Simon Foster

Dr

20112021

Research activity per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Dr. Simon Foster is an early career researcher in the Monash University Department of Biochemistry and Molecular Biology and the Monash Biomedicine Discovery Institute. He received his BA/BSc (Hons) degrees from the University of Melbourne (Australia) and his PhD from the University of Queensland (Australia). He was an independently-funded Postdoctoral Research Fellow at the University of Copenhagen (Denmark) from 2015-18 before moving to Monash in September 2018. 

Simon has a strong grounding in G protein-coupled receptors, molecular pharmacology and cardiovascular physiology. His specific interest centres on the identification and understanding of novel aspects of biology. After three years at the University of Copenhagen working on orphan GPCRs, he has recently returned to Australia to work on chemokine receptor signalling.

Research interests

Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue by phagocytosis and proteolytic degradation. However, excessive leukocyte recruitment or activity leads to the release of toxic substances and degradation of healthy tissue, i.e. inflammatory disease.

Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leukocytes. A detailed understanding of chemokine-receptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases. Our group is investigating several important aspects of chemokine and chemokine receptor biochemistry with the overall goals of better understanding and ultimately controlling their biological functions.

External positions

Postdoctoral Research Fellow, Københavns Universitet (University of Copenhagen)

1 Jun 201531 Jul 2018

Research area keywords

  • G Protein-Coupled Receptors
  • Chemokine receptors
  • Cell Signalling
  • Orphan receptors

Network

Recent external collaboration on country level. Dive into details by clicking on the dots or
If you made any changes in Pure these will be visible here soon.