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OCRF L’Oreal Paris Research Fellow
Ovarian Cancer Biomarkers/Steroid Receptor Biology
Hudson Institute for Medical Research


Dr. Simon Chu completed his PhD at Prince Henry’s Institute (PHI) in 2005. His studies focused on the roles of the estrogen receptor in the pathogenesis of a subset of ovarian tumours, and in particular, the impact that molecular signalling pathways of the cell have on this receptor. After gaining his PhD, Dr. Chu continued his work at PHI, examining the consequences of blocking this mechanism using new therapeutic compounds to explore whether this might lead to a new chemotherapeutic approach to treating this disease.

In 2007, Dr Chu left PHI to take up a postdoctoral position at the Pasteur Institute located in Cambodia, where he helped develop a new molecular technique to investigate the incidence of exposure to avian influenza in the human population in that country.

On his return to Australia in April 2009, Dr Chu joined PHI as the OCRF L’Oreal Paris Australia Research Fellow. His work focuses on the underlying causes of the more common type of ovarian cancer, as well as the less common granulosa cell tumour of the ovary. He is currently investigating an exciting potential therapeutic option for treating these cancers, using a combination treatment that targets two important biological pathways in the cancer cells. This presents a new chemotherapeutic approach for the treatment of ovarian cancer.


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Research Output

Combined PPARγ Activation and XIAP Inhibition as a Potential Therapeutic Strategy for Ovarian Granulosa Cell Tumors

Leung, D. T. H., Nguyen, T., Oliver, E. M., Matti, J., Alexiadis, M., Silke, J., Jobling, T. W., Fuller, P. J. & Chu, S., 1 Feb 2019, In : Molecular Cancer Therapeutics. 18, 2, p. 364-375 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Mutational landscape of ovarian adult granulosa cell tumors from whole exome and targeted TERT promoter sequencing

Alexiadis, M., Rowley, S. M., Chu, S., Leung, D. T. H., Stewart, C. J. R., Amarasinghe, K. C., Campbell, I. G. & Fuller, P. J., 1 Jan 2019, In : Molecular Cancer Research. 17, 1, p. 177-185 9 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Targeting XIAP and PPARγ in granulosa cell tumors alters metabolic signaling

Leung, T. H., Rainczuk, A., Nguyen, T., Stephens, A., Silke, J., Fuller, P. J. & Chu, S., 5 Apr 2019, In : Journal of Proteome Research. 18, 4, p. 1691-1701 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Measurement of oxidative stress: mitochondrial function using the seahorse system

Leung, D. T. H. & Chu, S., 1 Jan 2018, Preeclampsia: Methods and Protocols . Murthi, P. & Vaillancourt, C. (eds.). Humana Press, p. 285-293 9 p. (Methods in Molecular Biology; vol. 1710).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Genetics and genomics of ovarian sex cord-stromal tumors

Fuller, P. J., Leung, D. & Chu, S., 1 Feb 2017, In : Clinical Genetics. 91, 2, p. 285-291 7 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

15 Citations (Scopus)