Projects per year
Personal profile
Biography
Dr. Muhammad Shahid Javaid is a postdoctoral research fellow in the Department of Neuroscience, School of Translational Medicine, Monash University. He completed his PhD from Monash University and presented his research work on national and international platforms.
In the Stem Cell laboratory, his research focus is on the development of precision medicines by generating human stem cell-based in vitro epilepsy models. He has developed expertise in the biological reprogramming of patients’ blood cells into stem cells- cells with the potential to become any part of the human body. Then converting stem cells into brain cells or neurons and 3D brain organoids to create personalised ‘disease-in-a-dish’ models for each patient with medically intractable epilepsy.
This work allows the screening and testing of a wide range of existing or new potential anti-epileptic drugs. This work recapitulates human pathophysiology without posing any risk to the patient and can be scaled up to an industrial level to screen thousands of potential drug candidates.
Shahid’s expertise also includes bioinformatics-based computer-aided medicine designing to predict the interaction of potential drug candidates with human receptor proteins.
His career objectives are to utilize his multidisciplinary research experience in the fields of Neuroscience, Stem Cells, and Bioinformatics to investigate the causative mechanisms underlying refractory epilepsy in Australian patients and to develop precision medicines.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
External positions
Authorised Officer | Public Health Officer, Department of Health (DH) (Victoria)
Feb 2021 → Jun 2022
Research area keywords
- Neuroscience
- Stem cell research
- Precision Medicine
- Translational Medical Research
- Organoids
- Drug screening
- Bioinformatics
- In vitro model systems
Collaborations and top research areas from the last five years
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Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P., May, L., Rollo, B., O'Brien, T., Casillas-Espinosa, P., Howden, S., Christopoulos, A., Gregory, K., Scammells, P., Baltos, J., Elliot, D., TN Nguyen, A., Langmead, C., Antonic-Baker, A., Sumer, H., Javaid, S. & Gu, J.
1/06/22 → 31/05/27
Project: Research
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Drug screening using Homer1 patient’s iPSCs-derived neurons for clinical trials of precision medicine
Javaid, S., Rollo, B., Antonic-Baker, A., Kwan, P. & O'Brien, T.
17/04/23 → 30/09/24
Project: Research
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Testing of Epidarex Exeed compounds for anti-epileptiform activity in a human neural in vitro assay
Rollo, B., O'Brien, T., Kwan, P. & Javaid, S.
1/09/21 → 1/03/22
Project: Research
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Transforming the paradigm of epilepsy care with precision medicine
Wolvetang, E. J., Kwan, P., Vadlamudi, L., O'Brien, T., Ge, Z., Anderson, A., Shaker, M., Antonic-Baker, A., Leeson, H., Rollo, B. & Javaid, S.
Department of Health and Aged Care (Australia)
1/06/21 → 31/05/24
Project: Research
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An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds
Zhao, C., Rollo, B., Shahid Javaid, M., Huang, Z., He, W., Xu, H., Kwan, P. & Zhang, C., Oct 2024, In: Journal of Advanced Research. 64, p. 249-262 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Alpha-lipoic acid analogues in the regulation of redox balance in epilepsy: A molecular docking and simulation study
Javaid, M. S., Antonic-Baker, A., Pitsillou, E., Liang, J., French, C., Hung, A., O'Brien, T. J., Kwan, P., Karagiannis, T. C. & Anderson, A., May 2022, In: Journal of Molecular Graphics and Modelling. 112, 8 p., 108116.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Human In Vitro Models of Epilepsy Using Embryonic and Induced Pluripotent Stem Cells
Javaid, M. S., Tan, T., Dvir, N., Anderson, A., J. O’Brien, T., Kwan, P. & Antonic-Baker, A., Dec 2022, In: Cells. 11, 24, 16 p., 3957.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access8 Citations (Scopus) -
In silico analysis to reveal underlying trans differentiation mechanism of Mesenchymal Stem Cells into Osteocytes
Javaid, M. S., Kaul, H., Fazal, N., Yaqub, F., Naseer, N., Hanif, M. & Latief, N., Dec 2021, In: Advancements in Life Sciences. 8, 4, p. 412-418 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Sex Differences in the Risk of Cutaneous Adverse Drug Reactions Induced by Antiseizure Medications: A Systematic Review and Meta-analysis
Alfares, I., Javaid, M. S., Chen, Z., Anderson, A., Antonic-Baker, A. & Kwan, P., Feb 2021, In: CNS Drugs. 35, 2, p. 161-176 16 p.Research output: Contribution to journal › Review Article › Research › peer-review
8 Citations (Scopus)
Prizes
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Monash Graduate Scholarship (MGS)
Javaid, Shahid (Recipient), 2018
Prize: Prize (including medals and awards)
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Monash International Tuition Scholarship (MITS)
Javaid, Shahid (Recipient), 2018
Prize: Prize (including medals and awards)
Activities
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Translation Neurogenetics Retreat 2022, University of Melbourne
Shahid Javaid (Invited speaker)
10 Feb 2022 → 11 Feb 2022Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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2021 Central Clinical School Graduate Research Symposium
Shahid Javaid (Organiser)
26 Nov 2021Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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2021 MGA HDR Mentor Semester 1, Monash University
Shahid Javaid (Mentor)
Mar 2021 → Jun 2021Activity: Other Teaching Engagements and non-HDR Supervisions › Mentor/ Internship supervision
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2021 EMBL Australia Postgraduate Symposium – On Giants’ Shoulders: Adapting to an Ever-Changing World
Shahid Javaid (Organiser)
10 Nov 2021 → 12 Nov 2021Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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Invited Talk: The University of Queensland
Shahid Javaid (Invited speaker)
7 Sept 2021Activity: Participating in or organising an event types › Contribution to workshop, seminar, course