1984 …2021

Research output per year

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Research Output

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Article
2006

A pathogenetic role for mast cells in experimental crescentic glomerulonephritis

Timoshanko, J. R., Kitching, A. R., Semple, T. J., Tipping, P. G. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 1, p. 150 - 159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Assessing immune function in adult bronchiectasis

King, P. T., Hutchinson, P. E., Holmes, P., Freezer, N., Bennett-Wood, V. R., Robins-Browne, R. M. & Holdsworth, S. R., 2006, In : Clinical and Experimental Immunology. 144, 3, p. 440 - 446 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N. & Holmes, P., 2006, In : Internal Medicine Journal. 36, 11, p. 729 - 737 9 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis

Li, M., O'Sullivan, K., Jones, L. K., Semple, T. J., Kumanogoh, A., Kikutani, H., Holdsworth, S. R. & Kitching, A. R., 2006, In : Journal of Immunology. 177, 5, p. 3406 - 3412 7 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Characterisation of the onset and presenting clinical features of adult bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N., Villanueva, E. V. & Holmes, P., 2006, In : Respiratory Medicine. 100, 12, p. 2183 - 2189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

138 Citations (Scopus)
16 Citations (Scopus)

T cells in crescentic glomerulonephritis

Tipping, P. G. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 5, p. 1253 - 1263 11 p.

Research output: Contribution to journalArticleResearchpeer-review

128 Citations (Scopus)

The isolation and purification of biologically active recombinant and native autoantigens for the study of autoimmune disease

Apostolopoulos, J., Ooi, J. D. K., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2006, In : Journal of Immunological Methods. 308, 1-2, p. 167 - 178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2005

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms

Odobasic, D., Kitching, A. R., Tipping, P. G. & Holdsworth, S. R., 2005, In : Kidney International. 68, 2, p. 584 - 594 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Diagnosis of Mycobacterium tuberculosis infection using ESAT-6 and intracellular cytokine cytometry

Hughes, A. J., Hutchinson, P. E., Gooding, T., Freezer, N. J., Holdsworth, S. R. & Johnson, P. D. R., 2005, In : Clinical and Experimental Immunology. 142, 1, p. 132 - 139 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury

Dean, E. G., Wilson, G. R. A-M., Li, M., Edgtton, K. L., O'Sullivan, K., Hudson, B. G., Holdsworth, S. R. & Kitching, A. R., 2005, In : Kidney International. 67, 2, p. 566 - 575 10 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Glomerular expression of CD80 and CD86 is required for leukocyte accumulation and injury in crescentic glomerulonephritis

Odobasic, D., Kitching, A. R., Semple, T. J., Timoshanko, J. R., Tipping, P. G. & Holdsworth, S. R., 2005, In : Journal of the American Society of Nephrology. 16, 7, p. 2012 - 2022 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Granulocyte macrophage colony-stimulating factor expression by both renal parenchymal and immune cells mediates murine crescentic glomerulonephritis

Timoshanko, J. R., Kitching, A. R., Semple, T. J., Holdsworth, S. R. & Tipping, P. G., 2005, In : Journal of the American Society of Nephrology. 16, 9, p. 2646 - 2656 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

IL-12p40 and IL-18 in crescentic glomerulonephritis: IL-12p40 is the key Th1-defining cytokine chain, whereas IL-18 promotes local inflammation and leukocyte recruitment

Kitching, A. R., Turner, A. L., Wilson, G. R. A-M., Semple, T. J., Odobasic, D., Timoshanko, J. R., O'Sullivan, K. M., Tipping, P. G., Takeda, K., Akira, S. & Holdsworth, S. R., 2005, In : Journal of the American Society of Nephrology. 16, 7, p. 2023 - 2033 11 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Leukocyte phenotype and function predicts infection risk in renal transplant recipients

Blazik, M., Hutchinson, P. E., Matthew, J. D., Polkinghorne, K. R., Holdsworth, S. R., Atkins, R. C. & Chadban, S. J., 2005, In : Nephrology Dialysis Transplantation. 20, 10, p. 2226 - 2230 5 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Outcome in adult bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N. J., Villanueva, E. V., Gallagher, M. & Holmes, P., 2005, In : COPD: Journal of Chronic Obstructive Pulmonary Disease. 2, 1, p. 27 - 34 8 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)
2004

An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity

Ruth, A-J., Kitching, A. R., Li, M., Semple, T. J., Timoshanko, J. R., Tipping, P. G. & Holdsworth, S. R., 2004, In : Journal of Immunology. 173, 1, p. 136 - 144 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Contributions of IL-1 and IL-1to crescentic glomerulonephritis in mice

Timoshanko, J. R., Kitching, A. R., Iwakura, Y., Holdsworth, S. R. & Tipping, P. G., 2004, In : Journal of the American Society of Nephrology. 15, 4, p. 910 - 918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Contributions of IL-1β and IL-1α to Crescentic Glomerulonephritis in Mice

Timoshanko, J. R., Kitching, A. R., Iwakura, Y., Holdsworth, S. R. & Tipping, P. G., 1 Apr 2004, In : Journal of the American Society of Nephrology. 15, 4, p. 910-918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis

Kitching, A. R., Turner, A. L., Wilson, G. R. A-M., Edgtton, K. L., Tipping, P. G. & Holdsworth, S. R., 2004, In : Journal of the American Society of Nephrology. 15, 9, p. 2373 - 2382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: A protective role for IFN-

Kitching, A. R., Turner, A. L., Semple, T. J., Li, M., Edgtton, K. L., Wilson, G. R. A-M., Timoshanko, J. R., Hudson, B. G. & Holdsworth, S. R., 2004, In : Journal of the American Society of Nephrology. 15, 7, p. 1764 - 1774 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Ex vivo lymphocyte proliferative function is severely inhibited in renal transplant patients on mycophenolate mofetil treatment

Hutchinson, P., Jose, M., Atkins, R. C. & Holdsworth, S. R., 2004, In : Transplant Immunology. 13, 1, p. 55 - 61 7 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Fibrin independent proinflammatory effects of tissue factor in experimental crescentic glomerulonephritis

Cunningham, M. A., Kitching, A. R., Tipping, P. G. & Holdsworth, S. R., 2004, In : Kidney International. 66, 2, p. 647 - 654 8 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
46 Citations (Scopus)

The role of flow cytometric ANCA detection in screening for acute pauci-immune crescentic glomerulonephritis

Kitching, A. R., Hutchinson, P., Atkins, R. C. & Holdsworth, S. R., 2004, In : Nephrology Dialysis Transplantation. 19, 2, p. 365 - 370 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2003

Adaptive immunity to nontypeable Haemophilus influenzae.

King, P. T., Hutchinson, P. E., Johnson, P. D., Holmes, P. W., Freezer, N. J. & Holdsworth, S. R., 1 Jan 2003, In : American Journal of Respiratory and Critical Care Medicine. 167, 4, p. 587-592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Intrinsic renal cell expression of CD40 directs Th1 effectors inducing experimental crescentic glomerulonephritis

Ruth, A-J., Kitching, A. R., Semple, T. J., Tipping, P. G. & Holdsworth, S. R., 2003, In : Journal of the American Society of Nephrology. 14, 11, p. 2813 - 2822 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Intrinsic renal cells are the major source of tumor necrosis factor contributing to renal injury in murine crescentic glomerulonephritis

Timoshanko, J. R., Sedgwick, J. D., Holdsworth, S. R. & Tipping, P. G., 2003, In : Journal of the American Society of Nephrology. 14, 7, p. 1785 - 1793 9 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Plasminogen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomerulonephritis

Kitching, A. R., Kong, Y. Z., Huang, X. R., Davenport, P. R., Edgtton, K. L., Carmeliet, P., Holdsworth, S. R. & Tipping, P. G., 2003, In : Journal of the American Society of Nephrology. 14, 6, p. 1487 - 1495 9 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

T cells in glomerulonephritis

Tipping, P. G. & Holdsworth, S. R., 2003, In : Springer Seminars in Immunopathology. 24, 4, p. 377 - 393 17 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)
2002

effects of CRLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice

Kitching, A. R., Huang, X. R., Tipping, P. G. & Holdsworth, S. R., 2002, In : Clinical and Experimental Immunology. 128, p. 429 - 435 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of CTLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice

Kitching, A. R., Huang, X. R., Ruth, A. J., Tipping, P. G. & Holdsworth, S. R., 26 Jun 2002, In : Clinical and Experimental Immunology. 128, 3, p. 429-435 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

IFN-g Production by Intrinsic Renal Cells and Bone Marrow-Derived Cells is Required for Full Expression of Crescentic Glomerulonephritis in Mice

Timoshanko, J. R., Holdsworth, S. R., Kitching, A. R. & Tipping, P. G., 2002, In : Journal of Immunology. 168, p. 4135 - 4141 7 p.

Research output: Contribution to journalArticleResearchpeer-review

IFN-γ production by intrinsic renal cells and bone marrow-derived cells is required for full expression of crescentic glomerulonephritis in mice

Timoshanko, J. R., Holdsworth, S. R., Kitching, A. R. & Tipping, P. G., 15 Apr 2002, In : Journal of Immunology. 168, 8, p. 4135-4141 7 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Interleukin-10 inhibits experimental mesangial proliferative glomerulonephritis

Kitching, A. R., Katerelos, M., Mudge, S. J., Tipping, P. G., Power, D. A. & Holdsworth, S. R., 2002, In : Clinical and Experimental Immunology. 128, 1, p. 36 - 43 8 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

The Requirement for Granulocyte-Macrophage Colony-Stimulating Factor and Granulocyte Colony-Stimulating Factor in Leukocyte-Mediated Immune Glomerular Injury

Kitching, A. R., Huang, X. R., Turner, A. L., Tipping, P. G., Dunn, A. R. & Holdsworth, S. R., 2002, In : Journal of the American Society of Nephrology. 13, 2, p. 350 - 358 9 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)
2001

Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis

Timoshanko, J. R., Kitching, A. R., Holdsworth, S. R. & Tipping, P. G., 2001, In : Journal of the American Society of Nephrology. 12, p. 464 - 471 8 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)

Microbiologic profile in bronchiectasis

King, P. T., Johnson, P., Freezer, N. J., Holdsworth, S. R. & Holmes, P. W., 1 Dec 2001, In : Respirology. 6, SUPPL. 1

Research output: Contribution to journalArticleResearchpeer-review

2000

Chemokines as therapeutic targets in renal disease

Holdsworth, S. R., Kitching, A. R. & Tipping, P. G., 2000, In : Current Opinion in Nephrology and Hypertension. p. 505 - 511 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Crescentic glomerulonephritis - a manifestation of a nephritogenic Th1 response?

Kitching, A. R., Holdsworth, S. R. & Tipping, P. G., 2000, In : Histology and Histopathology. p. 993 - 1003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Endogenous glucocorticoids modulate experimental anti-glomerular basement membrane glomerulonephritis

Leech, M., Huang, X. R. R., Morand, E. F. & Holdsworth, S. R., 2000, In : Clinical and Experimental Immunology. p. 161 - 168 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Endogenous interleukin-10 regulates Th1 responses that induce crescentic glomerulonephritis

Kitching, A. R., Tipping, P. G., Timoshanko, J. R. & Holdsworth, S. R., 2000, In : Kidney International. p. 518 - 525 8 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

IL-18 Has IL-12-Independent Effects in Delayed-Type Hypersensitivity: Studies in Cell-Mediated Crescentic Glomerulonephritis

Kitching, A. R., Tipping, P. G., Kurimoto, M. & Holdsworth, S. R., 2000, In : Journal of Immunology. p. 4649 - 4657 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Interleukin-10 Inhibits Macrophage-Induced Glomerular Injury

Huang, X. R. R., Kitching, A. R., Tipping, P. G. & Holdsworth, S. R., 2000, In : Journal of the American Society of Nephrology. p. 262 - 269 8 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

MHC class I pathway is not required for the development of crescentic glomerulonephritis in mice

Li, S., Holdsworth, S. R. & Tipping, P. G., 2000, In : Clinical and Experimental Immunology. p. 453 - 458 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Protease-activated Receptor 1 Mediates Thrombin-dependent, Cell-mediated Renal Inflammation in Crescentic Glomerulonephritis

Cunningham, M. A., Rondeau, E., Chen, X., Coughlin, S. R., Holdsworth, S. R. & Tipping, P. G., 2000, In : The Journal of Experimental Medicine. p. 455 - 461 7 p.

Research output: Contribution to journalArticleResearchpeer-review

161 Citations (Scopus)

IFN-γ mediates crescent formation and cell-mediated immune injury in murine glomerulonephritis

Kitching, A. R., Holdsworth, S. R. & Tipping, P. G., 1 Apr 1999, In : Journal of the American Society of Nephrology. 10, 4, p. 752-759 8 p.

Research output: Contribution to journalArticleResearchpeer-review

114 Citations (Scopus)
70 Citations (Scopus)