Sandeep Chhabra

Dr

20082019
If you made any changes in Pure these will be visible here soon.

Research Output 2010 2018

2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

Distribution and kinetics of the Kv1.3-blocking peptide HsTX1[R14A] in experimental rats

Bergmann, R., Kubeil, M., Zarschler, K., Chhabra, S., Tajhya, R. B., Beeton, C., Pennington, M. W., Bachmann, M. H., Norton, R. S. & Stephan, H., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 3756.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Reinvestigation of the biological activity of D-allo-ShK protein

Dang, B., Chhabra, S., Pennington, M. W., Norton, R. S. & Kent, S. B. H., 2017, In : Journal of Biological Chemistry. 292, 30, p. 12599-12605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure and activity of contryphan-Vc2: importance of the D-amino acid residue

Drane, S. B., Robinson, S. D., MacRaild, C., Chhabra, S., Chittoor, B., A V Morales, R., Leung, E. W. W., Belgi, A., Espino, S. S., Olivera, B. M., Robinson, A. J., Chalmers, D. K. & Norton, R. S., 1 Apr 2017, In : Toxicon : official journal of the International Society on Toxinology. 129, p. 113-122 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

A naturally occurring peptide with an elementary single disulfide-directed β-hairpin fold

Robinson, S., Chhabra, S., Belgi, A., Chittoor, B., Safavi-Hemami, H., Robinson, A. J., Papenfuss, A. T., Purcell, A. & Norton, R., 2 Feb 2016, In : Structure. 24, 2, p. 293-299 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Installation of a rigid EDTA-like motif into a protein α-helix for paramagnetic NMR spectroscopy with cobalt(II) ions

Swarbrick, J. D., Ung, P., Dennis, M. L., Lee, M. D., Chhabra, S. & Graham, B., 22 Jan 2016, In : Chemistry - A European Journal. 22, 4, p. 1228-1232 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Stereoselective synthesis and structural elucidation of dicarba peptides

Gleeson, E. C., Wang, Z. J., Robinson, S. D., Chhabra, S., MacRaild, C. A., Jackson, W. R., Norton, R. S. & Robinson, A. J., 2016, In : Chemical Communications. 52, 24, p. 4446-4449 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Structural basis for the inhibition of voltage-gated sodium channels by conotoxin μO§-GVIIJ

Green, B. R., Gajewiak, J., Chhabra, S., Skalicky, J. J., Zhang, M. M., Rivier, J. E., Bulaj, G., Olivera, B. M., Yoshikami, D. & Norton, R., 25 Mar 2016, In : Journal of Biological Chemistry. 291, 13, p. 7205-7220 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Compact, hydrophilic, lanthanide-binding tags for paramagnetic NMR spectroscopy

Lee, M. D., Loh, C. T., Shin, J., Chhabra, S., Dennis, M. L., Otting, G., Swarbrick, J. D. & Graham, B., 2015, In : Chemical Science. 6, 4, p. 2614-2624 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK

Pennington, M. W., Chang, S. J., Chauhan, S., Huq, R., Tajhya, R. B., Chhabra, S., Norton, R. S. & Beeton, C., 2015, In : Marine Drugs. 13, 1, p. 529 - 542 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3

Chang, S. C., Huq, R., Chhabra, S., Beeton, C., Pennington, M. W., Smith, B. J. & Norton, R. S., 2015, In : FEBS Journal. 282, 12, p. 2247-2259 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2014

A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases

Rashid, H., Huq, R., Tanner, M. R., Chhabra, S., Khoo, K. K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M. W., Beeton, C., Kuyucak, S. & Norton, R. S., 2014, In : Scientific Reports. 4, 4509, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent

Yap, B. K., Leung, E. W. W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D. K., Nicholson, S. E., Thompson, P. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 16, p. 7006 - 7015 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Conformational flexibility in the binding surface of the potassium channel blocker ShK

Sher, I., Chang, S. J., Li, Y., Chhabra, S., Palmer III, A. G., Norton, R. S. & Chill, J., 2014, In : ChemBioChem. 15, 16, p. 2402 - 2410 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B. J., Robinson, S., Kompella, S. N., Hung, A., Callaghan, B., Adams, D. J., Robinson, A. J. & Norton, R. S., 2014, In : Journal of Medicinal Chemistry. 57, 23, p. 9933 - 9944 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Interactions of disulfide-deficient selenocysteine analogs of u-conotoxin BuIIIB with the a-subunit of the voltage-gated sodium channel subtype 1.3

Green, B. R., Zhang, M., Chhabra, S., Robinson, S., Wilson, M. J., Redding, A., Olivera, B. M., Yoshikami, D., Bulaj, G. & Norton, R. S., 2014, In : FEBS Journal. 281, 13, p. 2885 - 2898 14 p.

Research output: Contribution to journalEditorialResearchpeer-review

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases

Chhabra, S., Chang, S. J., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W. & 2 othersNorton, R. S. & Chandy, G. K., 2014, In : FASEB Journal. 28, p. 3952 - 3964 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus

Dennis, M., Chhabra, S., Wang, Z-C., Debono, A. J., Dolezal, O., Newman, J., Pitcher, N. P., Rahmani, R. S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 2014, In : Journal of Medicinal Chemistry. 57, 22, p. 9612 - 9626 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

A novel inhibitor of alpha 9 alpha 10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R. S. & McIntosh, J. M., 2013, In : PLoS ONE. 8, 1, 10 p., e54648.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation

Rashid, M. H., Heinzelmann, G., Huq, R., Tajhya, R. B., Chang, S. J., Chhabra, S., Pennington, M. W., Beeton, C., Norton, R. S. & Kuyucak, S., 2013, In : PLoS ONE. 8, 11, 10 p., e78712.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Exploring the chemical space around 8-mercaptoguanine as a route to new inhibitors of the folate biosynthesis enzyme HPPK

Chhabra, S., Barlow, N., Dolezal, O., Hattarki, M., Newman, J., Peat, T., Graham, B. & Swarbrick, J. D., 2013, In : PLoS ONE. 8, 4, 15 p., e59535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Fragment screening on Staphylococcus aureus HPPK - A folate pathway target

Chhabra, S., Dolezal, O., Hattarki, M., Peat, T., Simpson, J. S. & Swarbrick, J. D., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1537 - 1543 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor

Chhabra, S., Dolezal, O., Collins, B. M., Newman, J., Simpson, J. S., Macreadie, I. G., Fernley, R., Peat, T. & Swarbrick, J. D., 2012, In : PLoS ONE. 7, 1, 16 p., e29444.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2011

An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy

Swarbrick, J., Ung, P., Chhabra, S. & Graham, B., 2011, In : Angewandte Chemie - International Edition. 50, 19, p. 4403 - 4406 4 p.

Research output: Contribution to journalArticleResearchpeer-review

DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra

Graham, B., Loh, C., Swarbrick, J., Ung, P., Shin, J., Yagi, H., Jia, X., Chhabra, S., Barlow, N., Pintacuda, G., Huber, T. & Otting, G., 2011, In : Bioconjugate Chemistry. 22, 10, p. 2118 - 2125 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Engineering of a bis-chelator motif into a protein alpha-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy

Swarbrick, J., Ung, P., Su, X-C., Maleckis, A., Chhabra, S., Huber, T., Otting, G. & Graham, B., 2011, In : Chemical Communications. 47, p. 7368 - 7370 3 p.

Research output: Contribution to journalArticleResearchpeer-review

VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins

Swarbrick, J., Shaw, D., Chhabra, S., Ghai, R., Valkov, E., Norwood, S., Seaman, M. & Collins, B., 2011, In : PLoS ONE. 6, 5, 15 p., e20420.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus

Chhabra, S., Newman, J., Peat, T. S., Fernley, R. T., Caine, J., Simpson, J. S. & Swarbrick, J. D., 2010, In : Acta Crystallographica. Section F: Structural Biology Communications. 66, 5, p. 575 - 578 4 p.

Research output: Contribution to journalArticleResearchpeer-review