20082018
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Research Output 2008 2018

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2018

Lipoxins protect against inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Mohan, M., McClelland, A., De Gaetano, M., Tikellis, C., Marai, M., Crean, D., Dai, A., Beuscart, O., Derouiche, S., Gray, S. P., Pickering, R., Tan, S. M., Godson-Treacy, M., Sheehan, S., Dowdall, J. F., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P. J. & 4 othersJandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Dec 2018, In : Diabetes. 67, 12, p. 2657-2667 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease

Gray, S. P., Jha, J. C., Kennedy, K., Bommel, E. V., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E. & Jandeleit-Dahm, K. A. M., May 2017, In : Diabetologia. 60, 5, p. 927-937 11 p.

Research output: Contribution to journalArticleResearchpeer-review

NADPH oxidase Nox5 accelerates renal injury in diabetic nephropathy

Jha, J. C., Banal, C., Okabe, J., Gray, S. P., Hettige, T., Chow, B. S. M., Thallas-Bonke, V., Vos, L. D., Holterman, C. E., Coughlan, M. T., Power, D. A., Skene, A., Ekinci, E. I., Cooper, M. E., Touyz, R. M., Kennedy, C. R. & Jandeleit-Dahm, K., 1 Oct 2017, In : Diabetes. 66, 10, p. 2691-2703 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective effect of let-7 miRNA family in regulating inflammation in diabetes-associated atherosclerosis

Brennan, E. P., Wang, B., McClelland, A., Mohan, M., Marai, M., Beuscart, O., Derouiche, S., Gray, S., Pickering, R., Tikellis, C., De Gaetano, M., Barry, M., Belton, O., Ali-Shah, S. T., Guiry, P., Jandeleit-Dahm, K. A. M., Cooper, M. E., Godson, C. & Kantharidis, P., 1 Aug 2017, In : Diabetes. 66, 8, p. 2266-2277 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Differential effects of NOX4 and NOX1 on immune cell-mediated inflammation in the aortic sinus of diabetic ApoE−/− mice

Di Marco, E., Gray, S. P., Chew, P., Kennedy, K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., Aug 2016, In : Clinical Science. 130, 15, p. 1363-1374 12 p.

Research output: Contribution to journalArticleResearchpeer-review

NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis

Di Marco, E., Gray, S. P., Kennedy, K., Szyndralewiez, C., Griendling, K. K., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K., 1 Aug 2016, In : Free Radical Biology and Medicine. 97, p. 556-567 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy

Jha, J. C., Thallas-Bonke, V., Banal, C., Gray, S. P., Chow, B. S. M., Ramm, G., Quaggin, S. E., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A., 1 Feb 2016, In : Diabetologia. 59, 2, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Feb 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 2, p. 295-307 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

The role of NADPH Oxidase in Vascular Disease – Hypertension, Atherosclerosis & Stroke

Gray, S. P. & Jandeleit-Dahm, K. A. M., 2015, In : Current Pharmaceutical Design. 21, 41, p. 5933 - 5944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in longterm diabetic nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox-4 deletion reduces oxidative stress and injury by PKC-α-associated mechanisms in diabetic nephropathy

Thallas-Bonke, V., Jha, J. C., Gray, S. P., Barit, D., Haller, H., Schmidt, H. H. H. W., Coughlan, M. T., Cooper, M. E., Forbes, J. M. & Jandeleit-Dahm, K. A. M., 2014, In : Physiological Reports. 2, 11, 13 p., e12192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacological inhibition of NOX reduces atherosclerotic lesions, vascular ROS and immune-inflammatory responses in diabetic Apoe −/− mice

Di Marco, E., Gray, S. P., Chew, P., Koulis, C., Ziegler, A. I., Szyndralewiez, C., Touyz, R. M., Schmidt, H., Cooper, M. E., Slattery, R. M. & Jandeleit-Dahm, K. A. M., 2014, In : Diabetologia. 57, 3, p. 633 - 642 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

Koulis, C., Kanellakis, P., Pickering, R. J., Tsorotes, D., Murphy, A. J., Gray, S. P., Thomas, M. C., Jandeleit-Dahm, K. A. M., Cooper, M. E. & Allen, T. J., 2014, In : Clinical Science. 127, 7, p. 485-497 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., De Haan-Klein, J. B., Koulis, C., El-Osta, A., Andrews, K. L., Chin-Dusting, J. PF., Touyz, R. M., Wingler, K., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2013, In : Circulation. 127, 18, p. 1888 - 1902 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the upregulation of reactive oxygen species subsequent to hyperglycemia prevents type 1 diabetic cardiomyopathy in mice

Huynh, K., Kiriazis, H., Du, X-J., Love, J. E., Gray, S. P., Jandeleit-Dahm, K. A. M., McMullen, J. R. & Ritchie, R. H., 2013, In : Free Radical Biology and Medicine. 60, p. 307 - 317 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGE activation in diabetic apolipoprotein E knockout mice

Watson, A. M. D., Gray, S. P., Jiaze, L., Soro-Paavonen, A., Wong, B., Cooper, M. E., Bierhaus, A., Pickering, R., Tikellis, C., Tsorotes, D., Thomas, M. C. & Jandeleit-Dahm, K. A. M., Aug 2012, In : Diabetes. 61, 8, p. 2105-2113 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Alcohol exposure during late gestation: multiple developmental outcomes in sheep

Kenna, K. R., Sozo, F., De Matteo, R. M., Hanita, T., Gray, S. P., Tare, M., Moritz, K. M., Bertram, J. F., Black, M. J., Brien, J. F., Parkington, H. C., Walker, D. W. & Harding, R., 2012, In : Journal of Developmental Origins of Health and Disease. 3, 4, p. 224 - 236 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Insulin and cardiovascular disease: Biomarker or association?

Jandeleit-Dahm, K. A. M. & Gray, S. P., Dec 2012, In : Diabetologia. 55, 12, p. 3145-3151 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanism of alcohol-induced impairment in renal development: Could it be reduced by retinoic acid?

Gray, S., Cullen-McEwen, L., Bertram, J. & Moritz, K., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 9, p. 807 - 813 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxidative stress, nox isoforms and complications of diabetes-potential targets for novel therapies

Sedeek, M., Montezano, A. C., Hebert, R. L., Gray, S. P., Di Marco, E., Jha, J. C., Cooper, M., Jandeleit-Dahm, K. A. M., Schiffrin, E. L., Wilkinson-Berka, J. & Touyz, R. M., 2012, In : Journal of Cardiovascular Translational Research. 5, 4, p. 509 - 518 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Prenatal exposure to alcohol reduces nephron number and raises blood pressure in progeny

Gray, S. P., Denton, K. M., Cullen-McEwen, L. A., Bertram, J. F. & Moritz, K. M., 2010, In : Journal of the American Society of Nephrology. 21, 11, p. 1891 - 1902 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Compensatory growth of healthy cardiac cells in the presence of diseased cells restores tissue homeostasis during heart development

Drenckhahn, J-D. C., Schwarz, Q. P., Gray, S. P., Laskowski, A., Kiriazis, H., Ming, Z., Harvey, R. P., Du, X-J., Thorburn, D. R. & Cox, T. C., 2008, In : Developmental Cell. 15, 4, p. 521 - 533 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Repeated ethanol exposure during late gestation decreases nephron endowment in fetal sheep

Gray, S. P., Kenna, K. R., Bertram, J. F., Hoy, W. E., Yan, E. B., Bocking, A. D., Brien, J. F., Walker, D. W., Harding, R. & Moritz, K. M., 2008, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295, 2, p. 568 - 574 7 p.

Research output: Contribution to journalArticleResearchpeer-review