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Research Output 1985 2019

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2019

OX40 ligand is inhibitory during the effector phase of crescentic glomerulonephritis

Odobasic, D., Ruth, A. J., Oudin, V., Kitching, A. R. & Holdsworth, S. R., 1 Mar 2019, In : Nephrology Dialysis Transplantation. 34, 3, p. 429-441 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Delayed diagnosis and complications of predominantly antibody deficiencies in a cohort of Australian adults

Slade, C. A., Bosco, J. J., Giang, T. B., Kruse, E., Stirling, R. G., Cameron, P. U., Hore-Lacy, F., Sutherland, M. F., Barnes, S. L., Holdsworth, S., Ojaimi, S., Unglik, G. A., De Luca, J., Patel, M., McComish, J., Spriggs, K., Tran, Y., Auyeung, P., Nicholls, K., O'Hehir, R. E. & 4 othersHodgkin, P. D., Douglass, J. A., Bryant, V. L. & van Zelm, M. C., 14 May 2018, In : Frontiers in Immunology. 9, MAY, 9 p., 694.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Measurement of Humoral Immune Competence and the Risk of Sinopulmonary Infection in a Cohort of Kidney Transplant Recipients

Dendle, C., Stuart, R. L., Mulley, W. R., Polkinghorne, K. R., Gan, P. Y., Kanellis, J., Ngui, J., Laurie, K., Thursky, K., Leung, V. K. & Holdsworth, S. R., 1 Dec 2018, In : Transplantation Proceedings. 50, 10, p. 3367-3370 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Seroresponses and safety of 13-valent pneumococcal conjugate vaccination in kidney transplant recipients

Dendle, C., Stuart, R. L., Polkinghorne, K. R., Balloch, A., Kanellis, J., Ling, J., Kummrow, M., Moore, C., Thursky, K., Buttery, J., Mulholland, K., Gan, P. Y., Holdsworth, S. & Mulley, W. R., 1 Apr 2018, In : Transplant Infectious Disease. 20, 2, 9 p., e12866.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Activated renal dendritic cells cross present intrarenal antigens after ischemia reperfusion injury

Snelgrove, S. L. L., Lo, C., Hall, P., Lo, C. Y. Y., Alikhan, M. A. A., Coates, T. T., Holdsworth, S. R. R., Hickey, M. J. J. & Kitching, R. R., May 2017, In : Transplantation. 101, 5, p. 1013-1024 12 p.

Research output: Contribution to journalArticleResearchpeer-review

CD8+ T cells effect glomerular injury in experimental anti-myeloperoxidase GN

Chang, J., Eggenhuizen, P., O'Sullivan, K. M., Alikhan, M. A., Holdsworth, S. R., Ooi, J. D. & Kitching, A. R., 1 Jan 2017, In : Journal of the American Society of Nephrology. 28, 1, p. 47-55 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Deoxyribonuclease 1 reduces pathogenic effects of cigarette smoke exposure in the lung

King, P. T., Sharma, R., O'Sullivan, K. M., Callaghan, J., Dousha, L., Thomas, B., Ruwanpura, S., Lim, S., Farmer, M. W., Jennings, B. R., Finsterbusch, M., Brooks, G., Selemidis, S., Anderson, G. P., Holdsworth, S. R. & Bardin, P. G., 1 Dec 2017, In : Scientific Reports. 7, 1, 9 p., 12128.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Ooi, J. D., Petersen, J., Tan, Y. H., Huynh, M., Willett, Z. J., Ramarathinam, S. H., Eggenhuizen, P. J., Loh, K. L., Watson, K. A., Gan, P. Y., Alikhan, M. A., Dudek, N. L., Handel, A., Hudson, B. G., Fugger, L., Power, D. A., Holt, S. G., Coates, P. T., Gregersen, J. W., Purcell, A. W. & 5 othersHoldsworth, S. R., La Gruta, N. L., Reid, H. H., Rossjohn, J. & Kitching, A. R., 11 May 2017, In : Nature. 545, 7653, p. 243-247 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Induced regulatory T cells are phenotypically unstable and do not protect mice from rapidly progressive glomerulonephritis

Ghali, J. R., Alikhan, M. A., Holdsworth, S. R. & Kitching, A. R., Jan 2017, In : Immunology. 150, 1, p. 100-114 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-17RA Promotes Humoral Responses and Glomerular Injury in Experimental Rapidly Progressive Glomerulonephritis

Ghali, J. R., O'Sullivan, K. M., Eggenhuizen, P. J., Holdsworth, S. R. & Kitching, A. R., Mar 2017, In : Nephron. 135, 3, p. 207-223 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenic role for γδ T cells in autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P. Y., Fujita, T., Ooi, J. D., Alikhan, M. A., Dick, J., Shim, R., Odobasic, D., O'Sullivan, K. M., Kitching, A. R. & Holdsworth, S. R., 1 Nov 2017, In : Journal of Immunology. 199, 9, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell receptor assessment in autoimmune disease requires access to the most adjacent immunologically active organ

Oftedal, B. E., Ardesjö Lundgren, B., Hamm, D., Gan, P. Y., Holdsworth, S. R., Hahn, C. N., Schreiber, A. W. & Scott, H. S., 1 Jul 2017, In : Journal of Autoimmunity. 81, p. 24-33 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Biologics for the treatment of autoimmune renal diseases

Holdsworth, S. R., Gan, P. Y. & Kitching, A. R., 1 Apr 2016, In : Nature Reviews Nephrology. 12, 4, p. 217-231 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous toll-like receptor 9 regulates AKI by promoting regulatory T cell recruitment

Alikhan, M., Summers, S. A., Gan, P. Y., Chan, A., Khouri, M., Ooi, J., Ghali, J., Odobasic, D., Hickey, M. J., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 3, p. 706 - 714 9 p.

Research output: Contribution to journalArticleResearchpeer-review

ISN Nexus 2016 Symposia: Translational Immunology in Kidney Disease—The Berlin Roadmap

Anders, H. J., Rovin, B., Jayne, D., Brunetta, P., Coppo, R., Davidson, A., Devarapu, S. K., de Zeeuw, D., Duffield, J. S., Eulberg, D., Fierro, A., Floege, J., Frese, S., Guillevin, L., Holdsworth, S., Hughes, J., Kettritz, R., Kluger, M., Krebs, C., Lapteva, L. & 25 othersLevin, A., Li, J., Lightstone, L., Mack, M., Mansouri, L., McAdoo, S., McKinney, E., Panzer, U., Parikh, S., Pusey, C., Putterman, C., Rabelink, T. J., Radbruch, A., Rees, A., Reilly, M. M., Reinders, M., Remuzzi, G., Ruggenenti, P., Sacks, S., Schall, T. J., Meyer-Schwesinger, C., Sharma, S. K., Suzuki, Y., Tomas, N. M. & Zhao, M. H., 2016, In : Kidney International Reports. 1, 4, p. 327-339 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mast cell stabilization ameliorates autoimmune anti-myeloperoxidase glomerulonephritis

Gan, P-Y., O'Sullivan, K. M., Ooi, J. D., Alikhan, M. A., Odobasic, D., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 1 May 2016, In : Journal of the American Society of Nephrology. 27, 5, p. 1321 - 1333 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloperoxidase peptide-based nasal tolerance in experimental ANCA-associated GN

Gan, P. Y., Tan, D. S. Y., Ooi, J., Alikhan, M., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of the American Society of Nephrology. 27, 2, p. 385 - 391 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Neutrophil-mediated regulation of innate and adaptive immunity: The role of myeloperoxidase

Odobasic, D., Kitching, A. R. & Holdsworth, S. R., 2016, In : Journal of Immunology Research. 2016, p. 1 - 11 11 p., 2349817.

Research output: Contribution to journalArticleOtherpeer-review

Regulatory T cells in immune mediated renal disease

Ghali, J., Wang, Y. M., Holdsworth, S. R. & Kitching, A. R., 2016, In : Nephrology. 21, 2, p. 86 - 96 11 p.

Research output: Contribution to journalArticleOtherpeer-review

The NLRP3 inflammasome in kidney disease and autoimmunity

Hutton, H. L., Ooi, J., Holdsworth, S. R. & Kitching, A. R., 2016, In : Nephrology. 21, 9, p. 736 - 744 9 p.

Research output: Contribution to journalArticleOtherpeer-review

2015

Cytokines: Names and numbers you should care about

Holdsworth, S. R. & Gan, P. Y., 2015, In : Clinical Journal of the American Society of Nephrology. 10, 12, p. 2243 - 2254 12 p.

Research output: Contribution to journalArticleResearchpeer-review

FMS-like tyrosine kinase 3 ligand treatment does not ameliorate experimental rapidly progressive glomerulonephritis

Ghali, J., O'Sullivan, K., Eggenhuizen, P. J., Holdsworth, S. R. & Kitching, A. R., 2015, In : PLoS ONE. 10, 4, 17 p., e0123118.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Local IL-17 production exerts a protective role in murine experimental glomerulonephritis

Hamour, S., Gan, P. Y., Pepper, R., Florez-Barros, F., Wang, H-H., O'Sullivan, K., Iwakura, Y., Cook, T., Pusey, C., Holdsworth, S. R. & Salama, A., 2015, In : PLoS ONE. 10, 8, 16 p., e0136238.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mouse models of anti-neutrophil cytoplasmic antibody-associated vasculitis

Gan, P. Y., Ooi, J., Kitching, A. R. & Holdsworth, S. R., 2015, In : Current Pharmaceutical Design. 21, 18, p. 2380 - 2390 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression

King, P. T., Sharma, R., O'Sullivan, K., Selemidis, S., Lim, S., Radhakrishna, N., Lo, C. Y-W., Prasad, J., Callaghan, J. M., McLaughlin, P., Farmer, M., Steinfort, D. P., Jennings, B. R., Ngui, J., Broughton, B. R. S., Thomas, B., Essilfie, A-T., Hickey, M. J., Holmes, P., Hansbro, P. M. & 2 othersBardin, P. G. & Holdsworth, S. R., 2015, In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Programmed death 1 and its ligands do not limit experimental foreign antigen-induced immune complex glomerulonephritis

Ooi, J., Li, M., Kourkoutzelos, K., Yagita, H., Azuma, M., Holdsworth, S. R. & Kitching, A. R., 2015, In : Nephrology. 20, 12, p. 892 - 898 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis

O'Sullivan, K., Lo, C. Y-W., Summers, S. A., Elgass, K., McMillan, P., Longano, A., Ford, S. L., Gan, P. Y., Kerr, P. G., Kitching, A. R. & Holdsworth, S. R., 2015, In : Kidney International. 88, 5, p. 1030 - 1046 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppression of autoimmunity and renal disease in pristane-induced lupus by myeloperoxidase

Odobasic, D., Muljadi, R. C. M., O'Sullivan, K., Kettle, A. J., Dickerhof, N., Summers, S. A., Kitching, A. R. & Holdsworth, S. R., 2015, In : Arthritis and Rheumatology. 67, 7, p. 1868 - 1880 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting IL-17 and IL-23 in immune mediated renal disease

Ghali, J., Holdsworth, S. R. & Kitching, A. R., 2015, In : Current Medicinal Chemistry. 22, 38, p. 4341 - 4365 25 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Absence of the lysosomal protein Limp-2 attenuates renal injury in crescentic glomerulonephritis

Lee, D. H. K., Gan, P. Y., Katerelos, M., Fraser, S. A., Gleich, K., Holdsworth, S. R. & Power, D. A., 2014, In : Immunology and Cell Biology. 92, 5, p. 400 - 408 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous interleukin (IL)-17A promotes pristane-induced systemic autoimmunity and lupus nephritis induced by pristane

Summers, S. A., Odobasic, D., Khouri, M., Steinmetz, O., Yang, Y. H., Holdsworth, S. R. & Kitching, A. R., 2014, In : Clinical and Experimental Immunology. 176, 3, p. 341 - 350 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Endogenous myeloperoxidase is a mediator of joint inflammation and damage in experimental arthritis

Odobasic, D., Yang, Y. H., Muljadi, R. C. M., O'Sullivan, K., Kao, W., Smith, M. D., Morand, E. F. & Holdsworth, S. R., 2014, In : Arthritis and Rheumatology. 66, 4, p. 907 - 917 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Fc(gamma)RIIB regulates T-cell autoreactivity, ANCA production, and neutrophil activation to suppress anti-myeloperoxidase glomerulonephritis

Ooi, J., Gan, P. Y., Chen, T., Eggenhuizen, P. J., Chang, J., Alikhan, M., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Kidney International. 86, 6, p. 1140 - 1149 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Histopathologic and clinical predictors of kidney outcomes in ANCA-associated vasculitis

Ford, S., Polkinghorne, K. R., Longano, A., Dowling, J., Dayan, S., Kerr, P., Holdsworth, S. R., Kitching, A. R. & Summers, S. A., 2014, In : American Journal of Kidney Diseases. 63, 2, p. 227 - 235 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation

Chan, A., Alikhan, M., Odobasic, D., Gan, P. Y., Khouri, M., Steinmetz, O., Mansell, A. S., Kitching, A. R., Holdsworth, S. R. & Summers, S. A., 2014, In : American Journal of Pathology. 184, 5, p. 1411 - 1418 8 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell mediated autoimmune glomerular disease in mice

Ooi, J., Gan, P. Y., Odobasic, D., Holdsworth, S. R. & Kitching, A. R., 2014, In : Current Protocols in Immunology. 107, p. 1 - 19 19 p.

Research output: Contribution to journalArticleOther

2013

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis

Roth, A. J., Ooi, J., Hess, J. J., van Timmeren, M. M., Berg, E. A., Poulton, C. E., McGregor, J., Burkart, M., Hogan, S. L., Hu, Y., Winnik, W., Nachman, P. H., Stegeman, C. A., Niles, J., Heeringa, P., Kitching, A. R., Holdsworth, S. R., Jennette, J. C., Preston, G. A. & Falk, R. J., 2013, In : Journal of Clinical Investigation. 123, 4, p. 1773 - 1783 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lung T-cell responses to nontypeable Haemophilus influenzae in patients with chronic obstructive pulmonary disease

King, P. T., Lim, S., Pick, A., Ngui, J., Prodanovic, Z., Downey, W., Choong, C. K. C., Kelman, A., Baranyai, E., Francis, M. J., Moshinsky, R., Bardin, P. G., Holmes, P. & Holdsworth, S. R., 2013, In : Journal of Allergy and Clinical Immunology. 131, 5 (Art. ID: e.14), p. 1314 - 1321 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Neutrophil myeloperoxidase regulates T-cell-driven tissue inflammation in mice by inhibiting dendritic cell function

Odobasic, D., Kitching, A. R., Yang, Y. H., O'Sullivan, K., Muljadi, R. C. M., Edgtton, K. L., Tan, D. S. Y., Summers, S. A., Morand, E. F. & Holdsworth, S. R., 2013, In : Blood. 121, 20, p. 4195 - 4204 10 p.

Research output: Contribution to journalArticleResearchpeer-review

The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN

Ooi, J., Chang, J., O'Sullivan, K., Pedchenko, V., Hudson, B. G., Vandenbark, A. A., Fugger, L., Holdsworth, S. R. & Kitching, A. R., 2013, In : Journal of the American Society of Nephrology. 24, 3, p. 419 - 431 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Thymic deletion and regulatory T cells prevent antimyeloperoxidase GN

Tan, D. S. Y., Gan, P. Y., O'Sullivan, K., Hammett, M. V., Summers, S. A., Ooi, J., Lundgren, B. A., Boyd, R. L., Scott, H. S., Kitching, A. R., Chidgey, A. P. & Holdsworth, S. R., 2013, In : Journal of the American Society of Nephrology. 24, 4, p. 573 - 585 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Chest pain and exacerbations of bronchiectasis

King, P. T., Holdsworth, S. R., Farmer, M., Freezer, N. & Holmes, P., 2012, In : International Journal of General Medicine. 5, p. 1019 - 1024 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis

Nozaki, Y., Nikolic-Paterson, D., Snelgrove, S., Akiba, H., Yagita, H., Holdsworth, S. & Kitching, A., 2012, In : Kidney International. 81, 9, p. 844 - 855 12 p.

Research output: Contribution to journalArticleResearchpeer-review