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Research Output 2007 2019

2019

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R. & Jones, N. C., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 27-41 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Disease-modifying effects of a novel T-type calcium channel antagonist, Z944, in a model of temporal lobe epilepsy

Casillas-Espinosa, P. M., Shultz, S. R., Braine, E. L., Jones, N. C., Snutch, T. P., Powell, K. L. & O'Brien, T. J., 13 Aug 2019, (Accepted/In press) In : Progress in Neurobiology. 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study

Tubi, M. A., Lutkenhoff, E., Blanco, M. B., McArthur, D., Villablanca, P., Ellingson, B., Diaz-Arrastia, R., Van Ness, P., Real, C., Shrestha, V., Engel, J., Vespa, P. M., EpiBioS4Rx Study Group Investigators, Agoston, D., Au, A., Bell, M. J., Bleck, T., Branch, C., Buitrago Blanco, M., Bullock, R. & 41 others, Burrows, B. T., Claassen, J., Clarke, R., Cloyd, J., Coles, L., Crawford, K., Diaz-Arrastia, R., Duncan, D., Ellingson, B., Engel, J., Foreman, B., Galanopoulou, A., Gilmore, E., Olli, G., Harris, N., Hartings, J., Lawrence, H., Hunn, M., Jette, N., Johnston, L., Jones, N., Kanner, A., McArthur, D., Monti, M., Morokoff, A., Moshe, S., Mowrey, W., O'Brien, T., O'Phelan, K., Pitkanen, A., Raman, R., Robertson, C., Rosenthal, E., Shultz, S., Snutch, T., Staba, R., Toga, A., Van Horn, J., Vespa, P., Willyerd, F. & Zimmermann, L., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 115-121 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Harmonization of lateral fluid-percussion injury model production and post-injury monitoring in a preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ndode-Ekane, X. E., Santana-Gomez, C., Casillas-Espinosa, P. M., Ali, I., Brady, R. D., Smith, G., Andrade, P., Immonen, R., Puhakka, N., Hudson, M. R., Braine, E. L., Shultz, S. R., Staba, R. J., O'Brien, T. J. & Pitkänen, A., 1 Mar 2019, In : Epilepsy Research. 151, p. 7-16 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for detection of HFOs in a rat model of post-traumatic epilepsy in preclinical multicenter study on post-traumatic epileptogenesis

Santana-Gomez, C., Andrade, P., Hudson, M. R., Paananen, T., Ciszek, R., Smith, G., Ali, I., Rundle, B. K., Ndode-Ekane, X. E., Casillas-Espinosa, P. M., Immonen, R., Puhakka, N., Jones, N., Brady, R. D., Perucca, P., Shultz, S. R., Pitkänen, A., O'Brien, T. J. & Staba, R., Oct 2019, In : Epilepsy Research. 156, 8 p., 106110.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis

Immonen, R., Smith, G., Brady, R. D., Wright, D., Johnston, L., Harris, N. G., Manninen, E., Salo, R., Branch, C., Duncan, D., Cabeen, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Shultz, S. R., Andrade, P., Puhakka, N., Staba, R. J., O'Brien, T. J. & 3 others, Toga, A. W., Pitkänen, A. & Gröhn, O., 1 Feb 2019, In : Epilepsy Research. 150, p. 46-57 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of pipeline for preclinical multicenter plasma protein and miRNA biomarker discovery in a rat model of post-traumatic epileptogenesis

Kamnaksh, A., Puhakka, N., Ali, I., Smith, G., Aniceto, R., McCullough, J., Das Gupta, S., Ndode-Ekane, X. E., Brady, R., Casillas-Espinosa, P., Hudson, M., Santana-Gomez, C., Immonen, R., Abreu, P. A. D., Jones, N., Shultz, S., Staba, R. J., O'Brien, T. J., Agoston, D. & Pitkänen, A., 1 Jan 2019, In : Epilepsy Research. 149, p. 92-101 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Harmonization of the pipeline for seizure detection to phenotype post-traumatic epilepsy in a preclinical multicenter study on post-traumatic epileptogenesis

Casillas-Espinosa, P. M., Andrade, P., Santana-Gomez, C., Paananen, T., Smith, G., Ali, I., Ciszek, R., Ndode-Ekane, X. E., Brady, R. D., Tohka, J., Hudson, M. R., Perucca, P., Braine, E. L., Immonen, R., Puhakka, N., Shultz, S. R., Jones, N. C., Staba, R. J., Pitkänen, A. & O'Brien, T. J., Oct 2019, In : Epilepsy Research. 156, 10 p., 106131.

Research output: Contribution to journalArticleResearchpeer-review

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Sharma, R., Shultz, S. R., Robinson, M. J., Belli, A., Hibbs, M. L., O'Brien, T. J. & Semple, B. D., Jul 2019, In : Brain, Behavior, and Immunity. 79, p. 63-74 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Inflammation in Traumatic Brain Injury: Roles for Toxic A1 Astrocytes and Microglial–Astrocytic Crosstalk

Clark, D. P. Q., Perreau, V. M., Shultz, S. R., Brady, R. D., Lei, E., Dixit, S., Taylor, J. M., Beart, P. M. & Boon, W. C., 1 Jun 2019, In : Neurochemical Research. 44, 6, p. 1410–1424 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Informatics tools to assess the success of procedural harmonization in preclinical multicenter biomarker discovery study on post-traumatic epileptogenesis

Ciszek, R., Ndode-Ekane, X. E., Gomez, C. S., Casillas-Espinosa, P. M., Ali, I., Smith, G., Puhakka, N., Lapinlampi, N., Andrade, P., Kamnaksh, A., Immonen, R., Paananen, T., Hudson, M. R., Brady, R. D., Shultz, S. R., O'Brien, T. J., Staba, R. J., Tohka, J. & Pitkänen, A., 1 Feb 2019, In : Epilepsy Research. 150, p. 17-26 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibitory neuronal changes following a mixed diffuse-focal model of traumatic brain injury

Carron, S. F., Sun, M., Shultz, S. R. & Rajan, R., 25 Jul 2019, (Accepted/In press) In : Journal of Comparative Neurology. 24 p.

Research output: Contribution to journalArticleResearchpeer-review

Mild closed-head injury in conscious rats causes transient neurobehavioral and glial disturbances: A novel experimental model of concussion

Pham, L., Shultz, S. R., Kim, H. A., Brady, R., Wortman, R. C., Genders, S. G., Hale, M. W., O'Shea, R., Djouma, E., van den Buuse, M., Church, J. E., Christie, B. R., Drummond, G., Sobey, C. G. & McDonald, S., 15 Jul 2019, In : Journal of Neurotrauma. 36, 14, p. 2260-2271 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Ozturk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P., Jones, N. C., Crack, P. J., O'Brien, T. J. & Semple, B. D., 1 Oct 2019, In : Experimental Neurology. 320, 14 p., 112979.

Research output: Contribution to journalArticleResearchpeer-review

Targeting neurodegeneration to prevent post-traumatic epilepsy

Ali, I., de Castro e Silva, J., Liu, S., Shultz, S. R., Kwan, P., Jones, N. C. & O'Brien, T. J., Mar 2019, In : Neurobiology of Disease. 123, p. 100-109 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injur

Shultz, S. R., McDonald, S., Corrigan, F., Semple, B., Salberg, S., Zamani, A., Jones, N. & Mychasiuk, R., 24 May 2019, (Accepted/In press) In : Journal of Neurotrauma. 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol

Vespa, P. M., Shrestha, V., Abend, N., Agoston, D., Au, A., Bell, M. J., Bleck, T. P., Blanco, M. B., Ellingson, B., Gilmore, E. J., Hirsch, L., Hunn, M., Kamnaksh, A., McArthur, D., Morokoff, A., O'Brien, T., O'Phelan, K., Robertson, C. L., Rosenthal, E., Staba, R. & 52 others, Willyerd, F. A., Yam, E., Martinez, S., Real, C., Engel, J., For the EpiBioS4Rx Study Group, Agoston, D., Au, A., Bell, M. J., Bleck Thomas, P., Branch, C., Buitrago Blanco, M., Bullock, R., Burrows, B. T., Claassen, J., Clarke, R., Cloyd, J., Coles, L., Crawford, K., Diaz-Arrastia, R., Duncan, D., Ellingson, B., Engel, J., Foreman, B., Galanopoulou, A., Gilmore, E., Grohn, O., Harris, N., Hartings, J., Lawrence, H., Jette, N., Johnston, L., Jones, N., Kanner, A., McArthur, D., Monti, M., Morokoff, A., Moshe, S., Mowrey, W., O'Phelan, K., Pitkanen, A., Raman, R., Robertson, C., Rosenthal, E., Shultz, S., Snutch, T., Staba, R., Toga, A., Van Horn, J., Vespa, P., Willyerd, F. & Zimmermann, L., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 110-114 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Transactive Response DNA-Binding Protein 43 Abnormalities after Traumatic Brain Injury

Tan, X. L., Sun, M., Brady, R. D., Liu, S., Llanos, R. M., Cheung, S., Wright, D. K., Casillas-Espinosa, P. M., Sashindranath, M., O'Brien, T. J., McDonald, S. J., Turner, B. J. & Shultz, S., 1 Jan 2019, In : Journal of Neurotrauma. 36, 1, p. 87-99 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

A concomitant muscle injury does not worsen traumatic brain injury outcomes in mice

Sun, M., Brady, R. D., Poel, C. V. D., Apted, D., Semple, B. D., Church, J. E., O'Brien, T. J., McDonald, S. J. & Shultz, S. R., 11 Dec 2018, In : Frontiers in Neurology. 9, 11 p., 1089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Concussion incidence in amateur Australian Rules Footballers

Costello, D. M., Ernest, J., Kaye, A. H., O'Brien, T. J. & Shultz, S. R., 1 Oct 2018, In : Journal of Clinical Neuroscience. 56, p. 88-89 2 p.

Research output: Contribution to journalArticleResearchpeer-review

Diffusion MRI abnormalities in adolescent rats given repeated mild traumatic brain injury

Wortman, R. C., Meconi, A., Neale, K. J., Brady, R. D., McDonald, S. J., Christie, B. R., Wright, D. K. & Shultz, S. R., 1 Dec 2018, In : Annals of Clinical and Translational Neurology. 5, 12, p. 1588-1598 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Elimination of vesicular zinc alters the behavioural and neuroanatomical effects of social defeat stress in mice

McAllister, B. B., Wright, D. K., Wortman, R. C., Shultz, S. R. & Dyck, R. H., 1 Nov 2018, In : Neurobiology of Stress. 9, p. 199-213 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Gambogic amide, a selective TrkA agonist, does not improve outcomes from traumatic brain injury in mice

Johnstone, M. R., Sun, M., Taylor, C. J., Brady, R. D., Grills, B. L., Church, J. E., Shultz, S. R. & McDonald, S. J., 28 Jan 2018, In : Brain Injury. 32, 2, p. 257-268 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Mild traumatic brain injury in adolescent mice alters skull bone properties to influence a subsequent brain impact at adulthood: A pilot study

McColl, T. J., Brady, R. D., Shultz, S. R., Lovick, L., Webster, K. M., Sun, M., McDonald, S. J., O'Brien, T. J. & Semple, B. D., 25 May 2018, In : Frontiers in Neurology. 9, 15 p., 372.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Brady, R. D., Casillas-Espinosa, P. M., Agoston, D. V., Bertram, E. H., Kamnaksh, A., Semple, B. D. & Shultz, S. R., 1 Mar 2018, In : Neurobiology of Disease. 123, p. 8-19 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Neurological heterotopic ossification: Current understanding and future directions

Brady, R. D., Shultz, S. R., McDonald, S. J. & O'Brien, T. J., Apr 2018, In : Bone. 109, p. 35-42 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Pre-clinical testing of therapies for traumatic brain injury

DeWitt, D. S., Hawkins, B. E., Dixon, C. E., Kochanek, P. M., Armstead, W., Bass, C. R., Bramlett, H. M., Buki, A., Dietrich, W. D., Ferguson, A. R., Hall, E. D., Hayes, R. L., Hinds, S. R., Laplaca, M. C., Long, J. B., Meaney, D. F., Mondello, S., Noble-Haeusslein, L. J., Poloyac, S. M., Prough, D. S. & 8 others, Robertson, C. S., Saatman, K. E., Shultz, S. R., Shear, D. A., Smith, D. H., Valadka, A. B., Vandevord, P. & Zhang, L., 1 Dec 2018, In : Journal of Neurotrauma. 35, 23, p. 2737-2754 18 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Repeated mild traumatic brain injury can cause acute neurologic impairment without overt structural damage in juvenile rats

Meconi, A., Wortman, R. C., Wright, D. K., Neale, K. J., Clarkson, M., Shultz, S. R. & Christie, B. R., 1 May 2018, In : PLoS ONE. 13, 5, 24 p., e0197187.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Sport related concussion – Potential for biomarkers to improve acute management

Costello, D. M., Kaye, A. H., O'Brien, T. J. & Shultz, S. R., 1 Oct 2018, In : Journal of Clinical Neuroscience. 56, p. 1-6 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

The influence of immunological stressors on traumatic brain injury

Sun, M., McDonald, S. J., Brady, R. D., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Brain, Behavior, and Immunity. 69, p. 618-628 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2017

Accelerated kindling epileptogenesis in Tg4510 tau transgenic mice, but not in tau knockout mice

Liu, S., Shen, Y., Shultz, S. R., Nguyen, A., Hovens, C., Adlard, P. A., Bush, A. I., Chan, J., Kwan, P., O'Brien, T. J. & Jones, N. C., 1 Sep 2017, In : Epilepsia. 58, 9, p. e136-e141 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Animal Models of Acquired Epilepsy and Tauopathies

Zheng, P., Shultz, S., Hovens, C. & O'Brien, T. J., 1 Jan 2017, Models of Seizures and Epilepsy: Second Edition. Pitkänen, A., Buckmaster, P. S., Galanopoulou, A. S. & Moshé, S. L. (eds.). Academic Press, p. 1031-1041 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury

Wright, D. K., Johnston, L. A., Kershaw, J., Ordidge, R., O'Brien, T. J. & Shultz, S. R., 1 Jul 2017, In : Journal of Neurotrauma. 34, 13, p. 2109-2118 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains

Sharma, P., Wright, D. K., Johnston, L. A., Powell, K. L., Wlodek, M. E., Shultz, S. R., O'Brien, T. J. & Gilby, K. L., 1 Aug 2017, In : Neurobiology of Disease. 104, p. 33-40 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation in epileptogenesis after traumatic brain injury

Webster, K. M., Sun, M., Crack, P., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 13 Jan 2017, In : Journal of Neuroinflammation. 14, 1, 17 p., 10.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

MR spectroscopy findings in retired professional rugby league players

Gardner, A. J., Iverson, G. L., Wojtowicz, M., Levi, C. R., Kay-Lambkin, F., Schofield, P. W., Zafonte, R., Shultz, S. R., Lin, A. P. & Stanwell, P., 1 Mar 2017, In : International Journal of Sports Medicine. 38, 3, p. 241-252 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Semple, B. D., Dixit, S., Shultz, S. R., Boon, W. C. & O'Brien, T. J., 15 Feb 2017, In : Behavioural Brain Research. 319, p. 48-62 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex matters: repetitive mild traumatic brain injury in adolescent rats

Wright, D. K., O'Brien, T. J., Shultz, S. R. & Mychasiuk, R., 1 Sep 2017, In : Annals of Clinical and Translational Neurology. 4, 9, p. 640-654 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies

Shultz, S. R., McDonald, S. J., Vonder Haar, C., Meconi, A., Vink, R., van Donkelaar, P., Taneja, C., Iverson, G. L. & Christie, B. R., 1 May 2017, In : Neuroscience and Biobehavioral Reviews. 76, p. 396-414 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Traumatic brain injury results in cellular, structural and functional changes resembling motor neuron disease

Wright, D. K., Liu, S., Van Der Poel, C., McDonald, S. J., Brady, R. D., Taylor, L., Yang, L., Gardner, A. J., Ordidge, R., O'Brien, T. J., Johnston, L. A. & Shultz, S. R., 2017, In : Cerebral Cortex. 27, 9, p. 4503-4515 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

Wright, D. K., Trezise, J., Kamnaksh, A., Bekdash, R., Johnston, L. A., Ordidge, R., Semple, B. D., Gardner, A. J., Stanwell, P., O'Brien, T. J., Agoston, D. V. & Shultz, S. R., 28 Jun 2016, In : Scientific Reports. 6, 16 p., 28713.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fracture

Brady, R. D., Grills, B. L., Church, J. E., Walsh, N. C., McDonald, A. C., Agoston, D. V., Sun, M., O'Brien, T. J., Shultz, S. R. & McDonald, S. J., 29 Sep 2016, In : Scientific Reports. 6, 9 p., 34491.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Deletion of the type-1 interferon receptor in APPSWE/PS1ΔE9 mice preserves cognitive function and alters glial phenotype

Minter, M. R., Moore, Z., Zhang, M., Brody, K. M., Jones, N. C., Shultz, S. R., Taylor, J. M. & Crack, P. J., 11 Jul 2016, In : Acta neuropathologica communications. 4, 1, 23 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Experimental traumatic brain injury induces bone loss in rats

Brady, R. D., Shultz, S. R., Sun, M., Romano, T., Van Der Poel, C., Wright, D. K., Wark, J. D., O'Brien, T. J., Grills, B. L. & McDonald, S. J., 1 Dec 2016, In : Journal of Neurotrauma. 33, 23, p. 2154-2160 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Neuroanatomical differences in FAST and SLOW rat strains with differential vulnerability to kindling and behavioral comorbidities

Sharma, P., Dedeurwaerdere, S., Vandenberg, M. A. D., Fang, K., Johnston, L. A., Shultz, S. R., O'Brien, T. J. & Gilby, K. L., 1 Dec 2016, In : Epilepsy & Behavior. 65, p. 42-48 7 p.

Research output: Contribution to journalArticleResearchpeer-review