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Personal profile


Sam is interested in understanding how cells within a growing organ coordinate a range of mechanical and signalling inputs to ensure robustness and consistency of size and shape during development. These processes are vital for correct tissue and organ function and are deregulated in many diseases, including cancer. He uses live imaging and genetic approaches to investigate gene function in normal and disease settings.

He completed his PhD in Kieran Harvey's laboratory, using the vinegar fly as a model system to investigate the regulation of a key component of the Hippo growth control pathway.

Research area keywords

  • Growth Control
  • Cell Signalling
  • Drosophila
  • Live Imaging
  • Organ Size and Pattern

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Research Output 2012 2019

The dPix-Git complex is essential to coordinate epithelial morphogenesis and regulate myosin during Drosophila egg chamber development

Dent, L. G., Manning, S. A., Kroeger, B., Williams, A. M., Saiful Hilmi, A. J., Crea, L., Kondo, S., Horne-Badovinac, S. & Harvey, K. F., 22 May 2019, In : PLoS Genetics. 15, 5, 31 p., e1008083.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
15 Citations (Scopus)

Dynamic Fluctuations in Subcellular Localization of the Hippo Pathway Effector Yorkie In Vivo

Manning, S. A., Dent, L. G., Kondo, S., Zhao, Z. W., Plachta, N. & Harvey, K. F., 21 May 2018, In : Current Biology. 28, 10, p. 1651-1660 11 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth

Vissers, J. H. A., Manning, S. A., Kulkarni, A. & Harvey, K. F., 13 Jan 2016, In : Nature Communications. 7, 6 p., 10368.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
3 Citations (Scopus)

Warts Opens Up for Activation

Manning, S. A. & Harvey, K. F., 21 Dec 2015, In : Developmental Cell. 35, 6, p. 666-668 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
70 Citations (Scopus)

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

Willoughby, L. F., Schlosser, T., Manning, S. A., Parisot, J. P., Street, I. P., Richardson, H. E., Humbert, P. O. & Brumby, A. M., Mar 2013, In : Disease Models and Mechanisms. 6, 2, p. 521-529 9 p.

Research output: Contribution to journalArticleResearchpeer-review