Projects per year
Personal profile
Biography
Sheena McGowan was formally trained in microbiology, completing her PhD in 2004. During her PhD she studied the structure and function of a toxin regulator from the causative agent of gas gangrene, developing what would become a long-standing interest in structure and function of proteins. During her post-doctoral work she was trained in protein crystallography and biophysics and she now applies these skills in microbiology and structural biology to investigate novel methods for microbial disease control.
The McGowan laboratory is interested in characterising novel molecular drug targets. The lab has a strong research focus in the design of novel anti-malarial drugs as well as other parasitic and bacterial diseases. Primarily we are a structural biology laboratory using techniques in X-ray crystallography, biochemistry and biophysics to analyse our proteins of interest. We use this mechanistic information to design inhibitors or analogues with potential applications in human medicine.
Keywords
- Protease
- Protease Inhibitors
- Drug Discovery
- Structural Biology
- Microbiology
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Projects 2009 2021
Mechanism of action of a novel multifunctional bacterial secretion system
Lyras, D., McGowan, S. & Rood, J.
1/01/18 → 31/12/20
Project: Research
Anti-sporulation strategies for Clostridium difficile infections
Lyras, D., McGowan, S., Pyne, S. G., Keller, P. A. & Yu, H.
1/01/18 → 31/12/21
Project: Research
Beckman Coulter Optima Analytical Ultracentrifuge (AUC)
Dunstone, M., Whisstock, J., Daly, R., Atkinson, S., Turner, S., Lithgow, T., Gras, S., Stone, M., Davidovich, C., Rood, J., Coulibaly, F., Wilce, J., Borg, N., McGowan, S., Buckle, A., Elmlund, D., Elmlund, H., Belousoff, M., Ellisdon, A., Law, R., Purcell, A., Cryle, M., Nold, M., Nold, C., Warr, C., Johnson, T., Henstridge, M., Aguilar, M., Stroud, D. & Ryan, M.
1/12/16 → 31/12/17
Project: Research
Research Output 2002 2019
Cephamycins inhibit pathogen sporulation and effectively treat recurrent Clostridioides difficile infection
Srikhanta, Y. N., Hutton, M. L., Awad, M. M., Drinkwater, N., Singleton, J., Day, S. L., Cunningham, B. A., McGowan, S. & Lyras, D., 12 Aug 2019, (Accepted/In press) In : Nature Microbiology. 9 p.Research output: Contribution to journal › Article › Research › peer-review
Hydroxamic Acid Inhibitors Provide Cross-Species Inhibition of Plasmodium M1 and M17 Aminopeptidases
Vinh, N. B., Drinkwater, N., Malcolm, T. R., Kassiou, M., Lucantoni, L., Grin, P. M., Butler, G. S., Duffy, S., Overall, C. M., Avery, V. M., Scammells, P. J. & McGowan, S., 24 Jan 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 622-640 19 p.Research output: Contribution to journal › Article › Research › peer-review
Identification of the Binding Site of Apical Membrane Antigen 1 (AMA1) Inhibitors Using a Paramagnetic Probe
Akter, M., Drinkwater, N., Devine, S. M., Drew, S. C., Krishnarjuna, B., Debono, C. O., Wang, G., Scanlon, M. J., Scammells, P. J., McGowan, S., MacRaild, C. A. & Norton, R. S., 5 Mar 2019, In : ChemMedChem. 14, 5, p. 603-612 10 p.Research output: Contribution to journal › Article › Research › peer-review
M17 aminopeptidases diversify function by moderating their macromolecular assemblies and active site environment
Drinkwater, N., Malcolm, T. R. & McGowan, S., 14 Jan 2019, (Accepted/In press) In : Biochimie. 14 p.Research output: Contribution to journal › Review Article › Research › peer-review
Reactive centre loop dynamics and serpin specificity
Marijanovic, E. M., Fodor, J., Riley, B. T., Porebski, B. T., Costa, M. G. S., Kass, I., Hoke, D. E., McGowan, S. & Buckle, A. M., 7 Mar 2019, In : Scientific Reports. 9, 1, 15 p., 3870.Research output: Contribution to journal › Article › Research › peer-review
Open Access
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Activities 2017 2017
- 1 Membership of industry collaboration/ network
Monash Antimicrobial Resistance Group (Event)
Trevor Lithgow (Chair/Co-Chair), Max Cryle (Member), Kellie Tuck (Member), Ana Traven (Member), Thomas Naderer (Member), Julian Rood (Member), Dena Lyras (Member), Anton Peleg (Member), Mibel Aguilar (Member), Fasseli Coulibaly (Member), Sheena McGowan (Member), Meredith Anne Okeeffe (Member), Matthew Belousoff (Member), Philip Heraud (Member)1 Mar 2017
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Membership of industry collaboration/ network
Press / Media
Aussie biotech accelerator launches 1st round of project investments
31/07/18
1 item of media coverage
Press/Media: Research
Sewer to saviour, PlyC is back
Ashley Buckle & Sheena McGowan
1/02/13
1 item of media coverage
Press/Media: Research
Monash scientists score breakthrough on non-antibiotic bug killer
Ashley Buckle & Sheena McGowan
29/07/12
1 item of media coverage
Press/Media: Research
New recruits in the fight against disease
Ashley Buckle & Sheena McGowan
22/07/12
1 item of media coverage
Press/Media: Research