20012020

Research output per year

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Research Output

2016

Identifying Key Drivers of the Impact of an HIV Cure Intervention in Sub-Saharan Africa

Phillips, A. N., Cambiano, V., Revill, P., Nakagawa, F., Lundgren, J. D., Bansi-Matharu, L., Mabugu, T., Sculpher, M., Garnett, G., Staprans, S., Becker, S., Murungu, J., Lewin, S. R., Deeks, S. G. & Hallett, T. B., 1 Jul 2016, In : Journal of Infectious Diseases. 214, 1, p. 73-79 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Immunity in young adult survivors of childhood leukemia is similar to the elderly rather than age-matched controls: Role of cytomegalovirus

Azanan, M. S., Abdullah, N. K., Chua, L. L., Lum, S. H., Abdul Ghafar, S. S., Kamarulzaman, A., Kamaruzzaman, S. B., Lewin, S. R., Woo, Y. L., Ariffin, H. & Rajasuriar, R., 1 Jul 2016, In : European Journal of Immunology. 46, 7, p. 1715-1726 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

International AIDS Society global scientific strategy: Towards an HIV cure 2016

Deeks, S. G., Lewin, S. R., Ross, A. L., Ananworanich, J., Benkirane, M., Cannon, P., Chomont, N., Douek, D. C., Lifson, J. D., Lo, Y-R., Kuritzkes, D., Margolis, D. J., Mellors, J. W., Persaud, D., Tucker, J. D., Barre-Sinoussi, F. & International AIDS Society Towards a Cure Working Group, 1 Aug 2016, In : Nature Medicine. 22, 8, p. 839-850 12 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

195 Citations (Scopus)

Liver fibrosis regression measured by transient elastography in human immunodeficiency virus (HIV)-hepatitis B virus (HBV)-coinfected individuals on long-term HBV-active combination antiretroviral therapy

Audsley, J., Robson, C., Aitchison, S., Matthews, G. V., Iser, D., Sasadeusz, J. & Lewin, S. R., 1 Jan 2016, In : Open Forum Infectious Diseases. 3, 1, 7 p., ofw035.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
9 Citations (Scopus)

Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5–8 Days

Pinkevych, M., Kent, S. J., Tolstrup, M., Lewin, S. R., Cooper, D. A., SØgaard, O. S., Rasmussen, T. A., Kelleher, A. D., Cromer, D. & Davenport, M. P., 1 Aug 2016, In : PLoS Pathogens. 12, 8, e1005740.

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
9 Citations (Scopus)

Molecular gymnastics: Mechanisms of HIV-1 resistance to CCR5 antagonists and impact on virus phenotypes

Roche, M., Borm, K., Flynn, J. K., Lewin, S. R., Churchill, M. J. & Gorry, P. R., 2016, In : Current Topics in Medicinal Chemistry. 16, 10, p. 1091-1106 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Ongoing clinical trials of human immunodeficiency virus latency-reversing and immunomodulatory agents

Delagrèverie, H. M., Delaugerre, C., Lewin, S. R., Deeks, S. G. & Li, J. Z., 2016, In : Open Forum Infectious Diseases. 3, 4, ofw189.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
47 Citations (Scopus)

Paediatric HIV infection: The potential for cure

Goulder, P. JR., Lewin, S. R. & Leitman, E. M., 30 Mar 2016, In : Nature Reviews Immunology. 16, 4, p. 259-271 13 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File
39 Citations (Scopus)

Persistence of integrated HIV DNA in CXCR3 + CCR6 + memory CD4R T cells in HIV-infected individuals on antiretroviral therapy

Khoury, G., Anderson, J. L., Fromentin, R., Hartogenesis, W., Smith, M. Z., Bacchetti, P., Hecht, F. M., Chomont, N., Cameron, P. U., Deeks, S. G. & Lewin, S. R., 19 Jun 2016, In : AIDS. 30, 10, p. 1511-1520 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Polymorphisms in the CD14 and TLR4 genes independently predict CD4+ T-cell recovery in HIV-infected individuals on antiretroviral therapy

Yong, Y. K., Shankar, E. M., Solomon, A., Spelman, T., Fairley, C. K., Elliott, J. H., Hoy, J., Cameron, P., Kamarulzaman, A. & Lewin, S. R., 16 Aug 2016, In : AIDS. 30, 14, p. 2159-2168 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
5 Citations (Scopus)

Quantifying adaptive and innate immune responses in HIV-infected participants using a novel high throughput assay

Yong, M. K., Cameron, P. U., Spelman, T., Elliott, J. H., Fairley, C. K., Boyle, J., Miyamasu, M. & Lewin, S. R., 1 Dec 2016, In : PLoS ONE. 11, 12, p. 1-8 8 p., e0166549.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2 Citations (Scopus)

Sexual transmission of HIV and the law: An Australian medical consensus statement

Boyd, M., Cooper, D., Crock, E. A., Crooks, L., Giles, M., Grulich, A., Lewin, S. R., Nolan, D. & Yarwood, T., 7 Nov 2016, In : The Medical Journal of Australia. 205, 9, p. 409-412 4 p.

Research output: Contribution to journalArticleOtherpeer-review

6 Citations (Scopus)

Shocking HIV out of hiding: Where are we with clinical trials of latency reversing agents?

Rasmussen, T. A. & Lewin, S. R., 1 Jul 2016, In : Current Opinion in HIV and AIDS. 11, 4, p. 394-401 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

The Stanley Wilkinson Oration

Lewin, S., 1 May 2016, In : Australian Orthodontic Journal. 32, 1, p. 114-118 5 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Toxicity and in vitro activity of HIV-1 latency-reversing agents in primary CNS cells

Gray, L. R., On, H., Roberts, E., Lu, H. K., Moso, M. A., Raison, J. A., Papaioannou, C., Cheng, W-J., Ellett, A. M., Jacobson, J. C., Purcell, D. F. J., Wesselingh, S. L., Gorry, P. R., Lewin, S. R. & Churchill, M. J., 1 Aug 2016, In : Journal of Neurovirology. 22, 4, p. 455-463 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Understanding factors that modulate the establishment of HIV latency in resting CD4+ T-Cells in vitro

Anderson, J. L., Mota, T. M., Evans, V. A., Kumar, N., Rezaei, S. D., Cheong, K., Solomon, A., Wightman, F., Cameron, P. U. & Lewin, S. R., 1 Jul 2016, In : PLoS ONE. 11, 7, 14 p., e0158778.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Voices of biotech

Amit, I., Baker, D., Barker, R., Berger, B., Bertozzi, C., Bhatia, S., Biffi, A., Demichelis, F., Doudna, J., Dowdy, S. F., Endy, D., Helmstaedter, M., Junca, H., June, C., Kamb, S., Khvorova, A., Kim, D-H., Kim, J-S., Krishnan, Y., Lakadamyali, M. & 36 others, Lappalainen, T., Lewin, S., Liao, J., Loman, N., Lundberg, E., Lynd, L., Martin, C., Mellman, I., Miyawaki, A., Mummery, C., Nelson, K., Paz, J., Peralta-Yahya, P., Picotti, P., Polyak, K., Prather, K., Qin, J., Quake, S., Regev, A., Rogers, J. A., Shetty, R., Sommer, M., Stevens, M., Stolovitzky, G., Takahashi, M., Tang, F., Teichmann, S., Torres-Padilla, M-E., Tripathi, L., Vemula, P., Verdine, G., Vollmer, F., Wang, J., Ying, J. Y., Zhang, F. & Zhang, T., Mar 2016, In : Nature Biotechnology. 34, 3, p. 270-275 6 p.

Research output: Contribution to journalArticleOtherpeer-review

4 Citations (Scopus)
2015

Clinical and virological predictors of hepatic flares in pregnant women with chronic hepatitis B

Giles, M., Visvanathan, K., Lewin, S., Bowden, S., Locarnini, S., Spelman, T. & Sasadeusz, J., 1 Nov 2015, In : Gut. 64, 11, p. 1810-1815 6 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Effect of ipilimumab on the HIV reservoir in an HIV-infected individual with metastatic melanoma

Wightman, F., Solomon, A., Kumar, S. S., Urriola, N., Gallagher, K., Hiener, B., Palmer, S. E., McNeil, C. M., Garsia, R. & Lewin, S. R., 2015, In : AIDS. 29, 4, p. 504 - 506 3 p.

Research output: Contribution to journalArticleOther

67 Citations (Scopus)

Experiences and expectations of participants completing an HIV cure focused clinical trial: AIDS

McMahon, J. H., Elliott, J. H., Roney, J., Hagenauer, M. & Lewin, S., 2015, In : AIDS. 29, 2, p. 248-250 3 p.

Research output: Contribution to journalLetterOtherpeer-review

15 Citations (Scopus)

Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage

Rajasuriar, R., Wright, E. J. & Lewin, S. R., 2015, In : Current Opinion in HIV and AIDS. 10, 1, p. 35 - 42 8 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

Ke, R., Lewin, S. R., Elliott, J. H. & Perelson, A. S., 2015, In : PLoS Pathogens. 11, 10, 20 p., e1005237.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
28 Citations (Scopus)

Our democracy and health crises: Reflections on the Australian response to HIV

Lewin, S., Apr 2015, In : Meanjin. 74, 3, p. 186-188 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Population pharmacokinetics of tenofovir in HIV/HBV co-infected patients

Punyawudho, B., Thammajaruk, N., Thongpeang, P., Matthews, G., Lewin, S. R., Burger, D. M., Ruxrungtham, K. & Avihingsanon, A., 1 Nov 2015, In : International Journal of Clinical Pharmacology and Therapeutics. 53, 11, p. 947-954 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Short-term administration of disulfiram for reversal of latent HIV infection: A phase 2 dose-escalation study

Elliott, J. H., McMahon, J. H., Chang, C. C., Lee, S. A., Hartogensis, W., Bumpus, N., Savic, R., Roney, J., Hoh, R., Solomon, A., Piatak, M., Gorelick, R. J., Lifson, J., Bacchetti, P., Deeks, S. G. & Lewin, S. R., 1 Dec 2015, In : The Lancet HIV. 2, 12, p. e520-e529 10 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)

The CD14 C-260T single nucleotide polymorphism (SNP) modulates monocyte/macrophage activation in treated HIV-infected individuals

Rajasuriar, R., Kong, Y. Y., Nadarajah, R., Abdullah, N. K., Spelman, T., Yuhana, M. Y., Ponampalavanar, S., Kamarulzaman, A. & Lewin, S. R., 27 Jan 2015, In : Journal of Translational Medicine. 13, 30, 30.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

The Frequency of Cytomegalovirus (CMV)-Specific CD8+ T Cells Distinguishes CMV Clinical Outcomes Following Hematopoietic Allogeneic Stem Cell Transplant: A Prospective Multicentre Cohort Study

Yong, M. K., Slavin, M., Ritchie, D., Spencer, A., Cameron, P., Morrissey, O., Cheng, A. C., Samri, A., Carcelain, G., Autran, B. & Lewin, S., 2015, In : Blood. 126, 23

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Open Access

The role of antigen presenting cells in the induction of HIV-1 latency in resting CD4+ T-cells

Kumar, N. A., Cheong, K., Powell, D. R., da Fonseca Pereira, C., Anderson, J., Evans, V. A., Lewin, S. R. & Cameron, P. U., 11 Sep 2015, In : Retrovirology. 12, 76, p. 1-16 16 p., 76.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
19 Citations (Scopus)
2014

112: The mechanism and application of a superagonistic antibody for human IL-21

Leong, Y. A., Cui, Y., Chen, Z., Wightman, F., Chen, Y., Lewin, S., Landay, A., Mackay, C. & Yu, D., Nov 2014, In : Cytokine. 70, 1, p. 54-54 1 p., 112.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Activation of HIV transcription with short-course vorinostat in HIV-infected patients on suppressive antiretroviral therapy

Elliott, J., Wightman, F., Solomon, A., Khader, G., Ahlers, J. D., Cameron, M. J., Smith, M. Z. D., Spelman, T., McMahon, J. H., Velayudham, P., Brown, G., Roney, J., Watson, J., Prince, M. H., Hoy, J. F., Chomont, N., Fromentin, R., Procopio, F. A., Zeidan, J., Palmer, S. & 9 others, Odevall, L., Johnstone, R. W., Martin, B. P., Sinclair, E. J., Deeks, S. G., Hazuda, D. J., Cameron, P. U., Sekaly, R-P. & Lewin, S. R., 1 Oct 2014, In : PLoS Pathogens. 10, 11, 19 p., e1004473.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
266 Citations (Scopus)

Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals

Westhorpe, C. L., Maisa, A., Spelman, T. D., Hoy, J. F., Dewar, E. M., Karapanagiotidis, S., Hearps, A., Cheng, W-J., Trevillyan, J. M., Lewin, S. R., Sviridov, D., Elliott, J., Jaworowski, A., Dart, A. M. & Crowe, S. M., 2014, In : Immunology and Cell Biology. 92, 2, p. 133 - 138 6 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

Challenges, progress and strategies in the search for a cure for HIV

Chang, C. C. & Lewin, S. R., May 2014, In : Microbiology Australia. 35, 2, p. 72-78 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Comparison of Etests and Vitek 2 {R }to broth microdilution for the susceptibility testing of Cryptococcus neoformans

Yesholata, M., Chang, C. C., Naidu, D., Dorasamy, A. A., Lewin, S. R., Ndung'u, T., Moosa, M-Y. S., French, M. A., Mlisana, K. & Coovadia, Y., 2014, In : Diagnostic Microbiology and Infectious Disease. 80, 4, p. 294 - 298 5 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Compartmentalization of innate immune responses in the central nervous system during cryptococcal meningitis/HIV coinfection

Naranbhai, V., Chang, C. C., Durgiah, R., Omarjee, S., Lim, A., Moosa, M-Y. S., Elliott, J., Ndung'u, T., Lewin, S. R., French, M. A. & Carr, W. H., 2014, In : AIDS. 28, 5, p. 657 - 666 10 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

CXCL-10, interleukin-12 and interleukin-21 are not immunological predictors of HBeAg seroconversion in HIV-1-HBV coinfection following HBV-active antiretroviral therapy

Giarda, P., Avihingsanon, A., Sasadeusz, J., Audsley, J., Marks, P., Matthews, G., Ruxrungtham, K., Lewin, S. R. & Crane, M., 2014, In : Antiviral Therapy. 19, 4, p. 429-433 5 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Decline in serum 25 hydroxyvitamin D levels in HIV-HBV-coinfected patients after long-term antiretroviral therapy

Avihingsanon, A., Apornpong, T., Ramautarsing, R., Ubolyam, S., Tangkijvanich, P., Ananworanich, J., Lange, J., Matthews, G., Lewin, S. R. & Ruxrungtham, K., 2014, In : Antiviral Therapy. 19, 1, p. 41 - 49 9 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Ebola and HIV: Managing febrile times

Lewin, S. R., 2014, In : The Lancet HIV. 1, 3, p. e101-e102

Research output: Contribution to journalComment / DebateOtherpeer-review

Entry of HIV in primary human resting CD4{+} T cells pretreated with the chemokine CCL19

Anderson, J. L., Cheong, K., Lee, A. K. H., Saleh, S. M., Pereira, C. D. F., Cameron, P. U. & Lewin, S. R., 2014, In : AIDS Research and Human Retroviruses. 30, 3, p. 207 - 208 2 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

Open Access
2 Citations (Scopus)

Erratum: HIV infection: Epidemiology, pathogenesis, treatment, and prevention (Lancet (2014) 384 (258-71))

Maartens, G., Celum, C. L. & Lewin, S. R., 20 Sep 2014, In : The Lancet. 384, 9948, p. 1098 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Ex vivo response to histone deacetylase (HDAC) inhibitors of the HIV long terminal repeat (LTR) derived from HIV-infected patients on antiretroviral therapy

Lu, H. K., Gray, L. R., Wightman, F., Ellenberg, P. C., Khoury, G., Cheng, W-J., Mota, T. M., Wesselingh, S. L., Gorry, P. R., Cameron, P. U., Churchill, M. J. & Lewin, S. R., 2014, In : PLoS ONE. 9, 11, 9 p., e113341.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Finding a cure for HIV: Much work to do

Lewin, S. R., 2 Sep 2014, In : Annals of Internal Medicine. 161, 5, p. 368-369 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

4 Citations (Scopus)

Hepatitis B and Delta virus are prevalent but often subclinical co-infections among HIV infected patients in Guinea-Bissau, West Africa: a cross-sectional study

Langhoff Honge, B., Jespersen, S., Medina, C., Da Silva Te, D., Da Silva, Z. J., Lewin, S. R., Ostergaard, L. J., Erikstrup, C., Wejse, C., Laursen, A. L. & Krarup, H. B., 2014, In : PLoS ONE. 9, 6, 8 p., e99971.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
31 Citations (Scopus)

Hepatitis C prevalence among HIV-infected patients in Guinea-Bissau: a descriptive cross-sectional study

Langhoff Honge, B., Jespersen, S., Medina, C., Da Silva Te, D., Da Silva, Z. J., Lewin, S. R., Ostergaard, L. J., Laursen, A. L., Krarup, H. B., Erikstrup, C. & Wejse, C., 2014, In : International Journal of Infectious Diseases. 28, p. 35 - 40 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
10 Citations (Scopus)

HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

Gorry, P. R., Francella, N., Lewin, S. R. & Collman, R. G., 2014, In : Journal of leukocyte biology. 95, 1, p. 71 - 81 11 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

HIV infection: epidemiology, pathogenesis, treatment, and prevention

Maartens, G., Celum, C. L. & Lewin, S. R., 2014, In : The Lancet. 384, 9939, p. 258 - 271 14 p.

Research output: Contribution to journalArticleResearchpeer-review

335 Citations (Scopus)

Immunopathogenesis of HIV co-infections

Chang, C. C., Crane, M., Jaworowski, A., Lloyd, A., French, M. A. & Lewin, S. R., 2014, Encyclopaedia of AIDS. Hope, T. J., Stevenson, M. & Richman, D. (eds.). New York NY USA: Springer, 15 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Increased glucose metabolic activity is associated with CD4+ T-cell activation and depletion during chronic HIV infection

Palmer, C. P-S., Ostrowski, M., Gouillou, M., Tsai, L. M-C., Yu, D., Zhou, J., Henstridge, D. C., Maisa, A., Hearps, A. C., Lewin, S. R., Landay, A. L., Jaworowski, A., McCune, J. M. & Crowe, S. M., 2014, In : AIDS. 28, 3, p. 297 - 309 13 p.

Research output: Contribution to journalArticleResearchpeer-review

63 Citations (Scopus)

Lipopolysaccharide, immune activation, and liver abnormalities in HIV/hepatitis B virus (HBV)-coinfected individuals receiving HBV-active combination antiretroviral therapy

Crane, M., Avihingsanon, A., Rajasuriar, R., Velayudham, P., Iser, D., Solomon, A., Sebolao, B., Tran, A., Spelman, T., Matthews, G. V., Cameron, P. U., Tangkijvanich, P., Dore, G. J., Ruxrungtham, K. & Lewin, S. R., 2014, In : Journal of Infectious Diseases. 210, 5, p. 745 - 751 7 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

No difference in the rate of change in telomere length or telomerase activity in HIV-Infected patients after three years of darunavir/Ritonavir with and without nucleoside analogues in the monet trial

Solomon, A., Tennakoon, S., Leeansyah, E., Arribas, J. M., Hill, A., Van Delft, Y., Moecklinghoff, C. & Lewin, S. R., 1 Nov 2014, In : PLoS ONE. 9, 11, 5 p., e109718.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

Rasmussen, T. A., Tolstrup, M., Brinkmann, C., Olesen, R., Erikstrup, C., Solomon, A., Winkelmann, A., Palmer, S. E., Dinarello, C. A., Buzon, M. J., Lichterfeld, M., Lewin, S. R., Ostergaard, L. J. & Sogaard, O. S., 2014, In : The Lancet HIV. 1, 1, p. e13 - e21 9 p.

Research output: Contribution to journalArticleResearchpeer-review

307 Citations (Scopus)