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Research Output 1988 2019

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2019

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse

de Vries, M., Carpinelli, M., Rutland, E., Hatzipantelis, A., Partridge, D., Auden, A., Anderson, P. J., De Groef, B., Wu, H., Osterwalder, M., Visel, A., Jane, S. M. & Dworkin, S., 26 Nov 2019, (Accepted/In press) In : Developmental Biology. 10 p.

Research output: Contribution to journalArticleResearchpeer-review

KCC1 Activation protects Mice from the Development of Experimental Cerebral Malaria

Hortle, E., Starrs, L., Brown, F., Jane, S., Curtis, D., McMorran, B. J., Foote, S. J. & Burgio, G., 1 Dec 2019, In : Scientific Reports. 9, 1, 11 p., 6356.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018
2 Citations (Scopus)

Bone marrow transplantation corrects haemolytic anaemia in a novel ENU mutagenesis mouse model of TPI deficiency

Conway, A., Brown, F. C., Hortle, E. J., Burgio, G., Foote, S. J., Morton, C. J., Jane, S. M. & Curtis, D. J., 21 May 2018, In : Disease Models and Mechanisms. 11, 5, 8 p., dmm034678.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of Tfrc-mutant mice with microcytic phenotypes

Conway, A. J., Brown, F. C., Rank, G., Kile, B. T., Morton, C. J., Jane, S. M. & Curtis, D. J., 14 Aug 2018, In : Blood Advances. 2, 15, p. 1914-1922 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell Death and Disease. 9, 11, 12 p., 1072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs

Kersbergen, A., Best, S. A., Dworkin, S., Ah-Cann, C., de Vries, M. E., Asselin-Labat, M. L., Ritchie, M. E., Jane, S. M. & Sutherland, K. D., 1 Nov 2018, In : Developmental Biology. 443, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Restricted cell cycle is essential for clonal evolution and therapeutic resistance of pre-leukemic stem cells

Tremblay, C., Saw, J., Chiu, S. K., Wong, N. C., Tsyganov, K., Ghotb, S., Graham, A. N., Yan, F., Guirguis, A., Sonderegger, S., Lee, N., Kalitsis, P., Reynolds, J., Ting, S., Powell, D., Jane, S. & Curtis, D., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 3535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
16 Citations (Scopus)

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In : Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017
2 Citations (Scopus)

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

Conway, A. J., Brown, F. C., Fullinfaw, R. O., Kile, B. T., Jane, S. M. & Curtis, D. J., 1 Aug 2017, In : Disease Models and Mechanisms. 10, 8, p. 1005-1013 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Brown, F., Collett, M., Tremblay, C. S., Rank, G., De Camilli, P., Booth, C. J., Bitoun, M., Robinson, P. J., Kile, B. T., Jane, S. M. & Curtis, D. J., Sep 2017, In : British Journal of Haematology. 178, 4, p. 616 - 628 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension

Miles, L. B., Darido, C., Kaslin, J., Heath, J. K., Jane, S. M. & Dworkin, S., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 17607.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016
25 Citations (Scopus)

Loss-of-function mutations of Dynamin 2 promote T-ALL by enhancing IL-7 signalling

Tremblay, CS., Brown, FC., Collett, M., Saw, J., Chiu, SK., Sonderegger, SE., Lucas, SE., Alserihi, R., Chau, N., Toribio, ML., McCormack, MP., Chircop, M., Robinson, PJ., Jane, SM. & Curtis, DJ., 1 Oct 2016, In : Leukemia. 30, 10, p. 1993-2001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

Goldie, S. J., Arhatari, B. D., Anderson, P., Auden, A., Partridge, D. D., Jane, S. M. & Dworkin, S., 18 Oct 2016, In : BMC Developmental Biology. 16, 1, 37.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)

The role of barrier genes in epidermal malignancy

Darido, C., Georgy, S. R. & Jane, S. M., 2016, In : Oncogene. 1, p. 1 - 8 8 p.

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)

Two ancient gene families are critical for maintenance of the mammalian skin barrier in postnatal life

Cangkrama, M., Darido, C., Georgy, S. R., Partridge, D., Auden, A., Srivastava, S., Wilanowski, T. & Jane, S. M., 2016, In : Journal of Investigative Dermatology. 136, 7, p. 1438 - 1448 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
9 Citations (Scopus)

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

Brown, F. C., Conway, A. J., Cerruti, L., Collinge, J. E., McLean, C., Wiley, J. S., Kile, B. T., Jane, S. M. & Curtis, D. J., 2015, In : Blood. 126, 26, p. 2863-2870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Consequences of the loss of the Grainyhead-like 1 gene for renal gene expression, regulation of blood pressure and heart rate in a mouse model

Pawlak, M., Walkowska, A., Mlacki, M., Pistolic, J., Wrzesinski, T., Benes, V., Jane, S. M., Wesoly, J., Kompanowska-Jezierska, E. & Wilanowski, T., 2015, In : Acta Biochimica Polonica. 62, 2, p. 287 - 296 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Identification of a novel proto-oncogenic network in head and neck squamous cell carcinoma

Georgy, S. R., Cangkrama, M., Srivastava, S., Partridge, D., Auden, A., Dworkin, S., McLean, C. A., Jane, S. M. & Darido, C., 2015, In : Journal of the National Cancer Institute. 107, 9, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
22 Citations (Scopus)

Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton

Dworkin, S., Simkin, J. E., Darido, C., Partridge, D., Georgy, S. R., Caddy, J., Wilanowski, T., Lieschke, G., Doggett, K., Heath, J. K. & Jane, S. M., 2014, In : Mechanisms of Development. 133, p. 77 - 90 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Human fetal globin gene expression is regulated by LYA R

Ju, J., Wang, Y., Liu, R., Zhang, Y., Xu, Z., Wang, Y., Wu, Y., Liu, M., Cerruti, L., Zou, F., Ma, C., Fang, M., Tan, R., Jane, S. M. & Zhao, Q., 2 Sep 2014, In : Nucleic Acids Research. 42, 15, 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Loss of grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin

Mlacki, M., Darido, C., Jane, S. M. & Wilanowski, T., 2014, In : PLoS ONE. 9, 2, 9 p., e89247.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2013
12 Citations (Scopus)

ENU mutagenesis identifies the first mouse mutants reproducing human beta-thalassemia at the genomic level

Brown, F., Scott, N., Rank, G., Collinge, J. E., Vadolas, J., Vickaryous, N., Whitelaw, N. C., Whitelaw, E., Kile, B., Jane, S. M. & Curtis, D. J., 2013, In : Blood Cells, Molecules, and Diseases. 50, 2, p. 86-92 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Golgi feels its own wound

Darido, C. & Jane, S., 2013, In : Advances in Wound Care. 2, 3, p. 87 - 92 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Induction of human fetal hemoglobin expression by adenosine-2',3'-dialdehyde

He, Y., Rank, G., Zhang, M., Ju, J., Liu, R., Xu, Z., Brown, F., Cerruti, L., Ma, C., Tan, R., Jane, S. M. & Zhao, Q., 2013, In : Journal of Translational Medicine. 11, p. 1 - 7 7 p., 14.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Novel mechanisms that pattern and shape the midbrain-hindbrain boundary

Dworkin, S. & Jane, S. M., 2013, In : Cellular and Molecular Life Sciences. 70, 18, p. 3365 - 3374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
26 Citations (Scopus)

Inhibition of apoptosis by BCL2 prevents leukemic transformation of a murine myelodysplastic syndrome

Slape, C. I., Saw, J. M. Y., Jowett, J. B., Aplan, P. D., Strasser, A., Jane, S. M. & Curtis, D. J., 2012, In : Blood. 120, 12, p. 2475 - 2483 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways

Dworkin, S., Darido, C., Georgy, S. R., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J., Lieschke, G. & Jane, S., 2012, In : Development. 139, 3, p. 525 - 536 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Regulation of delta-aminolevulinic acid dehydratase by kruppel-like factor 1

Desgardin, A. D., Abramova, T., Rosanwo, T. O., Kartha, S., Shim, E-H., Jane, S. M. & Cunningham, J., 2012, In : PLoS ONE. 7, 10, 11 p., e46482.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

The role of WDR5 in silencing human fetal globin gene expression

Xu, Z., He, Y., Ju, J., Rank, G., Cerruti, L., Ma, C., Simpson, R. J., Moritz, R. L., Jane, S. M. & Zhao, Q., 2012, In : Haematologica: the hematology journal. 97, 11, p. 1632 - 1640 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2011
14 Citations (Scopus)

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation

Nguyen, N-Y. N., Maxwell, M. J., Ooms, L., Davies, E. M., Hilton, A. A., Collinge, J. E., Hilton, D. J., Kile, B. T., Mitchell, C. A., Hibbs, M. L., Jane, S. M. & Curtis, D. J., 2011, In : Blood. 117, 20, p. 5362-5371 10 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis

Darido, C., Georgy, S. R., Wilanowski, T., Dworkin, S., Auden, A., Zhao, Q., Rank, G., Srivastava, S., Finlay, M. J., Papenfuss, A. T., Pandolfi, P. P., Pearson, R. B. & Jane, S., 2011, In : Cancer Cell. 20, 5, p. 635 - 648 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair

Dworkin, S., Jane, S. & Darido, C., 2011, In : Organogenesis. 7, 3, p. 202 - 208 7 p.

Research output: Contribution to journalArticleOther

62 Citations (Scopus)

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity

Boglev, Y., Wilanowski, T., Caddy, J., Parekh, V., Auden, A., Darido, C., Hislop, N., Cangkrama, M., Ting, S. & Jane, S., 2011, In : Developmental Biology. 349, 2, p. 512 - 522 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
115 Citations (Scopus)

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

Caddy, J., Wilanowski, T., Darido, C., Dworkin, S., Ting, S., Zhao, Q., Rank, G., Auden, A., Srivastava, S., Cunningham, J. & Jane, S., 2010, In : Developmental Cell. 19, 1, p. 138 - 147 10 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

Rank, G., Cerruti, L., Simpson, R., Moritz, R., Jane, S. & Zhao, Q., 2010, In : Blood. 116, 9, p. 1585 - 1592 8 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Regional neural tube closure defined by the Grainy head-like transcription factors

Rifat, Y., Parekh, V., Wilanowski, T., Hislop, N., Auden, A., Ting, S., Cunningham, J. & Jane, S., 2010, In : Developmental Biology. 345, p. 237 - 245 9 p.

Research output: Contribution to journalArticleResearchpeer-review

151 Citations (Scopus)

The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal

McCormack, M., Young, L., Vasudevan, S., de Graaf, C., Codrington, R., Rabbitts, T., Jane, S. & Curtis, D., 2010, In : Science. 327, 12, p. 879 - 883 5 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The TAL1/SCL transcription factor regulates cell cycle progression and proliferation in differentiating murine bone marrow monocyte precursors

Dey, S., Curtis, D., Jane, S. & Brandt, S., 2010, In : Molecular and Cellular Biology. 30, 9, p. 2181 - 2192 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
37 Citations (Scopus)

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., Fernandez, K. M., McCormack, M. P., Cooke, B. M., Foote, S. J., Crabb, B. S., Curtis, D. J., Hilton, D. J., Kile, B. T. & Jane, S. M., 2009, In : Blood. 113, 14, p. 3352 - 3362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

301 Citations (Scopus)

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

Zhao, Q., Rank, G., Tan, Y., Moritz, R., Simpson, R., Cerruti, L., Curtis, D. & Jane, S., 2009, In : Nature Structural and Molecular Biology. 16, 3, p. 304 - 311 8 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The Hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms

Siggins, S., Nguyen, N-Y., McCormack, M., Vasudevan, S., Vilani, R., Jane, S., Wainwright, B. & Curtis, D., 2009, In : Blood. 114, 5, p. 995 - 1004 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
32 Citations (Scopus)

Grhl3 and Lmo4 play coordinate roles in epidermal migration

Hislop, N., Caddy, J., Ting, S., Auden, A., Vasudevan, S., King, S., Lineman, G., Visvader, J., Cunningham, J. & Jane, S., 2008, In : Developmental Biology. 321, p. 263 - 272 10 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

Perturbed desmosomal cadherin expression in grainy head-like 1-null mice

Wilanowski, T., Caddy, J., Ting, S., Cerruti, L., Auden, A., Zhao, L-L. & Jane, S., 2008, In : EMBO Journal. 27, p. 886 - 897 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
23 Citations (Scopus)

Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene

Salmon, J., Slater, N., Hall, M., McCormack, M., Jane, S. & Curtis, D., 2007, In : Blood. 110, 10, p. 3573 - 3581 9 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

The tumour-suppressor scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

Dow, L., Kauffman, J., Caddy, J., Peterson, A., Jane, S., Russell, S. & Humbert, P., 2007, In : Oncogene. 26, p. 2272 - 2282 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
35 Citations (Scopus)

A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis

McCormack, M. P., Hall, M. A., Schoenwaelder, S. M., Zhao, Q., Ellis, S. L., Prentice, J. A., Clarke, A. J., Slater, N. J., Salmon, J. M., Jackson, S. P., Jane, S. M. & Curtis, D. J., 2006, In : Blood. 108, 7, p. 2248-2256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Functional Interaction of CP2 with GATA-1 in the Regulation of Erythroid Promoters

Bose, F., Fugazza, C., Casalgrandi, M., Capelli, A., Cunningham, J., Zhao, Q., Jane, S., Ottolenghi, S. & Ronchi, A., 2006, In : Molecular and Cellular Biology. 26, 10, p. 3942 - 3954 13 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter

Zhao, Q., Cerruti, L., Cunningham, J. & Jane, S., 2006, In : Blood. 107, 5, p. 2138 - 2145 8 p.

Research output: Contribution to journalArticleResearchpeer-review