20062022
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Personal profile

Biography

Position

ARC Future Fellow - Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology - MIPS

How do GPCR's signal?

The membrane at the surface of cells is their defining feature, maintaining internal organisation in the face of external disorder. GPCRs are the largest class of molecular machines that allow communication across this barrier. This family enables cells to sense local and distant signals from other cells, nutrients in the gastro-intestinal tract, odours and tastes and even allow us to see.

Dr. Furness' research seeks to develop a deeper understanding of the molecular basis for communication across the cell membrane by GPCRs using a variety of biochemical, molecular, cell biological and pharmacological methods. This molecular description of how GPCRs work is used to inform our understanding of whole organism physiology and pathology.  A short video explainer of his work published in Cell can be found here.

Research interests

Research Interests

See the laboratory website under or links under my photo for more information.

Supervision interests

Dr. Furness is keen to supervisor interested and motivated undergraduates for directed research projects, honours students and PhD candidates.

Current projects include:

Other projects may be available including, please contact Dr. Furness directly to discuss current research projects and training opportunities in the lab.

Monash teaching commitment

  • MIPS Teching Fellow
  • Course co-ordinator for Doctoral training unit in "Applied Drug Discovery Biology"
  • Teaches into Doctoral training units on "Research Integrity & Scientific Methods" and "Applied Drug Discovery Biology"
  • Lectures on Metabolic Disorders to Pharmacutical Science students
  • Mentors undergraduate students for a variety of short research project opportunities
  • Supervision of honours student in Drug Discovery Biology
  • Has previously delivered Molecular Biology and Genomics lectures to both Pharmaceutical Sciences and Pharmacy students

External positions

Editorial Advisory Board, Biochemical Pharmacology

24 Oct 2018 → …

Keywords

  • Allosteric Modulation
  • Biased Signalling
  • G Protein-Coupled Receptors
  • Family B GPCRs
  • Calcitonin Receptor
  • Efficacy
  • Biochemistry
  • Molecular Pharmacology
  • Chemical Biology
  • Glp-1r

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2014 2022

Research Output 2006 2018

Characterization of signalling and regulation of common calcitonin receptor splice variants and polymorphisms

Dal Maso, E., Just, R., Hick, C., Christopoulos, A., Sexton, P. M., Wootten, D. & Furness, S. G. B., 1 Feb 2018, In : Biochemical Pharmacology. 148, p. 111-129 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy

Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., Yang, D., Christopoulos, A., Hay, D. L., Wang, M. W., Sexton, P. M., Furness, S. G. B. & Wootten, D., 1 Apr 2018, In : Biochemical Pharmacology. 150, p. 214-244 31 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Phase-plate cryo-EM structure of a biased agonistbound human GLP-1 receptor-Gs complex

Liang, Y. L., Khoshouei, M., Glukhova, A., Furness, S. G. B., Zhao, P., Clydesdale, L., Koole, C., Truong, T. T., Thal, D. M., Lei, S., Radjainia, M., Danev, R., Baumeister, W., Wang, M. W., Miller, L. J., Christopoulos, A., Sexton, P. M. & Wootten, D., 1 Mar 2018, In : Nature. 555, 7694, p. 121-125 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prizes

Post-doctoral fellow prize

Sebastian Furness (Recipient), 2010

Prize: Prize (including medals and awards)

Activities 1998 2013

  • 4 Membership of an advisory panel/policy group/ board
  • 3 Submissions to industry or govt committees, commissions and inquiries

Metabolic Symposium Committee

Sebastian Furness (Member)
1 Jan 2013

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries

Drug Discovery Biology Seminar Committee

Sebastian Furness (Member)
1 Jan 2013

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries

F1000 (External organisation)

Sebastian Furness (Member)
10 Feb 2012

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board

Drug Discovery Biology

Sebastian Furness (Member)
29 Nov 2011

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries

ASCEPT (External organisation)

Sebastian Furness (Member)
26 Mar 2007

Activity: Industry, Government and Philanthropy Engagement and PartnershipsMembership of an advisory panel/policy group/ board