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Personal profile


Dr Senthil Arumugam obtained his PhD training in the lab of Prof Petra Schwille at the Max Planck Institute for Cell Biology and Genetics in Dresden, Germany, focusing on self-organisation of proteins involved in bacterial cell division.His post-doctoral work in the labs of Prof Patricia Bassereau and Prof Ludger Johannes at the Curie Institute, Paris, France, focused on protein-membrane interactions and cellular trafficking.Dr Arumugam joined Single Molecule Science at the University of New South Wales as an independent group leader in September 2016 and established the Lattice Light-Sheet Imaging infrastructure with his research focused on endosomal trafficking.Since October 2019, he is an EMBL Australia Group Leader at the Monash Biomedicine Discovery Institute, with the lab focussing on fundamental questions in intracellular trafficking and their role in cell fate specification and pattern formation in development using LLSM and MOSAIC. 

Research interests

We aim to understand how complex properties arise out of molecules and their interactions, with a primary focus on endosomal trafficking at the level of single cells and in the context of intercellular communications in development. To enable this, we use advanced fluorescence imaging and spectroscopy methods that include Lattice Light Sheets, Adaptive Optics based light sheets, single molecule imaging and other related techniques, complemented by computational data analysis and mathematical modelling. Our broad areas of interests are:

  • Cell biology and developmental biology
  • Advanced fluorescence imaging, optogenetics, image and data analysis
  • Self-organisation, and pattern formation

Education/Academic qualification

Biophysics, PhD, Max Planck Institute for Cell Biology and Genetics

Biophysics, M.Sc, Tata Institute of Fundamental Research

Chemistry, B.Sc

Physiology Course - 2011, Marine Biological Laboratory

External positions

Group Leader, University of New South Wales

29 Aug 20164 Oct 2019

Visiting Researcher, National Centre for Biological Sciences

1 Jun 20167 Aug 2016

Post doctoral Researcher, L'institut Curie (Curie Institute)

7 Jan 201331 Mar 2016

Research area keywords

  • Biophysics
  • Self-organization and Self-assembly
  • cell biology
  • Imaging Biological Processes
  • Lattice Light Sheet Microscopy
  • Adaptive Optics

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Research Output 2008 2019

Ordered and Disordered Segments of Amyloid-β Drive Sequential Steps of the Toxic Pathway

Maity, B. K., Das, A. K., Dey, S., Moorthi, U. K., Kaur, A., Dey, A., Surendran, D., Pandit, R., Kallianpur, M., Chandra, B., Chandrakesan, M., Arumugam, S. & Maiti, S., 15 May 2019, In : ACS Chemical Neuroscience. 10, 5, p. 2498-2509 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The set1 complex is dimeric and acts with jhd2 demethylation to convey symmetrical h3k4 trimethylation

Choudhury, R., Singh, S., Arumugam, S., Roguev, A. & Francis Stewart, A., 1 May 2019, In : Genes & development. 33, 9-10, p. 550-564 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

Toolbox of Diverse Linkers for Navigating the Cellular Efficacy Landscape of Stapled Peptides

Wu, Y., Kaur, A., Fowler, E., Wiedmann, M. M., Young, R., Galloway, W. R. J. D., Olsen, L., Sore, H. F., Chattopadhyay, A., Kwan, T. T. L., Xu, W., Walsh, S. J., De Andrade, P., Janecek, M., Arumugam, S., Itzhaki, L. S., Lau, Y. H. & Spring, D. R., 15 Mar 2019, In : ACS Chemical Biology. 14, 3, p. 526-533 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Mechanism of Shiga Toxin Clustering on Membranes

Pezeshkian, W., Gao, H., Arumugam, S., Becken, U., Bassereau, P., Florent, J. C., Ipsen, J. H., Johannes, L. & Shillcock, J. C., 24 Jan 2017, In : ACS Nano. 11, 1, p. 314-324 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

The Lipids of the Early Endosomes: Making Multimodality Work

Arumugam, S. & Kaur, A., 19 Jun 2017, In : ChemBioChem. 18, 12, p. 1053-1060 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review