Sebastian Dworkin

Dr

20022018
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Research Output 2002 2018

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2018

Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis

Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In : Cell death & disease. 9, 11, 12 p., 1072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Lung morphogenesis is orchestrated through Grainyhead-like 2 (Grhl2) transcriptional programs

Kersbergen, A., Best, S. A., Dworkin, S., Ah-Cann, C., de Vries, M. E., Asselin-Labat, M. L., Ritchie, M. E., Jane, S. M. & Sutherland, K. D., 1 Nov 2018, In : Developmental Biology. 443, 1, p. 1-9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin

Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In : Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intratumor heterogeneity

Brown, D. V., Filiz, G., Daniel, P. M., Hollande, F., Dworkin, S., Amiridis, S., Kountouri, N., Ng, W. T. W., Morokoff, A. P. & Mantamadiotis, T., 1 Feb 2017, In : PLoS ONE. 12, 2, 17 p., e0172791.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Grainyhead-like 3 (Grhl3) deficiency in brain leads to altered locomotor activity and decreased anxiety-like behaviors in aged mice

Dworkin, S., Auden, A., Partridge, D. D., Daglas, M., Medcalf, R. L., Mantamadiotis, T., Georgy, S. R., Darido, C., Jane, S. M. & Ting, S. B., Jun 2017, In : Developmental Neurobiology. 77, 6, p. 775-788 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension

Miles, L. B., Darido, C., Kaslin, J., Heath, J. K., Jane, S. M. & Dworkin, S., 1 Dec 2017, In : Scientific Reports. 7, 1, 14 p., 17607.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Mice lacking the conserved transcription factor Grainyhead-like 3 (Grhl3) display increased apposition of the frontal and parietal bones during embryonic development

Goldie, S. J., Arhatari, B. D., Anderson, P., Auden, A., Partridge, D. D., Jane, S. M. & Dworkin, S., 18 Oct 2016, In : BMC Developmental Biology. 16, 1, 37.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Identification of a novel proto-oncogenic network in head and neck squamous cell carcinoma

Georgy, S. R., Cangkrama, M., Srivastava, S., Partridge, D., Auden, A., Dworkin, S., McLean, C. A., Jane, S. M. & Darido, C., 2015, In : Journal of the National Cancer Institute. 107, 9, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Grainyhead-like 3 regulation of endothelin-1 in the pharyngeal endoderm is critical for growth and development of the craniofacial skeleton

Dworkin, S., Simkin, J. E., Darido, C., Partridge, D., Georgy, S. R., Caddy, J., Wilanowski, T., Lieschke, G., Doggett, K., Heath, J. K. & Jane, S. M., 2014, In : Mechanisms of Development. 133, p. 77 - 90 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Novel mechanisms that pattern and shape the midbrain-hindbrain boundary

Dworkin, S. & Jane, S. M., 2013, In : Cellular and Molecular Life Sciences. 70, 18, p. 3365 - 3374 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

CREB signalling in neural stem/progenitor cells: Recent developments and the implications for brain tumour biology

Mantamadiotis, T., Papalexis, N. & Dworkin, S., 2012, In : BioEssays. 34, 4, p. 293 - 300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Midbrain-hindbrain boundary patterning and morphogenesis are regulated by diverse grainy head-like 2-dependent pathways

Dworkin, S., Darido, C., Georgy, S. R., Wilanowski, T., Srivastava, S., Ellett, F., Pase, L., Han, Y., Meng, A., Heath, J., Lieschke, G. & Jane, S., 2012, In : Development. 139, 3, p. 525 - 536 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Targeting of the tumor suppressor GRHL3 by a miR-21-dependent proto-oncogenic network results in PTEN loss and tumorigenesis

Darido, C., Georgy, S. R., Wilanowski, T., Dworkin, S., Auden, A., Zhao, Q., Rank, G., Srivastava, S., Finlay, M. J., Papenfuss, A. T., Pandolfi, P. P., Pearson, R. B. & Jane, S., 2011, In : Cancer Cell. 20, 5, p. 635 - 648 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The planar cell polarity pathway in vertebrate epidermal development, homeostasis and repair

Dworkin, S., Jane, S. & Darido, C., 2011, In : Organogenesis. 7, 3, p. 202 - 208 7 p.

Research output: Contribution to journalArticleOther

2010

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

Caddy, J., Wilanowski, T., Darido, C., Dworkin, S., Ting, S., Zhao, Q., Rank, G., Auden, A., Srivastava, S., Cunningham, J. & Jane, S., 2010, In : Developmental Cell. 19, 1, p. 138 - 147 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting CREB signalling in neurogenesis

Dworkin, S. & Mantamadiotis, T., 2010, In : Expert Opinion on Therapeutic Targets. 14, 8, p. 869 - 879 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

cAMP response element binding protein is required for mouse neural progenitor cell survival and expansion

Dworkin, S., Malaterre, J., Hollande, F., Darcy, P. K., Ramsay, R. G. & Mantamadiotis, T., 2009, In : Stem Cells. 27, 6, p. 1347 - 1357 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

A Microenvironment-Induced Myeloproliferative Syndrome caused by Retinoic Acid Receptor ? Deficiency

Walkley, C. R., Olsen, G., Dworkin, S., Fabb, S. A., Swann, J. B., McArthur, G. A., Westmoreland, S. V., Chambon, P., Scadden, D. T. & Purton, L. E., 2007, In : Cell. 129, 6, p. 1097 - 1110 14 p.

Research output: Contribution to journalArticleResearchpeer-review

c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain

Malaterre, J., Mantamadiotis, T., Dworkin, S., Lightowler, S., Yang, Q., Ransome, M. I., Turnley, A., Nichols, N. R., Emambokus, N., Frampton, J. & Ramsay, R. G., 2007, In : Stem Cells. 1, p. 1 - 18 18 p.

Research output: Contribution to journalArticleResearchpeer-review

c-Myb is required for progenitor cell homeostasis in colonic crypts

Malaterre, J., Carpinelli, M., Ernst, M. R., Alexander, W., Cooke, M. P., Sutton, S., Dworkin, S., Heath, J. K., Frampton, J., McArthur, G., Clevers, H., Hilton, D. J., Mantamadiotis, T. & Ramsay, R. G., 2007, In : Proceedings of the National Academy of Sciences. 104, 10, p. 3829 - 3834 6 p.

Research output: Contribution to journalArticleResearchpeer-review

CREB activity modulates neural cell proliferation, midbrain-hindbrain organization and patterning in zebrafish

Dworkin, S., Heath, J. K., deJong-Curtain, T. A., Hogan, B. M., Lieschke, G. J., Malaterre, J., Ramsay, R. G. & Mantamadiotis, T., 2007, In : Developmental Biology. 307, 1, p. 127 - 141 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Hypothalamic 3',5' -Cyclic Adenosine Monophosphate Response Element-Binding Protein loss Causes Anterior Pituitary Hypoplasia and Dwarfism in Mice

Mantamadiotis, T., Kretz, O., Ridder, S., Bleckmann, S. C., Bock, D., Grone, H-J., Malaterre, J., Dworkin, S., Ramsay, R. G. & Schutz, G., 2006, In : Molecular Endocrinology. 20, 1, p. 204 - 211 8 p.

Research output: Contribution to journalArticleResearchpeer-review

RAR? is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

Purton, L. E., Dworkin, S., Olsen, G., Walkley, C. R., Fabb, S. A., Collins, S. J. & Chambon, P., 2006, In : Journal of Experimental Medicine. 203, 5, p. 1283 - 1293 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

An oxysterol-binding protein family identified in the mouse

Anniss, A. M., Apostolopoulos, J., Dworkin, S., Purton, L. E. & Sparrow, R., 2002, In : DNA and Cell Biology. 21, 8, p. 571 - 580 10 p.

Research output: Contribution to journalArticleResearchpeer-review