Sarah Lockie

Dr

Accepting PhD Students

20092021
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Personal profile

Biography

I completed my PhD in 2012 with joint supervision between Monash University, Australia and the University of Cincinnati, OH, USA. I have published on a number of aspects of metabolic homeostasis in mice, including neural control of feeding, ghrelin resistance in obesity, efficacy and side effects of antiobesity drugs, central control of brown adipose tissue thermogenesis, and reward pathway control of feeding and motivation. I  having worked extensively on site-specific brain cannulations and tracer injections. I have an exceptional working knowledge of mouse brain anatomy and a deep, critical understanding of mouse behaviour work. 

My current research interest are focued on loss of appetite in conditions such as cancer cachexia, and severe food avoidance, and how hunger-regulating circuits control other functions such as motivation and mood-related behaviours. 

Keywords

  • Metabolic neuroscience
  • endocannabinoids
  • obesity
  • glucose metabolism
  • ghrelin
  • AgRP neurons
  • GFRAL neurons
  • GDF15
  • Cancer cachexia
  • Anxiety
  • GLP-1
  • Glucagon
  • Hypothalamus
  • Ventral tegmental area

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Projects 2014 2021

Research Output 2009 2019

Glucose availability regulates ghrelin-induced food intake in the ventral tegmental area

Lockie, S. H., Stark, R., Spanswick, D. C. & Andrews, Z. B., 11 Feb 2019, (Accepted/In press) In : Journal of Neuroendocrinology. 6 p., e12696.

Research output: Contribution to journalArticleResearchpeer-review

AgRP Neurons Require Carnitine Acetyltransferase to Regulate Metabolic Flexibility and Peripheral Nutrient Partitioning

Reichenbach, A., Stark, R., Mequinion, M., Denis, R. R. G., Goularte, J. F., Clarke, R. E., Lockie, S. H., Lemus, M. B., Kowalski, G. M., Bruce, C. R., Huang, C., Schittenhelm, R. B., Mynatt, R. L., Oldfield, B. J., Watt, M. J., Luquet, S. & Andrews, Z. B., 13 Feb 2018, In : Cell Reports. 22, 7, p. 1745-1759 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Carnitine acetyltransferase (Crat) in hunger-sensing AgRP neurons permits adaptation to calorie restriction

Reichenbach, A., Stark, R., Mequinion, M., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Luquet, S. & Andrews, Z. B., 1 Dec 2018, In : FASEB Journal. 32, 12, p. 6923-6933 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Carnitine Acetyltransferase in AgRP Neurons Is Required for the Homeostatic Adaptation to Restricted Feeding in Male Mice

Reichenbach, A., Mequinion, M., Bayliss, J. A., Lockie, S. H., Lemus, M. B., Mynatt, R. L., Stark, R. & Andrews, Z. B., 1 Jun 2018, In : Endocrinology. 159, 6, p. 2473-2483 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Glucose Availability Predicts the Feeding Response to Ghrelin in Male Mice, an Effect Dependent on AMPK in AgRP Neurons

Lockie, S. H., Stark, R., Mequinion, M., Ch'ng, S., Kong, D., Spanswick, D. C., Lawrence, A. J. & Andrews, Z. B., 1 Nov 2018, In : Endocrinology. 159, 11, p. 3605-3614 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Harold Mitchell ECR travel fellowship

Sarah Lockie (Recipient), 2 Aug 2018

Prize: Prize (including medals and awards)

Vice Chancellor's Commendation for Doctoral Thesis Excellence

Sarah Lockie (Recipient), 6 Dec 2012

Prize: Prize (including medals and awards)

Young Investigator Prize

Sarah Lockie (Recipient), 15 Sep 2015

Prize: Prize (including medals and awards)