1994 …2024

Research output per year

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Personal profile


I obtained my PhD in Statistics from Geneva University, Switzerland, in 1993, with my thesis involving methodological issues in robust inference. I started my biostatistician career at the Clinical Epidemiology Unit of Geneva University Hospital, followed by an experience in the pharmaceutical industry with Merck-Serono. I moved to Australia in 2002 to be appointed Senior Research Fellow at the NHMRC Clinical Trials Centre, Sydney University, gaining experience in biostatistical methodology, design and analyses of clinical trials and collaboration with clinicians. I was also involved in teaching for postgraduate students in biostatistics. In 2006, I joined the George Institute to work mainly on large-scale studies in cardiovascular and renal diseases, neurological and mental health, critical care and injury prevention. As Head of Statistical Research, I led an innovative statistical research program in clinical trial methodology and survival analysis. I became Associate Professor of biostatistics at the University of Sydney in 2009. In September 2014, I moved to Melbourne to become Associate Professor of Biostatistics at DEPM, Monash University. My research interests include adaptive designs, cluster randomised trials, robust methods in biostatistics, multistage disease modelling and penalised likelihood for survival data. I am a chief investigator on several NHMRC grants - 4 of them active - and am involved in statistical consulting within the Faculty of Medicine and for other institutions including the pharmaceutical industry. I am the lead author of a book entitled "Robust Methods in Biostatistics" published in 2009 with 3 Swiss coauthors.


Monash teaching commitment

BCA Master of Statistics, Linear models (LMR): main coordinator, semester 1

MPH5200, Regression methods for epidemiology: coordinator, semester 1

MPH5270, Advanced statistical methods for clinical research: coordinator, semester 2

Supervision interests

Clinical trial methodology, adaptive designs, robust biostatistics, survival analysis, cluster stepped-wedge/cross-over trials, joint modelling

External positions

Honorary Associate Professor of Biostatistics, University of Sydney

21 Oct 201320 Oct 2016

Research area keywords

  • Biostatistics
  • Clinical trial methodology
  • Adaptive designs
  • Cluster randomised trials
  • Robust statistics
  • Survival analysis
  • Semi-Markov processes
  • Stepped-wedge designs
  • Joint modelling
  • cluster cross-over trials

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Research Output

Accounting for a decaying correlation structure in cluster randomized trials with continuous recruitment

Grantham, K. L., Kasza, J., Heritier, S., Hemming, K. & Forbes, A. B., 20 May 2019, In : Statistics in Medicine. 38, 11, p. 1918-1934

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Adaptive platform trials: definition, design, conduct and reporting considerations

The Adaptive Platform Trials Coalition, 1 Oct 2019, In : Nature Reviews Drug Discovery. 18, 10, p. 797-807 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
Open Access

Associations between non-anaemic iron deficiency and outcomes following surgery for colorectal cancer: An exploratory study of outcomes relevant to prospective observational studies

Miles, L. F., Sandhu, R. N. S., Grobler, A. C., Heritier, S., Burgess, A., Burbury, K. L. & Story, D. A., Mar 2019, In : Anaesthesia and intensive care. 47, 2, p. 152-159 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)