Sarah Lockie

Research output

Research output per year 2009 2009 2012 2013 2015 2018 2022 2023

• 33 Article
• 1 Letter
• 1 Review Article

Research output per year

Research output per year

Search results

• 2023

  Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice

  Reed, F., Reichenbach, A., Dempsey, H., Clarke, R. E., Mequinion, M., Stark, R., Rawlinson, S., Foldi, C. J., Lockie, S. H. & Andrews, Z. B., Nov 2023, In: Molecular Metabolism. 77, 13 p., 101803.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  3 Citations (Scopus)

• Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus

  Clarke, R. E., Voigt, K., Reichenbach, A., Stark, R., Bharania, U., Dempsey, H., Lockie, S. H., Mequinion, M., Lemus, M., Wei, B., Reed, F., Rawlinson, S., Nunez-Iglesias, J., Foldi, C. J., Kravitz, A. V., Verdejo-Garcia, A. & Andrews, Z. B., 15 Feb 2023, In: Biological Psychiatry. 93, 4, p. 309-321 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  6 Citations (Scopus)
• 2022

  In Vivo Photometry Reveals Insulin and 2-Deoxyglucose Maintain Prolonged Inhibition of VMH Vglut2 Neurons in Male Mice

  Rawlinson, S., Reichenbach, A., Clarke, R. E., Nuñez-Iglesias, J., Dempsey, H., Lockie, S. H. & Andrews, Z. B., 1 Aug 2022, In: Endocrinology. 163, 8, p. 1-11 11 p., bqac095.

  Research output: Contribution to journal › Article › Research › peer-review
  2 Citations (Scopus)

• Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum

  Reichenbach, A., Clarke, R. E., Stark, R., Lockie, S. H., Mequinion, M., Dempsey, H., Rawlinson, S., Reed, F., Sepehrizadeh, T., Deveer, M., Munder, A. C., Nunez-Iglesias, J., Spanswick, D. C., Mynatt, R., Kravitz, A. V., Dayas, C. V., Brown, R. & Andrews, Z. B., Jan 2022, In: eLife. 11, 24 p., e72668.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  27 Citations (Scopus)
• 2020

  Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans

  Hornsby, A. K. E., Buntwal, L., Carisi, M. C., Santos, V. V., Johnston, F., Roberts, L. D., Sassi, M., Mequinion, M., Stark, R., Reichenbach, A., Lockie, S. H., Siervo, M., Howell, O., Morgan, A. H., Wells, T., Andrews, Z. B., Burn, D. J. & Davies, J. S., 20 Oct 2020, In: Cell Reports Medicine. 1, 7, p. 1-e9 23 p., 100120.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  15 Citations (Scopus)
• 2019

  Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area

  Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., Jul 2019, In: Journal of Neuroendocrinology. 31, 7, 6 p., e12696.

  Research output: Contribution to journal › Article › Research › peer-review
  5 Citations (Scopus)
• 2018

  AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

  Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In: Cell Reports. 22, 7, p. 1745-1759 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  27 Citations (Scopus)

• Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

  Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S. & Andrews, Z. B., 1 Dec 2018, In: The FASEB Journal. 32, 12, p. 6923-6933 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  14 Citations (Scopus)

• Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice

  Reichenbach, A., Mequinion, M., Bayliss, J. A., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Stark, R. & Andrews, Z. B., 1 Jun 2018, In: Endocrinology. 159, 6, p. 2473-2483 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  7 Citations (Scopus)

• Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

  Lockie, S. H., Stark, R., Mequinion, M., Ch'ng, S., Kong, D., Spanswick, D. C., Lawrence, A. J. & Andrews, Z. B., 1 Nov 2018, In: Endocrinology. 159, 11, p. 3605-3614 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  22 Citations (Scopus)
• 2017

  Food seeking in a risky environment: A method for evaluating risk and reward value in food seeking and consumption in mice

  Lockie, S. H., McAuley, C. V., Rawlinson, S., Guiney, N. & Andrews, Z. B., 30 Jan 2017, In: Frontiers in Neuroscience. 11, 1 p., 24.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  13 Citations (Scopus)
• 2016

  Des-acyl ghrelin and ghrelin O-acyltransferase regulate hypothalamic-pituitary-adrenal axis activation and anxiety in response to acute stress

  Stark, R., Santos, V. V., Geenen, B., Cabral, A., Dinan, T., Bayliss, J. A., Lockie, S. H., Reichenbach, A., Lemus, M. B., Perello, M., Spencer, S. J., Kozicz, T. & Andrews, Z. B., Oct 2016, In: Endocrinology. 157, 10, p. 3946-3957 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  34 Citations (Scopus)
• 2015

  Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice

  Stark, R., Reichenbach, A., Lockie, S. K. H., Pracht, C., Wu, Q., Tups, A. & Andrews, Z. B., 2015, In: Endocrinology. 156, 3, p. 858 - 868 11 p.

  Research output: Contribution to journal › Article › Research › peer-review
  30 Citations (Scopus)

• A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell A stereological analysis of NPY, POMC, Orexin, GFAP astrocyte, and Iba1 microglia cell number and volume in diet-induced obese male mice

  Lemus, M. B., Bayliss, J. A., Lockie, S. K. H., Santos, V. V., Reichenbach, A., Stark, R. & Andrews, Z. B., 2015, In: Endocrinology. 156, 5, p. 1701 - 1713 13 p.

  Research output: Contribution to journal › Article › Research › peer-review
  64 Citations (Scopus)

• Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice

  Lockie, S. K. H., Stefanidis, A., Tschop, M. H. & Oldfield, B. J., 2015, In: Molecular and Cellular Endocrinology. 417, p. 10 - 19 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  4 Citations (Scopus)

• Diet-induced obesity causes ghrelin resistance in reward processing tasks

  Lockie, S. K. H., Dinan, T., Lawrence, A. J., Spencer, S. J. & Andrews, Z. B., 2015, In: Psychoneuroendocrinology. 62, p. 114 - 120 7 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  File
  46 Citations (Scopus)

• Neonatal ghrelin programs development of hypothalamic feeding circuits

  Steculorum, S. M., Collden, G., Coupe, B., Croizier, S., Lockie, S., Andrews, Z. B., Jarosch, F., Klussmann, S. & Bouret, S. G., 2 Feb 2015, In: The Journal of Clinical Investigation. 125, 2, p. 846-858 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  124 Citations (Scopus)
• 2014

  Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice

  Briggs, D. I., Lockie, S. K. H., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A. J., Lemus, M. B., Coleman, H. A., Parkington, H. C., Tups, A. & Andrews, Z. B., 2014, In: Endocrinology. 155, 7, p. 2411 - 2422 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  55 Citations (Scopus)

• The temporal pattern of cfos activation in hypothalamic, cortical, and brainstem nuclei in response to fasting and refeeding in male mice

  Wu, Q., Lemus, M. B., Stark, R., Bayliss, J., Reichenbach, A., Lockie, S. K. H. & Andrews, Z. B., 2014, In: Endocrinology. 155, 3, p. 840 - 853 14 p.

  Research output: Contribution to journal › Article › Research › peer-review
  89 Citations (Scopus)
• 2013

  Anti-obesity effects of the combined administration of CB1 receptor antagonist rimonabant and melanin-concentrating hormone antagonist SNAP-94847 in diet-induced obese mice

  Verty, A. N. A., Lockie, S. K. H., Stefanidis, A. & Oldfield, B. J., 2013, In: International Journal of Obesity. 37, 2, p. 279 - 287 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  28 Citations (Scopus)

• Brown adipose tissue thermogenesis in the resistance to and reversal of obesity: A potential new mechanism contributing to the metabolic benefits of proglucagon-derived peptides

  Lockie, S. K. H., Stefanidis, A., Oldfield, B. J. & Perez-Tilve, D., 2013, In: Adipocyte. 2, 4, p. 196 - 200 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

• Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner

  Briggs, D. I., Lockie, S. K. H., Wu, Q., Lemus, M. B., Stark, R. & Andrews, Z. B., 2013, In: Endocrinology. 154, 2, p. 709 - 717 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  67 Citations (Scopus)

• Glucagon-like peptide-1 receptor in the brain: role in neuroendocrine control of energy metabolism and treatment target for obesity

  Lockie, S. K. H., 2013, In: Journal of Neuroendocrinology. 25, 7, p. 597 - 604 8 p.

  Research output: Contribution to journal › Article › Research › peer-review
  28 Citations (Scopus)

• The hormonal signature of energy deficit: increasing the value of food reward

  Lockie, S. K. H. & Andrews, Z. B., 2013, In: Molecular Metabolism. 2, 4, p. 329 - 336 8 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  38 Citations (Scopus)

• Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

  Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K., Heppner, K., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. K. H., Smiley, D., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J., & 13 othersVignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. & Tschop, M. H., 2013, In: Science Translational Medicine. 5, 209 (Art. No.: 209ra151), p. 1 - 17 17 p.

  Research output: Contribution to journal › Article › Research › peer-review
  498 Citations (Scopus)
• 2012

  Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice

  Tsoli, M., Moore, M., Burg, D., Painter, A., Taylor, R., Lockie, S. K. H., Turner, N., Warren, A., Cooney, G. J., Oldfield, B. J., Clarke, S. & Robertson, G., 2012, In: Cancer Research. 72, 17, p. 4372 - 4382 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access
  124 Citations (Scopus)

• Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

  Lockie, S. K. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H. & Perez-Tilve, D., 2012, In: Diabetes. 61, 11, p. 2753 - 2762 10 p.

  Research output: Contribution to journal › Article › Research › peer-review
  189 Citations (Scopus)

• Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model

  Kampe, J., Stefanidis, A., Lockie, S. K. H., Brown, W. A., Dixon, J., Odoi, A., Spencer, S. J., Raven, J. & Oldfield, B. J., 2012, In: International Journal of Obesity. 36, 11, p. 1403 - 1411 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  30 Citations (Scopus)
• 2011

  CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice

  Lockie, S. K. H., Czyzyk, T. A., Chaudhary, N., Perez-Tilve, D., Woods, S. C., Oldfield, B. J., Statnick, M. A. & Tschop, M. H., 2011, In: Endocrinology. 152, 10, p. 3661 - 3667 7 p.

  Research output: Contribution to journal › Article › Research › peer-review
  21 Citations (Scopus)

• Ghrelin-induced adiposity is independent of orexigenic effects

  Perez-Tilve, D., Heppner, K., Kirchner, H., Lockie, S. K. H., Woods, S., Smiley, D., Tschop, M. & Pfluger, P., 2011, In: The FASEB Journal. 25, 8, p. 2814 - 2822 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  96 Citations (Scopus)
• 2010

  CNS leptin action modulates immune response and survival in sepsis

  Tschop, J., Nogueiras, R., Lockie, S. K. H., Kasten, K. R., Castaneda, T. R., Huber, N., Guanciale, K., Perez-Tilve, D., Habegger, K., Ottaway, N., Woods, S. C., Oldfield, B., Clarke, I., Chua Jr., S., Farooqi, I. S., O'Rahilly, S., Caldwell, C. C. & Tschop, M. H., 2010, In: The Journal of Neuroscience. 30, 17, p. 6036 - 6047 12 p.

  Research output: Contribution to journal › Article › Research › peer-review
  79 Citations (Scopus)
• 2009

  A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

  Day, J., Ottaway, N., Patterson, J., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S. K. H., Hofmann, S., Woods, S. C., & 5 othersNogueiras, R., Pfluger, P. T., Perez-Tilve, D., DiMarchi, R. & Tschop, M. H., 2009, In: Nature Chemical Biology. 5, 10, p. 749 - 757 9 p.

  Research output: Contribution to journal › Article › Research › peer-review
  503 Citations (Scopus)

• The endocannabinoid system: role in glucose and energy metabolism

  Nogueiras, R., Diaz-Arteaga, A., Lockie, S. K. H., Velasquez, D. A., Tschop, J., Lopez, M., Cadwell, C. C., Dieguez, C. & Tschop, M. H., 2009, In: Pharmacological Research. 60, 2, p. 93 - 98 6 p.

  Research output: Contribution to journal › Article › Research › peer-review
  57 Citations (Scopus)