• Room B109, 39 Rainforest Walk, Building 13B

    3800 Clayton

    Australia

20112019
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Personal profile

Biography

Dr. Simon Foster is an early career researcher in the Monash University Department of Biochemistry and Molecular Biology and the Monash Biomedicine Discovery Institute. He received his BA/BSc (Hons) degrees from the University of Melbourne (Australia) and his PhD from the University of Queensland (Australia). He was an independently-funded Postdoctoral Research Fellow at the University of Copenhagen (Denmark) from 2015-18 before moving to Monash in September 2018. 

Simon has a strong grounding in G protein-coupled receptors, molecular pharmacology and cardiovascular physiology. His specific interest centres on the identification and understanding of novel aspects of biology. After three years at the University of Copenhagen working on orphan GPCRs, he has recently returned to Australia to work on chemokine receptor signalling.

Research interests

Inflammation is the response of a tissue and its microvascular system to injury or infection. A hallmark of inflammation is the accumulation of leukocytes (white blood cells), which remove pathogens and necrotic tissue by phagocytosis and proteolytic degradation. However, excessive leukocyte recruitment or activity leads to the release of toxic substances and degradation of healthy tissue, i.e. inflammatory disease.

Leukocyte recruitment in inflammation is controlled by the expression and secretion of small proteins called chemokines at the site of inflammation and by the subsequent interaction of those chemokines with chemokine receptors located on the surfaces of circulating leukocytes. A detailed understanding of chemokine-receptor interactions is required in order to rationally develop novel therapeutic agents against inflammatory diseases. Our group is investigating several important aspects of chemokine and chemokine receptor biochemistry with the overall goals of better understanding and ultimately controlling their biological functions.

External positions

Postdoctoral Research Fellow, Københavns Universitet (University of Copenhagen)

1 Jun 201531 Jul 2018

Keywords

  • G Protein-Coupled Receptors
  • Chemokine receptors
  • Cell Signalling
  • Orphan receptors

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Research Output 2011 2019

Identification of a novel scaffold for a small molecule GPR139 receptor agonist

Nøhr, A. C., Shehata, M. A., Palmer, D., Pokhrel, R., Vallianou, M., Foster, S. R., Gentry, P. R., Gloriam, D. E. & Bräuner-Osborne, H., 7 Mar 2019, In : Scientific Reports. 9, 1, 9 p., 3802.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Investigating internalization and intracellular trafficking of GPCRs: New techniques and real-time experimental approaches

Foster, S. R. & Bräuner-Osborne, H., 1 Jan 2018, Targeting Trafficking in Drug Development. Ulloa-Aguirre, A. & Tao, Y-X. (eds.). Springer, p. 41-61 21 p. (Handbook of Experimental Pharmacology; vol. 245).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Bitter taste receptor agonists elicit G-protein-dependent negative inotropy in the murine heart

Foster, S. R., Blank, K., See Hoe, L. E., Behrens, M., Meyerhof, W., Peart, J. N. & Thomas, W. G., 1 Oct 2014, In : FASEB Journal. 28, 10, p. 4497-4508 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Extrasensory perception: Odorant and taste receptors beyond the nose and mouth

Foster, S. R., Roura, E. & Thomas, W. G., 1 Apr 2014, In : Pharmacology and Therapeutics. 142, 1, p. 41-61 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

Foster, S. R., Porrello, E. R., Purdue, B. W., Chan, H. W., Voigt, A., Frenzel, S., Hannan, R. D., Moritz, K. M., Simmons, D. G., Molenaar, P., Roura, E., Boehm, U., Meyerhof, W. & Thomas, W. G., 15 May 2013, In : PLoS ONE. 8, 5, e64579.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Prizes

Postdoctoral Research Fellowship

Simon Foster (Recipient), 2015

Prize: Competitive Fellowships

Postdoctoral Research Fellowship

Simon Foster (Recipient), 2015

Prize: Competitive Fellowships

Activities 2005 2019

Journal of Biological Chemistry (Journal)

Simon Foster (Peer reviewer)
2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Drug Discovery Special Interest Group Committee Victorian representative, ASCEPT (2019)

Simon Foster (Member)
2019

Activity: External Academic EngagementCommittees and working groups

Science Signaling (Journal)

Simon Foster (Peer reviewer)
2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Frontiers in Physiology (Journal)

Simon Foster (Peer reviewer)
2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Frontiers in Endocrinology (Journal)

Simon Foster (Peer reviewer)
2016

Activity: Publication peer-review and editorial work typesPeer review responsibility