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Research Output 2005 2019

2019

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Shahine, A., Reinink, P., Reijneveld, J. F., Gras, S., Holzheimer, M., Cheng, T. Y., Minnaard, A. J., Altman, J. D., Lenz, S., Prandi, J., Kubler-Kielb, J., Moody, D. B., Rossjohn, J. & Van Rhijn, I., 4 Jan 2019, In : Nature Communications. 10, 1, 12 p., 56.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Human CD8 + T cell cross-reactivity across influenza A, B and C viruses

Koutsakos, M., Illing, P. T., Nguyen, T. H. O., Mifsud, N. A., Crawford, J. C., Rizzetto, S., Eltahla, A. A., Clemens, E. B., Sant, S., Chua, B. Y., Wong, C. Y., Allen, E. K., Teng, D., Dash, P., Boyd, D. F., Grzelak, L., Zeng, W., Hurt, A. C., Barr, I., Rockman, S. & 17 othersJackson, D. C., Kotsimbos, T. C., Cheng, A. C., Richards, M., Westall, G. P., Loudovaris, T., Mannering, S. I., Elliott, M., Tangye, S. G., Wakim, L. M., Rossjohn, J., Vijaykrishna, D., Luciani, F., Thomas, P. G., Gras, S., Purcell, A. W. & Kedzierska, K., 2019, (Accepted/In press) In : Nature Immunology. 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Broad CD8+ T cell cross-recognition of distinct influenza A strains in humans

Grant, E. J., Josephs, T. M., Loh, L., Clemens, E. B., Sant, S., Bharadwaj, M., Chen, W., Rossjohn, J., Gras, S. & Kedzierska, K., 21 Dec 2018, In : Nature Communications. 9, 1, 16 p., 5427.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers

Galperin, M., Farenc, C., Mukhopadhyay, M., Jayasinghe, D., Decroos, A., Benati, D., Tan, L. L., Ciacchi, L., Reid, H. H., Rossjohn, J., Chakrabarti, L. & Gras, S., 8 Jun 2018, In : Science Immunology. 3, 24, 13 p., eaat0687.

Research output: Contribution to journalArticleResearchpeer-review

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Chan, K. F., Gully, B. S., Gras, S., Beringer, D. X., Kjer-Nielsen, L., Cebon, J., McCluskey, J., Chen, W. & Rossjohn, J., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 1026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Identification of native and posttranslationally modified HLA-B*57:01- restricted HIV envelope derived epitopes using immunoproteomics

Ramarathinam, S. H., Gras, S., Alcantara, S., Yeung, A. W. S., Mifsud, N. A., Sonza, S., Illing, P., Glaros, E. N., Center, R. J., Thomas, S. R., Kent, S. J., Ternette, N., Purcell, D. F. J., Rossjohn, J. & Purcell, A. W., Jun 2018, In : Proteomics. 18, 12, 11 p., 1700253.

Research output: Contribution to journalArticleResearchpeer-review

Inability to detect cross-reactive memory T cells challenges the frequency of heterologous immunity among common viruses

Rowntree, L. C., Nguyen, T. H. O., Halim, H., Purcell, A. W., Rossjohn, J., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 15 Jun 2018, In : Journal of Immunology. 200, 12, p. 3993-4003 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular features of lipid-based antigen presentation by group 1 CD1 molecules

Nours, J. L., Shahine, A. & Gras, S., 1 Dec 2018, In : Seminars in Cell and Developmental Biology. 84, p. 48-57 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Molecular recognition of microbial lipid-based antigens by T cells

Gras, S., van Rhijn, I., Shahine, A. & Le Nours, J., May 2018, In : Cellular and Molecular Life Sciences. 75, 9, p. 1623-1639 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry

Miles, J. J., Tan, M. P., Dolton, G., Edwards, E. S. J., Galloway, S. A. E., Laugel, B., Clement, M., Makinde, J., Ladell, K., Matthews, K. K., Watkins, T. S., Tungatt, K., Wong, Y., Lee, H. S., Clark, R. J., Pentier, J. M., Attaf, M., Lissina, A., Ager, A., Gallimore, A. & 7 othersRizkallah, P. J., Gras, S., Rossjohn, J., Burrows, S. R., Cole, D. K., Price, D. A. & Sewell, A. K., 2 Apr 2018, In : Journal of Clinical Investigation. 128, 4, p. 1569-1580 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Perturbed CD8+ T cell immunity across universal influenza epitopes in the elderly

Nguyen, T. H. O., Sant, S., Bird, N. L., Grant, E. J., Clemens, E. B., Koutsakos, M., Valkenburg, S. A., Gras, S., Lappas, M., Jaworowski, A., Crowe, J., Loh, L. & Kedzierska, K., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 321-339 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Single-cell approach to influenza-specific CD8+ T cell receptor repertoires across different age groups, tissues, and following influenza virus infection

Sant, S., Grzelak, L., Wang, Z., Pizzolla, A., Koutsakos, M., Crowe, J., Loudovaris, T., Mannering, S. I., Westall, G. P., Wakim, L. M., Rossjohn, J., Gras, S., Richards, M., Xu, J., Thomas, P. G., Loh, L., Nguyen, T. H. O. & Kedzierska, K., 27 Jun 2018, In : Frontiers in Immunology. 9, 18 p., 1453.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., Miners, K. L., McLaren, J. E., Grant, E. J., Haigh, O. L., Watkins, T. S., Suliman, S., Iwany, S., Jimenez, J., Calderon, R., Tamara, K. L., Leon, S. R., Murray, M. B., Mayfield, J. A., Altman, J. D. & 8 othersPurcell, A. W., Miles, J. J., Godfrey, D. I., Gras, S., Price, D. A., Van Rhijn, I., Moody, D. B. & Rossjohn, J., 1 Apr 2018, In : Nature Immunology. 19, 4, p. 397-406 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the drivers of MHC restriction of T cell receptors

La Gruta, N. L., Gras, S., Daley, S. R., Thomas, P. G. & Rossjohn, J., 10 Apr 2018, (Accepted/In press) In : Nature Reviews Immunology. 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct αβ T cell receptors

Sullivan, L. C., Walpole, N. G., Farenc, C., Pietra, G., Sum, M. J. W., Clements, C. S., Lee, E. J., Beddoe, T., Falco, M., Mingari, M. C., Moretta, L., Gras, S., Rossjohn, J. & Brooks, A. G., 22 Dec 2017, In : Journal of Biological Chemistry. 292, 51, p. 21149-21158 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A molecular basis of human T cell receptor autoreactivity toward self-phospholipids

Shahine, A., Van Rhijn, I., Cheng, T-Y., Iwany, S., Gras, S., Moody, D. B. & Rossjohn, J., 20 Oct 2017, In : Science Immunology. 2, 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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A T Cell Receptor Locus Harbors a Malaria-Specific Immune Response Gene

Van Braeckel-Budimir, N., Gras, S., Ladell, K., Josephs, T. M., Pewe, L., Urban, S. L., Miners, K. L., Farenc, C., Price, D. A., Rossjohn, J. & Harty, J. T., 21 Nov 2017, In : Immunity. 47, 5, p. 835-847 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians (Immunology and cell biology (2016) 94 4 (367-377))

Clemens, E. B., Grant, E. J., Wang, Z., Gras, S., Tipping, P., Rossjohn, J., Miller, A., Tong, S. Y. C. & Kedzierska, K., 1 Aug 2017, In : Immunology and Cell Biology. 95, 7, p. 648-648 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access

Germline bias dictates cross-serotype reactivity in a common dengue-virus-specific CD8 + T cell response

Culshaw, A., Ladell, K., Gras, S., McLaren, J. E., Miners, K. L., Farenc, C., Van Den Heuvel, H., Gostick, E., Dejnirattisai, W., Wangteeraprasert, A., Duangchinda, T., Chotiyarnwong, P., Limpitikul, W., Vasanawathana, S., Malasit, P., Dong, T., Rossjohn, J., Mongkolsapaya, J., Price, D. A. & Screaton, G. R., 18 Oct 2017, In : Nature Immunology. 18, 11, p. 1228-1237 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular challenges imposed by MHC-I restricted long epitopes on T cell immunity

Josephs, T. M., Grant, E. J. & Gras, S., 28 Aug 2017, In : Biological Chemistry. 398, 9, p. 1027-1036 10 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Structural and regulatory diversity shape HLA-C protein expression levels

Kaur, G., Gras, S., Mobbs, J. I., Vivian, J. P., Cortes, A., Barber, T., Kuttikkatte, S. B., Jensen, L. T., Attfield, K. E., Dendrou, C. A., Carrington, M., McVean, G., Purcell, A. W., Rossjohn, J. & Fugger, L., 26 Jun 2017, In : Nature Communications. 8, 12 p., 15924.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens

Le Nours, J., Praveena, T., Pellicci, D. G., Gherardin, N. A., Ross, F. J., Lim, R. T., Besra, G. S., Keshipeddy, S., Richardson, S. K., Howell, A. R., Gras, S., Godfrey, D. I., Rossjohn, J. & Uldrich, A. P., 2016, In : Nature Communications. 7, 14 p., 10570.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Deciphering the clinical relevance of allo-human leukocyte antigen cross-reactivity in mediating alloimmunity following transplantation.

Rowntree, L. C., Nguyen, T. H. O., Gras, S., Kotsimbos, T. C. & Mifsud, N. A., 2016, In : Current Opinion in Organ Transplantation. 21, 1, p. 29-39 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection

Du, V. Y., Bansal, A., Carlson, J., Salazar-Gonzalez, J. F., Salazar, M. G., Ladell, K., Gras, S., Josephs, T. M., Heath, S. L., Price, D. A., Rossjohn, J., Hunter, E. & Goepfert, P. A., 15 Apr 2016, In : Journal of Immunology. 196, 8, p. 3276-3286 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Lack of heterologous cross-reactivity toward HLA-A02: 01 restricted viral epitopes is underpinned by distinct αβT cell receptor signatures

Grant, E. J., Josephs, T. M., Valkenburg, S. A., Wooldridge, L., Hellard, M., Rossjohn, J., Bharadwaj, M., Kedzierska, K. & Gras, S., 18 Nov 2016, In : Journal of Biological Chemistry. 291, 47, p. 24335-24351 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses

Valkenburg, S. A., Josephs, T. M., Clemens, E. B., Grant, E. J., Nguyen, T. H. O., Wang, G. C., Price, D. A., Miller, A., Tong, S. Y. C., Thomas, P. G., Doherty, P. C., Rossjohn, J., Gras, S. & Kedzierska, K., 19 Apr 2016, In : Proceedings of the National Academy of Sciences. 113, 16, p. 4440-4445 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Public T cell receptors confer high-avidity CD4 responses to HIV controllers

Benati, D., Galperin, M., Lambotte, O., Gras, S., Lim, A., Mukhopadhyay, M., Nouel, A., Campbell, K-A., Lemercier, B., Claireaux, M., Hendou, S., Lechat, P., De Truchis, P., Boufassa, F., Rossjohn, J., Delfraissy, J-F., Arenzana-Seisdedos, F. & Chakrabarti, L., 1 Jun 2016, In : Journal of Clinical Investigation. 126, 6, p. 2093-2108 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Reversed T cell receptor docking on a major histocompatibility class I complex limits involvement in the immune response

Gras, S., Chadderton, J., Del Campo, C. M., Farenc, C., Wiede, F., Josephs, T. M., Sng, X. Y. X., Mirams, M., Watson, K. A., Tiganis, T., Quinn, K. M., Rossjohn, J. & La Gruta, N. L., 18 Oct 2016, In : Immunity. 45, 4, p. 749-760 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies

Clement, M., Pearson, J. A., Gras, S., Van Den Berg, H. A., Lissina, A., Llewellyn-Lacey, S., Willis, M. D., Docree, T., McLaren, J. E., Ekeruche-Makinde, J., Gostick, E., Robertson, N. P., Rossjohn, J., Burrows, S. R., Price, D. A., Wong, F. S., Peakman, M., Skowera, A. & Wooldridge, L., 17 Oct 2016, In : Scientific Reports. 6, 14 p., 35332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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T cell receptor recognition of CD1b presenting a mycobacterial glycolipid

Gras, S., Van Rhijn, I., Shahine, A., Cheng, T-Y., Bhati, M., Tan, L. L., Halim, H., Tuttle, K. D., Gapin, L., Le Nours, J., Moody, D. B. & Rossjohn, J., 27 Oct 2016, In : Nature Communications. 7, 12 p., 13257.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Towards identification of immune and genetic correlates of severe influenza disease in Indigenous Australians

Clemens, E. B., Grant, E. J., Wang, Z., Gras, S., Tipping, P., Rossjohn, J., Miller, A., Tong, S. Y. C. & Kedzierska, K., 1 Apr 2016, In : Immunology and Cell Biology. 94, 4, p. 367-377 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Naturally processed non-canonical HLA-A*02:01 presented peptides

Hassan, C., Chabrol, E., Jahn, L., Kester, M. G. D., De Ru, A. H., Drijfhout, J. W., Rossjohn, J., Falkenburg, F. J. H., Heemskerk, M. H. M., Gras, S. & Van Veelen, P. A., 2015, In : Journal of Biological Chemistry. 290, 5, p. 2593 - 2603 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Paired TCRαβ analysis of virus-specific CD8+ T cells exposes diversity in a previously defined 'narrow' repertoire

Cukalac, T., Kan, W-T., Dash, P. K., Guan, J., Quinn, K. M., Gras, S., Thomas, P. G. & La Gruta, N. L., 2015, In : Immunology and Cell Biology. 93, 9, p. 804-814 11 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell antigen receptor recognition of antigen-presenting molecules

Rossjohn, J., Gras, S., Miles, J. J., Turner, S. J., Godfrey, D. I. & McCluskey, J., 2015, In : Annual Review of Immunology. 33, p. 169 - 200 32 p.

Research output: Contribution to journalArticleResearchpeer-review

T cell cross-reactivity between a highly immunogenic EBV epitope and a self-peptide naturally presented by HLA-B*18:01+ cells

Rist, M. J., Hibbert, K. M., Croft, N. P., Smith, C., Neller, M. A., Burrows, J. M., Miles, J. J., Purcell, A. W., Rossjohn, J., Gras, S. & Burrows, S. R., 2015, In : Journal of Immunology. 194, 10, p. 4668 - 4675 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The interaction of KIR3DL1*001 with HLA class I molecules is dependent upon molecular microarchitecture within the Bw4 epitope

Saunders, P. M., Vivian, J. P., Baschuk, N., Beddoe, T. C., Widjaja, J. M. L., O'Connor, G. M., Hitchen, C. R., Pymm, P. G., Andrews, D. M. K., Gras, S., McVicar, D. W., Rossjohn, J. & Brooks, A. G., 2015, In : Journal of Immunology. 194, 2, p. 781 - 789 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Understanding the complexity and malleability of T-cell recognition

Miles, J. J., McCluskey, J., Rossjohn, J. & Gras, S., 28 May 2015, In : Immunology and Cell Biology. 93, 5, p. 433 - 441 9 p.

Research output: Contribution to journalArticleResearchpeer-review

αβ T cell antigen receptor recognition of CD1a presenting self lipid ligands

Birkinshaw, R. W., Pellicci, D. G., Cheng, T-Y., Keller, A. N., Sandoval-Romero, M. L., Gras, S., de Jong, A., Uldrich, A. P., Moody, D. B., Godfrey, D. I. & Rossjohn, J., 2015, In : Nature Immunology. 16, 3, p. 258-266 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

A molecular basis for the interplay between T cells, viral mutants, and human leukocyte antigen micropolymorphism

Liu, Y. C., Chen, Z., Neller, M. A., Miles, J. J., Purcell, A. W., McCluskey, J., Burrows, S. R., Rossjohn, J. & Gras, S., 2014, In : Journal of Biological Chemistry. 289, 24, p. 16688 - 16698 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of relationships between peptide/MHC structural features and naive T cell frequency in humans

Reiser, J-B., Legoux, F. P., Gras, S., Trudel, E., Chouquet, A., Leger, A., Le Gorrec, M., Machillot, P., Bonneville, M., Saulquin, X. & Housset, D., 2014, In : Journal of Immunology. 193, 12, p. 5816 - 5826 11 p.

Research output: Contribution to journalArticleResearchpeer-review

An extensive antigenic footprint underpins immunodominant TCR adaptability against a hypervariable viral determinant

Nivarthi, U. K., Gras, S., Kjer-Nielsen, L., Berry, R., Lucet, I. S., Miles, J., Tracy, S. L., Purcell, A. W., Bowden, D. S., Hellard, M. E., Rossjohn, J., McCluskey, J. & Bharadwaj, M., 2014, In : Journal of Immunology. 193, 11, p. 5402 - 5413 12 p.

Research output: Contribution to journalArticleResearchpeer-review

CD1a-autoreactive T cells recognize natural skin oils that function as headless antigens

de Jong, A., Cheng, T-Y., Huang, S., Gras, S., Birkinshaw, R. W., Kasmar, A., Van Rhijn, I., Pena-Cruz, V., Ruan, D., Altman, J. D., Rossjohn, J. & Moody, D. B., 2014, In : Nature Immunology. 15, 2, p. 177 - 185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Missense single nucleotide polymorphisms in the human T cell receptor loci control variable gene usage in the T cell repertoire

Brennan, R. M., Burrows, J. M., Elliott, T., Neller, M. A., Gras, S., Rossjohn, J., Miles, J. J. & Burrows, S., 2014, In : British Journal of Haematology. 166, 1, p. 142 - 153 12 p.

Research output: Contribution to journalLetterOther

Molecular imprint of exposure to naturally occurring genetic variants of human cytomegalovirus on the T cell repertoire

Smith, C., Gras, S., Brennan, R. M., Bird, N. L., Valkenburg, S. A., Twist, K-A., Burrows, J. M., Miles, J. J., Chambers, D. C., Bell, S. C., Campbell, S. B., Kedzierska, K., Burrows, S. R., Rossjohn, J. & Khanna, R., 2014, In : Scientific Reports. 4, 10 p., 3993.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Preexisting CD8+ T-cell immunity to the H7N9 influenza A virus varies across ethnicities

Quinones-Parra, S., Grant, E., Loh, L., Nguyen, T. H. O., Campbell, K-A., Tong, S. Y. C., Miller, A., Doherty, P. C., Vijaykrishna, D., Rossjohn, J., Gras, S. & Kedzierska, K., Mar 2014, In : Proceedings of the National Academy of Sciences. 111, 3, p. 1049 - 1054 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes

Trujillo, J. A., Gras, S., Twist, K-A., Croft, N. P., Channappanavar, R., Rossjohn, J., Purcell, A. W. & Perlman, S., 2014, In : Journal of Immunology. 192, 11, p. 5245 - 5256 12 p.

Research output: Contribution to journalArticleResearchpeer-review

TCR bias and affinity define two compartments of the CD1b-glycolipid-specific T Cell repertoire

Van Rhijn, I., Gherardin, N. A., Kasmar, A., de Jager, W., Pellicci, D. G., Kostenko, L., Tan, L. L., Bhati, M., Gras, S., Godfrey, D. I., Rossjohn, J. & Moody, D. B., 2014, In : Journal of Immunology. 192, 9, p. 4054 - 4060 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular bases of δ/αβ T cell-mediated antigen recognition

Pellicci, D. G., Uldrich, A. P., Le Nours, J., Ross, F., Chabrol, E., Eckle, S. B. G., de Boer, R., Lim, R. T., McPherson, K. G., Besra, G. S., Howell, A. R., Moretta, L., McCluskey, J., Heemskerk, M. H. M., Gras, S., Rossjohn, J. & Godfrey, D. I., 2014, In : Journal of Experimental Medicine. 211, 13, p. 2599-2615 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A conserved human T cell population targets mycobacterial antigens presented by CD1b

Van Rhijn, I., Kasmar, A., de Jong, A., Gras, S., Bhati, M., Doorenspleet, M. E., de Vries, N., Godfrey, D. I., Altman, J. D., de Jager, W., Rossjohn, J. & Moody, D. B., 2013, In : Nature Immunology. 14, 7, p. 706 - 713 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute emergence and reversion of influenza A virus quasispecies within CD8+ T cell antigenic peptides

Valkenburg, S. A., Quinones-Parra, S., Gras, S., Komadina, N., McVernon, J., Wang, Z. F., Abd Halim, N. H., Iannello, P., Cole, C., Laurie, K. L., Kelso, A., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2013, In : Nature Communications. 4, 10 p., 3663.

Research output: Contribution to journalArticleResearchpeer-review

Open Access