Projects per year
Personal profile
Biography
Sam is a Medical Research Fellow in the Blood Cancer Therapeutics laboratory of Assoc.Prof Jake Shortt at the Department of Medicine, Monash University . Trained as an immunopathologist, he has become an expert in the analysis and application of antibody and small molecule based therepeutics against aggressive brain cancer and liver cancer and how cancers can resist these treatments. He is now applying his extensive expertise in antibody-receptor and therapeutics analysis to the discovery of new targets for Burkitt's lymphoma and liver cancer to better treat these diseases in the clinic.
Research interests
Sam is interested in anything related to antibody-based or small molecule based inhibition of targets in several different kinds of cancer including blood and liver cancers. His primary interest is two-fold and stems from his accumulated expertise in oncology research - 1) to discover new druggable therapeutic targets for improved treatment and response in patients with Burkitt's lymphoma and 2) to discover new and effective combinations of therapies to better treat the causes of liver cancer, resulting in its prevention.
Supervision interests
Sam is an enthusiastic teacher and mentor, having supervised three past honours students who have all obtained H1 scores for their theses and have been awarded prizes, such as the Nairn Prize, for top interdepartmental thesis marks. He is also the current supervisor of one PhD student and has mentored several others that have come through the laboratory. Highly attentive and supportive of his student's education and progress, he is passionate about his mission to better treat and eradicate cancer and believes strongly in passing this onto his students so that they may get the best education possible and obtain the same enthusiasm for cancer research.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Science, Doctor of Philosophy, University of Melbourne
Award Date: 5 Dec 2008
Science, Bachelor of Science (Honours), University of Melbourne
Award Date: 30 Oct 2002
Research area keywords
- druggable targets
- therapy
- antibody
- small molecule inhibitor
- Burkitt's lymphoma
- liver cancer
- Virology, viral mechanisms, innate immunity, anti-virals, lipidomics
Network
Projects
- 2 Finished
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Using the power of cord blood stem cells to humanize mice for effective cancer immunotherapy research
Greenall, S., Watt, A., Ho, G., Segelov, E., O'Keeffe, M. & Jenkin, G.
1/01/20 → 31/12/21
Project: Research
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in glioma
Greenall, S. A., McKenzie, M., Seminova, E., Dolezal, O., Pearce, L., Bentley, J., Kuchibhotla, M., Chen, S. C., McDonald, K. L., Kornblum, H. I., Endersby, R., Adams, T. E. & Johns, T. G., 1 Aug 2019, In: Neuro-Oncology. 21, 8, p. 1016-1027 12 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus) -
Activation of ERBB4 in glioblastoma can contribute to increased tumorigenicity and influence therapeutic response
Donoghue, J. F., Kerr, L. T., Alexander, N. W., Greenall, S. A., Longano, A. B., Gottardo, N. G., Wang, R., Tabar, V., Adams, T. E., Mischel, P. S. & Johns, T. G., 1 Aug 2018, In: Cancers. 10, 8, 16 p., 243.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile18 Citations (Scopus) -
A Pre-Clinical Assessment of the Pan-ERBB Inhibitor Dacomitinib in Pediatric and Adult Brain Tumors
Endersby, R., Whitehouse, J., Hii, H., Greenall, S. A., Johns, T. G. & Gottardo, N. G., 1 May 2018, In: Neoplasia. 20, 5, p. 432-442 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile15 Citations (Scopus) -
Differential Sensitivity of Human Hepatocellular Carcinoma Xenografts to an IGF-II Neutralizing Antibody May Involve Activated STAT3
Greenall, S. A., Donoghue, J., Johns, T. G. & Adams, T. E., 1 Aug 2018, In: Translational Oncology. 11, 4, p. 971-978 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile5 Citations (Scopus) -
Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma
Greenall, S. A., Lim, Y. C., Mitchell, C. B., Ensbey, K. S., Stringer, B. W., Wilding, A. L., O'Neill, G. M., McDonald, K. L., Gough, D. J., Day, B. W. & Johns, T. G., 1 Jan 2017, In: Oncogenesis. 6, 5, 13 p., e336.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile49 Citations (Scopus)
Prizes
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CASS Foundation Travel Grant
Greenall, Sameer (Recipient), 2015
Prize: Prize (including medals and awards)
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CSIRO Livestock Industries Postgraduate Fellowship
Greenall, Sameer (Recipient), 2004
Prize: Competitive Fellowships
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IGF Society Travel Grant
Greenall, Sameer (Recipient), 2014
Prize: Prize (including medals and awards)
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IGF Society Travel Grant
Greenall, Sameer (Recipient), 2012
Prize: Prize (including medals and awards)