults with Obesity

  Nicholls, S.

  30/11/22 → 29/11/27

  Project: Research

• A Phase 2 Open-Label Extension Study To Evaluate The Long-Term Safety And Efficacy of ARO-APOC3 In Adults with Dyslipidemia

  Nicholls, S.

  1/09/22 → 31/08/27

  Project: Research

• A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study of ISIS 678354 Administered Subcutaneously to Patients with Severe Hypertriglyceridemia

  Nicholls, S.

  25/08/22 → 24/08/27

  Project: Research

• Atheroma Progression in Clonal Haematopoiesis Investigation with iMaging, biomarkers and Genomic Sequencing (ARCHIMEDES)

  Nicholls, S., Bubb, K., Southey, M., Nelson, A., Milne, R., Nerlekar, N., Shortt, J., Hughes, T. P., Breen, J., Sargeant, T. J. & Zoungas, S.

  1/06/22 → 31/05/25

  Project: Research

• Using co-design to improve accessibility and acceptability of cardiac services for vulnerable populations: The Equal Hearts Study

  Beauchamp, A., Nicholls, S., Jessup, R., Wong Shee, A., Van Gaal, W. J., Talevski, J., Oqueli, E., Sharma, L., Harris, J. & Alston, L. V.

  1/06/22 → 30/09/25

  Project: Research

• ZEUS - Effects of ziltivekimab versus placebo on cardiovascular outcomes in participants with established atherosclerotic cardiovascular disease, chronic kidney disease and systemic inflammation

  Nicholls, S. & Kerr, P.

  27/01/22 → 26/01/27

  Project: Research

• ASHRA: Australian Stroke and Heart Research Accelerator (ASHRA)

  Nicholls, S., Kovacic, J. C., Zoungas, S., Neal, B. C., Chow, C., Figtree, G., Campbell, B. C. V., Maple-Brown, L. J., Brown, A., Hayward, C. S., Hill, A., Hool, L. C., Currie, P., Rodgers, A., Arnott, C., Wu, J. H. Y., Kritharides, L., Ugander, M., Chiang, J., Davis, S. M., Donnan, G. A., Yan, B., Barr, E. L. M., Breen, J., Barclay, J., Brown, H., Correa, M., Wu, C., Butters, J., Glass, P., Ritchie, R., Vandenburg, J., Patel, A., Semsarian, C., Martino, M., Laranjo, L., Thiagalingam, A., Sivagangabalan, G., Fox, K., Rice, H., Ali, M., Francisco, J., Dawidowska, I. & Greenway, A.

  10/01/22 → 15/02/26

  Project: Research

• A novel approach integrating genomics into the health economic modelling of therapeutics

  Ademi Delaney, Z., Liew, D., Zoungas, S. & Nicholls, S.

  1/01/22 → 31/12/25

  Project: Research

• Predicting Renal, Ophthalmic and Heart Events in the Aboriginal Community: The PROPHECY Diabetes Multi-Omics Cohort Study

  Brown, A., Zimmet, P., Cooper, M., Shaw, J., El-Osta, S., Willerslev, E., Maple-Brown, L. J., James, D. E., Nicholls, S. & Craig, J. E.

  1/01/22 → 30/06/25

  Project: Research

• A Double-blind, Placebo-controlled Phase 2b Study to Evaluate the efficacy and safety of ARO-APOC3 in Adults with Mixed Dyslipidemia

  Nicholls, S.

  25/11/21 → 24/11/26

  Project: Research

• A randomised, double-blind, placebo controlled, first-in-human study to investigate the safety, tolerability, and pharmacokinetic and pharmacodynamic response of SLN360 in subjects with elevated lipoprotein(a)

  Nicholls, S.

  30/09/21 → 29/09/26

  Project: Research

• A Double-Blind Placebo-Controlled Phase 2b Study to Evaluate the Efficacy and Safety of ARO-APOC3 in Adults with Severe Hypertriglyceridemia

  Nicholls, S.

  17/08/21 → 16/08/26

  Project: Research

• Statins and Progression of Coronary Atherosclerosis in Melanoma Patients Treated with Immune Checkpoint Inhibitors (V2)

  Nicholls, S., Segelov, E., Shackleton, M., McArthur, G., Haydon, A., Zoungas, S., Mar, V., Nerlekar, N., Liew, D., Ahern, E., Wolfe, R., Nelson, A., Sverdlov, A. L., Button-Sloan, A. E. & Reid, C. M.

  1/06/21 → 31/05/25

  Project: Research

• NHMRC Centre of Research Excellence for Better Outcomes in Coronary Artery Disease

  Figtree, G., Nicholls, S., Chow, C., Grieve, S. M., Brown, A., Jenkins, A., Karlheinz, P., Psaltis, P. J., Yang, J. Y. H. & Meikle, P. J.

  1/11/20 → 31/10/25

  Project: Research

• A randomized double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein(a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease

  Nicholls, S.

  7/07/20 → 6/07/25

  Project: Research

• The Effect of Tirzepatide versus Dulaglutide on Major Adverse Cardiovascular Events in Patients with Type 2 Diabetes (SURPASS-CVOT)

  Nicholls, S.

  2/06/20 → 1/06/25

  Project: Research

• Using Polygenic Risk Scores to Target Statin Therapy in Primary Prevention

  Nicholls, S., Semsarian, C., Wong, D., Zoungas, S., Ingles, J. & Nelson, A.

  1/06/20 → 30/03/25

  Project: Research

• A Double-blind, Randomized, Placebo-controlled Phase 2 Study to Evaluate Efficacy, Safety, and Tolerability of AMG 890 (a GalNAc conjugated Small Interfering RNA [siRNA]) in Subjects with Elevated Lipoprotein(a)

  Nicholls, S.

  26/05/20 → 25/05/25

  Project: Research

• Not started

  A Phase 3 Randomized, Placebo-Controlled Clinical Study to Evaluate the Efficacy and Safety of MK-0616 in Reducing Major Adverse Cardiovascular Events in Participants at High Cardiovascular Risk

  Nicholls, S.

  Project: Research

• A randomized double-blind, placebo controlled, multicenter trial, assessing the impact of inclisiran on major adverse cardiovascular events in participants with established cardiovascular disease (VICTORION-2 PREVENT)

  Nicholls, S.

  Project: Research

• Finished

  Open-label, phase 1b, single ascending dose study to evaluate the safety of VERVE-102 administered to patients with heterozygous familial hypercholesterolemia or premature coronary artery disease who require additional lowering of low-density lipoprotein cholesterol

  Nicholls, S.

  12/08/24 → 21/11/24

  Project: Research

• The Association between Cardiovascular Disease and Cancer

  Nerlekar, N., Tan, S. & Nicholls, S.

  9/06/23 → 8/06/24

  Project: Research

• Improving cardiovascular medtech adoption with the Victorian Heart Institute

  Nicholls, S.

  30/04/23 → 28/02/24

  Project: Research

• Understanding the mechanisms and therapeutic potential of Fauna compounds in cardiothoracic pathophysiology

  Bubb, K. & Nicholls, S.

  Fauna Bio Incorporated

  1/03/23 → 31/12/24

  Project: Research

• INFLUENCE: INcreasing inFLUEnza immuNisation of Cardiovascular inpatiEnts (INFLUENCE): A multifaceted, multi-level systems approach to increasing adoption

  Nelson, A., Bonner, C., Hickman, J. & Nicholls, S.

  1/01/23 → 31/12/24

  Project: Research

• Obicetrapib and Cardiovascular Outcomes: A Placebo Controlled, Double Blind, Randomized Phase 3 Study to Evaluate the Effect of 10 mg Obicetrapib in Participants with Atherosclerotic Cardiovascular Disease (ASCVD) Who are Not Adequately Controlled Despite Maximally Tolerated Lipid Modifying Therapies

  Nicholls, S.

  1/07/22 → 30/04/23

  Project: Research

• Dual-API Drug-Coated Balloon for the treatment of coronary de-novo lesions, ISR or small vessel disease in patients with symptomatic ischemic heart disease

  Nicholls, S.

  Advanced NanoTherapies Inc, Advanced Nanotherapies Australia Pty Ltd

  1/03/22 → 30/06/24

  Project: Research

• Improving screening and management of women with cardio-metabolic conditions during pregnancy

  Moran, L., Palmer, K., Lim, S., Hutchesson, M. J., Lorber Rolnik, D., Teede, H., Nicholls, S., Mol, B., Morrison, M. K. & Sturgiss, L.

  1/10/21 → 30/09/24

  Project: Research

• New frontiers in personalised prevention of CAD

  Figtree, G., Saheli, S., Ritchie, R., Nicholls, S., Drummond, G. & Meikle, P. J.

  1/07/21 → 30/09/22

  Project: Research

• Victorian Health Innovation Centre

  Nicholls, S. & Zoungas, S.

  28/06/21 → 31/12/22

  Project: Research

• PARTNERSHIP FOR PRECISION PREVENTION IN CAD (PPP-CAD)

  Figtree, G. A., Nicholls, S., Redfern, J., Wilson, A., Walley, T., Usherwood, T. P., Kilov, G., Grieve, S. M., Meikle, P. J. & Jennings, G.

  30/04/21 → 29/04/24

  Project: Research

• Familial Hypercholesterolaemia Registry

  Nicholls, S.

  1/04/21 → 1/10/22

  Project: Research

• Investigating the protective role of C-type natriuretic peptide in preeclampsia and future cardiovascular risk.

  Bubb, K., Nicholls, S., Hobbs, A., Colafella, K. & Ashton, A.

  National Heart Foundation of Australia

  1/04/21 → 31/03/23

  Project: Research

• CLEER-HF01-001 early detection of heart failure study

  Nicholls, S.

  22/03/21 → 31/12/21

  Project: Research

• A randomized trial of evolocumab on saphenous vein graft patency following coronary artery bypass surgery ("NEWTON-CABG")

  Nicholls, S. & Skiba, M.

  Unity Health Toronto

  22/03/21 → 8/06/24

  Project: Research