Sarah Lockie

Dr

Accepting PhD Students

PhD projects

https://supervisorconnect.med.monash.edu/projects/behavioural-phenotyping-gfral-neurons-mood-and-motivation https://supervisorconnect.med.monash.edu/projects/neural-control-metabolism-cancer-cachexia-syndrome

20092021

Research output per year

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Research Output

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Article
2019

Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area

Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., Jul 2019, In : Journal of Neuroendocrinology. 31, 7, 6 p., e12696.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
14 Citations (Scopus)

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S. & Andrews, Z. B., 1 Dec 2018, In : The FASEB Journal. 32, 12, p. 6923-6933 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice

Reichenbach, A., Mequinion, M., Bayliss, J. A., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Stark, R. & Andrews, Z. B., 1 Jun 2018, In : Endocrinology. 159, 6, p. 2473-2483 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

Lockie, S. H., Stark, R., Mequinion, M., Ch'ng, S., Kong, D., Spanswick, D. C., Lawrence, A. J. & Andrews, Z. B., 1 Nov 2018, In : Endocrinology. 159, 11, p. 3605-3614 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2017

Food seeking in a risky environment: A method for evaluating risk and reward value in food seeking and consumption in mice

Lockie, S. H., McAuley, C. V., Rawlinson, S., Guiney, N. & Andrews, Z. B., 30 Jan 2017, In : Frontiers in Neuroscience. 11, 1 p., 24.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)
2016

Des-acyl ghrelin and ghrelin O-acyltransferase regulate hypothalamic-pituitary-adrenal axis activation and anxiety in response to acute stress

Stark, R., Santos, V. V., Geenen, B., Cabral, A., Dinan, T., Bayliss, J. A., Lockie, S. H., Reichenbach, A., Lemus, M. B., Perello, M., Spencer, S. J., Kozicz, T. & Andrews, Z. B., Oct 2016, In : Endocrinology. 157, 10, p. 3946-3957 12 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2015

Acyl ghrelin acts in the brain to control liver function and peripheral glucose homeostasis in male mice

Stark, R., Reichenbach, A., Lockie, S. K. H., Pracht, C., Wu, Q., Tups, A. & Andrews, Z. B., 2015, In : Endocrinology. 156, 3, p. 858 - 868 11 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Combination cannabinoid and opioid receptor antagonists improves metabolic outcomes in obese mice

Lockie, S. K. H., Stefanidis, A., Tschop, M. H. & Oldfield, B. J., 2015, In : Molecular and Cellular Endocrinology. 417, p. 10 - 19 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Diet-induced obesity causes ghrelin resistance in reward processing tasks

Lockie, S. K. H., Dinan, T., Lawrence, A. J., Spencer, S. J. & Andrews, Z. B., 2015, In : Psychoneuroendocrinology. 62, p. 114 - 120 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
32 Citations (Scopus)

Neonatal ghrelin programs development of hypothalamic feeding circuits

Steculorum, S. M., Collden, G., Coupe, B., Croizier, S., Lockie, S., Andrews, Z. B., Jarosch, F., Klussmann, S. & Bouret, S. G., 2 Feb 2015, In : Journal of Clinical Investigation. 125, 2, p. 846-858 13 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)
2014

Evidence that diet-induced hyperleptinemia, but not hypothalamic gliosis, causes ghrelin resistance in NPY/AgRP neurons of male mice

Briggs, D. I., Lockie, S. K. H., Benzler, J., Wu, Q., Stark, R., Reichenbach, A., Hoy, A. J., Lemus, M. B., Coleman, H. A., Parkington, H. C., Tups, A. & Andrews, Z. B., 2014, In : Endocrinology. 155, 7, p. 2411 - 2422 12 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

The temporal pattern of cfos activation in hypothalamic, cortical, and brainstem nuclei in response to fasting and refeeding in male mice

Wu, Q., Lemus, M. B., Stark, R., Bayliss, J., Reichenbach, A., Lockie, S. K. H. & Andrews, Z. B., 2014, In : Endocrinology. 155, 3, p. 840 - 853 14 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Calorie-restricted weight loss reverses high-fat diet-induced ghrelin resistance, which contributes to rebound weight gain in a ghrelin-dependent manner

Briggs, D. I., Lockie, S. K. H., Wu, Q., Lemus, M. B., Stark, R. & Andrews, Z. B., 2013, In : Endocrinology. 154, 2, p. 709 - 717 9 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Glucagon-like peptide-1 receptor in the brain: role in neuroendocrine control of energy metabolism and treatment target for obesity

Lockie, S. K. H., 2013, In : Journal of Neuroendocrinology. 25, 7, p. 597 - 604 8 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The hormonal signature of energy deficit: increasing the value of food reward

Lockie, S. K. H. & Andrews, Z. B., 2013, In : Molecular Metabolism. 2, 4, p. 329 - 336 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
31 Citations (Scopus)

Unimolecular dual incretins maximize metabolic benefits in rodents, monkeys, and humans

Finan, B., Ma, T., Ottaway, N., Muller, T. D., Habegger, K., Heppner, K., Kirchner, H., Holland, J., Hembree, J., Raver, C., Lockie, S. K. H., Smiley, D., Gelfanov, V., Yang, B., Hofmann, S., Bruemmer, D., Drucker, D. J., Pfluger, P. T., Perez-Tilve, D., Gidda, J. & 13 others, Vignati, L., Zhang, L., Hauptman, J. B., Lau, M., Brecheisen, M., Uhles, S., Riboulet, W., Hainaut, E., Sebokova, E., Conde-Knape, K., Konkar, A., DiMarchi, R. & Tschop, M. H., 2013, In : Science Translational Medicine. 5, 209 (Art. No.: 209ra151), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

229 Citations (Scopus)
2012

Activation of thermogenesis in brown adipose tissue and dysregulated lipid metabolism associated with cancer cachexia in mice

Tsoli, M., Moore, M., Burg, D., Painter, A., Taylor, R., Lockie, S. K. H., Turner, N., Warren, A., Cooney, G. J., Oldfield, B. J., Clarke, S. & Robertson, G., 2012, In : Cancer Research. 72, 17, p. 4372 - 4382 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
65 Citations (Scopus)

Direct control of brown adipose tissue thermogenesis by central nervous system glucagon-like peptide-1 receptor signaling

Lockie, S. K. H., Heppner, K. M., Chaudhary, N., Chabenne, J. R., Morgan, D. A., Veyrat-Durebex, C., Ananthakrishnan, G., Rohner-Jeanrenaud, F., Drucker, D. J., DiMarchi, R., Rahmouni, K., Oldfield, B. J., Tschop, M. H. & Perez-Tilve, D., 2012, In : Diabetes. 61, 11, p. 2753 - 2762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

127 Citations (Scopus)

Neural and humoral changes associated with the adjustable gastric band: insights from a rodent model

Kampe, J., Stefanidis, A., Lockie, S. K. H., Brown, W. A., Dixon, J., Odoi, A., Spencer, S. J., Raven, J. & Oldfield, B. J., 2012, In : International Journal of Obesity. 36, 11, p. 1403 - 1411 9 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2011

CNS opioid signaling separates cannabinoid receptor 1-mediated effects on body weight and mood-related behavior in mice

Lockie, S. K. H., Czyzyk, T. A., Chaudhary, N., Perez-Tilve, D., Woods, S. C., Oldfield, B. J., Statnick, M. A. & Tschop, M. H., 2011, In : Endocrinology. 152, 10, p. 3661 - 3667 7 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Ghrelin-induced adiposity is independent of orexigenic effects

Perez-Tilve, D., Heppner, K., Kirchner, H., Lockie, S. K. H., Woods, S., Smiley, D., Tschop, M. & Pfluger, P., 2011, In : The FASEB Journal. 25, 8, p. 2814 - 2822 9 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)
2010

CNS leptin action modulates immune response and survival in sepsis

Tschop, J., Nogueiras, R., Lockie, S. K. H., Kasten, K. R., Castaneda, T. R., Huber, N., Guanciale, K., Perez-Tilve, D., Habegger, K., Ottaway, N., Woods, S. C., Oldfield, B., Clarke, I., Chua Jr., S., Farooqi, I. S., O'Rahilly, S., Caldwell, C. C. & Tschop, M. H., 2010, In : Journal of Neuroscience. 30, 17, p. 6036 - 6047 12 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)
2009

A new glucagon and GLP-1 co-agonist eliminates obesity in rodents

Day, J., Ottaway, N., Patterson, J., Gelfanov, V., Smiley, D., Gidda, J., Findeisen, H., Bruemmer, D., Drucker, D. J., Chaudhary, N., Holland, J., Hembree, J., Abplanalp, W., Grant, E., Ruehl, J., Wilson, H., Kirchner, H., Lockie, S. K. H., Hofmann, S., Woods, S. C. & 5 others, Nogueiras, R., Pfluger, P. T., Perez-Tilve, D., DiMarchi, R. & Tschop, M. H., 2009, In : Nature Chemical Biology. 5, 10, p. 749 - 757 9 p.

Research output: Contribution to journalArticleResearchpeer-review

329 Citations (Scopus)

The endocannabinoid system: role in glucose and energy metabolism

Nogueiras, R., Diaz-Arteaga, A., Lockie, S. K. H., Velasquez, D. A., Tschop, J., Lopez, M., Cadwell, C. C., Dieguez, C. & Tschop, M. H., 2009, In : Pharmacological Research. 60, 2, p. 93 - 98 6 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)