Sebastian Furness

Dr

Accepting PhD Students

PhD projects

1. Single molecule studies on receptor - G protein coupling 2. Molecular basis of cholesterol sensitivity of the cholecystokinin receptor 3. Molecular basis for G protein pleiotropy at the parathyroid hormone receptor

20062020

Research output per year

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Personal profile

Biography

Position

ARC Future Fellow - Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology - MIPS

How do GPCR's signal?

The membrane at the surface of cells is their defining feature, maintaining internal organisation in the face of external disorder. GPCRs are the largest class of molecular machines that allow communication across this barrier. This family enables cells to sense local and distant signals from other cells, nutrients in the gastro-intestinal tract, odours and tastes and even allow us to see.

Dr. Furness' research seeks to develop a deeper understanding of the molecular basis for communication across the cell membrane by GPCRs using a variety of biochemical, molecular, cell biological and pharmacological methods. This molecular description of how GPCRs work is used to inform our understanding of whole organism physiology and pathology.  A short video explainer of his work published in Cell can be found here.

Research interests

Research Interests

See the laboratory website under or links under my photo for more information.

Supervision interests

Dr. Furness is keen to supervisor interested and motivated undergraduates for directed research projects, honours students and PhD candidates.

Current projects include:

Other projects may be available including, please contact Dr. Furness directly to discuss current research projects and training opportunities in the lab.

Monash teaching commitment

  • MIPS Teching Fellow
  • Course co-ordinator for Doctoral training unit in "Applied Drug Discovery Biology"
  • Teaches into Doctoral training units on "Research Integrity & Scientific Methods" and "Applied Drug Discovery Biology"
  • Lectures on Metabolic Disorders to Pharmacutical Science students
  • Mentors undergraduate students for a variety of short research project opportunities
  • Supervision of honours student in Drug Discovery Biology
  • Has previously delivered Molecular Biology and Genomics lectures to both Pharmaceutical Sciences and Pharmacy students

External positions

STEM Wills Advisory Group

10 Jul 2019 → …

Editorial Advisory Board, Biochemical Pharmacology

24 Oct 2018 → …

Research area keywords

  • Allosteric Modulation
  • Biased Signalling
  • G Protein-Coupled Receptors
  • Family B GPCRs
  • Calcitonin Receptor
  • Efficacy
  • Biochemistry
  • Molecular Pharmacology
  • Chemical Biology
  • Glp-1r

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Research Output

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Conformational Transitions and the Activation of Heterotrimeric G Proteins by G Protein-Coupled Receptors

Draper-Joyce, C. & Furness, S. G. B., 26 Jul 2019, In : ACS Pharmacology & Translational Science. 2, 4, p. 285-290 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor

Pham, V., Zhu, Y., Dal Maso, E., Reynolds, C. A., Deganutti, G., Atanasio, S., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Furness, S. G. B., Wang, M-W., Wootten, D. & Sexton, P. M., 18 Mar 2019, In : ACS Pharmacology & Translational Science. 2, 3, p. 183-197 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas

Ostrovskaya, A., Hick, C., Hutchinson, D. S., Stringer, B. W., Wookey, P. J., Wootten, D., Sexton, P. M. & Furness, S. G. B., 18 Feb 2019, In : BMC Cancer. 19, 1, 12 p., 157.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

The Molecular Control of Calcitonin Receptor Signaling

dal Maso, E., Glukhova, A., Zhu, Y., Garcia-Nafria, J., Tate, C. G., Atanasio, S., Reynolds, C. A., Ramirez-Aportela, E., Carazo, J-M., Hick, C. A., Furness, S. G. B., Hay, D. L., Liang, Y-L., Miller, L. J., Christopoulos, A., Wang, M-W., Wootten, D. & Sexton, P. M., 11 Jan 2019, In : ACS Pharmacology & Translational Science. 2, 1, p. 31-51 21 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Post-doctoral fellow prize

Furness, Sebastian (Recipient), 2010

Prize: Prize (including medals and awards)

Activities

Journal of Molecular Biology (Journal)

Sebastian Furness (Peer reviewer)

9 Sep 2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

STEM Wills Advisory Group (External organisation)

Sebastian Furness (Member)

26 Apr 2019 → …

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

British Journal of Pharmacology (Journal)

Sebastian Furness (Peer reviewer)

26 Aug 2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Journal of Pharmacology and Experimental Therapeutics (Journal)

Sebastian Furness (Peer reviewer)

22 May 2019

Activity: Publication peer-review and editorial work typesPeer review responsibility

Australian Society for Medical Research (ASMR) (External organisation)

Sebastian Furness (Member)

2 Oct 2019 → …

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Press / Media

Toxic Free Fawkner public engagement

Sebastian Furness

28/04/18

1 Media contribution

Press/Media: Public Engagement Activities

Signalling under the microscope

Sebastian Furness

1/06/17

1 Media contribution

Press/Media: Expert Comment

Signaling Rides a Wave of Conformational Changes

Sebastian Furness

20/10/16

1 item of Media coverage

Press/Media: Article/Feature

F1000 recommendation

Sebastian Furness

20/10/16

1 item of Media coverage

Press/Media: Expert Comment