Sebastian Furness


Accepting PhD Students

PhD projects

1. Single molecule studies on receptor - G protein coupling 2. Molecular basis of cholesterol sensitivity of the cholecystokinin receptor 3. Molecular basis for G protein pleiotropy at the parathyroid hormone receptor


Research activity per year

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Personal profile



ARC Future Fellow - Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology - MIPS

How do GPCR's signal?

The membrane at the surface of cells is their defining feature, maintaining internal organisation in the face of external disorder. GPCRs are the largest class of molecular machines that allow communication across this barrier. This family enables cells to sense local and distant signals from other cells, nutrients in the gastro-intestinal tract, odours and tastes and even allow us to see.

Dr. Furness' research seeks to develop a deeper understanding of the molecular basis for communication across the cell membrane by GPCRs using a variety of biochemical, molecular, cell biological and pharmacological methods. This molecular description of how GPCRs work is used to inform our understanding of whole organism physiology and pathology.  A short video explainer of his work published in Cell can be found here.

Research interests

Research Interests

See the laboratory website under or links under my photo for more information.

Supervision interests

Dr. Furness is keen to supervisor interested and motivated undergraduates for directed research projects, honours students and PhD candidates.

Current projects include:

Other projects may be available including, please contact Dr. Furness directly to discuss current research projects and training opportunities in the lab.

Monash teaching commitment

  • MIPS Teching Fellow
  • Course co-ordinator for Doctoral training unit in "Applied Drug Discovery Biology"
  • Teaches into Doctoral training units on "Research Integrity & Scientific Methods" and "Applied Drug Discovery Biology"
  • Lectures on Metabolic Disorders to Pharmacutical Science students
  • Mentors undergraduate students for a variety of short research project opportunities
  • Supervision of honours student in Drug Discovery Biology
  • Has previously developed and delivered the 2nd year Biochemical Signalling unit for BPharmSci, 2nd year Chemical Biology for BPharmSci as well as Molecular Biology and Genomics lectures to both Pharmaceutical Sciences and Pharmacy students

External positions

Associate Editor - Frontiers in Endocrinology, Frontiers

31 Oct 2019 → …

Member, Australian Society for Medical Research (ASMR)

2 Oct 2019 → …

STEM Wills Advisory Group

10 Jul 2019 → …

Editorial Advisory Board, Biochemical Pharmacology

24 Oct 2018 → …

Member, Endocrine Society of Australia

24 Oct 2018 → …

Associate, Faculty 1000

10 Feb 2012 → …

Member, ASCEPT

2007 → …

Member, Australian Society for Biochemistry and Molecular Biology

1998 → …

Research area keywords

  • Allosteric Modulation
  • Biased Signalling
  • G Protein-Coupled Receptors
  • Family B GPCRs
  • Calcitonin Receptor
  • Efficacy
  • Biochemistry
  • Molecular Pharmacology
  • Chemical Biology
  • Glp-1r


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