20012020

Research output per year

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Research Output

2008

Phase 1 single dose studies to optimize the pharmacokinetics of DG17, a novel HIV-protease inhibitor pro-drug, using sodium bicarbonate and ritonavir

Cherry, C., Hoy, J. F., Altman, P., Rowe, J. S., Krum, H., Mills, J. & Lewin, S. R., 2008, In : Current HIV Research. 6, 3, p. 272 - 275 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2 Citations (Scopus)

The anti-HIV activity of entecavir: a multicentre evaluation of lamivudine-experienced and lamivudine-naive patients

Sasadeusz, J., Audsley, J. M., Mijch, A. M., Baden, R., Caro, J., Hunter, H., Matthews, G., McMahon, M. A., Olender, S. A., Siliciano, R. F., Lewin, S. R. & Thio, C., 2008, In : AIDS. 22, 8, p. 947 - 955 9 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Variable uptake of recommended interventions to reduce mother-to-child transmission of HIV in Australia, 1982-2005

Giles, M. L., McDonald, A. M., Elliott, E. J., Ziegler, J. B., Hellard, M. E., Lewin, S. R. & Kaldor, J. M., 2008, In : The Medical Journal of Australia. 189, 3, p. 151 - 154 4 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection

Lewin, S. R., Murray, J. M., Solomon, A., Wightman, F., Cameron, P. U., Purcell, D. J., Zaunders, J. J., Grey, P., Bloch, M., Smith, D., Cooper, D. A. & Kelleher, A. D., 2008, In : JAIDS. 47, 2, p. 140 - 147 8 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)
2007

CCR7 ligands CCL19 and CCL21 increase permissiveness of resting memory CD4+ T cells to HIV-1 infection: a novel model of HIV-1 latency

Saleh, S. M., Solomon, A., Wightman, F., Shehu-Xhilaga, M., Cameron, P. U. & Lewin, S. R., 2007, In : Blood. 110, 13, p. 4161 - 4164 4 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

Human cytomegalovirus (CMV)-specific CD8+ T cell responses are reduced in HIV-infected individuals with a history of CMV disease despite CD4+ T cell recovery

Singh, K. P., Howard, J. L., Wild, S. P., Jones, S. L., Hoy, J. F. & Lewin, S. R., 2007, In : Clinical Immunology. 124, 2, p. 200 - 206 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Identification of a novel hepatitis B virus precore/core deletion mutant in HIV/hepatitis B virus co-infected individuals

Revill, P., Littlejohn, M., Ayres, A., Yuen, L., Colledge, D., Bartholomeusz, A., Sasadeusz, J., Lewin, S. R., Dore, G., Matthews, G. V., Thio, C. L. & Locarnini, S., 2007, In : AIDS. 21, 13, p. 1701 - 1710 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Immune recovery uveitis in an HIV-negative individual

Baker, M. L., Allen, P. J., Shortt, J., Lewin, S. R. & Spencer, A., 2007, In : Clinical and Experimental Ophthalmology. 35, 2, p. 189 - 190 2 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Immunopathogenesis of hepatitis B virus infection

Chang, J-H. J. & Lewin, S. R., 2007, In : Immunology and Cell Biology. 85, 1, p. 16 - 23 8 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Impact of early viral kinetics on T-cell reactivity during antiviral therapy in chronic hepatitis B

Lau, G., Cooksley, H., Ribeiro, R. M., Powers, K. A., Shudo, E., Bowden, S., Hui, C-K., Anderson, J., Sorbel, J., Mondou, E., Rousseau, F., Lewin, S. R., Perelson, A. S., Locarnini, S. A. & Naoumov, N. V., 2007, In : Antiviral Therapy. 12, 5, p. 705 - 718 14 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

Gorry, P. R., McPhee, D. A., Verity, E. E., Dyer, W. B., Wesselingh, S. L., Learmont, J., Sullivan, J. S., Roche, M., Zaunders, J. J., Gabuzda, D., Crowe, S. M., Mills, J., Lewin, S. R., Brew, B. J., Cunningham, A. L. & Churchill, M., 2007, In : Retrovirology. 4, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

52 Citations (Scopus)

Preferential infection of dendritic cells during human immunodeficiency virus type 1 infection of blood leukocytes

Cameron, P. U., Handley, A., Baylis, D. C., Solomon, A., Bernard, N., Purcell, D. & Lewin, S. R., 2007, In : Journal of Virology. 81, 5, p. 2297 - 2306 10 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Regulation of toll-like receptor-2 expression in chronic hepatitis B by the precore protein

Visvanathan, K., Skinner, N. A., Thompson, A. J. V., Riordan, S. M., Sozzi, V., Edwards, R., Rodgers, S., Kurtovic, J., Chang, J., Lewin, S. R., Desmond, P. & Locarnini, S., 2007, In : Hepatology. 45, 1, p. 102 - 110 9 p.

Research output: Contribution to journalArticleResearchpeer-review

233 Citations (Scopus)

Substantial Improvements in Performance Indicators Achieved in a Peripheral Blood Mononuclear Cell Cryopreservation Quality Assurance Program Using Single Donor Samples

Dyer, W. B., Pett, S. L., Sullivan, J. S., Emery, S., Cooper, D. A., Kelleher, A. D., Lloyd, A. & Lewin, S. R., 2007, In : Clinical and Vaccine Immunology. 14, 1, p. 52 - 59 8 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Ten years of highly active antiretroviral therapy for HIV infection

Chen, L. F., Hoy, J. F. & Lewin, S. R., 2007, In : The Medical Journal of Australia. 186, 3, p. 146 - 151 6 p.

Research output: Contribution to journalArticleOther

68 Citations (Scopus)

The CD16+ monocyte subset is more permissive to infection and preferentially harbors HIV-1 in vivo

Ellery, P., Tippett, E. D., Chiu, Y-L., Paukovics, G., Cameron, P. U., Solomon, A., Lewin, S. R., Gorry, P. R., Jaworowski, A., Greene, W. C., Sonza, S. & Crowe, S. M., 2007, In : Journal of Immunology. 178, 10, p. 6581 - 6589 9 p.

Research output: Contribution to journalArticleResearchpeer-review

231 Citations (Scopus)

The phenotype of hepatitis B virus-specific T cells differ in the liver and blood in chronic hepatitis B virus infection

Chang, J-H. J., Thompson, A. J. V., Visvanathan, K., Kent, S. J., Cameron, P. U., Wightman, F., Desmond, P. V., Locarnini, S. & Lewin, S. R., 2007, In : Hepatology. 46, 5, p. 1332 - 1340 9 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The Sydney Declaration: a call to scale up research

Cooper, D., Cahn, P., Lewin, S. R., Kaldor, J. M., McClure, C., Kort, R. & Boyd, M., 2007, In : The Lancet. 370, 9581, p. 7 - 8 2 p.

Research output: Contribution to journalLetterOther

14 Citations (Scopus)

The testis and epididymis are productively infected by SIV and SHIV in juvenile macaques during the post-acute stage of infection

Shehu-Xhilaga, M., Kent, S. J., Batten, J., Ellis, S. L., Van der Meulen, J. D., O'Bryan, M. K., Cameron, P. U., Lewin, S. R. & Hedger, M. P., 2007, In : Retrovirology. 4, 1, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

What are the barriers to offering HIV testing in an antenatal setting? A national study of obstetricians

Giles, M. L., Garland, S. M., Lewin, S. R. & Hellard, M. E., 2007, In : AIDS. 21, 12, p. 1601 - 1606 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2006

Characteristics of drug resistant HBV in an international collaborative study of HIV-HBV-infected individuals on extended lamivudine therapy

Matthews, G. V., Bartholomeusz, A., Locarnini, S., Ayres, A., Sasadeusz, J., Seaberg, E., Cooper, D. A., Lewin, S. R., Dore, G. J. & Thio, C. L., 2006, In : AIDS. 20, 6, p. 863 - 870 8 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Comparison of Real-Time PCR assays for monitoring serum hepatitis B virus DNA levels during antiviral therapy

Hui, C-K., Bowden, D. S., Zhang, H-Y., Wong, A., Lewin, S. R., Rousseau, F., Mommeja-Marin, H., Lee, N. P., Luk, J. M., Locarnini, S., Leung, N., Naoumov, N. V. & Lau, G. K. K., 2006, In : Journal of Clinical Microbiology. 44, 8, p. 2983 - 2987 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

HIV research in Australia: linking basic research findings with clinical and public health outcomes

Lewin, S. R., Kaldor, J. M. & Cooper, D. A., 2006, In : Retrovirology. 3, 86, p. 1 - 5 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunopathogenesis: Role of innate and adaptive immune-responses

Visvanathan, K. & Lewin, S. R., 2006, In : Seminars in Liver Disease. 26, 2, p. 104 - 115 12 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Impact of an education campaign on management in pregnancy of women infected with a blood-borne virus

Giles, M. L., Garland, S. M., Grover, S., Lewin, S. R. & Hellard, M. E., 2006, In : The Medical Journal of Australia. 184, 8, p. 389 - 392 4 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

The evidence for a change in antenatal HIV screening policy in Australia

Giles, M. L., Hellard, M. E., Lewin, S. R. & Mijch, A. M., 2006, In : The Medical Journal of Australia. 185, 4, p. 217 - 220 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Thymic function in severely immunodeficient HIV type 1-infected patients receiving stable and effective antiretroviral therapy

Fernandez, S., Nolan, R. C., Price, P., Krueger, R., Wood, C., Solomon, A., Lewin, S. R. & French, M., 2006, In : AIDS Research and Human Retroviruses. 22, 2, p. 163 - 170 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)
2005

A randomised controlled trial of oral zinc on the immune response to tuberculosis in HIV-infected patients

Lewin, S. R., 2005, In : International Journal of Tuberculosis and Lung Disease. 9, 12, p. 1378 - 1384 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

CD31(+) naive T-cells are reduced in HIV-infected individuals and are permissive to HIV infection in vitro only following IL-7 stimulation

Wightman, F. & Lewin, S. R., 2005, In : Tissue Antigens. 66, 5, p. 476 - 476 1 p.

Research output: Contribution to journalLetterOther

Enhanced replicative capacity and pathogenicity of HIV-1 isolated from individuals infected with drug-resistant virus and declining CD4+ T-cell counts

Solomon, A., Lane, N., Wightman, F., Gorry, P. R. & Lewin, S. R., 2005, In : JAIDS. 40, 2, p. 140 - 148 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Reduced hepatitis B virus (HBV)-specific CD4+ T-cell responses in human immunodeficiency virus type 1-HBV-coinfected individuals receiving HBV-active antiretroviral therapy

Chang, J-H. J., Wightman, F., Bartholomeusz, A., Ayres, A., Kent, S. J., Sasadeusz, J. & Lewin, S. R., 2005, In : Journal of Virology. 79, 5, p. 3038 - 3051 14 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired immunodeficiency syndrome

Gray, L. R., Sterjovski, J., Churchill, M., Ellery, P., Nasr, N., Lewin, S. R., Crowe, S. M., Wesselingh, S. L., Cunningham, A. L. & Gorry, P. R., 2005, In : Virology. 337, 2, p. 384 - 398 15 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)
2004

Changes in Mitochondrial DNA in Peripheral Blood Mononuclear Cells from HIV-Infected Patients with Lipoatrophy Randomized to Receive Abacavir

Hoy, J. F., Gahan, M. E., Carr, A., Smith, D. E., Lewin, S. R., Wesselingh, S. L. & Cooper, D. A., 2004, In : Journal of Infectious Diseases. 190, p. 688 - 692 5 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Comparison of Sequence Analysis and a Novel Discriminatory Real-Time PCR Assay for Detection and Quantification of Lamivudine-Resistant Hepatitis B Virus Strains

Wightman, F., Walters, T., Ayres, A., Bowden, S., Bartholomeusz, A., Lau, D., Locarnini, S. & Lewin, S. R., 2004, In : Journal of Clinical Microbiology. 42, 8, p. 3809 - 3812 4 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Highly reproducible transient transfections for the study of hepatitis B virus replication based on an internal GFP reporter system

Gouskos, T., Wightman, F., Lewin, S. R. & Torresi, J., 2004, In : Journal of Virological Methods. 121, 1, p. 65 - 72 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Severe hepatitis and prolonged hepatitis B virus-specific CD8 T-cell response after selection of hepatitis B virus YMDD variant in an HIV/hepatitis B virus-co-infected patient

Gouskos, T., Wightman, F., Chang, J-H. J., Earnest-Silveira, L., Sasadeusz, J., Lewin, S. R. & Torresi, J., 2004, In : AIDS. 18, 12, p. 1734 - 1737 4 p.

Research output: Contribution to journalLetterOther

8 Citations (Scopus)
2003

Immunological and virological failure after antiretroviral therapy is associated with enhanced peripheral and thymic pathogenicity

Solomon, A., Cameron, P. U., Bailey, M., Dunne, A. L., Crowe, S. M., Hoy, J. F. & Lewin, S. R., 2003, In : Journal of Infectious Diseases. 187, 12, p. 1915 - 1923 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Prevalence and characterization of lamivudine-resistant hepatitis B virus mutations in HIV-HBV co-infected individuals

Cooley, L., Ayres, A., Bartholomeusz, A., Lewin, S. R., Crowe, S. M., Mijch, A. M., Locarnini, S. & Sasadeusz, J., 2003, In : AIDS. 17, 11, p. 1649 - 1657 9 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)
2002

Exposure to Dideoxynucleosides Is Reflected in Lowered Mitochondrial DNA in Subcutaneous Fat

Cherry, C., Gahan, M. E., McArthur, J., Lewin, S. R., Hoy, J. F. & Wesselingh, S. L., 2002, In : Journal of Acquired Immune Deficiency Syndromes. 30, 3, p. 271 - 277 7 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

HIV-1Down-Modulates Signaling Chain of Fcin Human Macrophages: A Possible Mechanism for Inhibition of Phagocytosis

Kedzierska, K., Ellery, P., Mak, J., Lewin, S. R., Crowe, S. & Jaworowski, A., 2002, In : Journal of Immunology. 168, 6, p. 2895 - 2903 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction

Gahan, M. E., Miller, F., Lewin, S. R., Cherry, C., Hoy, J., Mijch, A. M., Rosenfeldt, F. L. & Wesselingh, S. L., 2001, In : Journal of Clinical Virology. 22, p. 241 - 247 7 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)