Projects per year
Personal profile
Biography
Stefan works as a Staff Specialist in the Department of Anaesthesia at Westmead Hospital. He is a Clinical Associate Professor at The University of Sydney.
Stefan's main research interest is in the inter-patient variability of the perioperative inflammatory response to major surgery. When considering the large variability in the clinical phenotype of this response that is often observed, it is not surprising that the effects of therapies to modify the inflammatory response do largely vary between patients as well. When this phenotype variability is not taken into account while testing perioperative interventions in (large) therapeutic trials, this may lead to decreased effectiveness of these interventions. Stefan's research focusses on improving methods to predict the phenotype of the inflammatory response to major surgery in individual patients. This should eventually enable the use of more targeted prophylactic and/or therapeutic interventions to prevent adverse outcomes.
Stefan works as a Staff Specialist and is the Head of Research in the Department of Anaesthesia at Westmead Hospital. He is a full-time Associate Professor at Western Sydney University and a Clinical Associate Professor at The University of Sydney.
Stefan's main research interests include:
Inter-patient variability of the perioperative inflammatory response
The clinical phenotype of the perioperative inflammatory response is largely variable. When considering this variability, it is not surprising that the effects of therapies to modify the inflammatory response do significantly differ between patients as well. When this variability is not taken into account while testing perioperative interventions in (large) therapeutic trials, this may lead to decreased effectiveness of these interventions. Stefan's research focusses on improving methods to predict the phenotype of the inflammatory response to major surgery in individual patients. This should eventually enable the use of more targeted prophylactic and/or therapeutic interventions to prevent adverse outcomes.
Large-scale, registry-based perioperative outcomes research
Registry-based trials and cohort studies can be low-cost, can facilitate rapid consecutive enrolment of large numbers of patients. By harnessing variations in 'standard' clinical practice in the study design, registry-based trials will have enhanced generalizability of findings. In particular in the context of perioperative medicine, which traditionally has a relatively large variation in practice (and therefore in what is considered 'routine practice'), registry-based clinical trials are be ideally suited.
An overview of Stefan's publications is available online.
Research area keywords
- Perioperative medicine
- Perioperative inflammatory response
Network
Projects
- 1 Active
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TRIGS-D: Tranexamic acid to reduce delirium after gastrointestinal surgery: the TRIGS‐D trial
Myles, P., Medcalf, R., Shulman, M., Sanders, R., Evered, L., Dieleman, S. & McCulloch, T. J.
1/01/22 → 31/12/23
Project: Research
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Meta-analysis of randomised controlled trials of perioperative dexmedetomidine to reduce delirium and mortality after cardiac surgery
Sanders, R. D., Wehrman, J., Irons, J., Dieleman, J., Scott, D. & Shehabi, Y., Nov 2021, In: British Journal of Anaesthesia. 127, 5, p. e168-e170 3 p.Research output: Contribution to journal › Letter › Other › peer-review
2 Citations (Scopus) -
Cost-effectiveness of routine transoesophageal echocardiography during cardiac surgery: a discrete-event simulation study
Dieleman, J. M., Myles, P. S., Bulfone, L., Younie, S., van Zaane, B., McGiffin, D., Moodie, M. & Gao, L., 1 Feb 2020, In: British Journal of Anaesthesia. 124, 2, p. 136-145 10 p.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine (StEP) initiative: infection and sepsis
Barnes, J., Hunter, J., Harris, S., Shankar-Hari, M., Diouf, E., Jammer, I., Kalkman, C., Klein, A. A., Corcoran, T., Dieleman, S., Grocott, M. P. W., Mythen, M. G. & the StEP-COMPAC Group, 1 Apr 2019, In: British Journal of Anaesthesia. 122, 4, p. 500–508 9 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open AccessFile16 Citations (Scopus) -
Dexamethasone for Cardiac Surgery trial (DECS-II): Rationale and a novel, practice preference-randomized consent design
Myles, P. S., Dieleman, J. M., Forbes, A., Heritier, S. & Smith, J. A., 1 Oct 2018, In: American Heart Journal. 204, p. 52-57 6 p.Research output: Contribution to journal › Article › Other › peer-review
8 Citations (Scopus) -
Age and other perioperative risk factors for postoperative systemic inflammatory response syndrome after cardiac surgery
Dieleman, J. M., Peelen, L. M., Coulson, T. G., Tran, L., Reid, C. M., Smith, J. A., Myles, P. S. & Pilcher, D., 1 Oct 2017, In: British Journal of Anaesthesia. 119, 4, p. 637-644 8 p.Research output: Contribution to journal › Article › Research › peer-review
16 Citations (Scopus)