Sarah Turpin-Nolan

Dr

Accepting PhD Students

PhD projects

Please visit the Cellular and Molecular Metabolism website for projects. https://www.monash.edu/pharm/research/areas/drug-discovery/labs/Cellular-Molecular-Metabolism

20062020

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Personal profile

Research interests

Obesity rates continue to grow signifying the need to identify new therapeutic approaches.Different sized bioactive lipids (ceramide) have been associated with metabolic diseases and are currently being used as markers of heart disease and type II diabetes mellitus. Ceramide production is regulated by Ceramide Synthase enzymes which are vital for exclusive individual sized ceramide manipulation. From my own work, I believe that targeting a specific ceramide specie, could provide new avenues of treatment to help combat obesity and associated metabolic disorders.

My current research objective is to decipher the regulatory principles of how intestinal ceramides are packaged and circulate the body to influence lipid metabolism and contribute to the onset of obesity, type II diabetes mellitus and colorectal cancer pathogenesis.

Biography

Dr. Sarah Turpin-Nolan is currently a Research Fellow in the Cellular and Molecular Metabolism at the Monash Institute of Pharmaceutical Sciences (MIPS), Monash University. Her research focuses upon the role of ceramides during metabolic disease, namely in the gastrointestinal tract, lymphatic and circulatory transport systems.

Previously, Dr Turpin-Nolan discovered that reducing a specific ceramide specie in the liver could prevent diet-induced obesity and type 2 diabetes mellitus during her postdoctoral traiing in Prof. Jens Bruening's Laboratory at the Max Planck Institute for Metabolism Research. This work led to the development of inhibitors to treat type 2 diabetes mellitus.

Dr Sarah Turpin-Nolan completed her PhD in the Biology of Lipid Metabolism Laboratory supervised by Prof. Matthew Watt. Her PhD investigated the Metabolic consequences of lipid-oversupply in key glucoregulatory tissues and was awarded by The University of Melbourne (Dept of Medicine & Health Sciences).

Education/Academic qualification

PhD, University of Melbourne

20062010

Award Date: 9 Jun 2010

Bachelor of Applied Science (Biotechnology & Biomedical Science) Honours, RMIT University

2005

Award Date: 23 Dec 2005

Bachelor of Applied Science (Human Biology), RMIT University

20022004

Award Date: 24 Dec 2004

External positions

Victorian Representative, Australian Association of von Humboldt Fellows

2020 → …

Research area keywords

  • sphingolipids
  • overweight/obesity
  • Lipid Metabolism
  • lymphatics
  • ceramides
  • glucose metabolism

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