Projects per year
Personal profile
Biography
I completed my PhD in 2012 with joint supervision between Monash University, Australia and the University of Cincinnati, OH, USA. I have published on a number of aspects of metabolic homeostasis in mice, including neural control of feeding, ghrelin resistance in obesity, efficacy and side effects of antiobesity drugs, central control of brown adipose tissue thermogenesis, and reward pathway control of feeding and motivation. I having worked extensively on site-specific brain cannulations and tracer injections. I have an exceptional working knowledge of mouse brain anatomy and a deep, critical understanding of mouse behaviour work.
My current research interest are focued on loss of appetite in conditions such as cancer cachexia, and severe food avoidance, and how hunger-regulating circuits control other functions such as motivation and mood-related behaviours.
Keywords
- Metabolic neuroscience
- endocannabinoids
- obesity
- glucose metabolism
- ghrelin
- AgRP neurons
- GFRAL neurons
- GDF15
- Cancer cachexia
- Anxiety
- GLP-1
- Glucagon
- Hypothalamus
- Ventral tegmental area
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2014 2021
Defining reciprocal neural circuits that regulate appetite and memory
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
The Neurocircuitry of Food Choice in Obesity
Verdejo-Garcia, A., Andrews, Z., Lockie, S. & Harding, I.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/21
Project: Research
Research Output 2009 2019
Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area
Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., 11 Feb 2019, (Accepted/In press) In : Journal of Neuroendocrinology. 6 p., e12696.Research output: Contribution to journal › Article › Research › peer-review
AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning
Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction
Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S. & Andrews, Z. B., 1 Dec 2018, In : FASEB Journal. 32, 12, p. 6923-6933 11 p.Research output: Contribution to journal › Article › Research › peer-review
Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice
Reichenbach, A., Mequinion, M., Bayliss, J. A., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Stark, R. & Andrews, Z. B., 1 Jun 2018, In : Endocrinology. 159, 6, p. 2473-2483 11 p.Research output: Contribution to journal › Article › Research › peer-review
Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons
Lockie, S. H., Stark, R., Mequinion, M., Ch'ng, S., Kong, D., Spanswick, D. C., Lawrence, A. J. & Andrews, Z. B., 1 Nov 2018, In : Endocrinology. 159, 11, p. 3605-3614 10 p.Research output: Contribution to journal › Article › Research › peer-review
Prizes
Harold Mitchell ECR travel fellowship
Sarah Lockie (Recipient), 2 Aug 2018
Prize: Prize (including medals and awards)
Vice Chancellor's Commendation for Doctoral Thesis Excellence
Sarah Lockie (Recipient), 6 Dec 2012
Prize: Prize (including medals and awards)
Young Investigator Prize
Sarah Lockie (Recipient), 15 Sep 2015
Prize: Prize (including medals and awards)