20012020

Research output per year

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Research Output

2014

Short communication: CD4 T cell declines occurring during suppressive antiretroviral therapy reflect continued production of Casp8p41

Cummins, N. W., Neuhaus, J., Sainski, A. M., Strausbauch, M. A., Wettstein, P. J., Lewin, S. R., Plana, M., Rizza, S. A., Temesgen, Z., Touloumi, G., Freiberg, M. S., Neaton, J. D. & Badley, A. D., 2014, In : AIDS Research and Human Retroviruses. 30, 5, p. 476 - 479 4 p.

Research output: Contribution to journalArticleOtherpeer-review

8 Citations (Scopus)

Targets for intervention to improve virological outcomes for patients receiving free antiretroviral therapy in Tamil Nadu, India

McMahon, J. H., Manoharan, A., Wanke, C., Mammen, S., Jose, H., Thabeetha, M., Kadavanu, T., Jordan, M. R., Elliott, J., Lewin, S. R. & Mathai, D., 2014, In : Aids Care: Psychological and Socio-Medical Aspects of AIDS/HIV. 26, 5, p. 559-566 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Towards a cure for HIV-are we making progress?

Lewin, S. R., Deeks, S. G. & Barré-Sinoussi, F., 2014, In : The Lancet. 384, 9939, p. 209-210 2 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

19 Citations (Scopus)
2013

A common mechanism of clinical HIV-1 resistance to the CCR5 antagonist maraviroc despite divergent resistance levels and lack of common gp120 resistance mutations

Roche, M. J., Salimi, H., Duncan, R. C., Wilkinson, B., Chikere, K., Moore, M. S., Webb, N., Zappi, H., Sterjovski, J., Flynn, J. K., Ellett, A., Gray, L. R., Lee, B., Jubb, B., Westby, M., Ramsland, P. A., Lewin, S. R., Payne, R. J., Churchill, M. & Gorry, P. R., 2013, In : Retrovirology. 10, 1 (Art. No.: 43), p. 1 - 20 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
49 Citations (Scopus)

A cure for HIV: where we've been, and where we're headed

Lewin, S. R., 2013, In : The Lancet. 381, 9883, p. 2057 - 2058 2 p.

Research output: Contribution to journalLetterOther

8 Citations (Scopus)

Altering cell death pathways as an approach to cure HIV infection

Badley, A. D., Sainski, A. M., Wightman, F. & Lewin, S. R., 2013, In : Cell Death and Disease. 4, 7 (Art. No.: e718), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
46 Citations (Scopus)

An in-depth comparison of latent HIV-1 reactivation in multiple cell model systems and resting CD4+ T cells from aviremic patients

Spina, C. A., Anderson, J., Archin, N. M., Bosque, A., Chan, J., Famiglietti, M., Green, W., Kashuba, A., Lewin, S. R., Margolis, D. M., Mau, M., Ruelas, D., Saleh, S., Shirakawa, K., Siliciano, R. F., Singhania, A., Soto, P., Terry, V. H., Verdin, E., Woelk, C. & 3 others, Wooden, S., Xing, S. & Planelles, V., 2013, In : PLoS Pathogens. 9, 12, 15 p., e1003834.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
213 Citations (Scopus)

Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses

Andrade, B. B., Hullsiek, K. H., Boulware, D. R., Rupert, A., French, M. A., Ruxrungtham, K., Montes, M. L., Price, H., Barreiro, P., Audsley, J. M., Sher, A., Lewin, S. R. & Sereti, I., 2013, In : Journal of Infectious Diseases. 207, 9, p. 1379 - 1388 10 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

Chemokine levels and chemokine receptor expression in the blood and the cerebrospinal fluid of HIV-infected patients with cryptococcal meningitis and cryptococcosis-associated immune reconstitution inflammatory syndrome

Chang, C. C., Omarjee, S., Lim, A., Spelman, T., Gosnell, B., Carr, W. H., Elliott, J., Moosa, M-Y. S., Ndung'u, T., French, M. & Lewin, S. R., 2013, In : Journal of Infectious Diseases. 208, 10, p. 1604 - 1612 9 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome

Chang, C. C., Dorasamy, A. A., Gosnell, B., Elliott, J., Spelman, T. D., Omarjee, S., Naranbhai, V., Coovadia, Y., Ndung'u, T., Moosa, M-Y. S., Lewin, S. R. & French, M., 2013, In : AIDS. 27, 13, p. 2089 - 2099 11 p.

Research output: Contribution to journalArticleResearchpeer-review

60 Citations (Scopus)

Comparison of HDAC inhibitors in clinical development: effect on HIV production in latently infected cells and T-cell activation

Rasmussen, T. A., Sogaard, O. S., Brinkmann, C., Wightman, F., Lewin, S. R., Melchjorsen, J., Dinarello, C., Ostergaard, L. & Tolstrup, M., 2013, In : Human Vaccines & Immunotherapeutics. 9, 5, p. 993 - 1001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Cryptococcosis-IRIS is associated with lower Cryptococcus-specific IFN-gamma responses before antiretroviral therapy but not higher T-cell responses during therapy

Chang, C. C., Lim, A., Omarjee, S., Levitz, S. M., Gosnell, B., Spelman, T. D., Elliott, J., Carr, W. H., Moosa, M-Y. S., Ndung'u, T., Lewin, S. R. & French, M., 2013, In : Journal of Infectious Diseases. 208, 6, p. 898 - 906 9 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

Wightman, F., Lu, H. K., Solomon, A., Saleh, S. M., Harman, A. N., Cunningham, A. L., Gray, L. R., Churchill, M., Cameron, P. U., Dear, A. E. & Lewin, S. R., 2013, In : AIDS. 27, 18, p. 2853 - 2862 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
45 Citations (Scopus)

HIV and co-infections

Chang, C. C., Crane, M., Zhou, J., Mina, M., Post, J., Cameron, B., Lloyd, A., Jaworowski, A., French, M. & Lewin, S. R., 2013, In : Immunological Reviews. 254, 1, p. 114 - 142 29 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Identification of lineage relationships and novel markers of blood and skin human dendritic cells

Harman, A. N., Bye, C. R., Nasr, N., Sandgren, K. J., Kim, M., Mercier, S., Botting, R. A., Lewin, S. R., Cunningham, A. L. & Cameron, P. U., 2013, In : Journal of Immunology. 190, 1, p. 66 - 79 14 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Inhibition of telomerase activity by human immunodeficiency virus (HIV) nucleos(t)ide reverse transcriptase inhibitors: a potential factor contributing to HIV-associated accelerated aging

Leeansyah, E., Cameron, P. U., Solomon, A., Tennakoon, G. S., Velayudham, P., Gouillou, M., Spelman, T. D., Hearps, A. C., Fairley, C. K., Smit, D., Pierce, A., Armishaw, J., Crowe, S. M., Cooper, D. A., Koelsch, K. K., Liu, J-P., Chuah, J. & Lewin, S. R., 2013, In : Journal of Infectious Diseases. 207, 7, p. 1157 - 1165 9 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Is specific HIV eradication from the brain possible or needed?

Brew, B. J., Gray, L. R., Lewin, S. R. & Churchill, M., 2013, In : Expert Opinion on Biological Therapy. 13, 3, p. 403 - 409 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells

Evans, V. A., Kumar, N., Filali, A., Procopio, F. A., Yegorov, O., Goulet, J-P., Saleh, S. M., Haddad, E. K., Pereira, C. D. F., Ellenberg, P. C., Sekaly, R-P., Cameron, P. U. & Lewin, S. R., 2013, In : PLoS Pathogens. 9, 12 (Art. No.: e1003799), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
43 Citations (Scopus)

Patterns and causes of suboptimal response to tenofovir-based therapy in individuals coinfected with HIV and hepatitis B virus

Matthews, G., Seaberg, E. C., Avihingsanon, A., Bowden, S., Dore, G. J., Lewin, S. R., Sasadeusz, J., Revill, P., Littlejohn, M., Hoy, J. F., Finlayson, R., Ruxrungtham, K., Saulynas, M., Locarnini, S. & Thio, C. L., 2013, In : Clinical Infectious Diseases. 56, 9, p. 87 - 94 8 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Persistent immune activation in chronic HIV infection: do any interventions work?

Rajasuriar, R., Khoury, G., Kamarulzaman, A. B., French, M. A., Cameron, P. U. & Lewin, S. R., 2013, In : AIDS. 27, 8, p. 1199 - 1208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

Pharmacy and self-report adherence measures to predict virological outcomes for patients on free antiretroviral therapy in Tamil Nadu, India

McMahon, J., Manoharan, A., Wanke, C., Mammen, S., Jose, H., Thabeetha, M., Kadavanu, T., Jordan, M. R., Elliott, J., Lewin, S. R. & Mathai, D., 2013, In : AIDS and Behavior. 17, 6, p. 2253 - 2259 7 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Pustular skin lesions in a patient with advanced HIV infection and pneumonia

Macesic, N., Chang, C. C., Abbott, I. J., Trevillyan, J. M., Pham, A. & Lewin, S. R., 2013, In : Clinical Infectious Diseases. 57, 8, p. 1162 - 1163 2 p.

Research output: Contribution to journalArticleOther

Quantitative HBsAg and HBeAg Predict Hepatitis B Seroconversion after Initiation of HAART in HIV-HBV Coinfected Individuals

Matthews, G., Ali, R. J., Avihingsanon, A., Amin, J., Hammond, R. A., Bowden, S., Lewin, S. R., Sasadeusz, J., Littlejohn, M., Locarnini, S., Ruxrungtham, K. & Dore, G. J., 2013, In : PLoS ONE. 8, 4, 8 p., e61297.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Targeting antigen to bone marrow stromal cell-2 expressed by conventional and plasmacytoid dendritic cells elicits efficient antigen presentation

Moffat, J. M., Segura, E., Khoury, G., Caminschi, I., Cameron, P. U., Lewin, S. R., Villadangos, J. A. & Mintern, J., 2013, In : European Journal of Immunology. 43, 3, p. 595 - 605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

The end of AIDS: HIV infection as a chronic disease

Deeks, S. G., Lewin, S. R. & Havlir, D. V., 2013, In : The Lancet. 382, 9903, p. 1525 - 1533 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
764 Citations (Scopus)

The magnitude of HIV-1 resistance to the CCR5 antagonist maraviroc may impart a differential alteration in HIV-1 tropism for macrophages and T-cell subsets

Flynn, J. K., Paukovics, G., Moore, M. S., Ellett, A., Gray, L. R., Duncan, R., Salimi, H., Jubb, B., Westby, M., Purcell, D. F. J., Lewin, S. R., Lee, B., Churchill, M., Gorry, P. R. & Roche, M. J., 2013, In : Virology. 422, 1, p. 51 - 58 8 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

The search for an HIV cure: tackling latent infection

Kent, S. J., Reece, J. C., Petravic, J., Martyushev, A., Kramski, M., De Rose, R., Cooper, D. A., Kelleher, A. D., Emery, S., Cameron, P. U., Lewin, S. R. & Davenport, M., 2013, In : Lancet Infectious Diseases. 13, 7, p. 614 - 621 8 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)
2012

A new way of measuring apoptosis by absolute quantitation of inter-nucleosomally fragmented genomic DNA

Hooker, D. J., Mobarok, M., Anderson, J. L., Rajasuriar, R., Gray, L. R., Ellett, A. M., Lewin, S. R., Gorry, P. R. & Cherry, C. L., 2012, In : Nucleic Acids Research. 40, 15 (e113), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Assessment of HBV flare in a randomized clinical trial in HIV/HBV coinfected subjects initiating HBV-active antiretroviral therapy in Thailand

Avihingsanon, A., Matthews, G., Lewin, S. R., Marks, P., Sasadeusz, J., Cooper, D. A., Bowden, S., Locarnini, S., Dore, G. J. & Ruxrungtham, K., 2012, In : AIDS Research and Therapy. 9, p. 1 - 5 5 p., 6.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
18 Citations (Scopus)

Chronic hepatitis B infection and pregnancy

Giles, M., Visvanathan, K., Lewin, S. R. & Sasadeusz, J., 2012, In : Obstetrical and Gynecological Survey. 67, 1, p. 37 - 44 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Circulating heat shock protein 60 levels are elevated in HIV patients and are reduced by anti-retroviral therapy

Anraku, I., Rajasuriar, R., Dobbin, C. A., Brown, R., Lewin, S. R. & Suhrbier, A., 2012, In : PLoS ONE. 7, 9, 4 p., e45291.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)
5 Citations (Scopus)

Gene therapy as a cure for human immunodeficiency virus

Lewin, S. R., Purcell, D. F. J. & Van Lunzen, J., 2012, In : European Infectious Disease. 6, 2, p. 116-122 7 p.

Research output: Contribution to journalArticleOtherpeer-review

HDAC inhibitors in HIV

Wightman, F., Ellenberg, P. C., Churchill, M. & Lewin, S. R., 2012, In : Immunology and Cell Biology. 90, 1, p. 47 - 54 8 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

HIV Infection and TLR signalling in the liver

Crane, M., Visvanathan, K. & Lewin, S. R., 2012, In : Gastroenterology Research and Practice. 2012, p. e473925 - e473925 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

HIV persistence: chemokines and their signalling pathways

Evans, V. A., Khoury, G., Saleh, S. M., Cameron, P. U. & Lewin, S. R., 2012, In : Cytokine and Growth Factor Reviews. 23, 4-5, p. 151 - 157 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

HIV replication is associated with increased severity of liver biopsy changes in HIV-HBV and HIV-HCV co-infection

Audsley, J. M., Du Cros, P. A., Goodman, Z., McLean, C. A., Mijch, A. M., Lewin, S. R. & Sasadeusz, J., 2012, In : Journal of Medical Virology. 84, 7, p. 993 - 1001 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

HIV reservoirs and strategies for eradication

Smith, M. Z. D., Wightman, F. & Lewin, S. R., 2012, In : Current HIV/AIDS Reports. 9, 1, p. 5 - 15 11 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Human immunodeficiency virus infection and the liver

Crane, M., Iser, D. & Lewin, S. R., 27 Mar 2012, In : World Journal of Hepatology. 4, 3, p. 91-98 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

In vitro replication phenotype of a novel (-1G) hepatitis B virus variant associated with HIV co-infection

Cabuang, L. M., Shaw, T., Littlejohn, M., Colledge, D., Sozzi, V., Soppe, S., Warner, N., Thompson, A. J. V., Preiss, S., Lam, N., Walsh, R. B., Lewin, S. R., Thio, C. L., Matthews, G., Locarnini, S. & Revill, P., 2012, In : Journal of Medical Virology. 84, 8, p. 1166 - 1176 11 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

The role of SNPs in the a-chain of the IL-7R gene in CD4 T-cell recovery in HIV-infected African patients receiving suppressive cART

Rajasuriar, R., Booth, D. R., Gouillou, M., Spelman, T. D., James, I. R., Solomon, A., Chua, K., Stewart, G., Deeks, S. G., Bangsberg, D. R., Muzoora, C., Cameron, P., Hunt, P., Martin, J. & Lewin, S., 2012, In : Genes and Immunity. 13, p. 83 - 93 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Towards an HIV cure: a global scientific strategy

Deeks, S. G., Autran, B., Berkhout, B., Benkirane, M., Cairns, S., Chomont, N., Chun, T. W., Churchill, M., Di Mascio, M., Katlama, C., Lafeuillade, A., Landay, A., Lederman, M. M., Lewin, S. R., Maldarelli, F., Margolis, D. M., Markowitz, M. M., Martinez-Picado, J., Mullins, J., Mellors, J. W. & 16 others, Moreno, S., O'Doherty, U. M., Palmer, S., Penicaud, M. C., Peterlin, M. B., Poli, G., Routy, J. P., Rouzioux, C., Silvestri, G., Stevenson, M., Telenti, A., Van Lint, C., Verdin, E., Woolfrey, A., Zaia, J. A. & Barre-Sinoussi, F., 2012, In : Nature Reviews Immunology. 12, 8, p. 607 - 614 8 p.

Research output: Contribution to journalArticleResearchpeer-review

369 Citations (Scopus)

Viral adaptation to host immune responses occurs in chronic hepatitis B virus (HBV) infection, and adaptation is greatest in HBV e antigen-negative disease

Desmond, C., Gaudieri, S., James, I. R., Pfafferott, K., Chopra, A., Lau, G., Audsley, J., Day, C., Chivers, S., Gordon, A., Revill, P. A., Bowden, S., Ayres, A., Desmond, P. V., Thompson, A. J., Roberts, S. K., Locarnini, S. A., Mallal, S. A. & Lewin, S. R., 2012, In : Journal of Virology. 86, 2, p. 1181 - 1192 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

Virologically suppressed HIV patients show activation of NK cells and persistent innate immune activation

Lichtfuss, G. F., Cheng, W-J., Farsakoglu, Y., Paukovics, G., Rajasuriar, R., Velayudham, P., Kramski, M., Hearps, A., Cameron, P. U., Lewin, S. R., Crowe, S. M. & Jaworowski, A., 2012, In : Journal of Immunology. 189, 3, p. 1491 - 1499 9 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)
2011

Antibody and B-cell responses may control circulating lipopolysaccharide in patients with HIV infection

Lim, A., Amini, A., D'Orsogna, L. J., Rajasuriar, R., Kramski, M., Lewin, S. R., Purcell, D. F., Price, P. & French, M. A., 2011, In : AIDS. 25, 11, p. 1379 - 1383 5 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Balamuthia mandrillaris brain abscess successfully treated with complete surgical excision and prolonged combination antimicrobial therapy: Case report

Doyle, J. S., Campbell, E., Fuller, A., Spelman, D. W., Cameron, R., Malham, G., Gin, D. & Lewin, S. R., 2011, In : Journal of Neurosurgery. 114, 2, p. 458-462 5 p.

Research output: Contribution to journalArticleOtherpeer-review

19 Citations (Scopus)

Biomarkers of immune dysfunction following combination antiretroviral therapy for HIV infection

Lichtfuss, G., Hoy, J., Rajasuriar, R., Kramski, M., Crowe, S. & Lewin, S., 2011, In : Biomarkers in Medicine. 5, 2, p. 171 - 186 16 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Fernandez, S., Tanaskovic, S., Helbig, K., Rajasuriar, R., Kramski, M., Murray, J. M., Beard, M. R., Purcell, A. W., Lewin, S. R., Price, P. & French, M., 2011, In : Journal of Infectious Diseases. 204, 12, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

67 Citations (Scopus)

Clinical predictors of immune reconstitution following combination antiretroviral therapy in patients from the Australian HIV Observational Database

Rajasuriar, R., Gouillou, M., Spelman, T. D., Read, T., Hoy, J., Law, M., Cameron, P., Petoumenos, K. & Lewin, S. R., 2011, In : PLoS ONE. 6, 6, 10 p., e20713.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
24 Citations (Scopus)

Differential expression of CD163 on monocyte subsets in healthy and HIV-1 infected individuals

Tippett, E., Cheng, W-J., Westhorpe, C., Cameron, P., Brew, B., Lewin, S., Jaworowski, A. & Crowe, S., 2011, In : PLoS ONE. 6, 5, 11 p., e19968.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
62 Citations (Scopus)