Projects per year
Personal profile
Biography
Sarah completed her PhD in 2012 with joint supervision between Monash University, Australia and the University of Cincinnati, OH, USA. She has published on a number of aspects of metabolic homeostasis in mice, including neural control of feeding, ghrelin resistance in obesity, efficacy and side effects of antiobesity drugs, central control of brown adipose tissue thermogenesis, and reward pathway control of feeding and motivation. Her current research interest are focused on loss of appetite in conditions such as cancer cachexia, and severe food avoidance, and how hunger-regulating circuits interact with higher order brain areas to control functions such as memory, motivation and mood-related behaviours. She heads the Appetite and Behavioural Control Group within the Metabolism, Diabetes and Obesity theme in the Monash Biomedicine Discovery Institute.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Metabolic neuroscience
- endocannabinoids
- obesity
- glucose metabolism
- ghrelin
- AgRP neurons
- GFRAL neurons
- GDF15
- Cancer cachexia
- Anxiety
- GLP-1
- Glucagon
- Hypothalamus
- Ventral tegmental area
Collaborations and top research areas from the last five years
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NHMRC Equipment Grant - Danish Myo-Technology Organ Bath 820MO and electrical stimulator
Rose, A., Mitchell, C., Tiganis, T., Mcgrath, M., Lockie, S., Harrison, C. & Eynon, N.
1/11/23 → 31/12/24
Project: Research
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Targeting the brain and sympathetic nervous system to improve outcomes in cancer cachexia
Lockie, S., Walton, K., Andrews, Z., Stark, R., Oldfield, B., Sloan, E. & Gregorevic, P.
1/01/22 → 31/12/25
Project: Research
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Therapeutic approaches for autonomic and neuroendocrine dysfunction in cancer cachexia
Grossberg, A., Lockie, S., Habecker, B. & Zhu, X.
10/09/21 → 31/08/26
Project: Research
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Acute inhibition of hunger-sensing AgRP neurons promotes context-specific learning in mice
Reed, F., Reichenbach, A., Dempsey, H., Clarke, R. E., Mequinion, M., Stark, R., Rawlinson, S., Foldi, C. J., Lockie, S. H. & Andrews, Z. B., Nov 2023, In: Molecular Metabolism. 77, 13 p., 101803.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Identification of a Stress-Sensitive Anorexigenic Neurocircuit From Medial Prefrontal Cortex to Lateral Hypothalamus
Clarke, R. E., Voigt, K., Reichenbach, A., Stark, R., Bharania, U., Dempsey, H., Lockie, S. H., Mequinion, M., Lemus, M., Wei, B., Reed, F., Rawlinson, S., Nunez-Iglesias, J., Foldi, C. J., Kravitz, A. V., Verdejo-Garcia, A. & Andrews, Z. B., 15 Feb 2023, In: Biological Psychiatry. 93, 4, p. 309-321 13 p.Research output: Contribution to journal › Article › Research › peer-review
6 Citations (Scopus) -
Appetite to learn: An allostatic role for AgRP neurons in the maintenance of energy balance
Reed, F., Lockie, S. H., Reichenbach, A., Foldi, C. J. & Andrews, Z. B., Jun 2022, In: Current Opinion in Endocrine and Metabolic Research. 24, 13 p., 100337.Research output: Contribution to journal › Review Article › Research › peer-review
5 Citations (Scopus) -
In Vivo Photometry Reveals Insulin and 2-Deoxyglucose Maintain Prolonged Inhibition of VMH Vglut2 Neurons in Male Mice
Rawlinson, S., Reichenbach, A., Clarke, R. E., Nuñez-Iglesias, J., Dempsey, H., Lockie, S. H. & Andrews, Z. B., 1 Aug 2022, In: Endocrinology. 163, 8, p. 1-11 11 p., bqac095.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum
Reichenbach, A., Clarke, R. E., Stark, R., Lockie, S. H., Mequinion, M., Dempsey, H., Rawlinson, S., Reed, F., Sepehrizadeh, T., Deveer, M., Munder, A. C., Nunez-Iglesias, J., Spanswick, D. C., Mynatt, R., Kravitz, A. V., Dayas, C. V., Brown, R. & Andrews, Z. B., Jan 2022, In: eLife. 11, 24 p., e72668.Research output: Contribution to journal › Article › Research › peer-review
Open Access27 Citations (Scopus)
Prizes
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Harold Mitchell ECR travel fellowship
Lockie, Sarah (Recipient), 2 Aug 2018
Prize: Prize (including medals and awards)
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Vice Chancellor's Commendation for Doctoral Thesis Excellence
Lockie, Sarah (Recipient), 6 Dec 2012
Prize: Prize (including medals and awards)
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Young Investigator Prize
Lockie, Sarah (Recipient), 15 Sept 2015
Prize: Prize (including medals and awards)
Press/Media
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So you think you can pitch? competition
Jennifer Payne, Sri Ramarathinam, Sarah Lockie & Amlan Chakraborty
16/12/20
1 item of Media coverage
Press/Media: Article/Feature