Personal profile


D r   S i m o n    G .    R o y c e 

B.Sc. (Hons) (Melb), Ph.D. (Melb) Pathology

Senior Lecturer / Fellow



P106784 Samuel & Royce

Method (for the use of induced pluripotent stem cell-derived mesenchymal stem cells to treat asthma)


USA patent 11471493 Samuel & Royce

Method for treating allergic airways disease (AAD)/asthma




Victoria Medical Research Accelerator Fund (current 2023-2026)

iCARE NSW Dust Disease Board (current 2023-2025)

Monash / Penn. State USA Collaboration (current).

Cynata Therapeutics, Limited, Research Grants.

AusBio, Limited, Research Grant.

National Health and Medical Research Council, Project/Ideas Grants.


Doctoral Students

Dr Hamish Philpott, MBBS, MRCP, FRACP, Grad Dip Clin Res Methods, PhD

Dr Krupesh Patel, B.Biomed (Hons), PhD

Dr Maggie Lam, B.Biomed (Hons), PhD

Dr Vivian Mao, B.Biomed., M.Biotech, PhD

Dr Amlan Chakraborty, B.Tech (Biotechnology), M.Tech (Biotechnology), PhD

Ms Claudia Sim, B.Sc.


Publications (Journal Articles and Book Chapters)

Edirisinghe HS, Rajapaksa AE, Royce SG, Sourial M, Bischof RJ, Anderson J, Sarila G, Nguyen CD, Mulholland K, Do LAH, Licciardi PV. Aerosol delivery of palivizumab in a neonatal lamb model of Respiratory Syncytial Virus infection. Viruses Accepted 16/11/23. 

Studley WR, Lamanna E, Martin KA, Nold-Petry CA, Royce SG, Woodman OL, Ritchie RH, Qin CX, Bourke JE. The small-molecule formyl peptide receptor biased agonist, Compound 17b, is a vasodilator and anti-inflammatory in mouse precision-cut lung slices Br J Pharmacol. 2023 Accepted 6/7/23 IF9.47

Perera UE, Organ L, Royce SG, Samuel CS, Derseh HB, Dewage SNV, Koumoundouros E, Stent A, Snibson KJ. Comparative Study of Ectopic Lymphoid Aggregates in Sheep and Murine Models of Bleomycin-Induced Pulmonary Fibrosis. Can Respir J 2023 Jan 18;2023:1522593.

Royce SG, Licciardi PV, Beh RC, Bourke JE, Donovan C, Hung A, Khurana I, Liang JJ, Maxwell S, Mazarakis N, Pitsillou E, Siow YY, Snibson KJ, Tobin MJ, Ververis K, Vongsvivut J, Ziemann M, Samuel CS, Tang MLK, El-Osta A, Karagiannis TC. Sulforaphane prevents and reverses allergic airways disease in mice via anti-inflammatory, antioxidant, and epigenetic mechanisms. Cell Mol Life Sci 2022 Nov 1;79(11):579.

Zare H, Rezapour H, Fereidouni A, Nikpour S, Mahmoudzadeh S, Royce SG, Fereidouni M. Analysis and comparison of anti-RBD neutralizing antibodies from AZD-1222, Sputnik V, Sinopharm and Covaxin vaccines and its relationship with gender among health care workers. Immun Ageing 2022 Oct 22;19(1):47.

Z Bashiri, M Yousefi, SG Royce, M Fereidouni. Antibacterial activity of aqueous and lipid extracts of five common allergenic pollens. Journal of Medicinal Plants 2022; 21 (83), 1-8

Zangoue M, Safari H, Royce SG, Zangooie A, Rezapour H, Zangouei A, Fereidouni M. The high level of adherence to personal protective equipment in health care workers efficiently protects them from COVID-19 infection. Work 2021;69(4):1191-1196.

Amlan Chakraborty, Anita A Pinar, Maggie Lam, Jane E Bourke, Simon G Royce, Cordelia Selomulya, CS Samuel. Pulmonary myeloid cell uptake of biodegradable nanoparticles conjugated with an anti-fibrotic agent provides a novel strategy for treating chronic allergic airways disease.  Biomaterials. 2021 Jun;273:120796. IF 10.3

Ishant Khurana, Scott Maxwell, Simon Royce*, Prabhu Mathiyalagan, Tom Karagiannis, Nadia Mazarakis, Jitraporn Vongsvivut, Harikrishnan KN, Jun Okabe, Keith Al-Hasani, Chrishan Samuel Assam El-Osta,SAHA Attenuates Takotsubo-like Myocardial Injury by Targeting an Epigenetic Ac/Dc AxisSignal Transduction and Targeted Therapy IF13.49  2021;6 (1), 159  * Co first author

M Fereidouni, SG Royce, N Rezaei. Improving the Role of Medical Scientific Societies during Health Crises. Health Science Journal 2021;15 (5), 1-4

Chakraborty, A. & Royce, S., 2020, Use of biologics in the treatment of asthma, COPD, ACOS, and idiopathic pulmonary fibrosis. Chapter 5 In: Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems. Dua, K., Wadhwa, R., Pont, L. G., Hansbro, P. M., Haghi, M. & Williams, K. A. (eds.). London UK: Academic Press, p. 97-115 19 p.

Mazarakis N, Vongsvivut J, Bambery KR, Ververis K, Tobin MJ, Royce SG, Samuel CS, Snibson KJ, Licciardi PV, Karagiannis TC. Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.Sci Rep. 2020 Jul 16;10(1):11713. IF3.998

McDonald H, Peart J, Kurniawan ND, Galloway G, Royce SG, Samuel CS, Chen C. Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion. Biomed Pharmacother. 2020 May 8;127:110165. doi: 10.1016/j.biopha.2020.110165. Epub ahead of print. PMID: 32403043. IF3.7

Garg M, Royce SG, Lubel JS. Letter: intestinal inflammation, COVID-19 and gastrointestinal ACE2 - exploring RAS inhibitors. Aliment Pharmacol Ther. 2020 May 6. doi: 10.1111/apt.15814. Epub ahead of print. PMID: 32374032. IF7.4

Chakraborty A, Royce SG, Selomulya C, Plebanski M. A novel Approach for Non- Invasive Lung Imaging and Targeting Lung Immune Cells. Int J Mol Sci. 2020 Feb 27;21(5):1613. doi: 10.3390/ijms21051613. PMID: 32120819; PMCID: PMC7084491. IF4.2

Chakraborty A, Royce SG, Plebanski M, Selomulya C. Glycine microparticles loaded with functionalized nanoparticles for pulmonary delivery. Int J Pharm. 2019 Oct 30;570:118654.  IF4.2

Garg M, Royce SG, Tikellis C, Shallue C, Batu D, Velkoska E, Burrell LM, Patel SK, Beswick L, Jackson A, Britto K, Lukies M, Sluka P, Wardan H, Hirokawa Y, Tan CW, Faux M, Burgess AW, Hosking P, Monagle S, Thomas M, Gibson PR, Lubel J. Imbalance of the renin-angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target? Gut. 2020 May;69(5):841-851.   IF17.9

Royce SG, Patel KP, Mao W, Zhu D, Lim R, Samuel CS. Serelaxin enhances the therapeutic effects of human amnion epithelial cell-derived exosomes in experimental models of lung disease. Br J Pharmacol. 2019 Jul;176(13):2195-2208.  IF6.8

Kanai AJ, Konieczko EM, Bennett RG, Samuel CS, Royce SG. Relaxin and Fibrosis:Emerging Targets, Challenges, and Future Directions. Mol Cell Endo Accepted 5/2/19 IF 3.859

Royce SG, Mao WY, Lim R, Kelly K, Samuel CS. iPSC- and mesenchymoangioblast-derived mesenchymal stem cells provide greater protection against experimental chronic allergic airways disease compared to a clinically-used corticosteroid. FASEB J. Accepted 23/1/19 IF  5.595

Garg M, Royce SG, Tikellis C, Shallue C, Sluka P, Wardan H, Hosking P, Monagle S, Thomas M, Lubel JS, Gibson PR. The intestinal vitamin D receptor in inflammatory bowel disease: inverse correlation with inflammation but no relationship with circulating vitamin D status. Therapeutic Advances in Gastroenterology Accepted 29/11/18. IF 4.17

Chakraborty A, Boer JC, Selomulya C, Plebanski M, Royce SG. Insights into endotoxin-mediated lung inflammation and future treatment strategies. Expert Rev Respir Med. 2018 Nov;12(11):941-955.

McDonald H, Peart J, Kurniawan N, Galloway G, Royce S, Samuel C, Chen C. Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction. Physiological Reports Accepted 15/4/18.

Lam M, Royce SG, Samuel CS, Bourke JE. Serelaxin as a novel therapeutic opposing fibrosis and contraction in lung diseases. Pharmacol Ther. 2018 Jul;187:61-70. IF 10.38

Mazarakis N, Vongsvivut J, Bambery KR, Snibson KJ, Royce SG, Karagiannis TC. Synchrotron-Fourier transform infrared maps of ovalbumin-induced murine chronic allergic airways disease: Correlation with conventional histology. Hell J Nucl Med. 2017 Sep-Dec;20 Suppl:103-113. 

Royce SG, Rele S, Broughton BRS, Kelly K, Samuel CS. Intranasal administration of mesenchymoangioblast-derived mesenchymal stem cells abrogates airway fibrosis and airway hyperresponsiveness associated with chronic allergic airways disease. FASEB J. 2017;31:4168-4178. IF 5.498 

Lam M, Royce SG, Donovan C, Jelenic M, Parry LJ, Samuel CS, Bourke JE. Serelaxin Elicits Bronchodilation and Enhances β-Adrenoceptor-mediated Airway Relaxation. Front Pharmacol. 2016 Oct 27;7:406. IF4.418

Royce SG, Tominaga AM, Shen M, Patel K, Huuskes B, Lim R, Ricardo SD, and Samuel CS.  Serelaxin improves the therapeutic efficacy of RXFP1-expressing human amnion epithelial cells in experimental allergic airways disease. Clin Sci (Lond). 2016 Dec 1;130(23):2151-2165. IF5.629

Royce SG, Nold M, et al Airway remodeling and hyperreactivity in a model of bronchopulmonary dysplasia and their modulation by IL-1Ra.   Am J Respir Cell Mol Biol. 2016 Dec;55(6):858-868. IF3.985

Samuel CS, Royce SG, Hewitson TD, Denton KM, Cooney TE, Bennett RG. Anti-fibrotic actions of relaxin. Br J Pharmacol. 2017 May;174(10):962-976. IF 4.842

Royce SG, Samuel CS, Bathgate RAD. Promise and limitations of relaxin-based therapies in chronic fibrotic lung diseases. Am J Respir Crit Care Med. 2016 Dec 1;194(11):1434-1435.IF13.118

Philpott, H; Nandurkar, S; Thien, F; Royce S; Gibson, P.  Allergy tests do not predict food triggers in adult patients with eosinophilic oesophagitis. A comprehensive prospective study using five modalities: skin prick, skin patch, serum food-specific IgE and IgG, and basophil activation tests. Alimentary Pharmacology & Therapeutics 2016 Aug;44(3):223-33. IF 5.727

Samuel CS, Royce SG, Hewitson TD , Denton KM, Cooney TE and Bennett RG.  Anti-fibrotic actions of relaxin.  Br J Pharmacol. 2017 May;174(10):962-976.  IF 4.842

Hossain MA, Kocan M, Yao ST, Royce SG, Nair VB, Siwek C, Patil NA, Harrison IP, Rosengren KJ, Selemidis S, Summers RJ, Wade JD, Bathgate RAD, Samuel CS  A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1. Chem. Sci., 2016,7, 3805-3819. IF 9.211

Patel KP, Giraud AS, Samuel CS, Royce SG. Combining an epithelial repair factor and anti-fibrotic with a corticosteroid offers optimal treatment for allergic airways disease. Br J Pharmacol. 2016 Jun;173(12):2016-29. IF 4.842

FitzPatrick M, Royce SG, Langenbach S, McQualter J, Reading PC, Wijburg O, Anderson GP, Stewart A, Bourke J, Bozinovski S. Neonatal pneumococcal colonisation caused by Influenza A infection alters lung function in adult mice. Sci Rep. 2016 Mar 4;6:22751. IF 5.578

Philpott H, Nandurkar S, Royce SG, Thien F, Gibson PR. A prospective open clinical trial of a proton pump inhibitor, elimination diet and/or budesonide for eosinophilic oesophagitis. Aliment Pharmacol Ther. 2016 May;43(9):985-93. IF 5.727

Philpott H, Nandurkar S, Royce SG, Gibson PR. Ultrathin unsedated transnasal gastroscopy in monitoring eosinophilic esophagitis. J Gastroenterol Hepatol. 2016 Mar;31(3):590-4. IF 3.505

Schuliga M, Royce SG, Langenbach S, Berhan A, Harris T, Keenan CR, StewartAG. The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation. Am J Respir Cell Mol Biol. 2016 Feb;54(2):200-9. IF 3.985

Royce SG, Shen M, Patel KP, Huuskes BM, Ricardo SD, Samuel CS. Mesenchymal stem cells and serelaxin synergistically abrogate established airway fibrosis in an experimental model of chronic allergic airways disease. Stem Cell Res. 2015 Nov;15(3):495-505. IF 3.693

Philpott H, Nandurkar S, Thien F, Gibson PR, Royce SG. Eosinophilic esophagitis: a clinicopathological review. Pharmacol Ther. 2015 Feb;146:12-22. IF 9.723

Donovan C, Bailey SR, Tran J, Haitsma G, Ibrahim ZA, Foster SR, Tang ML, Royce SG, Bourke JE. Rosiglitazone elicits in vitro relaxation in airways and precision cut lung slices from a mouse model of chronic allergic airways disease. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1219-28. IF 4.080

Philpott H, Nandurkar S, Royce SG, Gibson PR. Letter: seasonality in eosinophilic oesophagitis and food bolus obstruction - what about recurrent episodes? Aliment Pharmacol Ther. 2015 Oct;42(7):936. IF 5.727

Mahajan R, Lau DH, Brooks AG, Shipp NJ, Manavis J, Wood JP, Finnie JW, Samuel CS, Royce SG, Twomey DJ, Thanigaimani S, Kalman JM, Sanders P. Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity. J Am Coll Cardiol. 2015 Jul 7;66(1):1-11. IF 16.503

Philpott HL, Nandurkar S, Thien F, Bloom S, Lin E, Goldberg R, Boyapati R, Finch A, Royce SG, Gibson PR. Seasonal recurrence of food bolus obstruction in eosinophilic esophagitis. Intern Med J. 2015 Sep;45(9):939-43. IF 1.644

Donovan C, Royce SG, Vlahos R, Bourke JE. Lipopolysaccharide does not alter small airway reactivity in mouse lung slices. PLoS One. 2015 Mar 30;10(3):e0122069. doi: 10.1371/journal.pone.0122069. IF 3.234

Donovan C, Seow HJ, Royce SG, Bourke JE, Vlahos R. Alteration of Airway Reactivity and Reduction of Ryanodine Receptor Expression by Cigarette Smoke in Mice. Am J Respir Cell Mol Biol. 2015 Oct;53(4):471-8. IF 3.985

Philpott H, Royce S, Nandurkar S, Thien F, Gibson P. IgG and EoE: too soon for a paradigm shift away from IgE. Gastroenterology. 2015 Feb;148(2):453-4. IF 16.716

Tortorella SM, Royce SG, Licciardi PV, Karagiannis TC. Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition. Antioxid Redox Signal. 2015 Jun 1;22(16):1382-424. IF 7.407

Philpott H, Royce S, Thien F, Nandurkar S, Gibson P. What gastroenterologists should know about testing patients with eosinophilic esophagitis for food allergies. Clin Gastroenterol Hepatol. 2015 May;13(5):1029-30. IF 7.896

Dharmakumara M, Prisk GK, Royce SG, Tawhai M, Thompson B. The effect of gas exchange on multiple breath nitrogen washout measures of ventilation inhomogeneity in the mouse. J Appl Physiol. 2014 Nov 1;117(9):1049-54.

Royce SG, Patel KP, Samuel CS. Characterization of a novel model incorporating airway epithelial damage and related fibrosis to the pathogenesis of asthma. Lab Invest. 2014 Dec;94(12):1326-39.

Royce SG, Lim CX, Patel KP, Wang B, Samuel CS, Tang ML. Intranasally-administered serelaxin abrogates airway remodeling and attenuates airway hyperresponsiveness in allergic airways disease. Clin Exp Allergy. 2014 Nov;44(11):1399-408.

Samuel CS, Bodaragama H, Chew JY, Widdop RE, Royce SG, Hewitson TD. Serelaxin Is a More Efficacious Antifibrotic Than Enalapril in an Experimental Model of Heart Disease. Hypertension. 2014 Aug;64(2):315-22.

Philpott H, Nandurkar S, Royce SG, Thien F, Gibson PR. Risk factors for eosinophilic esophagitis. Clin Exp Allergy. 2014 Aug;44(8):1012-9.

Philpott H, Royce S, Thien F, Nandurkar S, Gibson P. Food allergy testing in Eosinophilic Esophagitis: what the Gastroenterologist needs to know. Clin Gastroenterol Hepatol. 2014 Aug 12. pii: S1542-3565(14)01149-5.

Royce SG, Le Saux CJ. Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases. Expert Rev Respir Med. 2014 Jun;8(3):339-47.

Royce SG, Moodley Y, Samuel CS. Novel therapeutic strategies for lung disorders associated with airway remodelling and fibrosis. Pharmacol Ther. 2014 Mar;141(3):250-260.

Tortorella S, Royce SG*, Karagiannis TC*.  Molecular mechanisms in the development and progression of asthma: The role of epigenetic regulation and the airway epithelium. In Molecular mechanisms and physiology of disease Springer New York 2014, pp219-246. *Co-first author..

Royce SG, Karagiannis TC. Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions. Curr Opin Allergy Clin Immunol. 2014 Feb;14(1):44-8.

Royce SG, Li X, Tortorella S, Goodings L, Chow BS, Giraud AS, Tang ML, Samuel CS. Mechanistic insights into the contribution of epithelial damage to airway remodeling. Novel therapeutic targets for asthma. Am J Respir Cell Mol Biol. 2014 Jan;50(1):180-92.

Shelley Z, Royce SG, Ververis K, Karagiannis TC. Cell cycle effects of L-sulforaphane, a major antioxidant from cruciferous vegetables: The role of the anaphase promoting complex. Hell J Nucl Med. 2014 Jan-Apr;17 Suppl 1:11-6

Gabehart KE, Royce SG, Maselli DJ, Miyasato SK, Davis EC, Tang ML, Jourdan Le  Saux C. Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respir Res. 2013 Oct 21;14:110.

Royce SG, Lim C, Muljadi RC, Samuel CS, Ververis K, Karagiannis TC, Giraud AS, Tang ML. Trefoil factor-2 reverses airway remodeling changes in allergicairways disease. Am J Respir Cell Mol Biol. 2013 Jan;48(1):135-44.

Donovan C, Royce SG*, Esposito J, Tran J, Ibrahim ZA, Tang ML, Bailey S, Bourke JE. Differential effects of allergen challenge on large and small airway reactivity in mice. PLoS One. 2013 Sep 6;8(9):e74101. *Co-first author

Abed HS, Samuel CS, Lau DH, Kelly DJ, Royce SG, Alasady M, Mahajan R, Kuklik P, Zhang Y, Brooks AG, Nelson AJ, Worthley SG, Abhayaratna WP, Kalman JM, Wittert GA, Sanders P. Obesity results in progressive atrial structural and electrical remodeling: implications for atrial fibrillation. Heart Rhythm. 2013 Jan;10(1):90-100.

Stewart AG, Xia YC, Harris T, Royce S, Hamilton JA, Schuliga M. Plasminogen-stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin-activated cell signalling. Br J Pharmacol. 2013 Dec;170(7):1421-35.

Royce SG, Sedjahtera A, Samuel CS, Tang ML. Combination therapy with relaxin and methylprednisolone augments the effects of either treatment alone in inhibiting subepithelial fibrosis in an experimental model of allergic airways disease. Clin Sci (Lond). 2013 Jan;124(1):41-51.

Royce SG, Ververis K, Karagiannis TC. Histone deacetylase inhibitors: can we  consider potent anti-neoplastic agents for the treatment of asthma? Ann Clin Lab Sci. 2012 Summer;42(3):338-45.

Royce SG, Dang W, Yuan G, Tran J, El-Osta A, Karagiannis TC, Tang ML. Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice. Arch Immunol Ther Exp (Warsz). 2012 Aug;60(4):295-306.

Royce SG, Cheng V, Samuel CS, Tang ML. The regulation of fibrosis in airway remodeling in asthma. Mol Cell Endocrinol. 2012 Apr 4;351(2):167-75.

Royce SG, Ververis K, Karagiannis TC. Controversies surrounding the potential use of histone deacetylase Inhibitors for the treatment of asthma. ISRN Pulmonology. 2012, ID 452307, p. 1 - 10

Royce SG, Karagiannis TC. Histone deacetylases and their role in asthma. J Asthma. 2012 Mar;49(2):121-8.

Karagiannis TC, Li X, Tang MM, Orlowski C, El-Osta A, Tang ML, Royce SG. Molecular model of naphthalene-induced DNA damage in the murine lung. Hum Exp Toxicol. 2012 Jan;31(1):42-50.

Royce SG, Dang W, Ververis K, De Sampayo N, El-Osta A, Tang ML, Karagiannis TC. Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease. Epigenetics. 2011 Dec;6(12):1463-70.

Royce SG, Lim C, Muljadi RC, Tang ML. Trefoil factor 2 regulates airway remodeling in animal models of asthma. J Asthma. 2011 Sep;48(7):653-9.

Royce SG, Dang W, Yuan G, Tran J, El Osta A, Karagiannis TC, Tang ML. Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease. Pathobiol Aging Age Relat Dis. 2011;1.

Royce SG, Dang W, Tang MLK, El-Osta A, Karagiannis TC  Developmental origins of disease: effects of parental diet in asthma  Epigenomic Medicine - Vol I  (2011)    Chapter 6 -  

McKenzie R, Burton MD, Royce SG, Tang ML. Age and sex influences on airway hyperresponsiveness. J Asthma. 2010 Aug;47(6):651-4.

Tang MM, Mah LJ, Vasireddy RS, Georgiadis GT, El-Osta A, Royce SG, Karagiannis TC. Quantitation of gammaH2AX foci in tissue samples. J Vis Exp. 2010 Jun 28;(40). pii: 2063. doi: 10.3791/2063. 

Binos S, Royce SG, Oxley D, Bacic A, Bhathal PS, Underwood JR. A novel foregut mucin characterized by a murine monoclonal autoantibody. Hybridoma (Larchmt). 2010 Apr;29(2):87-100.

Royce SG, Lee M, Tang ML. The contribution of L-selectin to airway hyperresponsiveness in chronic allergic airways disease. J Asthma Allergy. 2010 Jun 28;3:9-17.

Royce SG, Tang MLK.  Histone deacetylases and their inhibitors in inflammatory lung diseases and lung cancers. In: HDAC inhibitors in medicine. Karagiannis, T. C., El-Osta, A. Eds.; Research Signpost: Trivandrum, India, Chapter 6; 2010

Royce SG, Alsop K, Haydon A, Mead L, Smith LD, Tesoriero AA, Giles GG, Jenkins MA, Hopper JL, Southey MC. The role of SMAD4 in early-onset colorectal cancer. Colorectal Dis. 2010 Mar;12(3):213-9.

Royce SG, Tang ML. The effects of current therapies on airway remodeling in asthma and new possibilities for treatment and prevention. Curr Mol Pharmacol. 2009 Jun;2(2):169-81.

Tang ML, Samuel CS, Royce SG. Role of relaxin in regulation of fibrosis in the lung. Ann N Y Acad Sci. 2009 Apr;1160:342-7.

Royce SG, Tan L, Koek AA, Tang ML. Effect of extracellular matrix composition on airway epithelial cell and fibroblast structure: implications for airway remodeling in asthma. Ann Allergy Asthma Immunol. 2009 Mar;102(3):238-46.

Royce SG, Miao YR, Lee M, Samuel CS, Tregear GW, Tang ML. Relaxin reverses airway remodeling and airway dysfunction in allergic airways disease. Endocrinology. 2009 Jun;150(6):2692-9.

Samuel CS, Royce SG*, Chen B, Cao H, Gossen JA, Tregear GW, Tang ML. Relaxin family peptide receptor-1 protects against airway fibrosis during homeostasis but not against fibrosis associated with chronic allergic airways disease. Endocrinology. 2009 Mar;150(3):1495-502. *Co-first author.

English DR, Young JP, Simpson JA, Jenkins MA, Southey MC, Walsh MD, Buchanan DD, Barker MA, Haydon AM,Royce SG, Roberts A, Parry S, Hopper JL, Jass JJ, Giles GG. Ethnicity and risk for colorectal cancers showing somatic BRAF V600E mutation or CpG island methylator phenotype. Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1774-80.

McKenzie R, Royce SG, Burton MD, Tang ML. Attenuated methacholine airway response following repeat testing in a murine model of allergic airways disease.  Exp Lung Res. 2008 Jun;34(5):277-86

Samuel CS, Royce SG*, Burton MD, Zhao C, Tregear GW, Tang ML. Relaxin plays an important role in the regulation of airway structure and function. Endocrinology. 2007 Sep;148(9):4259-66. *Co-first author

Mead LJ, Jenkins MA, Young J, Royce SG, Smith L, St John DJ, Macrae F, Giles  GG, Hopper JL, Southey MC. Microsatellite instability markers for identifying early-onset colorectal cancers caused by germ-line mutations in DNA mismatch repair genes. Clin Cancer Res. 2007 May 15;13(10):2865-9.

Smith LD, Tesoriero AA, Ramus SJ, Dite G, Royce SG, Giles GG, McCredie MR, Hopper JL, Southey MC. BRCA1 promoter deletions in young women with breast cancer and a strong family history: a population-based study. Eur J Cancer. 2007 Mar;43(5):823-7.

Locke NR, Royce SG*, Wainewright JS, Samuel CS, Tang ML. Comparison of airway  remodeling in acute, subacute, and chronic models of allergic airways disease. Am J Respir Cell Mol Biol. 2007 May;36(5):625-32. *Co-first author

Lekgabe ED, Royce SG, Hewitson TD, Tang ML, Zhao C, Moore XL, Tregear GW, Bathgate RA, Du XJ, Samuel CS. The effects of relaxin and estrogen deficiency on  collagen deposition and hypertrophy of nonreproductive organs. Endocrinology. 2006 Dec;147(12):5575-83.

Alsop K, Mead L, Smith LD, Royce SG, Tesoriero AA, Young JP, Haydon A, Grubb  G, Giles GG, Jenkins MA, Hopper JL, Southey MC. Low somatic K-ras mutation frequency in colorectal cancer diagnosed under the age of 45 years. Eur J Cancer. 2006 Jul;42(10):1357-61.

Tang ML, Wilson JW, Stewart AG, Royce SG. Airway remodelling in asthma: current understanding and implications for future therapies. Pharmacol Ther. 2006 Nov;112(2):474-88.

Hughes NR, Pairojkul C, Royce SG, Clouston A, Bhathal PS. Liver fluke-associated and sporadic cholangiocarcinoma: an immunohistochemical study of bile duct, peribiliary gland and tumour cell phenotypes. J Clin Pathol. 2006 Oct;59(10):1073-8.

Mookerjee I, Solly NR, Royce SG, Tregear GW, Samuel CS, Tang ML. Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease. Endocrinology. 2006 Feb;147(2):754-61.

Smith L, Tesoriero A, Mead L, Royce S, Grubb G, Young J, Giles G, Jenkins M, Macrae F, Hopper JL, Southey MC. Large genomic alterations in hMSH2 and hMLH1 in early-onset colorectal cancer: identification of a large complex de novo hMLH1 alteration. Clin Genet. 2006 Sep;70(3):250-2.

Southey MC, Jenkins MA, Mead L, Whitty J, Trivett M, Tesoriero AA, Smith LD, Jennings K, Grubb G, Royce SG, Walsh MD, Barker MA, Young JP, Jass JR, St John DJ, Macrae FA, Giles GG, Hopper JL. Use of molecular tumor characteristics to prioritize mismatch repair gene testing in early-onset colorectal cancer. J Clin Oncol. 2005 Sep 20;23(27):6524-32. 

Royce SG, Hughes NR, Binos S, Underwood JR, Bhathal PS. Vertebrate phylogeny of antigen D10: identification of a conserved foregut cell lineage. Histochem Cell Biol. 2000 Aug;114(2):125-35.

Tagkalidis PP, Royce SG, Macrae FA, Bhathal PS. Selective colonization by Helicobacter pylori of the deep gastric glands and intracellular canaliculi of parietal cells in the setting of chronic proton pump inhibitor use. Eur J Gastroenterol Hepatol. 2002 Apr;14(4):453-6.


Expertise related to UN Sustainable Development Goals

In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

  • SDG 3 - Good Health and Well-being

Research area keywords

  • Pharmacology
  • COPD
  • Asthma
  • Chronic lung disease

Collaborations and top research areas from the last five years

Recent external collaboration on country/territory level. Dive into details by clicking on the dots or