Projects per year
Personal profile
Biography
Dr Senthil Arumugam obtained his PhD training in the lab of Prof Petra Schwille at the Max Planck Institute for Cell Biology and Genetics in Dresden, Germany, focusing on self-organisation of proteins involved in bacterial cell division.His post-doctoral work in the labs of Prof Patricia Bassereau and Prof Ludger Johannes at the Curie Institute, Paris, France, focused on protein-membrane interactions and cellular trafficking.Dr Arumugam joined Single Molecule Science at the University of New South Wales as an independent group leader in September 2016 and established the Lattice Light-Sheet Imaging infrastructure with his research focused on endosomal trafficking.Since October 2019, he is an EMBL Australia Group Leader at the Monash Biomedicine Discovery Institute, with the lab focussing on fundamental questions in intracellular trafficking and their role in cell fate specification and pattern formation in development using LLSM and MOSAIC.
Research interests
We aim to understand how complex properties arise out of molecules and their interactions, with a primary focus on endosomal trafficking at the level of single cells and in the context of intercellular communications in development. To enable this, we use advanced fluorescence imaging and spectroscopy methods that include Lattice Light Sheets, Adaptive Optics based light sheets, single molecule imaging and other related techniques, complemented by computational data analysis and mathematical modelling. Our broad areas of interests are:
- Cell biology and developmental biology
- Advanced fluorescence imaging, optogenetics, image and data analysis
- Self-organisation, and pattern formation
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Biophysics, PhD, Reconsitution of Bacterial Cell Division, Max Planck Institut fur molekulare Zellbiologie und Genetik (Max Planck Institute of Molecular Cell Biology and Genetics)
Award Date: 7 Nov 2012
Biophysics, M.Sc, Imaging Somatic Exocytosis in Serotonergic Neurons, Tata Institute of Fundamental Research (TIFR)
Award Date: 30 Jun 2008
Chemistry, B.Sc
Award Date: 30 Jun 2006
Physiology Course - 2011, Marine Biological Laboratory (MBL)
External positions
Group Leader, University of New South Wales (UNSW)
29 Aug 2016 → 4 Oct 2019
Visiting Researcher, National Centre for Biological Sciences
1 Jun 2016 → 7 Aug 2016
Post doctoral Researcher, L'institut Curie (Curie Institute)
7 Jan 2013 → 31 Mar 2016
Research area keywords
- Biophysics
- Self-organization and Self-assembly
- cell biology
- Imaging Biological Processes
- Lattice Light Sheet Microscopy
- Adaptive Optics
Collaborations and top research areas from the last five years
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Mechanistic analyses of EHD proteins in cellular physiology
Pucadyil, T. J. (Primary Chief Investigator (PCI)), Arumugam, S. (Chief Investigator (CI)) & Srivastava, A. (Chief Investigator (CI))
1/10/23 → 30/09/28
Project: Research
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The HIV capsid is a functional scaffold that directs bidirectional cargo transport
Boecking, T. (Primary Chief Investigator (PCI)), Jacques, D. A. (Chief Investigator (CI)), Arumugam, S. (Chief Investigator (CI)), Stear, J. (Chief Investigator (CI)) & McKenney, R. (Chief Investigator (CI))
1/01/20 → 31/12/22
Project: Research
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Emergent Spatiotemporal Organization in Stochastic Intracellular Transport Dynamics
Joshi, K., York, H. M., Wright, C. S., Biswas, R. R., Arumugam, S. & Iyer-Biswas, S., Jul 2024, In: Annual Review of Biophysics . 53, 1, p. 193-220 28 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Organellar electrophysiology: DNA nanodevices charging at the unmeasured
Arumugam, S., Jan 2024, In: BMC Biology. 22, 1, 3 p., 21.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
SUMO protease FUG1, histone reader AL3 and chromodomain protein LHP1 are integral to repeat expansion-induced gene silencing in Arabidopsis thaliana
Sureshkumar, S., Bandaranayake, C., Lv, J., Dent, C. I., Bhagat, P. K., Mukherjee, S., Sarwade, R., Atri, C., York, H. M., Tamizhselvan, P., Shamaya, N., Folini, G., Bergey, B. G., Yadav, A. S., Kumar, S., Grummisch, O. S., Saini, P., Yadav, R. K., Arumugam, S. & Rosonina, E. & 3 others, , 19 Apr 2024, In: Nature Plants. 10, 5, p. 749–759 22 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Deterministic early endosomal maturations emerge from a stochastic trigger-and-convert mechanism
York, H. M., Joshi, K., Wright, C. S., Kreplin, L. Z., Rodgers, S. J., Moorthi, U. K., Gandhi, H., Patil, A., Mitchell, C. A., Iyer-Biswas, S. & Arumugam, S., 2 Aug 2023, In: Nature Communications. 14, 1, 15 p., 4652.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
High-resolution light-sheet microscopy for whole-cell sub-cellular dynamics
Kreplin, L. Z. & Arumugam, S., Dec 2023, In: Current Opinion in Cell Biology. 85, 7 p., 102272.Research output: Contribution to journal › Review Article › Research › peer-review
2 Citations (Scopus)
Activities
- 1 Editorial responsibility
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BMC Biology (Journal)
Senthil Arumugam (Editor in chief)
15 Dec 2021Activity: Publication peer-review and editorial work types › Editorial responsibility