Siew Chai

Research output

Research output per year 1984 2020

• 114 Article
• 8 Review Article
• 5 Chapter (Book)
• 2 Short Survey
• 3 More
  • 1 Abstract
  • 1 Comment / Debate
  • 1 Letter

Research output per year

Research output per year

Search results

• 2020

  Insulin-regulated aminopeptidase inhibitor-mediated increases in dendritic spine density are facilitated by glucose uptake

  Seyer, B., Diwakarla, S., Burns, P., Hallberg, A., Grӧnbladh, A., Hallberg, M. & Chai, S. Y., May 2020, In: Journal of Neurochemistry. 153, 4, p. 485-494 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)

• Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP)

  Barlow, N., Vanga, S. R., Sävmarker, J., Sandström, A., Burns, P., Hallberg, A., Åqvist, J., Gutiérrez-De-Terán, H., Hallberg, M., Larhed, M., Chai, S. Y. & Thompson, P. E., Feb 2020, In: RSC Medicinal Chemistry. 11, 2, p. 234-244 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)
• 2019

  Social behaviour is altered in the insulin-regulated aminopeptidase knockout mouse

  Burns, P., Bowditch, J., McFadyen, J., Loiacono, R., Albiston, A. L., Pham, V. & Chai, S. Y., 30 Dec 2019, In: Behavioural Brain Research. 376, 7 p., 112150.

  Research output: Contribution to journal › Article › Research › peer-review
  1 Citation (Scopus)
• 2018

  Reduced blood-brain barrier expression of fatty acid-binding protein 5 is associated with increased vulnerability of APP/PS1 mice to cognitive deficits from low omega-3 fatty acid diets

  Pan, Y., Choy, K. H. C., Marriott, P. J., Chai, S. Y., Scanlon, M. J., Porter, C. J. H., Short, J. L. & Nicolazzo, J. A., 1 Jan 2018, In: Journal of Neurochemistry. 144, 1, p. 81-92 12 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  9 Citations (Scopus)

• Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

  Vanga, S. R., Sävmarker, J., Ng, L., Larhed, M., Hallberg, M., Åqvist, J., Hallberg, A., Chai, S. Y. & Gutiérrez-De-Terán, H., 1 Jan 2018, In: ACS Omega. 3, 4, p. 4509-4521 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  10 Citations (Scopus)
• 2017

  Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats

  Albiston, A. L., Cacador, M., Sinnayah, P., Burns, P. & Chai, S. Y., 1 May 2017, In: Journal of Molecular Endocrinology. 58, 4, p. 193-198 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)
• 2016

  Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

  Diwakarla, S., Nylander, E., Grönbladh, A., Vanga, S. R., Khan, Y. S., Gutiérrez-De-Terán, H., Sävmarker, J., Ng, L., Pham, V., Lundbäck, T., Jenmalm-Jensen, A., Svensson, R., Artursson, P., Zelleroth, S., Engen, K., Rosenström, U., Larhed, M., Åqvist, J., Chai, S. Y. & Hallberg, M., 19 Oct 2016, In: ACS Chemical Neuroscience. 7, 10, p. 1383-1392 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  19 Citations (Scopus)

• Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density

  Diwakarla, S., Nylander, E., Gronbladh, A., Vanga, S. R., Khan, Y. S., Gutierrez-de-Teran, H., Ng, L., Pham, V., Savmarker, J., Lundback, T., Jenmalm-Jensen, A., Andersson, H., Engen, K., Rosenstrom, U., Larhed, M., Aqvist, J., Chai, S. Y. & Hallberg, M., Apr 2016, In: Molecular Pharmacology. 89, 4, p. 413-424 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  29 Citations (Scopus)

• Cannula implantation into the lateral ventricle does not adversely affect recognition or spatial working memory

  Seyer, B., Pham, V., Albiston, A. L. & Chai, S. Y., 15 Aug 2016, In: Neuroscience Letters. 628, p. 171-178 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory

  Yeatman, H. R., Albiston, A. L., Burns, P. & Chai, S. Y., 1 Dec 2016, In: Neurobiology of Learning and Memory. 136, p. 174-182 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)
• 2015

  Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

  Hermans, S. J., Ascher, D. B., Hancock, N. C., Holien, J. K., Michell, B. J., Chai, S. Y. Y., Morton, C. J. & Parker, M. W., 2015, In: Protein Science. 24, 2, p. 190 - 199 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  34 Citations (Scopus)

• Trans-modulation of the somatostatin type 2A receptor trafficking by insulin-regulated aminopeptidase decreases limbic seizures

  De Bundel, D., Fafouri, A., Csaba, Z., Loyens, E., Lebon, S., El Ghouzzi, V., Peineau, S., Vodjdani, G., Kiagiadaki, F., Aourz, N., Coppens, J., Walrave, L., Portelli, J., Vanderheyden, P., Chai, S. Y., Thermos, K., Bernard, V., Collingridge, G. L., Auvin, S., Gressens, P. & 2 others, Smolders, I. & Dournaud, P., 2015, In: Journal of Neuroscience. 35, 34, p. 11960 - 11975 16 p.

  Research output: Contribution to journal › Article › Research › peer-review
  11 Citations (Scopus)
• 2014

  Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages

  Nikolaou, A., Stijlemans, B., Laoui, D., Schouppe, E., Tran, H. TT., Tourwe, D., Chai, S. Y., Vanderheyden, P. & Van Ginderachter, J. A., 2014, In: Journal of the Renin-Angiotensin-Aldosterone System. 15, 4, p. 466 - 479 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  10 Citations (Scopus)

• Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

  Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In: Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  40 Citations (Scopus)
• 2013

  Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase

  Loyens, E., De Bundel, D., Demaegdt, H., Chai, S. Y., Vanderheyden, P., Michotte, Y., Gard, P. & Smolders, I., 2013, In: International Journal of Neuropsychopharmacology. 16, 5, p. 1153 - 1163 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  6 Citations (Scopus)
• 2012

  Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

  Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In: Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  18 Citations (Scopus)
• 2011

  Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures

  Loyens, E., Schallier, A., Chai, S., De Bundel, D., Vanderheyden, P., Michotte, Y. & Smolders, I., 2011, In: Seizure : the journal of the British Epilepsy Association. 20, 8, p. 602 - 605 4 p.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

  Albiston, A. L., Yeatman, H. R., Pham, V., Fuller, S. J., Diwakarla, S., Fernando, R. N. & Chai, S. Y., 2011, In: Regulatory Peptides. 166, 1-3, p. 83 - 89 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  20 Citations (Scopus)

• GLUT4 Associated Proteins as Therapeutic Targets for Diabetes

  Morgan, B. J., Chai, S. Y. & Albiston, A., 2011, In: Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 5, 1, p. 25 - 32 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  25 Citations (Scopus)

• Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

  Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P. & Chai, S., 2011, In: British Journal of Pharmacology. 164, 1, p. 37 - 47 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  55 Citations (Scopus)

• Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent

  Yang, R., Smolders, I., Vanderheyden, P., Demaegdt, H., Van Eeckhaut, A., Vauquelin, G., Lukaszuk, A., Tourwe, D., Chai, S., Albiston, A., Nahmias, C., Walther, T. & Dupont, A., 2011, In: Hypertension. 57, 5, p. 956 - 964 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  30 Citations (Scopus)

• Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

  Ascher, D., Cromer, B., Morton, C., Volitakis, I., Cherny, R., Albiston, A., Chai, S. & Parker, M., 2011, In: Biochemistry. 50, 13, p. 2611 - 2622 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  23 Citations (Scopus)
• 2010

  Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

  Albiston, A. L., Fernando, R. N., Yeatman, H. R., Burns, P., Ng, L., Daswani, D., Diwakarla, S., Pham, V. & Chai, S. Y., 2010, In: Neurobiology of Learning and Memory. 93, 1, p. 19 - 30 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  46 Citations (Scopus)

• Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

  Albiston, A., Pham, V., Ye, S., Ng, L., Lew, R., Thompson, P., Butler, J., Morton, C., Parker, M. & Chai, S., 2010, In: Molecular Pharmacology. 78, 4, p. 600 - 607 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  19 Citations (Scopus)

• Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated

  Yang, R., Walther, T., Gembardt, F., Smolders, I., Vanderheyden, P., Albiston, A., Chai, S. & Dupont, A., 2010, In: Journal of Hypertension. 28, 3, p. 487 - 494 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  24 Citations (Scopus)
• 2009

  Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: effects on hippocampal glucose levels and blood flow

  De Bundel, D., Smolders, I., Yang, R., Albiston, A., Michotte, Y. & Chai, S., 2009, In: Neurobiology of Learning and Memory. 92, 1, p. 19 - 26 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  50 Citations (Scopus)

• Different cross-presentation pathways in steady-state and inflammatory dendritic cells

  Segura, E., Albiston, A., Wicks, I., Chai, S. & Villadangos, J., 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 48, p. 20377 - 20381 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  120 Citations (Scopus)

• Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

  Pham, V., Burns, P., Albiston, A. L., Yeatman, H. R., Ng, L., Diwakarla, L. P. & Chai, S. Y., 2009, In: Peptides. 30, 10, p. 1861 - 1865 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  16 Citations (Scopus)
• 2008

  Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma

  Vinh, A., Widdop, R. E., Chai, S. Y. & Gaspari, T. A., 2008, In: Atherosclerosis. 200, 1, p. 37 - 44 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  19 Citations (Scopus)

• Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion

  Cohen, M., Wuillemin, C., Chai, S. & Bischof, P., 2008, In: Journal of Peptide Science. 14, 7, p. 883 - 887 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)

• Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

  Albiston, A. L., Morton, C. J., Ng, H. L., Pham, V., Yeatman, H. R., Ye, S., Fernando, R. N., De Bundel, D., Ascher, D. B., Mendelsohn, F. AO., Parker, M. W. & Chai, S. Y., 2008, In: The FASEB Journal. 22, 12, p. 4209 - 4217 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  81 Citations (Scopus)

• Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

  Ye, S., Chai, S. Y., Lew, R. A., Ascher, D. B., Morton, C. J., Parker, M. W. & Albiston, A. L., 2008, In: Biochemistry and Cell Biology. 86, 3, p. 251 - 261 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  17 Citations (Scopus)

• Lack of intra-cellular signalling by angiotensin IV in IRAP transfected cells

  Albiston, A. L., Pham, V. & Chai, S. Y., 1 Mar 2008, In: International Journal of Peptide Research and Therapeutics. 14, 1, p. 29-33 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  3 Citations (Scopus)

• The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - Potential role in modulation of glucose uptake in neurones?

  Frnando, R., Albiston, A. & Chai, S., 2008, In: European Journal of Neuroscience. 28, 3, p. 588 - 598 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  71 Citations (Scopus)
• 2007

  Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats

  Jenkins, T. & Chai, S., 2007, In: Neurobiology of Learning and Memory. 87, 2, p. 218 - 224 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain

  Ye, S., Chai, S. Y., Lew, R. A. & Albiston, A. L., 2007, In: Biological Chemistry. 388, 4, p. 399 - 403 5 p.

  Research output: Contribution to journal › Article › Research › peer-review

  23 Citations (Scopus)

• Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons

  Fernando, R. N., Luff, S. E., Albiston, A. L. & Chai, S. Y., 2007, In: Journal of Neurochemistry. 102, 3, p. 967 - 976 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  26 Citations (Scopus)

• Therapeutic targeting of insulin-regulated aminopeptidase: Heads and tails?

  Albiston, A. L., Peck, G. R., Yeatman, H. R., Fernando, R., Ye, S. & Chai, S. Y., 2007, In: Pharmacology and Therapeutics. 116, 3, p. 417 - 427 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  39 Citations (Scopus)
• 2006

  Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase

  Peck, G. R., Ye, S., Pham, V., Fernando, R. N., Macaulay, S. L., Chai, S. Y. & Albiston, A. L., 2006, In: Molecular Endocrinology. 20, 10, p. 2576 - 2583 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  75 Citations (Scopus)
• 2005

  Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system

  Fernando, R. N., Larm, J., Albiston, A. L. & Chai, S. Y., 11 Jul 2005, In: The Journal of Comparative Neurology. 487, 4, p. 372-390 19 p.

  Research output: Contribution to journal › Article › Research › peer-review
  62 Citations (Scopus)
• 2004

  Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms

  Albiston, A. L., Pederson, E. S., Burns, P., Purcell, B., Wright, J. W., Harding, J. W., Mendelsohn, F. A., Weisinger, R. S. & Chai, S. Y., 23 Sep 2004, In: Behavioural Brain Research. 154, 1, p. 239-243 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  58 Citations (Scopus)

• Effect of I.C.V. injection of AT4 receptor ligands, NLE 1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

  Lee, J., Albiston, A. L., Allen, A. M., Mendelsohn, F. A. O., Ping, S. E., Barrett, G. L., Murphy, M., Morris, M. J., Mcdowall, S. G. & Chai, S. Y., 2004, In: Neuroscience. 124, 2, p. 341-349 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  96 Citations (Scopus)

• In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

  Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In: Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

  Research output: Contribution to journal › Article › Research › peer-review

  49 Citations (Scopus)

• Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus

  Mustafa, T., Chai, S. Y., May, C. N., Mendelsohn, F. A. O. & Albiston, A. L., 15 Oct 2004, In: Regulatory Peptides. 122, 2, p. 85-89 5 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)
• 2003

  Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

  Lew, R. A., Mustafa, T., Ye, S., McDowall, S. G., Chai, S. Y. & Albiston, A. L., 2003, In: Journal of Neurochemistry. 86, 2, p. 344 - 350 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  134 Citations (Scopus)

• Effect of fimbria-fornix lesion on 125I-angiotensin IV (Ang IV) binding in the guinea pig hippocampus

  Lee, J., Chai, S. Y., Morris, M. J., Mendelsohn, F. A. O. & Allen, A. M., 25 Jul 2003, In: Brain Research. 979, 1-2, p. 7-14 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)

• Structure-activity study of LVV-Hemorphin-7: angiotensin AT4 receptor ligand and inhibitor of insulin-regulated aminopeptidase

  Lee, J., Mustafa, T., McDowall, S. G., Mendelsohn, F. A. O., Brennan, M., Lew, R. A., Albiston, A. L. & Chai, S. Y., 2003, In: Journal of Pharmacology and Experimental Therapeutics. 305, 1, p. 205 - 211 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  55 Citations (Scopus)

• The brain renin-angiotensin system: location and physiological roles

  McKinley, M. J., Albiston, A. L., Allen, A. M., Mathai, M. L., May, C. N., McAllen, R. M., Oldfield, B. J., Mendelsohn, F. A. O. & Chai, S. Y., 2003, In: International Journal of Biochemistry & Cell Biology. 35, 6, p. 901 - 918 18 p.

  Research output: Contribution to journal › Article › Research › peer-review

  393 Citations (Scopus)
• 2001

  Characterization of the AT₄ receptor in a human neuroblastoma cell line (SK-N-MC)

  Mustafa, T., Chai, S. Y., Mendelsohn, F. A. O., Moeller, I. & Albiston, A. L., 28 Mar 2001, In: Journal of Neurochemistry. 76, 6, p. 1679-1687 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  31 Citations (Scopus)

• Evidence That the Angiotensin IV (AT4) Receptor Is the Enzyme Insulin-regulated Aminopeptidase

  Albiston, A. L., McDowall, S. G., Matsacos, D., Sim, P., Clune, E., Mustafa, T., Lee, J., Mendelsohn, F. A. O., Simpson, R. J., Connolly, L. M. & Chai, S. Y., 28 Dec 2001, In: Journal of Biological Chemistry. 276, 52, p. 48623-48626 4 p.

  Research output: Contribution to journal › Article › Research › peer-review
  385 Citations (Scopus)