20012020

Research output per year

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Research Output

2011

Early events of HIV-1 infection: Can signaling be the next therapeutic target?

Jones, K. L., Smyth, R. P., Pereira, C. D. F., Cameron, P. U., Lewin, S. R., Jaworowski, A. & Mak, J., 2011, In : Journal of Neuroimmune Pharmacology. 6, 2, p. 269 - 283 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells

Saleh, S., Wightman, F., Ramanayake, S., Alexander, M., Kumar, N., Khoury, G., Pereira, C. D. F., Purcell, D., Cameron, P. & Lewin, S., 2011, In : Retrovirology. 8, 80, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
72 Citations (Scopus)

Factors associated with elevated ALT in an international HIV/HBV co-infected cohort on long-term HAART

Audsley, J., Seaberg, E., Sasadeusz, J., Matthews, G., Avihingsanon, A., Ruxrungtham, K., Fairley, K., Finlayson, R., Hwang, H. S., Littlejohn, M., Locarnini, S., Dore, G. J., Thio, C. L. & Lewin, S. R., 2011, In : PLoS ONE. 6, 11, 7 p., e26482.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Finding a cure for HIV: Will it ever be achievable?

Lewin, S., Evans, V., Elliott, J., Spire, B. & Chomont, N., 2011, In : Journal of the International AIDS Society. 14, 4, p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
39 Citations (Scopus)

HIV-1 escape from the CCR5 antagonist maraviroc associated with an altered and less-efficient mechanism of gp120-CCR5 engagement that attenuates macrophage tropism

Roche, M., Jakobsen, M., Sterjovski, J., Ellett, A., Posta, F., Lee, B., Jubb, B., Westby, M., Lewin, S. R., Ramsland, P. A., Churchill, M. & Gorry, P. R., 2011, In : Journal of Virology. 85, 9, p. 4330 - 4342 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
61 Citations (Scopus)

HIV-1 predisposed to acquiring resistance to maraviroc (MVC) and other CCR5 antagonists in vitro has an inherent, low-level ability to utilize MVC-bound CCR5 for entry

Roche, M., Jakobsen, M., Ellett, A., Salimiseyedabad, H., Jubb, B., Westby, M., Lee, B., Lewin, S. R., Churchill, M. & Gorry, P. R., 2011, In : Retrovirology. 8, 89, p. 1 - 7 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
36 Citations (Scopus)

HIV and aging: An overview of an emerging issue

Slavin, S., Elliott, J., Fairley, C., French, M., Hoy, J., Law, M. & Lewin, S., 9 Nov 2011, In : Sexual Health. 8, 4, p. 449-451 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

6 Citations (Scopus)

HIV cure and eradication: How will we get from the laboratory to effective clinical trials?

Lewin, S. R. & Rouzioux, C., 24 Apr 2011, In : AIDS. 25, 7, p. 885-897 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

96 Citations (Scopus)

HIV inhibits early signal transduction events triggered by CD16 cross-linking on NK cells, which are important for antibody-dependent cellular cytotoxicity

Lichtfuss, G., Meehan, A., Cheng, W-J., Cameron, P., Lewin, S., Crowe, S. & Jaworowski, A., 2011, In : Journal of leukocyte biology. 89, p. 149 - 158 9 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Increased intrahepatic apoptosis but reduced immune activation in HIV-HBV co-infected patients with advanced immunosuppression

Iser, D. M., Avihingsanon, A., Wisedopas, N., Thompson, A. J., Boyd, A., Matthews, G., Locarnini, S., Slavin, J., Desmond, P. V. & Lewin, S. R., 2011, In : AIDS. 25, 2, p. 197 - 205 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: a randomized controlled trial.

Byakwaga, H., Kelly, M., Purcell, D., French, M., Amin, J., Lewin, S., Haskelberg, H., Kelleher, A. D., Garsia, R., Boyd, M., Cooper, D. A. & Emery, S., 2011, In : Journal of Infectious Diseases. 204, 10, p. 1532 - 1540 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Novel sensitive real-time PCR for quantification of bacterial 16S rRNA genes in plasma of HIV-infected patients as a marker for microbial translocation

Kramski, M., Gaeguta, A. J., Lichtfuss, G. F., Rajasuriar, R., Crowe, S., French, M. A., Lewin, S. R., Center, R. J. & Purcell, D. F. J., 2011, In : Journal of Clinical Microbiology. 49, 10, p. 3691 - 3693 3 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)

Pharmacy adherence measures to assess adherence to antiretroviral therapy: Review of the literature and implications for treatment monitoring

McMahon, J., Jordon, M., Kelley, K., Bertagnolio, S., Hong, S., Wanke, C., Lewin, S. & Elliott, J., 2011, In : Clinical Infectious Diseases. 52, 4, p. 493 - 506 14 p.

Research output: Contribution to journalArticleResearchpeer-review

98 Citations (Scopus)

Plasma levels of soluble CD14 independently predict mortality in HIV infection

Sandler, N., Wand, H., Roque, A., Law, M. G., Nason, M. C., Nixon, D. E., Pedersen, C., Ruxrungtham, K., Lewin, S. R., Emery, S., Neaton, J. D., Brenchley, J. M., Deeks, S. G., Sereti, I. & Douek, D. C., 2011, In : Journal of Infectious Diseases. 203, 6, p. 780 - 790 11 p.

Research output: Contribution to journalArticleResearchpeer-review

661 Citations (Scopus)

Splenectomy associated changes in IgM memory B cells in an adult spleen registry cohort

Cameron, P., Jones, P., Gorniak, M., Dunster, K., Paul, E., Lewin, S., Woolley, I. & Spelman, D., 2011, In : PLoS ONE. 6, 8, 8 p., e23164.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
55 Citations (Scopus)

The role of naive T-cells in HIV-1 pathogenesis: An emerging key player.

Khoury, G., Rajasuriar, R., Lewin, S. & Cameron, P., 2011, In : Clinical Immunology. 141, 3, p. 253 - 267 15 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Thymic plasmacytoid dendritic cells are susceptible to productive HIV-1 infection and efficiently transfer R5 HIV-1 to thymocytes in vitro

Evans, V., Lal, L., Akkina, R., Solomon, A., Wright, E., Lewin, S. & Cameron, P., 2011, In : Retrovirology. 8, 43, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)
2010

A novel, rapid method to detect infectious HIV-1 from plasma of persons infected with HIV-1

Cornall, A., Sharma, L., Solomon, A., Gorry, P., Crowe, S., Cameron, P. U. & Lewin, S. R., 2010, In : Journal of Virological Methods. 165, 1, p. 90 - 96 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Biological determinants of immune reconstitution in HIV-infected patients receiving antiretroviral therapy: The role of interleukin 7 and interleukin 7 receptor alpha and microbial translocation

Rajasuriar, R., Booth, D., Solomon, A., Chua, K., Spelman, T. D., Gouillou, M., Schlub, T., Davenport, M., Crowe, S., Elliott, J., Hoy, J., Fairley, C., Stewart, G., Cameron, P. & Lewin, S., 2010, In : Journal of Infectious Diseases. 202, 8, p. 1254 - 1264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Both CD31+and CD31- naive CD4+ T cells are persistent HIV type 1-infected reservoirs in individuals receiving antiretroviral therapy

Wightman, F., Solomon, A., Khoury, G., Green, J., Gray, L. R., Gorry, P. R., Ho, Y., Saksena, N., Hoy, J. F., Crowe, S., Cameron, P. & Lewin, S., 2010, In : Journal of Infectious Diseases. 202, 11, p. 1738 - 1748 11 p.

Research output: Contribution to journalArticleResearchpeer-review

79 Citations (Scopus)

Coinfection of hepatic cell lines with human immunodeficiency virus and hepatitis B virus leads to an increase in intracellular hepatitis B surface antigen

Iser, D., Warner, N., Revill, P., Solomon, A., Wightman, F., Saleh, S., Crane, M., Cameron, P. U., Bowden, S., Nguyen, T., Pereira, C. D. F., Desmond, P., Locarnini, S. & Lewin, S., 2010, In : Journal of Virology. 84, 12, p. 5860 - 5867 8 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Decreased NK cell FcRgamma in HIV-1 infected individuals receiving combination antiretroviral therapy: A cross sectional study

Leeansyah, E., Zhou, J., Paukovics, G., Lewin, S. R., Crowe, S. M. & Jaworowski, A., 2010, In : PLoS ONE. 5, 3 (Art. No: e9643), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Efficacy of tenofovir disoproxil fumarate/emtricitabine compared with emtricitabine alone in antiretroviral-naive HIV-HBV coinfection in Thailand

Avihingsanon, A., Lewin, S. R., Kerr, S., Chang, J-H., Piyawat, K., Napissanant, N., Mathews, G. V., Dore, G. J., Bowden, S., Lange, J. & Ruxrungtham, K., 2010, In : Antiviral Therapy. 15, 6, p. 917 - 922 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Establishment of HIV-1 latency in resting CD4 + T cells depends on chemokine-induced changes in the actin cytoskeleton

Cameron, P., Saleh, S., Sallmann, G., Solomon, A., Wightman, F., Evans, V., Boucher, G., Haddad, E., Sekaly, R-P., Harman, A., Anderson, J., Jones, K. L., Mak, J., Cunningham, A., Jaworowski, A. & Lewin, S., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 39, p. 16934 - 16939 6 p.

Research output: Contribution to journalArticleResearchpeer-review

149 Citations (Scopus)

Extremely prolonged HIV seroconversion associated with an MHC haplotype carrying disease susceptibility genes for antibody deficiency disorders

Padiglione, A., Aleksic, E., French, M., Arnott, A., Wilson, K. M., Tippett, E., Kaye, M., Gray, L., Ellett, A., Crane, M., Leslie, D. E., Lewin, S. R., Breschkin, A., Birch, C., Gorry, P. R., McPhee, D. A. & Crowe, S. M., Nov 2010, In : Clinical Immunology. 137, 2, p. 199-208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

HBV mutations in untreated HIV-HBV co-infection using genomic length sequencing

Audsley, J. M., Littlejohn, M., Yuen, L., Sasadeusz, J., Ayres, A., Desmond, C., Spelman, T. D., Lau, G. K. K., Mathews, G. V., Avihingsanon, A., Seaberg, E., Philp, F., Saulynas, M., Ruxrungtham, K., Dore, G., Locarnini, S., Thio, C. L., Lewin, S. R. & Revill, P., 2010, In : Virology. 405, 2, p. 539 - 547 9 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

No increase in hepatitis B virus (HBV)-specific CD8+ T cells in patients with HIV-1-HBV coinfections following HBV-active highly active antiretroviral therapy

Crane, M., Sirivichayakul, S., Chang, J-H. J., Avihingsanon, A., Ubolyam, S., Buranapraditkun, S., Thantiworasit, P., Wightman, F., Locarnini, S., Mathews, G., Dore, G. J., Ruxrungtham, K. & Lewin, S. R., 2010, In : Journal of Virology. 84, 6, p. 2657 - 2665 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Preliminary assessment of Treponema pallidum-specific IgM antibody detection and a new rapid point-of-care assay for the diagnosis of syphilis in human immunodeficiency virus-1-infected patients

Rotty, J., Anderson, D. A., Garcia, M., Diaz, J., Van de Waarsenburg, S., Howard, T., Dennison, A., Lewin, S., Elliott, J. & Hoy, J., 2010, In : International Journal of STD and AIDS. 21, 11, p. 758 - 764 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Serum hepatitis B surface antigen and hepatitis B e antigen titers: disease phase influences correlation with viral load and intrahepatic hepatitis B virus markers

Thompson, A., Nguyen, T., Iser, D., Ayres, A., Jackson, K., Littlejohn, M., Slavin, J., Bowden, S., Gane, E., Abbott, W., Lau, G., Lewin, S., Visvanathan, K., Desmond, P. & Locarnini, S., 2010, In : Hepatology. 51, 6, p. 1933 - 1944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

293 Citations (Scopus)
2009

Antenatal screening practice for infectious diseases by general practitioners in Australia

Giles, M. L., Pedrana, A. E., Jones, C., Garland, S. M., Hellard, M. & Lewin, S. R., 2009, In : Australian and New Zealand Journal of Obstetrics and Gynaecology. 49, 1, p. 39 - 44 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Combination HBV therapy is linked to greater HBV DNA suppression in a cohort of lamivudine-experienced HIV/HBV coinfected individuals

Mathews, G., Seaberg, E., Dore, G., Bowden, S., Lewin, S. R., Sasadeusz, J., Marks, P., Goodman, Z., Philp, F. H., Tang, Y., Locarnini, S. & Thio, C., 2009, In : AIDS. 23, 13, p. 1707 - 1715 9 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Differential dynamics of donor DC and non-DC peripheral blood mononuclear cell microchimerism in lung transplantation

Van der Meulen, J. D., Mifsud, N. A., Abud, D., Paul, E., Varney, M., Lewin, S. R., Cameron, P. U. & Kotsimbos, T. C., 2009, In : Clinical Immunology. 133, 2, p. 179 - 183 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages

Westhorpe, C. L., Zhou, J., Webster, N., Kalionis, B., Lewin, S. R., Jaworowski, A., Muller, W. & Crowe, S. M., 2009, In : Journal of leukocyte biology. 85, 6, p. 1027 - 1035 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Future directions in the treatment of HIV-HBV coinfection

Iser, D. M. & Lewin, S. R., 2009, In : HIV Therapy. 3, 4, p. 405-415 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

HIV Management in Australasia: A Guide for Clinical Care

Hoy, J. F., Lewin, S. R., Post, J. J. & Street, A. C., 2009, 2009 ed. Darlinghurst, NSW, Australia: Australasian Society for HIV Medicine. 304 p.

Research output: Book/ReportEdited BookOther

Immunopathogenesis of hepatic flare in HIV/hepatitis B virus (HBV)-coinfected individuals after the initiation of HBV-active antiretroviral therapy

Crane, M., Oliver, B., Matthews, G., Avihingsanon, A., Ubolyam, S., Markovska, V., Chang, J-H. J., Dore, G., Price, P., Visvanathan, K., French, M., Ruxrungtham, K. & Lewin, S. R., 2009, In : Journal of Infectious Diseases. 199, 7, p. 974 - 981 8 p.

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Impaired quality of the hepatitis B virus (HBV)-specific T-cell response in human immunodeficiency virus type 1-HBV coinfection

Chang, J-H. J., Sirivichayakul, S., Avihingsanon, A., Thompson, A. J. V., Revill, P., Iser, D., Slavin, J., Buranapraditkun, S., Marks, P., Matthews, G., Cooper, D. A., Kent, S. J., Cameron, P. U., Sasadeusz, J., Desmond, P., Locarnini, S., Dore, G. J., Ruxrungtham, K. & Lewin, S. R., 2009, In : Journal of Virology. 83, 15, p. 7649 - 7658 10 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

In reply

Giles, M. L., McDonald, A. M., Elliott, E. J., Ziegler, J. B., Hellard, M. E., Lewin, S. R. & Kaldor, J. M., 16 Feb 2009, In : The Medical Journal of Australia. 190, 4, p. 220-221 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Prolonged use of tenofovir in HIV/hepatitis B virus (HBV)-coinfected individuals does not lead to HBV polymerase mutations and is associated with persistence of lamivudine HBV polymerase mutations

Audsley, J. M., Arrifin, N., Yuen, L., Ayres, A., Crowe, S. M., Bartholomeusz, A., Locarnini, S. A., Mijch, A. M., Lewin, S. R. & Sasadeusz, J., 2009, In : HIV Medicine. 10, 4, p. 229 - 235 7 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

The novel histone deacetylase inhibitors metacept-1 and metacept-3 potently increase HIV-1 transcription in latently infected cells

Shehu-Xhilaga, M., Rhodes, D., Wightman, F., Liu, H. B., Solomon, A., Saleh, S. M., Dear, A. E., Cameron, P. U. & Lewin, S. R., 2009, In : AIDS. 23, 15, p. 2047 - 2050 3 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The pathogenesis of liver disease in the setting of HIV-hepatitis B virus coinfection

Iser, D. M. & Lewin, S. R., 2009, In : Antiviral Therapy. 14, 2, p. 155-164 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

The work of women when considering and using interventions to reduce mother-to-child transmission (MTCT) of HIV

Giles, M. L., Hellard, M. E., Lewin, S. R. & O'Brien, M. L., 2009, In : Aids Care: Psychological and Socio-Medical Aspects of AIDS/HIV. 21, 10, p. 1230 - 1237 8 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Treatment of hepatitis B virus (HBV) in the setting of HIV-HBV co-infection

Iser, D. M. & Lewin, S. R., Feb 2009, In : Asian Biomedicine. 3, 1, p. 15-27 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Viral dynamics of hepatitis B virus DNA in human immunodeficiency virus-1-hepatitis B virus coinfected individuals: Similar effectiveness of lamivudine, tenofovir, or combination therapy

Lewin, S. R., Ribeiro, R., Avihingsanon, A., Bowden, S., Mathews, G., Marks, P., Locarnini, S., Ruxrungtham, K., Perelson, A. S. & Dore, G., 2009, In : Hepatology. 49, 4, p. 1113 - 1121 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)
2008

A randomized trial of combination hepatitis B therapy in HIV/HBV coinfected antiretroviral naive individuals in Thailand

Matthews, G. V., Avihingsanon, A., Lewin, S. R., Amin, J., Rerknimitr, R., Petcharapirat, P., Marks, P., Sasadeusz, J., Cooper, D. A., Bowden, S., Locarnini, S., Ruxrungtham, K. & Dore, G. J., 2008, In : Hepatology. 48, 4, p. 1062 - 1069 8 p.

Research output: Contribution to journalArticleResearchpeer-review

104 Citations (Scopus)

A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics

Desmond, C., Bartholomeusz, A., Gaudieri, S., Revill, P. & Lewin, S. R., 2008, In : Antiviral Therapy. 13, 2, p. 161 - 175 15 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Defective hepatitis B virus DNA is not associated with disease status but is reduced by polymerase mutations associated with drug resistance

Preiss, S., Littlejohn, M., Angus, P., Thompson, A. JV., Desmond, P., Lewin, S. R., Sasadeusz, J., Matthews, G., Dore, G. J., Shaw, T., Sozzi, V., Yuen, L., Lau, G., Ayres, A., Thio, C. L., Avihingsanon, A., Ruxrungtham, K., Locarnini, S. & Revill, P. A., 2008, In : Hepatology. 48, 3, p. 741 - 749 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Human thymic dendritic cells: regulators of T cell development in health and HIV-1 infection

Evans, V., Cameron, P. U. & Lewin, S. R., 2008, In : Clinical Immunology. 126, 1, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Incidence of putative HIV superinfection and sexual practices among HIV-infected men who have sex with men

Sidat, M. M., Mijch, A. M., Lewin, S. R., Hoy, J. F., Hocking, J. & Fairley, C. K., 2008, In : Sexual Health. 5, 1, p. 61 - 67 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)