1984 …2021

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2013

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease

King, P. T., Lim, S., Pick, A., Ngui, J., Prodanovic, Z., Downey, W., Choong, C. K. C., Kelman, A., Baranyai, E., Francis, M. J., Moshinsky, R., Bardin, P. G., Holmes, P. & Holdsworth, S. R., 2013, In : Journal of Allergy and Clinical Immunology. 131, 5 (Art. ID: e.14), p. 1314 - 1321 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)
14 Citations (Scopus)

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function

Odobasic, D., Kitching, A. R., Yang, Y. H., O'Sullivan, K., Muljadi, R. C. M., Edgtton, K. L., Tan, D. S. Y., Summers, S. A., Morand, E. F. & Holdsworth, S. R., 2013, In : Blood. 121, 20, p. 4195 - 4204 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN

Ooi, J., Chang, J., O'Sullivan, K., Pedchenko, V., Hudson, B. G., Vandenbark, A. A., Fugger, L., Holdsworth, S. R. & Kitching, A. R., 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 419 - 431 13 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN

Tan, D. S. Y., Gan, P. Y., O'Sullivan, K., Hammett, M. V., Summers, S. A., Ooi, J., Lundgren, B. A., Boyd, R. L., Scott, H. S., Kitching, A. R., Chidgey, A. P. & Holdsworth, S. R., 2013, In : Journal of the American Society of Nephrology. 24, 4, p. 573 - 585 13 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)
2012

Chest pain and exacerbations of bronchiectasis

King, P. T., Holdsworth, S. R., Farmer, M., Freezer, N. & Holmes, P., 2012, In : International Journal of General Medicine. 5, p. 1019 - 1024 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis

Nozaki, Y., Nikolic-Paterson, D., Snelgrove, S., Akiba, H., Yagita, H., Holdsworth, S. & Kitching, A., 2012, In : Kidney International. 81, 9, p. 844 - 855 12 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstruction

Summers, S. A., Gan, P-Y., Dewage, L. T., Ma, F., Ooi, J., O'Sullivan, K., Nikolic-Paterson, D. J., Kitching, A. R. & Holdsworth, S. R., 2012, In : Kidney International. 82, 6, p. 676 - 685 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Mast cells contribute to peripheral tolerance and attenuate autoimmune vasculitis

Gan, P. Y., Summers, S. A., Ooi, J., O'Sullivan, K., Tan, D. S. Y., Muljadi, R. C. M., Odobasic, D., Kitching, A. R. & Holdsworth, S. R., 2012, In : Journal of the American Society of Nephrology. 23, 12, p. 1955 - 1966 12 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Renal dendritic cells adopt a pro-inflammatory phenotype in obstructive uropathy to activate T cells but do not directly contribute to fibrosis

Snelgrove, S., Kausman, J., Lo, C., Lo, C., Ooi, J. D., Coates, P., Hickey, M., Holdsworth, S., Kurts, C., Engel, D. & Kitching, A., 2012, In : American Journal of Pathology. 180, 1, p. 91 - 103 13 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis

Ooi, J., Chang, J., Hickey, M. J., Borza, D-B., Fugger, L., Holdsworth, S. R. & Kitching, A. R., 2012, In : Proceedings of the National Academy of Sciences. 109, 39, p. E2615 - E2624 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
56 Citations (Scopus)
2011

Endogenous foxp3{+} T-regulatory cells suppress anti-glomerular basement membrane nephritis

Ooi, J., Snelgrove, S., Engel, D., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K., Hickey, M., Holdsworth, S., Kurts, C. & Kitching, A., 2011, In : Kidney International. 79, 9, p. 977 - 986 10 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Interleukin-17A promotes early but attenuates established disease in crescentic glomerulonephritis in mice

Odobasic, D., Gan, P-Y., Summers, S. A., Semple, T., Muljadi, R., Iwakura, Y., Kitching, A. & Holdsworth, S., 2011, In : American Journal of Pathology. 179, 3, p. 1188 - 1198 11 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Mast cells mediate acute kidney injury through the production of TNF

Summers, S. A., Chan, J., Gan, P-Y., Dewage, L., Nozaki, Y., Steinmetz, O., Nikolic-Paterson, D., Kitching, A. & Holdsworth, S., 2011, In : Journal of the American Society of Nephrology. 22, 12, p. 2226 - 2236 11 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Signal transducer and activation of transcription 6 (STAT6) regulates T helper type 1 (Th1) and Th17 nephritogenic immunity in experimental crescentic glomerulonephritis

Summers, S. A., Phoon, R., Odobasic, D., Dewage, L., Kitching, A. & Holdsworth, S., 2011, In : Clinical and Experimental Immunology. 166, 2, p. 227 - 234 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

The emergence of TH17 cells as effectors of renal injury

Kitching, A. & Holdsworth, S., 2011, In : Journal of the American Society of Nephrology. 22, 2, p. 235 - 238 4 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

The IL-27 receptor has biphasic effects in crescentic glomerulonephritis mediated through Th1 responses

Summers, S. A., Phoon, R., Ooi, J., Holdsworth, S. & Kitching, A., 2011, In : American Journal of Pathology. 178, 2, p. 580 - 590 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

The Th17-defining transcription factor RORgammat promotes glomerulonephritis

Steinmetz, O., Summers, S. A., Gan, P-Y., Semple, T., Holdsworth, S. & Kitching, A., 2011, In : Journal of the American Society of Nephrology. 22, 3, p. 472 - 483 12 p.

Research output: Contribution to journalArticleResearchpeer-review

54 Citations (Scopus)

Tim-1 promotes cisplatin nephrotoxicity

Nozaki, Y., Nikolic-Paterson, D., Yagita, H., Akiba, H., Holdsworth, S. & Kitching, A., 2011, In : American Journal of Physiology - Renal Physiology. 301, 5, p. F1098 - F1104 7 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis

Summers, S. A., Steinmetz, O., Gan, P-Y., Ooi, J., Odobasic, D., Kitching, A. & Holdsworth, S., 2011, In : Arthritis and Rheumatism. 63, 4, p. 1124 - 1135 12 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)
2010

Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis

Summers, S. A., van der Veen, B. S., O'Sullivan, K., Gan, P-Y., Ooi, J., Heeringa, P., Satchell, S. C., Mathieson, P. W., Saleem, M. A., Visvanathan, K., Holdsworth, S. R. & Kitching, A. R., 2010, In : Kidney International. 78, 12, p. 1263 - 1274 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Lung diffusing capacity in adult bronchiectasis: A longitudinal study

King, P., Holdsworth, S., Freezer, N., Villanueva, E. V., Farmer, M., Guy, P. & Holmes, P., 2010, In : Respiratory care. 55, 12, p. 1686 - 1692 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Review: T helper 17 cells: their role in glomerulonephritis

Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2010, In : Nephrology. 15, 5, p. 513 - 521 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., Steinmetz, O., Tan, D. S. Y., O'Sullivan, K., Ooi, J., Iwakura, Y., Kitching, A. R. & Holdsworth, S. R., 2010, In : Journal of the American Society of Nephrology. 21, 6, p. 925 - 931 7 p.

Research output: Contribution to journalArticleResearchpeer-review

117 Citations (Scopus)

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy

Summers, S. A., Hoi, A., Steinmetz, O., O'Sullivan, K., Ooi, J., Odobasic, D., Akira, S., Kitching, A. R. & Holdsworth, S. R., 2010, In : Journal of Autoimmunity. 35, 4, p. 291 - 298 8 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis

Summers, S. A., Steinmetz, O., Ooi, J., Gan, P-Y., O'Sullivan, K., Visvanathan, K., Akira, S., Kitching, A. R. & Holdsworth, S. R., 2010, In : American Journal of Pathology. 177, 5, p. 2234 - 2244 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
2009

Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis

Phoon, R. K. S., Kitching, A. R., Jones, L. K. & Holdsworth, S. R., 2009, In : Nephrology. 14, 7, p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Bactericidal activity of neutrophils with reduced oxidative burst from adults with bronchiectasis

King, P. T., Bennett-Wood, V. R., Hutchinson, P. E., Robins-Browne, R. M., Holmes, P., Freezer, N. & Holdsworth, S. R., 2009, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 117, 2, p. 133 - 139 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis

Li, M., O'Sullivan, K., Jones, L. K., Lo, C., Semple, T. J., Kumanogoh, A., Kikutani, H., Holdsworth, S. R. & Kitching, A. R., 2009, In : Immunology. 128, p. 114 - 122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis

Jones, L., O'Sullivan, K., Semple, T. J., Kuligowski, M., Fukami, K., Ma, F., Nicolic-Paterson, D., Holdsworth, S. R. & Kitching, A. R., 2009, In : Nephrology Dialysis Transplantation. 24, p. 3024 - 3032 9 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

IL-23, not IL-12, directs autoimmunity to the Goodpasture antigen

Ooi, J. D., Phoon, R. K. S., Holdsworth, S. R. & Kitching, A. R., 2009, In : Journal of the American Society of Nephrology. 20, p. 980 - 989 10 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Phenotypes of adult bronchiectasis: Onset of productive cough in childhood and adulthood

King, P. T., Holdsworth, S. R., Farmer, M., Freezer, N., Villanueva, E. V. & Holmes, P., 2009, In : COPD: Journal of Chronic Obstructive Pulmonary Disease. 6, 2, p. 130 - 136 7 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Th1 and Th17 cells induce proliferative glomerulonephritis

Summers, S. A., Steinmetz, O., Li, M., Kausman, J. Y., Semple, T. J., Edgtton, K. L., Borza, D-B., Braley, H., Holdsworth, S. R. & Kitching, A. R., 2009, In : Journal of the American Society of Nephrology. 20, 12, p. 2518 - 2524 7 p.

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)
2008

Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2008, In : Journal of Autoimmunity. 31, 3, p. 295 - 300 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae

King, P. T., Ngui, J., Farmer, M., Hutchinson, P. E., Holmes, P. W. & Holdsworth, S. R., 2008, In : Clinical and Experimental Immunology. 152, 3, p. 542 - 551 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis

Odobasic, D., Leech, M. T., Xue, J. R. & Holdsworth, S. R., 2008, In : Immunology. 124, 4, p. 503 - 513 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Effect of interferon gamma and CD40 ligation on intracellular monocyte survival of nontypeable Haemophilus influenzae

King, P. T., Ngui, J., Oppedisano, F., Robins-Browne, R. M., Holmes, P. & Holdsworth, S. R., 2008, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 116, 12, p. 1043 - 1049 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Intrarenal antigens activate CD4+ cells via co-stimulatory signals from dendritic cells

Edgtton, K. L., Kausman, J. Y., Li, M., O'Sullivan, K., Lo, C., Hutchinson, P. E., Yagita, H., Holdsworth, S. R. & Kitching, A. R., 2008, In : Journal of the American Society of Nephrology. 19, 3, p. 515 - 526 12 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Raised immunoglobulin E and idiopathic bronchiectasis

King, P. T., Holmes, P. W. & Holdsworth, S. R., 24 Oct 2008, In : Respiratory Medicine CME. 1, 4, p. 264-266 3 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Role of mast cells in progressive renal diseases

Holdsworth, S. R. & Summers, S. A., 2008, In : Journal of the American Society of Nephrology. 19, 12, p. 2254 - 2261 8 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Systemic humoral immunity to non-typeable Haemophilus influenzae

King, P. T., Ngui, J., Gunawardena, D. A., Holmes, P. W., Farmer, M. & Holdsworth, S. R., 2008, In : Clinical and Experimental Immunology. 153, 3, p. 376 - 384 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Targeting leukocytes in immune glomerular diseases

Kitching, A. R., Holdsworth, S. R. & Hickey, M. J., 2008, In : Current Medicinal Chemistry. 15, 5, p. 448 - 458 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

T-bet deficiency attenuates renal injury in experimental crescentic glomerulonephritis

Phoon, R. K. S., Kitching, A. R., Odobasic, D., Jones, L. K., Semple, T. J. & Holdsworth, S. R., 2008, In : Journal of the American Society of Nephrology. 19, 3, p. 477 - 485 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

The (re)challenging question of erythropoiesis-stimulating agents inducing pure red cell aplasia

Summers, S. A., Holdsworth, S. R. & Sharples, E., 2008, In : Nephrology Dialysis Transplantation. 23, 10, p. 3053 - 3055 3 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)
2007

Cytokines in glomerulonephritis

Tipping, P. G. & Holdsworth, S. R., 2007, In : Seminars in Nephrology. 27, 3, p. 275 - 285 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)
62 Citations (Scopus)

Leukocytes in glomerular injury

Holdsworth, S. R. & Tipping, P. G., 2007, In : Seminars in Immunopathology. 29, 4, p. 355 - 374 20 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Microbiologic follow-up study in adult bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N., Villanueva, E. V. & Holmes, P. W., 2007, In : Respiratory Medicine. 101, 8, p. 1633 - 1638 6 p.

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)
2006

Airway inflammation in asymptomatic children with episodic wheeze

Maclennan, C., Hutchinson, P. E., Holdsworth, S. R., Bardin, P. & Freezer, N., 2006, In : Pediatric Pulmonology. 41, 6, p. 577 - 583 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis

Ruth, A-J., Kitching, A. R., Kwan, R. Y. Q., Odobasic, D., Ooi, J. D. K., Timoshanko, J. R., Hickey, M. J. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 7, p. 1940 - 1949 10 p.

Research output: Contribution to journalArticleResearchpeer-review

99 Citations (Scopus)