Projects per year
Professor Stephane Heritier is a leading academic research statistician with expertise in the design and analysis of (complex) large-scale trials clinical trials gained over a 20+ year period. He worked previously at the NHMRC Clinical Trials Centre (2002-06) & the George Institute (2007-13), Sydney, and is now based at Monash University, Melbourne. Therapeutic areas of expertise include diabetes, cardiovascular and neurological diseases, critical care, anaesthesiology, and physiotherapy. He is recognised worldwide as an expert in adaptive designs since he was one of the first to design and analyse an adaptive phase II/III trial in paediatric dermatology (Hemangiol) accepted by regulators and published in NEJM. This study has now become a benchmark in confirmatory adaptive designs. Other statistical research interests include survival analysis, cluster randomized trials and robust biostatistics. He is an active member of the ACTA reference group on innovations in clinical trials. Heritier is a Chief Investigator on several NHMRC funded trials including REMAP-CAP, a Bayesian platform trial designed to evaluate what interventions best reduce mortality in patients with severe Community Acquired Pneumonia; ITACS, a large 2-arm trial assessing the impact of intravenous iron in anaemic patients having elective cardiac surgery; the STAREE-MIND trial ($2.7M) aiming at preventing cognitive decline in the elderly; and the Centre of Research Excellence in Clinical Trials Methodology AusTriM launched in 2020. More recently he received funding from the ARC to develop new methods of estimation for complex survival analysis models (2022-24) and 3 MRFF grants for EMPACT, a Bayesian adaptive design in severe depression, FEISTY-II, a clinical trial in trauma patients and RECOMMEND, a Bayesian platform trial in patients requiring ECMO. Heritier is involved in statistical consulting within the Faculty of Medicine and for other institutions including the pharmaceutical industry. He is the lead author of a book entitled "Robust Methods in Biostatistics" published in 2009 with 3 Swiss co-authors.
Monash teaching commitment
BCA Master of Statistics, Regression Modelling in Biostatistics (RM1): main coordinator, semester 2
MPH5200, Regression methods for epidemiology: main coordinator, semester 1
Clinical trial methodology, adaptive designs, robust biostatistics, survival analysis, cluster stepped-wedge/cross-over trials, joint modelling
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Honorary Associate Professor of Biostatistics, University of Sydney
21 Oct 2013 → 20 Oct 2016
Research area keywords
- Clinical trial methodology
- Adaptive designs
- Cluster randomised trials
- Robust statistics
- Survival analysis
- Semi-Markov processes
- Stepped-wedge designs
- Joint modelling
- cluster cross-over trials
Dive into details
Select a country/territory to view shared publications and projects
SemiParSurvReg: High predictive performance models via semi-parametric survival regression
Lo, S., Ma, J., Liquet, B. & Heritier, S.
Australian Research Council (ARC)
1/07/22 → 30/06/25
Fibrinogen Early In Severe Trauma StudY II (FEISTY II)
McQuilten, Z., Winearls, J., Cooper, J., Reade, M., French, C. J., Presneill, J., Higgins, L., Balogh, Z., Heritier, S. & Wood, E.
1/02/22 → 31/01/27
Clinical trial to determine the effects of statins on cognition: STAREE-Mind
Ryan, J., Zoungas, S., Law, M., Anderson, C. S., Chong, T., Heritier, S., Harding, I., Naismith, S., Liew, D. & O'Sullivan, M. J.
1/07/21 → 30/06/26
Better health through better trials: A national network to develop and implement innovative clinical trials methodology
Wolfe, R., Lee, K. J., Forbes, A., Webb, S. A. R., Marschner, I. C., Makrides, M., Snelling, T. L., Davidson, A., Heritier, S., Yelland, L. & Hawley, C. M.
National Health and Medical Research Council (NHMRC) (Australia)
1/11/19 → 31/10/24
DIAAMOND: Diagnosis of aplastic anaemia, management, and outcomes from a national dataset
Wood, E., Ting, S., McQuilten, Z., Szer, J., Hiwase, D. K., McNeil, J., Lacaze, P., Blombery, P. A., Mills, A. K., Heritier, S., Fox, L., Firkin, F. & Higgins, L.
13/06/18 → 15/02/24
A protocol for a prospective, multicentre observational study to determine if nonanaemic iron deficiency worsens postoperative outcome in patients undergoing elective surgery for resection of colorectal cancer: The NATO studyMiles, L. F., Pac Soo, V., Braat, S., Burgess, A., Heritier, S., Smart, P., Tan, N., Parker, A., Burbury, K. L., Story, D. A. & on behalf of the ANZCA Clinical Trials Network, Feb 2023, In: Colorectal Disease. 25, 2, p. 315-325 11 p.
Research output: Contribution to journal › Article › Other › peer-reviewOpen Access
Use of a novel smartphone-based application tool for enrolment and randomisation in pre-hospital clinical trialsBloom, J. E., Partovi, A., Bernard, S., Okyere, D., Heritier, S., Mahony, E., Eliakundu, A. L., Dawson, L. P., Voskoboinik, A., Anderson, D., Ball, J., Chan, W., Kaye, D. M., Nehme, Z. & Stub, D., Apr 2023, (Accepted/In press) In: Resuscitation. 6 p., 109787.
Research output: Contribution to journal › Comment / Debate › Other › peer-review
Associations between non-anaemic iron deficiency and outcomes following elective cardiac surgery (IDOCS): a prospective cohort studyMiles, L. F., Pac Soo, V., Braat, S., Bade-Boon, J., Heritier, S., Klein, A. A., Myles, P. S., Richards, T., Symons, J., Burbury, K. L. & Story, D. A., Jul 2022, In: The Lancet Haematology. 9, 7, p. e514-e522 9 p.
Research output: Contribution to journal › Article › Research › peer-review
Bayesian adaptive clinical trial designs for respiratory medicineRyan, E. G., Couturier, D. L. & Heritier, S., Oct 2022, In: Respirology. 27, 10, p. 834-843 10 p.
Research output: Contribution to journal › Review Article › Research › peer-reviewOpen Access
Evaluating the performance of Bayesian and restricted maximum likelihood estimation for stepped wedge cluster randomized trials with a small number of clustersGrantham, K. L., Kasza, J., Heritier, S., Carlin, J. B. & Forbes, A. B., 2022, In: BMC Medical Research Methodology. 22, 1, 18 p., 112.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access