Projects per year
Personal profile
Biography
POSITIONS HELD
ARC DECRA Fellow
Co-director of the Integrated Neurogenic Mechanisms Laboratory with Dr Daniel Poole and Dr Nicholas Veldhuis in Faculty of Pharmacy and Pharmaceutical Sciences, Drug Discovery Biology - MIPS
MIPS Teaching Fellow
Broad research program: The gut has an independent nervous system (Enteric Nervous System) which controls its functions such as bowel movement and absorbing nutrients. We aim to identify new ways to modulate the actions of this nervous system.
Research Impact: By identifying new sites that modulate the ENS, they can be targeted to treat a range of gut disorders (Hirschsprung Disease, Constipation, Irritable Bowel Syndrome, Inflammatory Bowel Disease)
Expertise: electrophysiology, enteric neurobiology, GI pharmacology, collaborate with clinical teams and industry.
Monash teaching commitment
MIPS Teaching Fellow (2018-present) This scheme aims to identify future leaders in research and provide them with teaching opportunities.
Curriculum design: Bachelor of Pharmaceutical Science Degree.
Lecturer: BPS2011 Pharmacology I: Biochemical signalling- designed interactive lectures, workshops, online discovery material, practicals and exam questions on GI physiology and pathophysiology.
Previously delivered lectures and tutorials on physiology and neuroscience at Victoria University and Flinders University.
Research interests
We aim to identify ways the ENS can be modulated by targeting:
- Specific sites on the enteric neurons: We study the roles of G Protein-Coupled Receptors (GPCRs) and mechanosensitive ion channels. Specific examples include delta-opioid receptors, muscarinic M1 receptor, Transient Receptor Potential channels (TRP) TRPV4 and Piezo 1.
Specific conditions of interest:
-The benefits of targeting GPCRs to promote/inhibit movement of the bowel using allosteric modulators
-Conditions promoting activation/internalisation/ desensitization of these receptors and ion channels
-The role of the inflamed bowel in altering the functions of these receptors and ion channels
- Cells that modulate the actions of ENS: There are a series of cells that can alter or assist in the communication pathways of the ENS. We specifically study the actions of enteric glia and muscularis macrophages.
Specific conditions of interest:
-Understanding the differences in the functions of cells in the ageing bowel
-Understanding the differences between cells in the rodent bowel versus the human bowel
-Studying the cellular environment of the "normal" or ganglionated region in the Hirschsprung Bowel
-Determining why patients with Hirschsprung Disease are prone to developing inflammation
Supervision interests
Interested in recruiting students for a broad range of projects
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Honorary Scientist, Murdoch Children's Research Institute
19 Feb 2019 → …
Honorary Scientist, Royal Melbourne Hospital
1 Jan 2015 → …
Research area keywords
- enteric nervous system
- Gastroenterology
- Gastrointestinal Pharmacology
- Gastrointestinal disease
- Gastrointestinal Function
- Glia
- Electrophysiology
- Image analysis
- colitis
- Hirschsprung disease
Network
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Functional insights into the roles of enteric glia
Australian Research Council (ARC)
4/05/20 → 4/04/24
Project: Research
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Mechanistic Overview of How Opioid Analgesics Promote Constipation
Poole, D. P., Di Cello, J., Gondin, A. B. & Carbone, S., 2022, Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics: Part III: Adverse effects, reactions, and outcomes. Academic Press, p. 227-234Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
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Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice
Retamal, J. S., Grace, M. S., Dill, L. K., Ramirez-Garcia, P., Peng, S., Gondin, A. B., Bennetts, F., Alvi, S., Rajasekhar, P., Almazi, J. G., Carbone, S. E., Bunnett, N. W., Davis, T. P., Veldhuis, N. A., Poole, D. P. & McIntyre, P., Jul 2021, In: Laboratory Investigation. 101, 7, p. 851–864 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain
Jiménez-Vargas, N. N., Gong, J., Wisdom, M. J., Jensen, D. D., Latorre, R., Hegron, A., Teng, S. L., Di Cello, J., Rajasekhar, P., Veldhuis, N. A., Carbone, S., Yu, Y., Lopez, C. L., Polanco, J. J., Canals, M., Reed, D., Lomax, A. E., Schmidt, B. L., Leong, K. W., Vanner, S. & 3 others, , 30 Jun 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 26, p. 15281-15292 12 p.Research output: Contribution to journal › Article › Research › peer-review
26 Citations (Scopus) -
Inflammation without pain: Immune-derived opioids hold the key
Carbone, S. & Poole, D. P., 1 Feb 2020, In: Neurogastroenterology & Motility. 32, 2, 5 p., e13787.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon
DiCello, J. J., Carbone, S. E., Saito, A., Rajasekhar, P., Ceredig, R. A., Pham, V., Valant, C., Christopoulos, A., Veldhuis, N. A., Canals, M., Massotte, D. & Poole, D. P., Mar 2020, In: Cellular and Molecular Gastroenterology and Hepatology. 9, 3, p. 465-483 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile11 Citations (Scopus)
Prizes
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Early Stage Investigator Prize awarded for abstract presentation at Digestive Diseases Week
Carbone, Simona (Recipient), 2016
Prize: Prize (including medals and awards)
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European Society of Neurogastroenterology and Motility Young Investigator Prize at the Federation of Neurogastroenterology and Motility meeting.
Carbone, Simona (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
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FASTtrack: Selling yourself as and early-mid career researcher
Emma van der Westhuizen (Organiser), Enyuan Cao (Organiser), Neil Owens (Organiser), Karen Gregory (Invited speaker), Simona Carbone (Invited speaker) & Nicolas Voelcker (Invited speaker)
2021 → …Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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Gut Microbes (Journal)
Simona Carbone (Peer reviewer)
2020Activity: Publication peer-review and editorial work types › Editorial responsibility
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Little Brain Big Brain
Simona Carbone (Organiser)
2020Activity: Participating in or organising an event types › Contribution to conference
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Frontiers Media SA (Publisher)
Simona Carbone (Editorial board member)
2019Activity: Publication peer-review and editorial work types › Editorial responsibility
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Neurogastroenterology and Motility (Journal)
Simona Carbone (Peer reviewer)
2018Activity: Publication peer-review and editorial work types › Editorial responsibility
Press / Media
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Einstein A Go-Go: 20 Postdocs Explain Their Research To Dr Shane In 20 Minutes
Simona Carbone & Pradeep Rajasekhar
5/07/20
1 Media contribution
Press/Media: Article/Feature