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Personal profile

Biography

Seth Redmond is a senior research fellow investigating vector and pathogen genomics at the Institute of Vector Borne Disease (IVBD). He completed his PhD with Prof Ken Vernick at the Pasteur Institute, Paris and was a Postdoctoral Associate at the Broad Institute with Prof Daniel Neafsey and the Harvard TH Chan School of Public Health with Prof Dyann Wirth studying mosquito genomics, population structure, and malaria transmission dynamics.

Research interests

Genetics can provide a unique window on disease transmission. By studying the distribution of standing variation and the acquisition of novel mutation we can derive valuable information on the characteristics of vectors that are transmitting disease and the movements of pathogens through these vector populations; improved knowledge of transmission dynamics can enable us to optimally target current disease interventions and ultimately can aid in the eradication of some of the major causes of death in the developing world such as Dengue Fever and Malaria.

Working in close collaboration with the World Mosquito Program we are able to take advantage of their global sampling framework and aim to support their work by characterising the effects of wolbachia release on natural populations. Projects within this context include the development of novel amplification and hybridisation techniques to assay mixed vector/pathogen samples; the study of structural variant distribution and evolution in vector species; transmission network reconstruction of vector-borne pathogens; and population structure analyses of mosquito vectors.

Education/Academic qualification

Vector Genomics, PhD, Institut Pasteur (Pasteur Institute)

1 Oct 20111 Oct 2014

External positions

Visiting Scientist, Harvard University

1 Jun 2015 → …

Postdoctoral Associate, Broad Institute of MIT and Harvard

1 May 20151 Apr 2019

Scientific Programmer, VectorBase, Imperial College London

1 Mar 20051 Sep 2011

Research area keywords

  • Infectious Disease
  • Genomic Epidemiology
  • Transmission Dynamics
  • Vector-borne disease
  • pathogens
  • vector-pathogen interactions
  • Malaria
  • Mosquitoes
  • Dengue
  • Arboviruses

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Research Output 2003 2019

A chromosome-scale assembly of the major African malaria vector Anopheles funestus

Ghurye, J., Koren, S., Small, S. T., Redmond, S., Howell, P., Phillippy, A. M. & Besansky, N. J., 1 Jun 2019, In : GigaScience. 8, 6, 8 p., giz063.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

De novo mutations resolve disease transmission pathways in clonal malaria

Redmond, S. N., MacInnis, B. M., Bopp, S., Bei, A. K., Ndiaye, D., Hartl, D. L., Wirth, D. F., Volkman, S. K. & Neafsey, D. E., Jul 2018, In : Molecular Biology and Evolution. 35, 7, p. 1678-1689 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Improved reference genome of Aedes aegypti informs arbovirus vector control

Matthews, B. J., Dudchenko, O., Kingan, S. B., Koren, S., Antoshechkin, I., Crawford, J. E., Glassford, W. J., Herre, M., Redmond, S. N., Rose, N. H., Weedall, G. D., Wu, Y., Batra, S. S., Brito-Sierra, C. A., Buckingham, S. D., Campbell, C. L., Chan, S., Cox, E., Evans, B. R., Fansiri, T. & 52 others, Filipović, I., Fontaine, A., Gloria-Soria, A., Hall, R., Joardar, V. S., Jones, A. K., Kay, R. G. G., Kodali, V. K., Lee, J., Lycett, G. J., Mitchell, S. N., Muehling, J., Murphy, M. R., Omer, A. D., Partridge, F. A., Peluso, P., Aiden, A. P., Ramasamy, V., Rašić, G., Roy, S., Saavedra-Rodriguez, K., Sharan, S., Sharma, A., Smith, M. L., Turner, J., Weakley, A. M., Zhao, Z., Akbari, O. S., Black, W. C., Cao, H., Darby, A. C., Hill, C. A., Johnston, J. S., Murphy, T. D., Raikhel, A. S., Sattelle, D. B., Sharakhov, I. V., White, B. J., Zhao, L., Aiden, E. L., Mann, R. S., Lambrechts, L., Powell, J. R., Sharakhova, M. V., Tu, Z., Robertson, H. M., McBride, C. S., Hastie, A. R., Korlach, J., Neafsey, D. E., Phillippy, A. M. & Vosshall, L. B., Nov 2018, In : Nature. 563, 7732, p. 501-507 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility

Demas, A. R., Sharma, A. I., Wong, W., Early, A. M., Redmond, S., Bopp, S., Neafsey, D. E., Volkman, S. K., Hartl, D. L. & Wirth, D. F., 11 Dec 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 50, p. 12799-12804 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Genetic diversity of the African malaria vector Anopheles gambiae

Anopheles gambiae 1000 Genomes Consortium, 7 Dec 2017, In : Nature. 552, 7683, p. 96-100 5 p.

Research output: Contribution to journalArticleResearchpeer-review