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Research Output 2007 2019

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2019

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Casillas-Espinosa, P. M., Shultz, S. R., Braine, E. L., Jones, N. C., Snutch, T. P., Powell, K. L. & O'Brien, T. J., 13 Aug 2019, (Accepted/In press) In : Progress in Neurobiology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ndode-Ekane, X. E., Santana-Gomez, C., Casillas-Espinosa, P. M., Ali, I., Brady, R. D., Smith, G., Andrade, P., Immonen, R., Puhakka, N., Hudson, M. R., Braine, E. L., Shultz, S. R., Staba, R. J., O'Brien, T. J. & Pitkänen, A., 1 Mar 2019, In : Epilepsy Research. 151, p. 7-16 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Santana-Gomez, C., Andrade, P., Hudson, M. R., Paananen, T., Ciszek, R., Smith, G., Ali, I., Rundle, B. K., Ndode-Ekane, X. E., Casillas-Espinosa, P. M., Immonen, R., Puhakka, N., Jones, N., Brady, R. D., Perucca, P., Shultz, S. R., Pitkänen, A., O'Brien, T. J. & Staba, R., Oct 2019, In : Epilepsy Research. 156, 8 p., 106110.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R., Smith, G., Brady, R. D., Wright, D., Johnston, L., Harris, N. G., Manninen, E., Salo, R., Branch, C., Duncan, D., Cabeen, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Shultz, S. R., Andrade, P., Puhakka, N., Staba, R. J., O'Brien, T. J. & 3 others, Toga, A. W., Pitkänen, A. & Gröhn, O., 1 Feb 2019, In : Epilepsy Research. 150, p. 46-57 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Kamnaksh, A., Puhakka, N., Ali, I., Smith, G., Aniceto, R., McCullough, J., Das Gupta, S., Ndode-Ekane, X. E., Brady, R., Casillas-Espinosa, P., Hudson, M., Santana-Gomez, C., Immonen, R., Abreu, P. A. D., Jones, N., Shultz, S., Staba, R. J., O'Brien, T. J., Agoston, D. & Pitkänen, A., 1 Jan 2019, In : Epilepsy Research. 149, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Casillas-Espinosa, P. M., Andrade, P., Santana-Gomez, C., Paananen, T., Smith, G., Ali, I., Ciszek, R., Ndode-Ekane, X. E., Brady, R. D., Tohka, J., Hudson, M. R., Perucca, P., Braine, E. L., Immonen, R., Puhakka, N., Shultz, S. R., Jones, N. C., Staba, R. J., Pitkänen, A. & O'Brien, T. J., Oct 2019, In : Epilepsy Research. 156, 10 p., 106131.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial–Astrocytic Crosstalk

Clark, D. P. Q., Perreau, V. M., Shultz, S. R., Brady, R. D., Lei, E., Dixit, S., Taylor, J. M., Beart, P. M. & Boon, W. C., 1 Jun 2019, In : Neurochemical Research. 44, 6, p. 1410–1424 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ciszek, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Smith, G., Puhakka, N., Lapinlampi, N., Andrade, P., Kamnaksh, A., Immonen, R., Paananen, T., Hudson, M. R., Brady, R. D., Shultz, S. R., O'Brien, T. J., Staba, R. J., Tohka, J. & Pitkänen, A., 1 Feb 2019, In : Epilepsy Research. 150, p. 17-26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitory neuronal changes following a mixed diffuse-focal model of traumatic brain injury

Carron, S. F., Sun, M., Shultz, S. R. & Rajan, R., 25 Jul 2019, (Accepted/In press) In : Journal of Comparative Neurology. 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Mild closed-head injury in conscious rats causes transient neurobehavioral and glial disturbances: A novel experimental model of concussion

Pham, L., Shultz, S. R., Kim, H. A., Brady, R., Wortman, R. C., Genders, S. G., Hale, M. W., O'Shea, R., Djouma, E., van den Buuse, M., Church, J. E., Christie, B. R., Drummond, G., Sobey, C. G. & McDonald, S., 15 Jul 2019, In : Journal of Neurotrauma. 36, 14, p. 2260-2271 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Ozturk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P., Jones, N. C., Crack, P. J., O'Brien, T. J. & Semple, B. D., 1 Oct 2019, In : Experimental Neurology. 320, 14 p., 112979.

Research output: Contribution to journalArticleResearchpeer-review

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Tan, X. L., Sun, M., Brady, R. D., Liu, S., Llanos, R. M., Cheung, S., Wright, D. K., Casillas-Espinosa, P. M., Sashindranath, M., O'Brien, T. J., McDonald, S. J., Turner, B. J. & Shultz, S., 1 Jan 2019, In : Journal of Neurotrauma. 36, 1, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A concomitant muscle injury does not worsen traumatic brain injury outcomes in mice

Sun, M., Brady, R. D., Poel, C. V. D., Apted, D., Semple, B. D., Church, J. E., O'Brien, T. J., McDonald, S. J. & Shultz, S. R., 11 Dec 2018, In : Frontiers in Neurology. 9, 11 p., 1089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Concussion incidence in amateur Australian Rules Footballers

Costello, D. M., Ernest, J., Kaye, A. H., O'Brien, T. J. & Shultz, S. R., 1 Oct 2018, In : Journal of Clinical Neuroscience. 56, p. 88-89 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Wortman, R. C., Meconi, A., Neale, K. J., Brady, R. D., McDonald, S. J., Christie, B. R., Wright, D. K. & Shultz, S. R., 1 Dec 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1588-1598 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice

McAllister, B. B., Wright, D. K., Wortman, R. C., Shultz, S. R. & Dyck, R. H., 1 Nov 2018, In : Neurobiology of Stress. 9, p. 199-213 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice

Johnstone, M. R., Sun, M., Taylor, C. J., Brady, R. D., Grills, B. L., Church, J. E., Shultz, S. R. & McDonald, S. J., 28 Jan 2018, In : Brain Injury. 32, 2, p. 257-268 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mild traumatic brain injury in adolescent mice alters skull bone properties to influence a subsequent brain impact at adulthood: A pilot study

McColl, T. J., Brady, R. D., Shultz, S. R., Lovick, L., Webster, K. M., Sun, M., McDonald, S. J., O'Brien, T. J. & Semple, B. D., 25 May 2018, In : Frontiers in Neurology. 9, 15 p., 372.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Meconi, A., Wortman, R. C., Wright, D. K., Neale, K. J., Clarkson, M., Shultz, S. R. & Christie, B. R., 1 May 2018, In : PLoS ONE. 13, 5, 24 p., e0197187.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Open Access
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2017

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Liu, S., Shen, Y., Shultz, S. R., Nguyen, A., Hovens, C., Adlard, P. A., Bush, A. I., Chan, J., Kwan, P., O'Brien, T. J. & Jones, N. C., 1 Sep 2017, In : Epilepsia. 58, 9, p. e136-e141 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

Wright, D. K., Johnston, L. A., Kershaw, J., Ordidge, R., O'Brien, T. J. & Shultz, S. R., 1 Jul 2017, In : Journal of Neurotrauma. 34, 13, p. 2109-2118 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

Sharma, P., Wright, D. K., Johnston, L. A., Powell, K. L., Wlodek, M. E., Shultz, S. R., O'Brien, T. J. & Gilby, K. L., 1 Aug 2017, In : Neurobiology of Disease. 104, p. 33-40 8 p.

Research output: Contribution to journalArticleResearchpeer-review

MR spectroscopy findings in retired professional rugby league players

Gardner, A. J., Iverson, G. L., Wojtowicz, M., Levi, C. R., Kay-Lambkin, F., Schofield, P. W., Zafonte, R., Shultz, S. R., Lin, A. P. & Stanwell, P., 1 Mar 2017, In : International Journal of Sports Medicine. 38, 3, p. 241-252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Semple, B. D., Dixit, S., Shultz, S. R., Boon, W. C. & O'Brien, T. J., 15 Feb 2017, In : Behavioural Brain Research. 319, p. 48-62 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex matters: repetitive mild traumatic brain injury in adolescent rats

Wright, D. K., O'Brien, T. J., Shultz, S. R. & Mychasiuk, R., 1 Sep 2017, In : Annals of Clinical and Translational Neurology. 4, 9, p. 640-654 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Traumatic brain injury results in cellular, structural and functional changes resembling motor neuron disease

Wright, D. K., Liu, S., Van Der Poel, C., McDonald, S. J., Brady, R. D., Taylor, L., Yang, L., Gardner, A. J., Ordidge, R., O'Brien, T. J., Johnston, L. A. & Shultz, S. R., 2017, In : Cerebral Cortex. 27, 9, p. 4503-4515 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

Wright, D. K., Trezise, J., Kamnaksh, A., Bekdash, R., Johnston, L. A., Ordidge, R., Semple, B. D., Gardner, A. J., Stanwell, P., O'Brien, T. J., Agoston, D. V. & Shultz, S. R., 28 Jun 2016, In : Scientific Reports. 6, 16 p., 28713.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fracture

Brady, R. D., Grills, B. L., Church, J. E., Walsh, N. C., McDonald, A. C., Agoston, D. V., Sun, M., O'Brien, T. J., Shultz, S. R. & McDonald, S. J., 29 Sep 2016, In : Scientific Reports. 6, 9 p., 34491.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

Minter, M. R., Moore, Z., Zhang, M., Brody, K. M., Jones, N. C., Shultz, S. R., Taylor, J. M. & Crack, P. J., 11 Jul 2016, In : Acta neuropathologica communications. 4, 1, 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Experimental traumatic brain injury induces bone loss in rats

Brady, R. D., Shultz, S. R., Sun, M., Romano, T., Van Der Poel, C., Wright, D. K., Wark, J. D., O'Brien, T. J., Grills, B. L. & McDonald, S. J., 1 Dec 2016, In : Journal of Neurotrauma. 33, 23, p. 2154-2160 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities

Sharma, P., Dedeurwaerdere, S., Vandenberg, M. A. D., Fang, K., Johnston, L. A., Shultz, S. R., O'Brien, T. J. & Gilby, K. L., 1 Dec 2016, In : Epilepsy & Behavior. 65, p. 42-48 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Sodium selenate, a protein phosphatase 2A activator, mitigates hyperphosphorylated tau and improves repeated mild traumatic brain injury outcomes

Tan, X. L., Wright, D. K., Liu, S., Hovens, C., O'Brien, T. J. & Shultz, S. R., 1 Sep 2016, In : Neuropharmacology. 108, p. 382-393 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Sodium selenate retards epileptogenesis in acquired epilepsy models reversing changes in protein phosphatase 2A and hyperphosphorylated tau

Liu, S. J., Zheng, P., Wright, D. K., Dezsi, G., Braine, E., Nguyen, T., Corcoran, N. M., Johnston, L. A., Hovens, C. M., Mayo, J. N., Hudson, M., Shultz, S. R., Jones, N. C. & O'Brien, T. J., 1 Jul 2016, In : Brain. 139, 7, p. 1919-1938 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Sodium selenate treatment mitigates reduction of bone volume following traumatic brain injury in rats

Brady, R. D., Grills, B. L., Romano, T., Wark, J. D., O’Brien, T. J., Shultz, S. R. & McDonald, S. J., 1 Dec 2016, In : Journal of Musculoskeletal Neuronal Interactions. 16, 4, p. 369-376 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A preliminary video analysis of concussion in the National Rugby League

Gardner, A. J., Iverson, G. L., Quinn, T. N., Makdissi, M., Levi, C. R., Shultz, S. R., Wright, D. K. & Stanwell, P., 24 Aug 2015, In : Brain Injury. 29, 10, p. 1182-1185 4 p.

Research output: Contribution to journalArticleResearchpeer-review

CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats

Weaver, L. C., Bao, F., Dekaban, G. A., Hryciw, T., Shultz, S. R., Cain, D. P. & Brown, A., 1 Sep 2015, In : Experimental Neurology. 271, p. 409-422 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Sodium selenate reduces hyperphosphorylated tau and improves outcomes after traumatic brain injury

Schultz, S. R., Wright, D. K., Zheng, P., Stuchbery, R., Liu, S-J., Sashindranath, M., Medcalf, R. L., Johnston, L. A., Hovens, C. M., Jones, N. C. & O'Brien, T. J., 2015, In : Brain. 138, 5, p. 1297 - 1313 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitrauma

Shultz, S. R., Sun, M., Wright, D. K., Brady, R. D., Liu, S., Beynon, S., Schmidt, S. F., Kaye, A. H., Hamilton, J. A., O'Brien, T. J., Grills, B. L. & McDonald, S., 2015, In : Journal of Cerebral Blood Flow and Metabolism. 35, p. 1339-1347 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

Shultz, S. R., Tan, X. L., Wright, D. K., Liu, S. J., Semple, B. D., Johnston, L., Jones, N. C., Cook, A. D., Hamilton, J. A. & O'Brien, T. J., 15 May 2014, In : Journal of Neurotrauma. 31, 10, p. 976-983 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The acute phase of mild traumatic brain injury is characterized by a distance-dependent neuronal hypoactivity

Johnstone, V. P. A., Shultz, S., Yan, E. B., O'Brien, T. J. & Rajan, R., 2014, In : Journal of Neurotrauma. 31, 22, p. 1881 - 1895 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Workshop on neurobiology of epilepsy appraisal: New systemic imaging technologies to study the brain in experimental models of epilepsy

Dedeurwaerdere, S., Shultz, S. R., Federico, P. & Engel, J., 1 Jan 2014, In : Epilepsia. 55, 6, p. 819-828 10 p.

Research output: Contribution to journalArticleOtherpeer-review