Sameer Greenall

Dr

20092018
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Personal profile

Biography

Sam is a Research Fellow in the laboratory of Prof Eva Segelov at the Department of Oncology, Monash University and Monash Health. Trained as an immunopathologist, he has become an expert in the analysis and application of antibody and small molecule based therepeutics against aggressive brain cancer and how cancers can resist these treatments. He is now applying his extensive expertise in antibody-receptor and ligand-receptor analysis and therapeutics analysis to the study of immune checkpoint biology and inhibition in brain cancer, lung cancer and metastatic colorectal cancer to discover how these promising class of therapies can be further augmented for greater efficacy in the clinic.

Research interests

Sam is interested in anything related to antibody-based or small molecule based inhibition of targets in several different kinds of cancer including brain, lung and colon cancers. His primary interest is two-fold and stems from his accumulated expertise in oncology research - 1) to discover why some patients respond to immunotherapy whilst some don't and discover the reasons why patients progress on immunotherapy and 2) to discover new and effective combinations of therapies to better augment the activity of immunotherapy in the clinic, resulting in immune system-mediated eradication of tumour growth and long term protection.

Supervision interests

Sam is an enthusiastic teacher and mentor, having supervised three past honours students who have all obtained H1 scores for their theses and have been awarded prizes, such as the Nairn Prize, for top interdepartmental thesis marks. He is also the current supervisor of one PhD student and has mentored several others that have come through the laboratory. Highly attentive and supportive of his student's education and progress, he is passionate about his mission to better treat and eradicate cancer and believes strongly in passing this onto his students so that they may get the best education possible and obtain the same enthusiasm for cancer research.

Keywords

  • immuno-oncology
  • therapy
  • antibody
  • small molecule inhibitor
  • immune checkpoints
  • glioma
  • NSCLC
  • mCRC

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Research Output 2009 2018

Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response

Donoghue, J. F., Kerr, L. T., Alexander, N. W., Greenall, S. A., Longano, A. B., Gottardo, N. G., Wang, R., Tabar, V., Adams, T. E., Mischel, P. S. & Johns, T. G., 1 Aug 2018, In : Cancers. 10, 8, 16 p., 243.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors

Endersby, R., Whitehouse, J., Hii, H., Greenall, S. A., Johns, T. G. & Gottardo, N. G., 1 May 2018, In : Neoplasia. 20, 5, p. 432-442 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3

Greenall, S. A., Donoghue, J., Johns, T. G. & Adams, T. E., 1 Aug 2018, In : Translational Oncology. 11, 4, p. 971-978 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma

Greenall, S. A., Lim, Y. C., Mitchell, C. B., Ensbey, K. S., Stringer, B. W., Wilding, A. L., O'Neill, G. M., McDonald, K. L., Gough, D. J., Day, B. W. & Johns, T. G., 1 Jan 2017, In : Oncogenesis. 6, 5, 13 p., e336.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

EGFRvIII: The promiscuous mutation

Greenall, S. A. & Johns, T. G., 4 Jul 2016, In : Cell Death Discovery. 2 p., 16049.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

Prizes

CASS Foundation Travel Grant

Sameer Greenall (Recipient), 2015

Prize: Prize (including medals and awards)

CSIRO Livestock Industries Postgraduate Fellowship

Sameer Greenall (Recipient), 2004

Prize: Competitive Fellowships

Ethan Davies Research Fellowship

Sameer Greenall (Recipient), 2017

Prize: Competitive Fellowships

IGF Society Travel Grant

Sameer Greenall (Recipient), 2014

Prize: Prize (including medals and awards)

IGF Society Travel Grant

Sameer Greenall (Recipient), 2012

Prize: Prize (including medals and awards)