Projects per year
Personal profile
Biography
Dr Senthil Arumugam obtained his PhD training in the lab of Prof Petra Schwille at the Max Planck Institute for Cell Biology and Genetics in Dresden, Germany, focusing on self-organisation of proteins involved in bacterial cell division.His post-doctoral work in the labs of Prof Patricia Bassereau and Prof Ludger Johannes at the Curie Institute, Paris, France, focused on protein-membrane interactions and cellular trafficking.Dr Arumugam joined Single Molecule Science at the University of New South Wales as an independent group leader in September 2016 and established the Lattice Light-Sheet Imaging infrastructure with his research focused on endosomal trafficking.Since October 2019, he is an EMBL Australia Group Leader at the Monash Biomedicine Discovery Institute, with the lab focussing on fundamental questions in intracellular trafficking and their role in cell fate specification and pattern formation in development using LLSM and MOSAIC.
Research interests
We aim to understand how complex properties arise out of molecules and their interactions, with a primary focus on endosomal trafficking at the level of single cells and in the context of intercellular communications in development. To enable this, we use advanced fluorescence imaging and spectroscopy methods that include Lattice Light Sheets, Adaptive Optics based light sheets, single molecule imaging and other related techniques, complemented by computational data analysis and mathematical modelling. Our broad areas of interests are:
- Cell biology and developmental biology
- Advanced fluorescence imaging, optogenetics, image and data analysis
- Self-organisation, and pattern formation
Education/Academic qualification
Biophysics, PhD, Max Planck Institut fur molekulare Zellbiologie und Genetik (Max Planck Institute of Molecular Cell Biology and Genetics)
Award Date: 7 Nov 2012
Biophysics, M.Sc, Tata Institute of Fundamental Research
Award Date: 30 Jun 2008
Chemistry, B.Sc
Award Date: 30 Jun 2006
Physiology Course - 2011, Marine Biological Laboratory
External positions
Group Leader, University of New South Wales
29 Aug 2016 → 4 Oct 2019
Visiting Researcher, National Centre for Biological Sciences
1 Jun 2016 → 7 Aug 2016
Post doctoral Researcher, L'institut Curie (Curie Institute)
7 Jan 2013 → 31 Mar 2016
Research area keywords
- Biophysics
- Self-organization and Self-assembly
- cell biology
- Imaging Biological Processes
- Lattice Light Sheet Microscopy
- Adaptive Optics
Network
Projects
- 2 Active
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The HIV capsid is a functional scaffold that directs bidirectional cargo transport
Boecking, T., Jacques, D. A., Arumugam, S., Stear, J. & McKenney, R.
1/01/20 → 31/12/22
Project: Research
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Ceramide structure dictates glycosphingolipid nanodomain assembly and function
Arumugam, S., Schmieder, S., Pezeshkian, W., Becken, U., Wunder, C., Chinnapen, D., Ipsen, J. H., Kenworthy, A. K., Lencer, W., Mayor, S. & Johannes, L., Dec 2021, In: Nature Communications. 12, 1, 12 p., 3675.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
FtsZ: The Force Awakens
Yadu, N., Namboothiri, A. & Arumugam, S., Jan 2021, In: Journal of the Indian Institute of Science. 101, 1, p. 31–38 8 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Rac1 activation can generate untemplated, lamellar membrane ruffles
Leyden, F., Uthishtran, S., Moorthi, U. K., York, H. M., Patil, A., Gandhi, H., Petrov, E. P., Bornschlögl, T. & Arumugam, S., 13 Apr 2021, In: BMC Biology. 19, 1, 14 p., 72.Research output: Contribution to journal › Article › Research › peer-review
Open Access4 Citations (Scopus) -
Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors
York, H. M., Patil, A., Moorthi, U. K., Kaur, A., Bhowmik, A., Hyde, G. J., Gandhi, H., Fulcher, A., Gaus, K. & Arumugam, S., 17 Feb 2021, In: Communications Biology. 4, 1, 13 p., 224.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Three-dimensional imaging on a chip using optofluidics light-sheet fluorescence microscopy
Vargas-Ordaz, E. J., Gorelick, S., York, H. M., Liu, B., Halls, M. L., Arumugam, S., Neild, A., de Marco, A. & Cadarso, V. J., 3 Jun 2021, In: Lab on a Chip. 21, 15, p. 2945-2954 10 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)