• 26 Innovation Walk , 13F

    3800 Clayton

    Australia

Accepting PhD Students

1984 …2021
If you made any changes in Pure these will be visible here soon.

Research Output 1984 2018

1 Citation (Scopus)

Structural Basis of Inhibition of Human Insulin-Regulated Aminopeptidase (IRAP) by Aryl Sulfonamides

Vanga, S. R., Sävmarker, J., Ng, L., Larhed, M., Hallberg, M., Åqvist, J., Hallberg, A., Chai, S. Y. & Gutiérrez-De-Terán, H., 1 Jan 2018, In : ACS Omega. 3, 4, p. 4509-4521 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017
2 Citations (Scopus)

Insulin-regulated aminopeptidase inhibitors do not alter glucose handling in normal and diabetic rats

Albiston, A. L., Cacador, M., Sinnayah, P., Burns, P. & Chai, S. Y., 1 May 2017, In : Journal of Molecular Endocrinology. 58, 4, p. 193-198 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
10 Citations (Scopus)

Aryl Sulfonamide Inhibitors of Insulin-Regulated Aminopeptidase Enhance Spine Density in Primary Hippocampal Neuron Cultures

Diwakarla, S., Nylander, E., Grönbladh, A., Vanga, S. R., Khan, Y. S., Gutiérrez-De-Terán, H., Sävmarker, J., Ng, L., Pham, V., Lundbäck, T., Jenmalm-Jensen, A., Svensson, R., Artursson, P., Zelleroth, S., Engen, K., Rosenström, U., Larhed, M., Åqvist, J., Chai, S. Y. & Hallberg, M., 19 Oct 2016, In : ACS Chemical Neuroscience. 7, 10, p. 1383-1392 10 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Binding to and inhibition of insulin-regulated aminopeptidase by macrocyclic disulfides enhances spine density

Diwakarla, S., Nylander, E., Gronbladh, A., Vanga, S. R., Khan, Y. S., Gutierrez-de-Teran, H., Ng, L., Pham, V., Savmarker, J., Lundback, T., Jenmalm-Jensen, A., Andersson, H., Engen, K., Rosenstrom, U., Larhed, M., Aqvist, J., Chai, S. Y. & Hallberg, M., Apr 2016, In : Molecular Pharmacology. 89, 4, p. 413-424 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Cannula implantation into the lateral ventricle does not adversely affect recognition or spatial working memory

Seyer, B., Pham, V., Albiston, A. L. & Chai, S. Y., 15 Aug 2016, In : Neuroscience Letters. 628, p. 171-178 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Forebrain neurone-specific deletion of insulin-regulated aminopeptidase causes age related deficits in memory

Yeatman, H. R., Albiston, A. L., Burns, P. & Chai, S. Y., 1 Dec 2016, In : Neurobiology of Learning and Memory. 136, p. 174-182 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
24 Citations (Scopus)

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Hermans, S. J., Ascher, D. B., Hancock, N. C., Holien, J. K., Michell, B. J., Chai, S. Y. Y., Morton, C. J. & Parker, M. W., 2015, In : Protein Science. 24, 2, p. 190 - 199 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Trans-modulation of the somatostatin type 2A receptor trafficking by insulin-regulated aminopeptidase decreases limbic seizures

De Bundel, D., Fafouri, A., Csaba, Z., Loyens, E., Lebon, S., El Ghouzzi, V., Peineau, S., Vodjdani, G., Kiagiadaki, F., Aourz, N., Coppens, J., Walrave, L., Portelli, J., Vanderheyden, P., Chai, S. Y., Thermos, K., Bernard, V., Collingridge, G. L., Auvin, S., Gressens, P. & 2 others, Smolders, I. & Dournaud, P., 2015, In : Journal of Neuroscience. 35, 34, p. 11960 - 11975 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
7 Citations (Scopus)

Presence and regulation of insulin-regulated aminopeptidase in mouse macrophages

Nikolaou, A., Stijlemans, B., Laoui, D., Schouppe, E., Tran, H. TT., Tourwe, D., Chai, S. Y., Vanderheyden, P. & Van Ginderachter, J. A., 2014, In : Journal of the Renin-Angiotensin-Aldosterone System. 15, 4, p. 466 - 479 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Synthesis, structure-activity relationships and brain uptake of a novel series of benzopyran inhibitors of insulin-regulated aminopeptidase

Mountford, S. J., Albiston, A. L., Charman, W. N., Ng, L., Holien, J. K., Parker, M. W., Nicolazzo, J., Thompson, P. & Chai, S. Y., 2014, In : Journal of Medicinal Chemistry. 57, 4, p. 1368 - 1377 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
6 Citations (Scopus)

Antidepressant-like effects of oxytocin in mice are dependent on the presence of insulin-regulated aminopeptidase

Loyens, E., De Bundel, D., Demaegdt, H., Chai, S. Y., Vanderheyden, P., Michotte, Y., Gard, P. & Smolders, I., 2013, In : International Journal of Neuropsychopharmacology. 16, 5, p. 1153 - 1163 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012
16 Citations (Scopus)

Insulin-regulated aminopeptidase deficiency provides protection against ischemic stroke in mice

Pham, V., Albiston, A., Downes, C., Wong, C. H. Y., Diwakarla, L. P., Ng, L., Lee, S., Crack, P. & Chai, S., 2012, In : Journal of Neurotrauma. 29, 6, p. 1243 - 1248 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
7 Citations (Scopus)

Deletion of insulin-regulated aminopeptidase in mice decreases susceptibility to pentylenetetrazol-induced generalized seizures

Loyens, E., Schallier, A., Chai, S., De Bundel, D., Vanderheyden, P., Michotte, Y. & Smolders, I., 2011, In : Seizure : the journal of the British Epilepsy Association. 20, 8, p. 602 - 605 4 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Distinct distribution of GLUT4 and insulin regulated aminopeptidase in the mouse kidney

Albiston, A. L., Yeatman, H. R., Pham, V., Fuller, S. J., Diwakarla, S., Fernando, R. N. & Chai, S. Y., 2011, In : Regulatory Peptides. 166, 1-3, p. 83 - 89 7 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

GLUT4 Associated Proteins as Therapeutic Targets for Diabetes

Morgan, B. J., Chai, S. Y. & Albiston, A., 2011, In : Recent Patents on Endocrine, Metabolic and Immune Drug Discovery. 5, 1, p. 25 - 32 8 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

Albiston, A., Diwakarla, S., Fernando, R., Mountford, S., Yeatman, H., Morgan, B., Pham, V., Holien, J., Parker, M., Thompson, P. & Chai, S., 2011, In : British Journal of Pharmacology. 164, 1, p. 37 - 47 11 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Pressor and renal hemodynamic effects of the novel angiotensin A peptide are angiotensin II type 1A receptor dependent

Yang, R., Smolders, I., Vanderheyden, P., Demaegdt, H., Van Eeckhaut, A., Vauquelin, G., Lukaszuk, A., Tourwe, D., Chai, S., Albiston, A., Nahmias, C., Walther, T. & Dupont, A., 2011, In : Hypertension. 57, 5, p. 956 - 964 9 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Regulation of insulin-regulated membrane aminopeptidase activity by its C-terminal domain

Ascher, D., Cromer, B., Morton, C., Volitakis, I., Cherny, R., Albiston, A., Chai, S. & Parker, M., 2011, In : Biochemistry. 50, 13, p. 2611 - 2622 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
42 Citations (Scopus)

Gene knockout of insulin-regulated aminopeptidase: Loss of the specific binding site for angiotensin IV and age-related deficit in spatial memory

Albiston, A. L., Fernando, R. N., Yeatman, H. R., Burns, P., Ng, L., Daswani, D., Diwakarla, S., Pham, V. & Chai, S. Y., 2010, In : Neurobiology of Learning and Memory. 93, 1, p. 19 - 30 12 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Neuronal Angiotensin

Allen, A., O'Callaghan, E., Mendelsohn, F. & Chai, S., 2010, Encyclopedia of Neuroscience. Squire, L. R. (ed.). 1st ed. UK: Elsevier, p. 697-702 6 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

14 Citations (Scopus)

Phenylalanine-544 plays a key role in substrate and inhibitor binding by providing a hydrophobic packing point at the active site of insulin-regulated aminopeptidase

Albiston, A., Pham, V., Ye, S., Ng, L., Lew, R., Thompson, P., Butler, J., Morton, C., Parker, M. & Chai, S., 2010, In : Molecular Pharmacology. 78, 4, p. 600 - 607 8 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Renal vasoconstrictor and pressor responses to angiotensin IV in mice are AT1a-receptor mediated

Yang, R., Walther, T., Gembardt, F., Smolders, I., Vanderheyden, P., Albiston, A., Chai, S. & Dupont, A., 2010, In : Journal of Hypertension. 28, 3, p. 487 - 494 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Reply to Burgdorf et al. The mannose receptor is not involved in antigen cross-presentation by steady-state dendritic cells

Segura, E., Gupta, N., Albiston, A. L., Wicks, I. P., Chai, S. Y. & Villadangosa, J. A., 30 Mar 2010, In : Proceedings of the National Academy of Sciences. 107, 13

Research output: Contribution to journalLetterOtherpeer-review

2009
44 Citations (Scopus)

Angiotensin IV and LVV-haemorphin 7 enhance spatial working memory in rats: effects on hippocampal glucose levels and blood flow

De Bundel, D., Smolders, I., Yang, R., Albiston, A., Michotte, Y. & Chai, S., 2009, In : Neurobiology of Learning and Memory. 92, 1, p. 19 - 26 8 p.

Research output: Contribution to journalArticleResearchpeer-review

108 Citations (Scopus)

Different cross-presentation pathways in steady-state and inflammatory dendritic cells

Segura, E., Albiston, A., Wicks, I., Chai, S. & Villadangos, J., 2009, In : Proceedings of the National Academy of Sciences. 106, 48, p. 20377 - 20381 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Is circulating insulin-regulated aminopeptidase (oxytocinase) during pregnancy restricted to humans?

Albiston, A. L., Burns, P., Yeatman, H. R., Ng, L. & Chai, S. Y., 2009, Handbook of Oxytocin Research: Synthesis, storage and release, actions and drug forms. Jastrow, H. & Feuerbach, D. (eds.). 1st ed. USA: Nova Publishers, p. 275 - 279 5 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

13 Citations (Scopus)

Reproduction and maternal behavior in insulin-regulated aminopeptidase (IRAP) knockout mice

Pham, V., Burns, P., Albiston, A. L., Yeatman, H. R., Ng, L., Diwakarla, L. P. & Chai, S. Y., 2009, In : Peptides. 30, 10, p. 1861 - 1865 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
18 Citations (Scopus)

Angiotensin IV-evoked vasoprotection is conserved in advanced atheroma

Vinh, A., Widdop, R. E., Chai, S. Y. & Gaspari, T. A., 2008, In : Atherosclerosis. 200, 1, p. 37 - 44 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase

Chai, S. Y., Fillit, H. (ed.), Yeatman, H. R., Parker, M. W., Ascher, D. B., Thompson, P., Mulvey, H. T. & Albiston, A. L., 2008, p. 0 - 0. 8 p.

Research output: Contribution to conferenceAbstractOther

3 Citations (Scopus)

Effects of ligands or substrate of insulin-regulated aminopeptidase (IRAP) on trophoblast invasion

Cohen, M., Wuillemin, C., Chai, S. & Bischof, P., 2008, In : Journal of Peptide Science. 14, 7, p. 883 - 887 5 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

Albiston, A. L., Morton, C. J., Ng, H. L., Pham, V., Yeatman, H. R., Ye, S., Fernando, R. N., De Bundel, D., Ascher, D. B., Mendelsohn, F. AO., Parker, M. W. & Chai, S. Y., 2008, In : FASEB Journal. 22, 12, p. 4209 - 4217 9 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Identification of modulating residues defining the catalytic cleft of insulin-regulated aminopeptidase

Ye, S., Chai, S. Y., Lew, R. A., Ascher, D. B., Morton, C. J., Parker, M. W. & Albiston, A. L., 2008, In : Biochemistry and Cell Biology. 86, 3, p. 251 - 261 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Lack of intra-cellular signalling by angiotensin IV in IRAP transfected cells

Albiston, A. L., Pham, V. & Chai, S. Y., 1 Mar 2008, In : International Journal of Peptide Research and Therapeutics. 14, 1, p. 29-33 5 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The insulin-regulated aminopeptidase IRAP is colocalised with GLUT4 in the mouse hippocampus - Potential role in modulation of glucose uptake in neurones?

Frnando, R., Albiston, A. & Chai, S., 2008, In : European Journal of Neuroscience. 28, 3, p. 588 - 598 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Angiotensin IV binding site: The AT4 receptor or insulin-regulated aminopeptidass

Jenkins, T., Mendelsohn, F., Albiston, A. & Chai, S., 2007, Hypertension and Hormone Mechanisms. Carey, R. M. & Harrison III, D. A. (eds.). 1st ed. USA: Humana Press, p. 61 - 74 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

21 Citations (Scopus)

Effect of chronic angiotensin converting enzyme inhibition on spatial memory and anxiety-like behaviours in rats

Jenkins, T. & Chai, S., 2007, In : Neurobiology of Learning and Memory. 87, 2, p. 218 - 224 7 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Insulin-regulated aminopeptidase: analysis of peptide substrate and inhibitor binding to the catalytic domain

Ye, S., Chai, S. Y., Lew, R. A. & Albiston, A. L., 2007, In : Biological Chemistry. 388, 4, p. 399 - 403 5 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Sub-cellular localization of insulin-regulated membrane aminopeptidase, IRAP to vesicles in neurons

Fernando, R. N., Luff, S. E., Albiston, A. L. & Chai, S. Y., 2007, In : Journal of Neurochemistry. 102, 3, p. 967 - 976 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Therapeutic targeting of insulin-regulated aminopeptidase: Heads and tails?

Albiston, A. L., Peck, G. R., Yeatman, H. R., Fernando, R., Ye, S. & Chai, S. Y., 2007, In : Pharmacology and Therapeutics. 116, 3, p. 417 - 427 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
71 Citations (Scopus)

Interaction of the Akt substrate, AS160, with the glucose transporter 4 vesicle marker protein, insulin-regulated aminopeptidase

Peck, G. R., Ye, S., Pham, V., Fernando, R. N., Macaulay, S. L., Chai, S. Y. & Albiston, A. L., 2006, In : Molecular Endocrinology. 20, 10, p. 2576 - 2583 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
56 Citations (Scopus)

Distribution and cellular localization of insulin-regulated aminopeptidase in the rat central nervous system

Fernando, R. N., Larm, J., Albiston, A. L. & Chai, S. Y., 11 Jul 2005, In : Journal of Comparative Neurology. 487, 4, p. 372-390 19 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
28 Citations (Scopus)

Alzheimer's, angiotensin IV and an aminopeptidase

Albiston, A. L., Fernando, R., Ye, S., Peck, G. R. & Chai, S. Y., 1 Jun 2004, In : Biological and Pharmaceutical Bulletin. 27, 6, p. 765-767 3 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

54 Citations (Scopus)

Attenuation of scopolamine-induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms

Albiston, A. L., Pederson, E. S., Burns, P., Purcell, B., Wright, J. W., Harding, J. W., Mendelsohn, F. A., Weisinger, R. S. & Chai, S. Y., 23 Sep 2004, In : Behavioural Brain Research. 154, 1, p. 239-243 5 p.

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Effect of I.C.V. injection of AT4 receptor ligands, NLE 1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats

Lee, J., Albiston, A. L., Allen, A. M., Mendelsohn, F. A. O., Ping, S. E., Barrett, G. L., Murphy, M., Morris, M. J., Mcdowall, S. G. & Chai, S. Y., 2004, In : Neuroscience. 124, 2, p. 341-349 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

In vitro autoradiographic localization of calcitonin and amylin binding sites in monkey brain

Paxinos, G., Chai, S. Y., Christopoulos, G., Huang, X-F., Toga, A. W., Wang, H. Q. & Sexton, P. M., 2004, In : Journal of Chemical Neuroanatomy. 27, 4, p. 217 - 236 20 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Membrane bound members of the M1 family: More than aminopeptidases

Albiston, A. L., Ye, S. & Siew, Y. C., 1 Oct 2004, In : Protein and Peptide Letters. 11, 5, p. 491-500 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Oxytocinase/insulin-regulated aminopeptidase is distributed throughout the sheep, female reproductive tract and is regulated by oestrogen in the uterus

Mustafa, T., Chai, S. Y., May, C. N., Mendelsohn, F. A. O. & Albiston, A. L., 15 Oct 2004, In : Regulatory Peptides. 122, 2, p. 85-89 5 p.

Research output: Contribution to journalArticleResearchpeer-review

156 Citations (Scopus)

The angiotensin IV/AT4 receptor

Chai, S. Y., Fernando, R., Peck, G., Ye, S. Y., Mendelsohn, F. A. O., Jenkins, T. A. & Albiston, A. L., 1 Nov 2004, In : Cellular and Molecular Life Sciences. 61, 21, p. 2728-2737 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2003
123 Citations (Scopus)

Angiotensin AT4 ligands are potent, competitive inhibitors of insulin regulated aminopeptidase (IRAP)

Lew, R. A., Mustafa, T., Ye, S., McDowall, S. G., Chai, S. Y. & Albiston, A. L., 2003, In : Journal of Neurochemistry. 86, 2, p. 344 - 350 7 p.

Research output: Contribution to journalArticleResearchpeer-review