Accepting PhD Students

PhD projects

Magnetic Resonance Imaging (MRI) represents the gold standard for radiological diagnosis and monitoring of brain disorders. My research aims to address the following critical problems: Problem 1: How to measure pathological and reparative changes in axonal myelination? Problem 2: How to measure loss of axons? Problem 3: How to identify stressed neurons that are at risk of degeneration? Problem 4: How to classify pathology and stratify patients? Problem 5: How to identify pathological and reparative changes in large scale brain networks? Problem 6: How to translate new imaging biomarkers into radiological practice?

20052020

Research output per year

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Research Output

Compressed sensing effects on quantitative analysis of undersampled human brain sodium MRI

Blunck, Y., Kolbe, S. C., Moffat, B. A., Ordidge, R. J., Cleary, J. O. & Johnston, L. A., 1 Mar 2020, In : Magnetic Resonance in Medicine. 83, 3, p. 1025-1033 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Extracting more for less: multi-echo MP2RAGE for simultaneous T1-weighted imaging, T1 mapping, R2∗ mapping, SWI, and QSM from a single acquisition

Sun, H., Cleary, J. O., Glarin, R., Kolbe, S. C., Ordidge, R. J., Moffat, B. A. & Pike, G. B., Apr 2020, In : Magnetic Resonance in Medicine. 83, 4, p. 1178-1191 14 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Functional neuroplasticity in response to cerebello-thalamic injury underpins the clinical presentation of tremor in multiple sclerosis

Boonstra, F. M. C., Noffs, G., Perera, T., Jokubaitis, V. G., Vogel, A. P., Moffat, B. A., Butzkueven, H., Evans, A., van der Walt, A. & Kolbe, S. C., May 2020, In : Multiple Sclerosis Journal. 26, 6, p. 696-705 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Microstructural correlates of 23Na relaxation in human brain at 7 Tesla

Kolbe, S. C., Syeda, W., Blunck, Y., Glarin, R., Law, M., Johnston, L. A. & Cleary, J. O., 1 May 2020, In : NeuroImage. 211, 8 p., 116609.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

A continuum of T2* components: Flexible fast fraction mapping in sodium MRI

Syeda, W., Blunck, Y., Kolbe, S., Cleary, J. O. & Johnston, L. A., 1 Jun 2019, In : Magnetic Resonance in Medicine. 81, 6, p. 3854-3864 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Functional correlates of cognitive dysfunction in clinically isolated syndromes

Gajamange, S., Shelton, A., Clough, M., White, O., Fielding, J. & Kolbe, S., 17 Jul 2019, In : PLoS ONE. 14, 7, 13 p., e0219590.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Repeated mild traumatic brain injuries induce persistent changes in plasma protein and magnetic resonance imaging biomarkers in the rat

Wright, D. K., Brady, R. D., Kamnaksh, A., Trezise, J., Sun, M., McDonald, S. J., Mychasiuk, R., Kolbe, S. C., Law, M., Johnston, L. A., O'Brien, T. J., Agoston, D. V. & Shultz, S. R., 10 Oct 2019, In : Scientific Reports. 9, 1, 13 p., 14626.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Validation of a precision tremor measurement system for multiple sclerosis

Perera, T., Lee, W. L., Yohanandan, S. A. C., Nguyen, A. L., Cruse, B., Boonstra, F. M. C., Noffs, G., Vogel, A. P., Kolbe, S. C., Butzkueven, H., Evans, A. & van der Walt, A., 1 Jan 2019, In : Journal of Neuroscience Methods. 311, p. 377-384 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Zero-gradient-excitation ramped hybrid encoding (zGRF-RHE) sodium MRI

Blunck, Y., Moffat, B. A., Kolbe, S. C., Ordidge, R. J., Cleary, J. O. & Johnston, L. A., 1 Feb 2019, In : Magnetic Resonance in Medicine. 81, 2, p. 1172-1180 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2018

A semantic system for answering questions in neuroinformatics

Eshghishargh, A., Gray, K., Milton, S. K. & Kolbe, S. C., 29 Jan 2018, Proceedings of the Australasian Computer Science Week Multiconference 2018, Brisbane, Australia, ACSW 2018. Dinh, M. N. (ed.). New York NY USA: Association for Computing Machinery (ACM), p. 1-5 5 p. 3167960

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearch

1 Citation (Scopus)

Fibre-specific white matter changes in multiple sclerosis patients with optic neuritis

Gajamange, S., Raffelt, D., Dhollander, T., Lui, E., van der Walt, A., Kilpatrick, T., Fielding, J., Connelly, A. & Kolbe, S., 1 Jan 2018, In : NeuroImage: Clinical. 17, p. 60-68 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Novel functional MRI task for studying the neural correlates of upper limb tremor

Boonstra, F. M. C., Perera, T., Noffs, G., Marotta, C., Vogel, A. P., Evans, A. H., Butzkueven, H., Moffat, B. A., van der Walt, A. & Kolbe, S. C., 2 Jul 2018, In : Frontiers in Neurology. 9, JUL, 7 p., 513.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Optimized partial-coverage functional analysis pipeline (OPFAP): a semi-automated pipeline for skull stripping and co-registration of partial-coverage, ultra-high-field functional images

Yoo, P. E., Cleary, J. O., Kolbe, S. C., Ordidge, R. J., O’Brien, T. J., Opie, N. L., John, S. E., Oxley, T. J. & Moffat, B. A., 1 Oct 2018, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 31, 5, p. 621-632 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Technologies for Advanced Gait and Balance Assessments in People with Multiple Sclerosis

Shanahan, C. J., Boonstra, F. M. C., Cofré Lizama, L. E., Strik, M., Moffat, B. A., Khan, F., Kilpatrick, T. J., Van Der Walt, A., Galea, M. P. & Kolbe, S., Feb 2018, In : Frontiers in Neurology. 8, 10 p., 708.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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What speech can tell us: A systematic review of dysarthria characteristics in Multiple Sclerosis

Noffs, G., Perera, T., Kolbe, S. C., Shanahan, C. J., Boonstra, F. M. C., Evans, A., Butzkueven, H., van der Walt, A. & Vogel, A. P., Dec 2018, In : Autoimmunity Reviews. 17, 12, p. 1202-1209 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)
2017

Disassociation between brain activation and executive function in fragile X premutation females

Shelton, A. L., Cornish, K., Clough, M., Gajamange, S., Kolbe, S. & Fielding, J., Feb 2017, In : Human Brain Mapping. 38, 2, p. 1056-1067 12 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Social isolation alters social and mating behavior in the R451C neuroligin mouse model of autism

Burrows, E. L., Eastwood, A. F., May, C., Kolbe, S. C., Hill, T., McLachlan, N. M., Churilov, L. & Hannan, A. J., 1 Jan 2017, In : Neural Plasticity. 2017, 10 p., 8361290.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Tremor in multiple sclerosis is associated with cerebello-thalamic pathology

Boonstra, F., Florescu, G., Evans, A., Steward, C., Mitchell, P., Desmond, P., Moffat, B., Butzkueven, H., Kolbe, S. & van der Walt, A., 1 Dec 2017, In : Journal of Neural Transmission. 124, 12, p. 1509-1514 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

White matter microstructure, cognition, and molecular markers in fragile X premutation females

Shelton, A. L., Cornish, K. M., Godler, D., Bui, Q. M., Kolbe, S. & Fielding, J., 30 May 2017, In : Neurology. 88, 22, p. 2080-2088 9 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2016

Brain structure and intragenic DNA methylation are correlated, and predict executive dysfunction in fragile X premutation females

Shelton, AL., Cornish, KM., Kolbe, S., Clough, M., Slater, HR., Li, X., Kraan, CM., Bui, QM., Godler, DE. & Fielding, J., 13 Dec 2016, In : Translational Psychiatry. 6, 12, e984.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

Serial Diffusion Tensor Imaging of the Optic Radiations after Acute Optic Neuritis

Kolbe, S., Walt, A. V. D., Butzkueven, H., Klistorner, A., Egan, G. F. & Kilpatrick, T. J., 2016, In : Journal of Neuro-Ophthalmology. 2016, 6 p., 2764538.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)
2015

Ocular motor signatures of cognitive dysfunction in multiple sclerosis

Fielding, J., Clough, M. J., Beh, S. C., Millist, L., Sears, D., Frohman, A. N., Lizak, N., Lim, J., Kolbe, S. C., Rennaker II, R. L., Frohman, T. C., White, O. B. & Frohman, E., 2015, In : Nature Reviews Neurology. 11, p. 637 - 645 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Parallel changes in structural and functional measures of optic nerve myelination after optic neuritis

van der Walt, A., Kolbe, S. C., Mitchell, P. J., Wang, Y., Butzkueven, H., Egan, G., Yiannikas, C., Graham, S., Kilpatrick, T. J. & Klistorner, A., 2015, In : PLoS ONE. 10, 5, 11 p., e0121084.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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10 Citations (Scopus)

The occurrence of dystonia in upper-limb multiple sclerosis tremor

Van der Walt, A., Buzzard, K., Sung, S., Spelman, T., Kolbe, S. C., Marriott, M., Butzkueven, H. & Evans, A., 1 Dec 2015, In : Multiple Sclerosis Journal. 21, 14, p. 1847-1855 9 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2014

Functional size of human visual area V1: a neural correlate of top-down attention

Verghese, A., Kolbe, S. C., Anderson, A. J., Egan, G. F. & Vidyasagar, T. R., 2014, In : NeuroImage. 93, P1, p. 47 - 52 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Inhibitory saccadic dysfunction is associated with cerebellar injury in multiple sclerosis

Kolbe, S., Kilpatrick, T. J., Mitchell, P., White, O. B., Egan, G. F. & Fielding, J., 2014, In : Human Brain Mapping. 35, 5, p. 2310 - 2319 10 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2013

Optic nerve diffusion tensor imaging after acute optic neuritis predicts axonal and visual outcomes

van der Walt, A., Kolbe, S. C., Wang, Y., Klistorner, A., Shuey, N., Ahmadi, G., Paine, M., Marriott, M., Mitchell, P. J., Egan, G. F., Butzkueven, H. & Kilpatrick, T. J., 2013, In : PLoS ONE. 8, 12, 9 p., e83825.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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33 Citations (Scopus)
2012

Adolescent Toluene Inhalation in Rats Affects White Matter Maturation with the Potential for Recovery Following Abstinence

Duncan, J. R., Dick, A. L. W., Egan, G. F., Kolbe, S. C., Gavrilescu, M., Wright, D. K., Lubman, D. & Lawrence, A. J., 2012, In : PLoS ONE. 7, 9, 13 p., e44790.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)

A double-blind, randomized, controlled study of botulinum toxin type A in MS-related tremor

van der Walt, A., Sung, S., Spelman, T. D., Marriott, M., Kolbe, S., Mitchell, P., Evans, A. & Butzkueven, H., 2012, In : Neurology. 79, 1, p. 92 - 99 8 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Diffusion tensor imaging correlates of visual impairment in multiple sclerosis and chronic optic neuritis

Kolbe, S. C., Marriott, M., van der Walt, A., Fielding, J., Klistorner, A., Mitchell, P. J., Butzkueven, H., Kilpatrick, T. J. & Egan, G. F., 2012, In : Investigative Ophthalmology and Visual Science. 53, 2, p. 825 - 832 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
25 Citations (Scopus)

Diffusion tensor imaging of acute inflammatory lesion evolution in multiple sclerosis

Liu, Y., Mitchell, P. J., Kilpatrick, T. J., Stein, M. S., Harrison, L., Baker, J., Ditchfield, M., Li, K., Egan, G. F., Butzkueven, H. & Kolbe, S. C., 2012, In : Journal of Clinical Neuroscience. 19, 12, p. 1689 - 1694 6 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Diffusion tensor imaging of the optic radiations after optic neuritis

Kolbe, S. C., Bajraszewski, C., Chapman, C., Nguyen, T., Mitchell, P. J., Paine, M., Butzkueven, H., Johnston, L., Kilpatrick, T. J. & Egan, G. F., 2012, In : Human Brain Mapping. 33, 9, p. 2047 - 2061 15 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Optic nerve magnetisation transfer ratio after acute optic neuritis predicts axonal and visual outcomes

Wang, Y., van der Walt, A., Paine, M., Klistorner, A., Butzkueven, H., Egan, G. F., Kilpatrick, T. & Kolbe, S. C., 2012, In : PLoS ONE. 7, 12, 7 p., e52291.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)
2011

A randomized trial of high-dose vitamin D2 in relapsing-remitting multiple sclerosis

Stein, M. S., Liu, Y., Gray, O. M., Baker, J. E., Kolbe, S. C., Ditchfield, M. R., Egan, G. F., Mitchell, P. J., Harrison, L. C., Butzkueven, H. & Kilpatrick, T. J., 2011, In : Neurology. 77, 17, p. 1611 - 1618 8 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)
2010

Neuroprotection in multiple sclerosis: A therapeutic challenge for the next decade

van der Walt, A., Butzkueven, H., Kolbe, S., Marriott, M., Alexandrou, E., Gresle, M., Egan, G. & Kilpatrick, T., 2010, In : Pharmacology and Therapeutics. 126, p. 82 - 93 12 p.

Research output: Contribution to journalArticleResearchpeer-review

50 Citations (Scopus)
2009

Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis

Kolbe, S., Chapman, C., Nguyen, T., Bajraszewski, C., Johnston, L., Kean, M., Mitchell, P., Paine, M., Butzkueven, H., Kilpatrick, T. & Egan, G., 2009, In : NeuroImage. 45, 3, p. 679 - 686 8 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)
2008

Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair

Marriott, M., Emery, B., Cate, H., Binder, M., Kemper, D., Wu, Q., Kolbe, S., Gordon, I., Wang, H., Egan, G., Murray, S., Butzkueven, H. & Kilpatrick, T., 2008, In : GLIA. 56, p. 686 - 698 13 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Validation of linear cerebral atrophy markers in multiple sclerosis

Butzkueven, H., Kolbe, S. C., Jolley, D. J., Brown, J. Y., Cook, M. J., van der Mei, I., Groom, P. S., Carey, J., Eckholdt, J., Rubio, J., Taylor, B. V., Mitchell, P. J., Egan, G. F. & Kilpatrick, T. J., 2008, In : Journal of Clinical Neuroscience. 15, p. 130 - 137 8 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Voxelwise regularisation of high angular resolution diffusion imaging data

Johnston, L. A., Kolbe, S., Mareels, I. M. Y. & Egan, G., 1 Dec 2008, Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08. Chon, K., Lain, A., Bonato, P., Vicini, P., Khoo, M., Buetra, R., Layton, B., Patton, J., Panescu, D., Lovell, N. & Monzon, J. (eds.). USA: IEEE, Institute of Electrical and Electronics Engineers, Vol. 30. p. 90-93 4 p. 4649098. (Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology").

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

2005

A Platform for Distributed Analysis of Neuroimaging Data on Global Grids

Kolbe, S., Ma, T., Liu, W., Soh, W. S., Buyya, R. & Egan, G., 2005, First International Conference on e-Science and Grid Computing. Stockinger, H., Buyya, R. & Perrott, R. (eds.). USA: IEEE, Institute of Electrical and Electronics Engineers, Vol. 1. p. 79 - 86 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

7 Citations (Scopus)