Projects per year
Personal profile
Biography
Leading infectious diseases expert, Professor Sharon Lewin, is the inaugural Director of the Doherty Institute. She is also a Professor of Medicine at The University of Melbourne and a National Health and Medical Research Council (NHMRC) Practitioner Fellow. As an infectious diseases physician and basic scientist, her laboratory focuses on basic, translational and clinical research aimed at finding a cure for HIV and understanding the interaction between HIV and hepatitis B virus. Her laboratory is funded by the NHMRC, the National Institutes of Health, The Wellcome Trust, the American Foundation for AIDS Research and multiple commercial partnerships. She is also the Chief Investigator of a NHMRC Centre of Research Excellence (CRE), The Australian Partnership for Preparedness Research on Infectious Diseases Emergencies (APPRISE) that aims to bring together Australia’s leading experts in clinical, laboratory and public health research to address the key components required for a rapid and effective emergency response to infectious diseases.
She has authored over 260 publications and given over 100 major international invited talks on HIV cure. Her work on in vitro models of latency, latency reversing agents and clinical trials of cure interventions has attracted widespread interest in the general and scientific media, including Science, Nature, Nature Medicine, The Economist and The New Yorker. She co-chairs the International AIDS Society’s Towards an HIV Cure initiative, and in 2014, was the local co-chair for the 20th International AIDS Conference in Melbourne, the largest health conference ever held in Australia. She is chair of the Ministerial Advisory Committee for Blood Borne Viruses and Sexually Transmitted Infections, the peak advisory committee to the Federal Minister for Health; a member of the NHMRC Council; an elected member of the Governing Council of the International AIDS Society representing the Asia-Pacific region; and was a foundation council member of the Australian Academy for Health and Medical Research. She was named Melburnian of the Year in 2014, and in 2015, was awarded the Peter Wills Medal by Research Australia. In 2019 Sharon was appointed an Officer of the Order of Australia (AO) in recognition of her distinguished service to medical research, and to education and clinical care, in the field of infectious diseases, particularly HIV and AIDS.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Immunology
- Viral infectious diseases
- Host pathogens interactions
- Hepatitis
- HIV
Network
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Imaging the HIV reservoir in vivo
McMahon, J., Lewin, S., Hagemeyer, C., Rasmussen, T. A. & Egan, G.
1/01/17 → 1/01/19
Project: Research
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Evaluation of HDACi (including Panobinostat) in reversing HIV latency in vitro
Danish Agency for Science, Technology and Innovation
1/01/13 → 31/12/16
Project: Research
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An open-label study to evaluate the safety of boceprevir or telaprvir in addition to pegylated interferon and ribavirin for the treatment of chronic Hepatitis C in patients with bleeding disorders
Sasadeusz, J., Audsley, J., Lewin, S., Strasser, S. I., Wright, E., Tran, H., Iser, D. M. & Dunkley, S.
Haemophilia Foundation Australia
1/01/13 → 31/12/13
Project: Research
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Short-Term Disulfiram Administration to Reverse Latent HIV Infection
Elliott, J., Deeks, S., Lewin, S. & Silicano, R.
American Foundation for AIDS Research
10/09/12 → 31/08/13
Project: Research
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Antiretroviral Initiation at ≥800 CD4+ Cells/mm3 Associated With Lower Human Immunodeficiency Virus Reservoir Size
Rasmussen, T. A., Ahuja, S. K., Kuwanda, L., Vjecha, M. J., Hudson, F., Lal, L., Rhodes, A., Chang, J., Palmer, S., Auberson-Munderi, P., Mugerwa, H., Wood, R., Badal-Faesen, S., Pillay, S., Mngqibisa, R., LaRosa, A., Hildago, J., Petoumenos, K., Chiu, C., Lutaakome, J., & 8 others , 14 Nov 2022, In: Clinical Infectious Diseases. 75, 10, p. 1781-1791 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Balancing statistical power and risk in HIV cure clinical trial design
Lau, J. S. Y., Cromer, D., Pinkevych, M., Lewin, S. R., Rasmussen, T. A., McMahon, J. H. & Davenport, M. P., 15 Jul 2022, In: The Journal of Infectious Diseases. 226, 2, p. 236-245 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Combination Immune Checkpoint Blockade Enhances IL-2 and CD107a Production from HIV-Specific T Cells Ex Vivo in People Living with HIV on Antiretroviral Therapy
Chiu, C. Y., Chang, J. J., Dantanarayana, A. I., Solomon, A., Evans, V. A., Pascoe, R., Gubser, C., Trautman, L., Fromentin, R., Chomont, N., McMahon, J. H., Cameron, P. U., Rasmussen, T. A. & Lewin, S. R., 1 Jan 2022, In: Journal of Immunology. 208, 1, p. 54-62 9 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access6 Citations (Scopus) -
Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4+ T Cells
Lee, M. Y. H., Khoury, G., Olshansky, M., Sonza, S., Carter, G. P., McMahon, J., Stinear, T. P., Turner, S. J., Lewin, S. R. & Purcell, D. F. J., 28 Apr 2022, In: Frontiers in Cellular and Infection Microbiology. 12, 23 p., 855290.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Memory CD4+ T cells that co-express PD1 and CTLA4 have reduced response to activating stimuli facilitating HIV latency
Rasmussen, T. A., Zerbato, J. M., Rhodes, A., Tumpach, C., Dantanarayana, A., McMahon, J. H., Lau, J. S. Y., Chang, J. J., Gubser, C., Brown, W., Hoh, R., Krone, M., Pascoe, R., Chiu, C. Y., Bramhall, M., Lee, H. J., Haque, A., Fromentin, R., Chomont, N., Milush, J., & 6 others , 18 Oct 2022, In: Cell Reports Medicine. 3, 10, 19 p., 100766.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus)