Simon Mountford

Dr

20092020

Research output per year

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Research Output

2020

Application of a Sulfoxonium Ylide Electrophile to Generate Cathepsin X-Selective Activity-Based Probes

Mountford, S. J., Anderson, B. M., Xu, B., Tay, E. S. V., Szabo, M., Hoang, M-L., Diao, J., Aurelio, L., Campden, R. I., Lindström, E., Sloan, E. K., Yates, R. M., Bunnett, N. W., Thompson, P. E. & Edgington-Mitchell, L. E., 20 Mar 2020, In : ACS Chemical Biology. 15, 3, p. 718-727 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Heterodimeric Analogues of the Potent Y1R Antagonist 1229U91, Lacking One of the Pharmacophoric C-Terminal Structures, Retain Potent Y1R Affinity and Show Improved Selectivity over Y4R

Richardson, R. R., Groenen, M., Liu, M., Mountford, S. J., Briddon, S. J., Holliday, N. D. & Thompson, P. E., 28 May 2020, In : Journal of Medicinal Chemistry. 63, 10, p. 5274-5286 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors

Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 1 Apr 2020, In : European Journal of Medicinal Chemistry. 191, 112120.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and biological evaluation of a novel photo-activated histone deacetylase inhibitor

Sama, G. R., Liu, H., Mountford, S., Thompson, P., Robinson, A. & Dear, A. E., 15 Aug 2020, In : Bioorganic and Medicinal Chemistry Letters. 30, 16, 5 p., 127291.

Research output: Contribution to journalArticleResearchpeer-review

2019

(S)-(−)-Fluorenylethylchloroformate (FLEC); preparation using asymmetric transfer hydrogenation and application to the analysis and resolution of amines

Al Amin, M., Camerino, M. A., Mountford, S. J., Ma, X., Manallack, D. T., Chalmers, D. K., Wills, M. & Thompson, P. E., 1 Jan 2019, In : Tetrahedron. 75, 43, p. 1-7 7 p., 130591.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Synthesis and elaboration of N-methylpyrrolidone as an acetamide fragment substitute in bromodomain inhibition

Hilton-Proctor, J. P., Ilyichova, O., Zheng, Z., Jennings, I. G., Johnstone, R. W., Shortt, J., Mountford, S. J., Scanlon, M. J. & Thompson, P. E., 15 Dec 2019, In : Bioorganic & Medicinal Chemistry. 27, 24, 9 p., 115157.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2017

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity

Mountford, S. J., Mohanty, B., Roberts, K. D., Yu, H. H., Scanlon, M. J., Nation, R. L., Velkov, T., Li, J. & Thompson, P. E., 2017, In : Organic and Biomolecular Chemistry. 15, 34, p. 7173-7180 8 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2016

Beta amino acid-modified and fluorescently labelled kisspeptin analogues with potent KISS1R activity

Camerino, M., Liu, M., Moriya, S., Kitahashi, T., Mahgoub, A., Mountford, S., Chalmers, D. K., Soga, T., Parhar, I. & Thompson, P., 1 Jun 2016, In : Journal of Peptide Science. 22, 6, p. 406-414 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Development of single and mixed isoform selectivity PI3Kδ inhibitors by targeting Asn836 of PI3Kδ

Miller, M. S., Mountford, S. J., Pinson, J-A., Zheng, Z., Künzli, M., Patel, V., Hogg, S. J., Shortt, J., Jennings, I. G. & Thompson, P. E., 1 Oct 2016, In : Bioorganic and Medicinal Chemistry Letters. 26, 19, p. 4790-4794 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Discovery and antiplatelet activity of a selective PI3Kβ inhibitor (MIPS-9922)

Zheng, Z., Pinson, J. A., Mountford, S. J., Orive, S., Schoenwaelder, S. M., Shackleford, D., Powell, A., Nelson, E. M., Hamilton, J. R., Jackson, S., Jennings, I. G. & Thompson, P. E., 21 Oct 2016, In : European Journal of Medicinal Chemistry. 122, p. 339-351 13 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Identification of a cyanine-dye labeled peptidic ligand for Y1R and Y4R, based upon the neuropeptide y C-terminal analogue, BVD-15

Liu, M., Richardson, R. R., Mountford, S. J., Zhang, L., Tempone, M. H., Herzog, H., Holliday, N. D. & Thompson, P. E., 21 Sep 2016, In : Bioconjugate Chemistry. 27, 9, p. 2166-2175 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optically pure, structural, and fluorescent analogues of a dimeric Y4 receptor agonist derived by an olefin metathesis approach

Liu, M., Mountford, S. J., Richardson, R. R., Groenen, M., Holliday, N. D. & Thompson, P. E., 14 Jul 2016, In : Journal of Medicinal Chemistry. 59, 13, p. 6059-6069 11 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2015

Class II but not second class - prospects for the development of class II PI3K inhibitors

Mountford, S. J., Zheng, Z., Sundaram, K., Jennings, I., Hamilton, J. R. & Thompson, P., 2015, In : ACS Medicinal Chemistry Letters. 6, 1, p. 3 - 6 4 p.

Research output: Contribution to journalEditorialResearchpeer-review

4 Citations (Scopus)

Propargyloxyproline regio- and stereoisomers for click-conjugation of peptides: synthesis and application in linear and cyclic peptides

Northfield, S. E., Mountford, S. J., Wielens, J., Liu, M., Zhang, L., Herzog, H., Holliday, N. D., Scanlon, M., Parker, M. W., Chalmers, D. K. & Thompson, P., 2015, In : Australian Journal of Chemistry. 68, 9, p. 1365-1372 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)
2014

Design, synthesis and evaluation of pyridine-based chromatographic adsorbents for antibody purification

Mountford, S. J., Daly, R., Robinson, A. J. & Hearn, M. T. W., 2014, In : Journal of Chromatography A. 1355, p. 15 - 25 11 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

N-Heterocyclic-based adsorbents for antibody purification-effect of ligand structure

Mountford, S. J., Daly, R., Campi, E. M., Bhagwat, A. M., Robinson, A. J. & Hearn, M. T. W., 2014, In : Journal of Molecular Recognition. 27, 5, p. 285 - 295 11 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Synthetic routes to the Neuropeptide Y Y1 receptor antagonist 1229U91 and related analogues for SAR studies and cell-based imaging

Mountford, S. J., Liu, M., Zhang, L., Groenen, M., Herzog, H., Holliday, N. D. & Thompson, P., 2014, In : Organic and Biomolecular Chemistry. 12, 20, p. 3271 - 3281 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2013

Synthesis of BVD15 peptide analogues as models for radioligands in tumour imaging

Liu, M., Mountford, S. J., Zhang, L., Lee, I. C. J., Herzog, H. & Thompson, P., 2013, In : International Journal of Peptide Research and Therapeutics. 19, p. 33 - 41 9 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2011

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P. & Chai, S., 2011, In : British Journal of Pharmacology. 164, 1, p. 37 - 47 11 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Synthesis of N-heterocyclic ligands for use in affinity and mixed mode chromatography

Mountford, S., Campi, E., Robinson, A. & Hearn, M. T. W., 2011, In : Tetrahedron. 67, 2, p. 471 - 485 15 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)
2010

S -> N type Smiles rearrangement of the aminoethanethiol moiety attached to heterocyclic compounds

Mountford, S. J., Campi, E. M., Robinson, A. J. & Hearn, M. T. W., 2010, In : Tetrahedron. 66, 19, p. 3452 - 3456 5 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Synthesis of "difficult" fluorescence quenched substrates of granzyme C

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P. & Thompson, P., 2010, In : International Journal of Peptide Research and Therapeutics. 16, p. 159 - 165 7 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2009

Morpholinone mediated oxazolone-free C-terminus amide coupling permitting a convergent strategy for peptide synthesis

Harwood, L. M., Mountford, S. J. & Yan, R., 2009, In : Journal of Peptide Science. 15, 1, p. 1-4 4 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)