Siew Chai

2018

Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets

Pan, Y., Choy, K. H. C., Marriott, P. J., Chai, S. Y., Scanlon, M. J., Porter, C. J. H., Short, J. L. & Nicolazzo, J. A., 1 Jan 2018, In : Journal of Neurochemistry. 144, 1, p. 81-92 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

1 Citation (Scopus)

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Vanga, S. R., Sävmarker, J., Ng, L., Larhed, M., Hallberg, M., Åqvist, J., Hallberg, A., Chai, S. Y. & Gutiérrez-De-Terán, H., 1 Jan 2018, In : ACS Omega. 3, 4, p. 4509-4521 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

File

2017

2 Citations (Scopus)

Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats

Albiston, A. L., Cacador, M., Sinnayah, P., Burns, P. & Chai, S. Y., 1 May 2017, In : Journal of Molecular Endocrinology. 58, 4, p. 193-198 6 p.

Research output: Contribution to journal › Article › Research › peer-review

2016

10 Citations (Scopus)

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, S., Nylander, E., Grönbladh, A., Vanga, S. R., Khan, Y. S., Gutiérrez-De-Terán, H., Sävmarker, J., Ng, L., Pham, V., Lundbäck, T., Jenmalm-Jensen, A., Svensson, R., Artursson, P., Zelleroth, S., Engen, K., Rosenström, U., Larhed, M., Åqvist, J., Chai, S. Y. & Hallberg, M., 19 Oct 2016, In : ACS Chemical Neuroscience. 7, 10, p. 1383-1392 10 p.

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density

Diwakarla, S., Nylander, E., Gronbladh, A., Vanga, S. R., Khan, Y. S., Gutierrez-de-Teran, H., Ng, L., Pham, V., Savmarker, J., Lundback, T., Jenmalm-Jensen, A., Andersson, H., Engen, K., Rosenstrom, U., Larhed, M., Aqvist, J., Chai, S. Y. & Hallberg, M., Apr 2016, In : Molecular Pharmacology. 89, 4, p. 413-424 12 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Cannula implantation into the lateral ventricle does not adversely affect recognition or spatial working memory

Seyer, B., Pham, V., Albiston, A. L. & Chai, S. Y., 15 Aug 2016, In : Neuroscience Letters. 628, p. 171-178 8 p.

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory

Yeatman, H. R., Albiston, A. L., Burns, P. & Chai, S. Y., 1 Dec 2016, In : Neurobiology of Learning and Memory. 136, p. 174-182 9 p.

Research output: Contribution to journal › Article › Research › peer-review

2015

24 Citations (Scopus)

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Hermans, S. J., Ascher, D. B., Hancock, N. C., Holien, J. K., Michell, B. J., Chai, S. Y. Y., Morton, C. J. & Parker, M. W., 2015, In : Protein Science. 24, 2, p. 190 - 199 10 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Trans-modulation of the somatostatin type 2A receptor trafficking by insulin-regulated aminopeptidase decreases limbic seizures

De Bundel, D., Fafouri, A., Csaba, Z., Loyens, E., Lebon, S., El Ghouzzi, V., Peineau, S., Vodjdani, G., Kiagiadaki, F., Aourz, N., Coppens, J., Walrave, L., Portelli, J., Vanderheyden, P., Chai, S. Y., Thermos, K., Bernard, V., Collingridge, G. L., Auvin, S., Gressens, P. & 2 others, Smolders, I. & Dournaud, P., 2015, In : Journal of Neuroscience. 35, 34, p. 11960 - 11975 16 p.

Research output: Contribution to journal › Article › Research › peer-review

2014

7 Citations (Scopus)

Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages

Nikolaou, A., Stijlemans, B., Laoui, D., Schouppe, E., Tran, H. TT., Tourwe, D., Chai, S. Y., Vanderheyden, P. & Van Ginderachter, J. A., 2014, In : Journal of the Renin-Angiotensin-Aldosterone System. 15, 4, p. 466 - 479 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

32 Citations (Scopus)

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journal › Article › Research › peer-review

2013

6 Citations (Scopus)

Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase

Loyens, E., De Bundel, D., Demaegdt, H., Chai, S. Y., Vanderheyden, P., Michotte, Y., Gard, P. & Smolders, I., 2013, In : International Journal of Neuropsychopharmacology. 16, 5, p. 1153 - 1163 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2012

16 Citations (Scopus)

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In : Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

Research output: Contribution to journal › Article › Research › peer-review

2011

7 Citations (Scopus)

Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures

Loyens, E., Schallier, A., Chai, S., De Bundel, D., Vanderheyden, P., Michotte, Y. & Smolders, I., 2011, In : Seizure : the journal of the British Epilepsy Association. 20, 8, p. 602 - 605 4 p.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

Albiston, A. L., Yeatman, H. R., Pham, V., Fuller, S. J., Diwakarla, S., Fernando, R. N. & Chai, S. Y., 2011, In : Regulatory Peptides. 166, 1-3, p. 83 - 89 7 p.

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

GLUT4 Associated Proteins as Therapeutic Targets for Diabetes

Morgan, B. J., Chai, S. Y. & Albiston, A., 2011, In : Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 5, 1, p. 25 - 32 8 p.

Research output: Contribution to journal › Article › Research › peer-review

48 Citations (Scopus)

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P. & Chai, S., 2011, In : British Journal of Pharmacology. 164, 1, p. 37 - 47 11 p.

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent

Yang, R., Smolders, I., Vanderheyden, P., Demaegdt, H., Van Eeckhaut, A., Vauquelin, G., Lukaszuk, A., Tourwe, D., Chai, S., Albiston, A., Nahmias, C., Walther, T. & Dupont, A., 2011, In : Hypertension. 57, 5, p. 956 - 964 9 p.

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

Ascher, D., Cromer, B., Morton, C., Volitakis, I., Cherny, R., Albiston, A., Chai, S. & Parker, M., 2011, In : Biochemistry. 50, 13, p. 2611 - 2622 12 p.

Research output: Contribution to journal › Article › Research › peer-review

2010

42 Citations (Scopus)

Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

Albiston, A. L., Fernando, R. N., Yeatman, H. R., Burns, P., Ng, L., Daswani, D., Diwakarla, S., Pham, V. & Chai, S. Y., 2010, In : Neurobiology of Learning and Memory. 93, 1, p. 19 - 30 12 p.

Research output: Contribution to journal › Article › Research › peer-review

14 Citations (Scopus)

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

Albiston, A., Pham, V., Ye, S., Ng, L., Lew, R., Thompson, P., Butler, J., Morton, C., Parker, M. & Chai, S., 2010, In : Molecular Pharmacology. 78, 4, p. 600 - 607 8 p.

Research output: Contribution to journal › Article › Research › peer-review

21 Citations (Scopus)

Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated

Yang, R., Walther, T., Gembardt, F., Smolders, I., Vanderheyden, P., Albiston, A., Chai, S. & Dupont, A., 2010, In : Journal of Hypertension. 28, 3, p. 487 - 494 8 p.

Research output: Contribution to journal › Article › Research › peer-review

2009

44 Citations (Scopus)

Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: effects on hippocampal glucose levels and blood flow

De Bundel, D., Smolders, I., Yang, R., Albiston, A., Michotte, Y. & Chai, S., 2009, In : Neurobiology of Learning and Memory. 92, 1, p. 19 - 26 8 p.

Research output: Contribution to journal › Article › Research › peer-review

109 Citations (Scopus)

Different cross-presentation pathways in steady-state and inflammatory dendritic cells

Segura, E., Albiston, A., Wicks, I., Chai, S. & Villadangos, J., 2009, In : Proceedings of the National Academy of Sciences. 106, 48, p. 20377 - 20381 5 p.

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

Pham, V., Burns, P., Albiston, A. L., Yeatman, H. R., Ng, L., Diwakarla, L. P. & Chai, S. Y., 2009, In : Peptides. 30, 10, p. 1861 - 1865 5 p.

Research output: Contribution to journal › Article › Research › peer-review

2008

18 Citations (Scopus)

Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma

Vinh, A., Widdop, R. E., Chai, S. Y. & Gaspari, T. A., 2008, In : Atherosclerosis. 200, 1, p. 37 - 44 8 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion

Cohen, M., Wuillemin, C., Chai, S. & Bischof, P., 2008, In : Journal of Peptide Science. 14, 7, p. 883 - 887 5 p.

Research output: Contribution to journal › Article › Research › peer-review

73 Citations (Scopus)

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Albiston, A. L., Morton, C. J., Ng, H. L., Pham, V., Yeatman, H. R., Ye, S., Fernando, R. N., De Bundel, D., Ascher, D. B., Mendelsohn, F. AO., Parker, M. W. & Chai, S. Y., 2008, In : FASEB Journal. 22, 12, p. 4209 - 4217 9 p.

Research output: Contribution to journal › Article › Research › peer-review

17 Citations (Scopus)

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Ye, S., Chai, S. Y., Lew, R. A., Ascher, D. B., Morton, C. J., Parker, M. W. & Albiston, A. L., 2008, In : Biochemistry and Cell Biology. 86, 3, p. 251 - 261 11 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Lack of intra-cellular signalling by angiotensin IV in IRAP transfected cells

Albiston, A. L., Pham, V. & Chai, S. Y., 1 Mar 2008, In : International Journal of Peptide Research and Therapeutics. 14, 1, p. 29-33 5 p.

Research output: Contribution to journal › Article › Research › peer-review

62 Citations (Scopus)

The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - Potential role in modulation of glucose uptake in neurones?

Frnando, R., Albiston, A. & Chai, S., 2008, In : European Journal of Neuroscience. 28, 3, p. 588 - 598 11 p.

Research output: Contribution to journal › Article › Research › peer-review

2007

21 Citations (Scopus)

Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats

Jenkins, T. & Chai, S., 2007, In : Neurobiology of Learning and Memory. 87, 2, p. 218 - 224 7 p.

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain

Ye, S., Chai, S. Y., Lew, R. A. & Albiston, A. L., 2007, In : Biological Chemistry. 388, 4, p. 399 - 403 5 p.

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons

Fernando, R. N., Luff, S. E., Albiston, A. L. & Chai, S. Y., 2007, In : Journal of Neurochemistry. 102, 3, p. 967 - 976 10 p.

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Therapeutic targeting of insulin-regulated aminopeptidase: Heads and tails?

Albiston, A. L., Peck, G. R., Yeatman, H. R., Fernando, R., Ye, S. & Chai, S. Y., 2007, In : Pharmacology and Therapeutics. 116, 3, p. 417 - 427 11 p.

Research output: Contribution to journal › Article › Research › peer-review

2006

71 Citations (Scopus)

Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase

Peck, G. R., Ye, S., Pham, V., Fernando, R. N., Macaulay, S. L., Chai, S. Y. & Albiston, A. L., 2006, In : Molecular Endocrinology. 20, 10, p. 2576 - 2583 8 p.

Research output: Contribution to journal › Article › Research › peer-review

2005

56 Citations (Scopus)

Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system

Fernando, R. N., Larm, J., Albiston, A. L. & Chai, S. Y., 11 Jul 2005, In : Journal of Comparative Neurology. 487, 4, p. 372-390 19 p.

Research output: Contribution to journal › Article › Research › peer-review

2004

54 Citations (Scopus)

Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms

Albiston, A. L., Pederson, E. S., Burns, P., Purcell, B., Wright, J. W., Harding, J. W., Mendelsohn, F. A., Weisinger, R. S. & Chai, S. Y., 23 Sep 2004, In : Behavioural Brain Research. 154, 1, p. 239-243 5 p.

Research output: Contribution to journal › Article › Research › peer-review

85 Citations (Scopus)

Effect of I.C.V. injection of AT4 receptor ligands, NLE 1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

Lee, J., Albiston, A. L., Allen, A. M., Mendelsohn, F. A. O., Ping, S. E., Barrett, G. L., Murphy, M., Morris, M. J., Mcdowall, S. G. & Chai, S. Y., 2004, In : Neuroscience. 124, 2, p. 341-349 9 p.

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In : Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus

Mustafa, T., Chai, S. Y., May, C. N., Mendelsohn, F. A. O. & Albiston, A. L., 15 Oct 2004, In : Regulatory Peptides. 122, 2, p. 85-89 5 p.

Research output: Contribution to journal › Article › Research › peer-review

2003

123 Citations (Scopus)

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

Lew, R. A., Mustafa, T., Ye, S., McDowall, S. G., Chai, S. Y. & Albiston, A. L., 2003, In : Journal of Neurochemistry. 86, 2, p. 344 - 350 7 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Effect of fimbria-fornix lesion on 125I-angiotensin IV (Ang IV) binding in the guinea pig hippocampus

Lee, J., Chai, S. Y., Morris, M. J., Mendelsohn, F. A. O. & Allen, A. M., 25 Jul 2003, In : Brain Research. 979, 1-2, p. 7-14 8 p.

Research output: Contribution to journal › Article › Research › peer-review

48 Citations (Scopus)

Structure-activity study of LVV-Hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase

Lee, J., Mustafa, T., McDowall, S. G., Mendelsohn, F. A. O., Brennan, M., Lew, R. A., Albiston, A. L. & Chai, S. Y., 2003, In : Journal of Pharmacology and Experimental Therapeutics. 305, 1, p. 205 - 211 7 p.

Research output: Contribution to journal › Article › Research › peer-review

371 Citations (Scopus)

The brain renin-angiotensin system: location and physiological roles

McKinley, M. J., Albiston, A. L., Allen, A. M., Mathai, M. L., May, C. N., McAllen, R. M., Oldfield, B. J., Mendelsohn, F. A. O. & Chai, S. Y., 2003, In : International Journal of Biochemistry and Cell Biology. 35, 6, p. 901 - 918 18 p.

Research output: Contribution to journal › Article › Research › peer-review

2001

31 Citations (Scopus)

Characterization of the AT₄ receptor in a human neuroblastoma cell line (SK-N-MC)

Mustafa, T., Chai, S. Y., Mendelsohn, F. A. O., Moeller, I. & Albiston, A. L., 28 Mar 2001, In : Journal of Neurochemistry. 76, 6, p. 1679-1687 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

362 Citations (Scopus)

Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase

Albiston, A. L., McDowall, S. G., Matsacos, D., Sim, P., Clune, E., Mustafa, T., Lee, J., Mendelsohn, F. A. O., Simpson, R. J., Connolly, L. M. & Chai, S. Y., 28 Dec 2001, In : Journal of Biological Chemistry. 276, 52, p. 48623-48626 4 p.

Research output: Contribution to journal › Article › Research › peer-review

86 Citations (Scopus)

Potentiation of cholinergic transmission in the rat hippocampus by angiotensin IV and LVV-hemorphin-7

Lee, J., Chai, S. Y., Mendelsohn, F. A. O., Morris, M. J. & Allen, A. M., 2001, In : Neuropharmacology. 40, 4, p. 618-623 6 p.

Research output: Contribution to journal › Article › Research › peer-review

2000

73 Citations (Scopus)

Distribution of angiotensin IV binding sites (AT₄ receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography

Chai, S. Y., Bastias, M. A., Clune, E. F., Matsacos, D. J., Mustafa, T., Lee, J., McDowall, S. G., Mendelsohn, F. A. O., Albiston, A. L. & Paxinos, G., 2000, In : Journal of Chemical Neuroanatomy. 20, 3-4, p. 339-348 10 p.

Research output: Contribution to journal › Article › Research › peer-review

73 Citations (Scopus)

The angiotensin converting enzyme (ACE) inhibitor, perindopril, modifies the clinical features of Parkinson's disease

Reardon, K. A., Mendelsohn, F. A. O., Chai, S. Y. & Horne, M. K., 1 Jan 2000, In : Australian and New Zealand Journal of Medicine. 30, 1, p. 48-53 6 p.

Research output: Contribution to journal › Article › Research › peer-review