1984 …2021

Research output per year

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Research Output

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Article

Absence of the lysosomal protein Limp-2 attenuates renal injury in crescentic glomerulonephritis

Lee, D. H. K., Gan, P. Y., Katerelos, M., Fraser, S. A., Gleich, K., Holdsworth, S. R. & Power, D. A., 2014, In : Immunology and Cell Biology. 92, 5, p. 400 - 408 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury

Snelgrove, S. L. L., Lo, C., Hall, P., Lo, C. Y. Y., Alikhan, M. A. A., Coates, T. T., Holdsworth, S. R. R., Hickey, M. J. J. & Kitching, R. R., May 2017, In : Transplantation. 101, 5, p. 1013-1024 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Adaptive immunity to nontypeable Haemophilus influenzae.

King, P. T., Hutchinson, P. E., Johnson, P. D., Holmes, P. W., Freezer, N. J. & Holdsworth, S. R., 1 Jan 2003, In : American Journal of Respiratory and Critical Care Medicine. 167, 4, p. 587-592 6 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Advances in the pathogenesis of Goodpasture's disease: From epitopes to autoantibodies to effector T cells

Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2008, In : Journal of Autoimmunity. 31, 3, p. 295 - 300 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Airway inflammation in asymptomatic children with episodic wheeze

Maclennan, C., Hutchinson, P. E., Holdsworth, S. R., Bardin, P. & Freezer, N., 2006, In : Pediatric Pulmonology. 41, 6, p. 577 - 583 7 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

An IL-12-Independent Role for CD40-CD154 in Mediating Effector Responses: Studies in Cell-Mediated Glomerulonephritis and Dermal Delayed-Type Hypersensitivity

Ruth, A-J., Kitching, A. R., Li, M., Semple, T. J., Timoshanko, J. R., Tipping, P. G. & Holdsworth, S. R., 2004, In : Journal of Immunology. 173, 1, p. 136 - 144 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Antibody independent crescentic glomerulonephritis in m chain deficient mice

Shuo, L., Holdsworth, S. R. & Tipping, P. G., 1997, In : Kidney International. p. 672 - 678 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Antiinflammatory effect of lipocortin 1 in experimental arthritis

Yang, Y., Leech, M., Hutchinson, P., Holdsworth, S. R. & Morand, E. F., 1997, In : Inflammation. p. 583 - 596 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Anti-neutrophil cytoplasmic antibodies and effector CD4+ cells play nonredundant roles in anti-myeloperoxidase crescentic glomerulonephritis

Ruth, A-J., Kitching, A. R., Kwan, R. Y. Q., Odobasic, D., Ooi, J. D. K., Timoshanko, J. R., Hickey, M. J. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 7, p. 1940 - 1949 10 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Anti-neutrophil monoclonal antibody therapy inhibits the development of adjuvant arthritis

Santos, L., Morand, E. F., Boyce, N. W. & Holdsworth, S. R., 1997, In : Clinical and Experimental Immunology. p. 248 - 253 6 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

A pathogenetic role for mast cells in experimental crescentic glomerulonephritis

Timoshanko, J. R., Kitching, A. R., Semple, T. J., Tipping, P. G. & Holdsworth, S. R., 2006, In : Journal of the American Society of Nephrology. 17, 1, p. 150 - 159 10 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

A plasmid-encoded peptide from Staphylococcus aureus induces anti-myeloperoxidase nephritogenic autoimmunity

Ooi, J. D., Jiang, J-H., Eggenhuizen, P. J., Chua, L. L., van Timmeren, M., Loh, K. L., O’Sullivan, K. M., Gan, P. Y., Zhong, Y., Tsyganov, K., Shochet, L. R., Ryan, J., Stegeman, C. A., Fugger, L., Reid, H. H., Rossjohn, J., Heeringa, P., Holdsworth, S. R., Peleg, A. Y. & Kitching, A. R., 29 Jul 2019, In : Nature Communications. 10, 1, 14 p., 3392.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Apoptotic Cell-Induced, Antigen-Specific Immunoregulation to Treat Experimental Antimyeloperoxidase GN

Gan, P. Y., Godfrey, A. S., Ooi, J. D., O'Sullivan, K. M., Oudin, V., Kitching, A. R. & Holdsworth, S. R., 1 Aug 2019, In : Journal of the American Society of Nephrology. 30, 8, p. 1365-1374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Assessing immune function in adult bronchiectasis

King, P. T., Hutchinson, P. E., Holmes, P., Freezer, N., Bennett-Wood, V. R., Robins-Browne, R. M. & Holdsworth, S. R., 2006, In : Clinical and Experimental Immunology. 144, 3, p. 440 - 446 7 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Atorvastatin enhances humoral immune responses but does not alter renal injury in experimental crescentic glomerulonephritis

Phoon, R. K. S., Kitching, A. R., Jones, L. K. & Holdsworth, S. R., 2009, In : Nephrology. 14, 7, p. 650 - 657 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Bactericidal activity of neutrophils with reduced oxidative burst from adults with bronchiectasis

King, P. T., Bennett-Wood, V. R., Hutchinson, P. E., Robins-Browne, R. M., Holmes, P., Freezer, N. & Holdsworth, S. R., 2009, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 117, 2, p. 133 - 139 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Biologicals targeting T helper cell subset differentiating cytokines are effective in the treatment of murine anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Chan, A., Ooi, J. D., Dick, J., Nagai, K., O'Sullivan, K. M., Oudin, V., Shim, R., Kitching, A. R. & Holdsworth, S. R., Nov 2019, In : Kidney International. 96, 5, p. 1121–1133 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Biologics for the treatment of autoimmune renal diseases

Holdsworth, S. R., Gan, P. Y. & Kitching, A. R., 1 Apr 2016, In : Nature Reviews Nephrology. 12, 4, p. 217-231 15 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N. & Holmes, P., 2006, In : Internal Medicine Journal. 36, 11, p. 729 - 737 9 p.

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

CD100 enhances dendritic cell and CD4+ cell activation leading to pathogenetic humoral responses and immune complex glomerulonephritis

Li, M., O'Sullivan, K., Jones, L. K., Semple, T. J., Kumanogoh, A., Kikutani, H., Holdsworth, S. R. & Kitching, A. R., 2006, In : Journal of Immunology. 177, 5, p. 3406 - 3412 7 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

CD8+ T cells effect glomerular injury in experimental anti-myeloperoxidase GN

Chang, J., Eggenhuizen, P., O'Sullivan, K. M., Alikhan, M. A., Holdsworth, S. R., Ooi, J. D. & Kitching, A. R., 1 Jan 2017, In : Journal of the American Society of Nephrology. 28, 1, p. 47-55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

CD80 and CD86 costimulatory molecules regulate crescentic glomerulonephritis by different mechanisms

Odobasic, D., Kitching, A. R., Tipping, P. G. & Holdsworth, S. R., 2005, In : Kidney International. 68, 2, p. 584 - 594 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Characterisation of the onset and presenting clinical features of adult bronchiectasis

King, P. T., Holdsworth, S. R., Freezer, N., Villanueva, E. V. & Holmes, P., 2006, In : Respiratory Medicine. 100, 12, p. 2183 - 2189 7 p.

Research output: Contribution to journalArticleResearchpeer-review

138 Citations (Scopus)

Chemokines as therapeutic targets in renal disease

Holdsworth, S. R., Kitching, A. R. & Tipping, P. G., 2000, In : Current Opinion in Nephrology and Hypertension. p. 505 - 511 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Chest pain and exacerbations of bronchiectasis

King, P. T., Holdsworth, S. R., Farmer, M., Freezer, N. & Holmes, P., 2012, In : International Journal of General Medicine. 5, p. 1019 - 1024 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Comparison of immunofluorescence and immunoperoxidase for demonstration of antinuclear antibodies on HEp-2 substrate

Tipping, P. G., Dimech, W. J., Littlejohn, G. O. & Holdsworth, S. R., 1 Jun 1987, In : Rheumatology. 26, 3, p. 188-192 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Contributions of IL-1 and IL-1to crescentic glomerulonephritis in mice

Timoshanko, J. R., Kitching, A. R., Iwakura, Y., Holdsworth, S. R. & Tipping, P. G., 2004, In : Journal of the American Society of Nephrology. 15, 4, p. 910 - 918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Contributions of IL-1β and IL-1α to Crescentic Glomerulonephritis in Mice

Timoshanko, J. R., Kitching, A. R., Iwakura, Y., Holdsworth, S. R. & Tipping, P. G., 1 Apr 2004, In : Journal of the American Society of Nephrology. 15, 4, p. 910-918 9 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Crescentic glomerulonephritis - a manifestation of a nephritogenic Th1 response?

Kitching, A. R., Holdsworth, S. R. & Tipping, P. G., 2000, In : Histology and Histopathology. p. 993 - 1003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Cytokines: Names and numbers you should care about

Holdsworth, S. R. & Gan, P. Y., 2015, In : Clinical Journal of the American Society of Nephrology. 10, 12, p. 2243 - 2254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Cytokines in glomerulonephritis

Tipping, P. G. & Holdsworth, S. R., 2007, In : Seminars in Nephrology. 27, 3, p. 275 - 285 11 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Cytotoxic T lymphocyte and natural killer cell responses to non-typeable Haemophilus influenzae

King, P. T., Ngui, J., Farmer, M., Hutchinson, P. E., Holmes, P. W. & Holdsworth, S. R., 2008, In : Clinical and Experimental Immunology. 152, 3, p. 542 - 551 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian adults

Slade, C. A., Bosco, J. J., Giang, T. B., Kruse, E., Stirling, R. G., Cameron, P. U., Hore-Lacy, F., Sutherland, M. F., Barnes, S. L., Holdsworth, S., Ojaimi, S., Unglik, G. A., De Luca, J., Patel, M., McComish, J., Spriggs, K., Tran, Y., Auyeung, P., Nicholls, K., O'Hehir, R. E. & 4 others, Hodgkin, P. D., Douglass, J. A., Bryant, V. L. & van Zelm, M. C., 14 May 2018, In : Frontiers in Immunology. 9, MAY, 9 p., 694.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

King, P. T., Sharma, R., O'Sullivan, K. M., Callaghan, J., Dousha, L., Thomas, B., Ruwanpura, S., Lim, S., Farmer, M. W., Jennings, B. R., Finsterbusch, M., Brooks, G., Selemidis, S., Anderson, G. P., Holdsworth, S. R. & Bardin, P. G., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 12128.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Detection of anti-dna antibodies: A comparison between two farr assays, Crithidia luciliae and a human chromosomal substrate assay

Tipping, P. G., Buchanan, R. R. C., Riglar, A. G., Dimech, W. J., Littlejohn, G. O. & Holdsworth, S. R., 1 Jun 1988, In : Rheumatology. 27, 3, p. 206-210 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Detection of intracellular lipocortin 1 in human leukocyte subsets

Morand, E. F., Hutchinson, P., Hargreaves, A., Goulding, N. J., Boyce, N. W. & Holdsworth, S. R., 1 Jan 1995, In : Clinical Immunology and Immunopathology. 76, 2, p. 195-202 8 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Diagnosis of Mycobacterium tuberculosis infection using ESAT-6 and intracellular cytokine cytometry

Hughes, A. J., Hutchinson, P. E., Gooding, T., Freezer, N. J., Holdsworth, S. R. & Johnson, P. D. R., 2005, In : Clinical and Experimental Immunology. 142, 1, p. 132 - 139 8 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Differential effects of steroids on leukocyte-mediated glomerulonephritis in the rabbit

Holdsworth, S. R. & Bellomo, R., 1 Jan 1984, In : Kidney International. 26, 2, p. 162-169 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
17 Citations (Scopus)

Distinct in vivo roles of CD80 and CD86 in the effector T-cell responses inducing antigen-induced arthritis

Odobasic, D., Leech, M. T., Xue, J. R. & Holdsworth, S. R., 2008, In : Immunology. 124, 4, p. 503 - 513 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 others, Holdsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Effect of interferon gamma and CD40 ligation on intracellular monocyte survival of nontypeable Haemophilus influenzae

King, P. T., Ngui, J., Oppedisano, F., Robins-Browne, R. M., Holmes, P. & Holdsworth, S. R., 2008, In : APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 116, 12, p. 1043 - 1049 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

effects of CRLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice

Kitching, A. R., Huang, X. R., Tipping, P. G. & Holdsworth, S. R., 2002, In : Clinical and Experimental Immunology. 128, p. 429 - 435 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of CTLA4-Fc on glomerular injury in humorally-mediated glomerulonephritis in BALB/c mice

Kitching, A. R., Huang, X. R., Ruth, A. J., Tipping, P. G. & Holdsworth, S. R., 26 Jun 2002, In : Clinical and Experimental Immunology. 128, 3, p. 429-435 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
6 Citations (Scopus)

Endogenous CD100 promotes glomerular injury and macrophage recruitment in experimental crescentic glomerulonephritis

Li, M., O'Sullivan, K., Jones, L. K., Lo, C., Semple, T. J., Kumanogoh, A., Kikutani, H., Holdsworth, S. R. & Kitching, A. R., 2009, In : Immunology. 128, p. 114 - 122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Endogenous foxp3{+} T-regulatory cells suppress anti-glomerular basement membrane nephritis

Ooi, J., Snelgrove, S., Engel, D., Hochheiser, K., Ludwig-Portugall, I., Nozaki, Y., O'Sullivan, K., Hickey, M., Holdsworth, S., Kurts, C. & Kitching, A., 2011, In : Kidney International. 79, 9, p. 977 - 986 10 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Endogenous glucocorticoids modulate experimental anti-glomerular basement membrane glomerulonephritis

Leech, M., Huang, X. R. R., Morand, E. F. & Holdsworth, S. R., 2000, In : Clinical and Experimental Immunology. p. 161 - 168 8 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
28 Citations (Scopus)

Endogenous IL-13 Limits Humoral Responses and Injury in Experimental Glomerulonephritis but Does Not Regulate Th1 Cell-Mediated Crescentic Glomerulonephritis

Kitching, A. R., Turner, A. L., Wilson, G. R. A-M., Edgtton, K. L., Tipping, P. G. & Holdsworth, S. R., 2004, In : Journal of the American Society of Nephrology. 15, 9, p. 2373 - 2382 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)