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Personal profile

Biography

Sam leads the Microbiota and Systems Biology Laboratory at the Hudson Institute of Medical Research. His team's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.

Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into why we get sick and how to maintain health. Sam’s research seeks to understand the relationship between our immune system, the microbiota community and susceptibility to diseases. His research is focused on:

  • Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
  • Wide scale metagenomic sequence based analysis to understand microbiota community structure
  • Computational modeling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease

This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health

Research area keywords

  • Microbiota
  • Metagenomics
  • Systems Biology
  • Innate Immunity
  • microRNA
  • Interferon
  • Bioinformatics

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Projects

Research Output

Distinct microbial and immune niches of the human colon

James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M. D., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., Polański, K., Forster, S. C., Jarvis, L. B., Suchanek, O., Howlett, S., James, L. K., Jones, J. L., Meyer, K. B., Clatworthy, M. R., Saeb-Parsy, K. & 2 others, Lawley, T. D. & Teichmann, S. A., 1 Mar 2020, In : Nature Immunology. 21, 3, p. 343-353 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Adaptation of host transmission cycle during Clostridium difficile speciation

Kumar, N., Browne, H. P., Viciani, E., Forster, S. C., Clare, S., Harcourt, K., Stares, M. D., Dougan, G., Fairley, D. J., Roberts, P., Pirmohamed, M., Clokie, M. R. J., Jensen, M. B. F., Hargreaves, K. R., Ip, M., Wieler, L. H., Seyboldt, C., Norén, T., Riley, T. V., Kuijper, E. J. & 2 others, Wren, B. W. & Lawley, T. D., 1 Sep 2019, In : Nature Genetics. 51, 9, p. 1315-1320 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A human gut bacterial genome and culture collection for improved metagenomic analyses

Forster, S. C., Kumar, N., Anonye, B. O., Almeida, A., Viciani, E., Stares, M. D., Dunn, M., Mkandawire, T. T., Zhu, A., Shao, Y., Pike, L. J., Louie, T., Browne, H. P., Mitchell, A. L., Neville, B. A., Finn, R. D. & Lawley, T. D., 1 Feb 2019, In : Nature Biotechnology. 37, 2, p. 186-192 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)

A new genomic blueprint of the human gut microbiota

Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D. & Finn, R. D., 25 Apr 2019, In : Nature. 568, 7753, p. 499-504 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
68 Citations (Scopus)

CiIIder: A tool for predicting and analysing transcription factor binding sites

Gearing, L. J., Cumming, H. E., Chapman, R., Finkel, A. M., Woodhouse, I. B., Luu, K., Gould, J. A., Forster, S. C. & Hertzog, P. J., 4 Sep 2019, In : PLoS ONE. 14, 9, 12 p., e0215495.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
1 Citation (Scopus)

Activities

  • 2 External research organisation, centre or institute

NHMRC CJ Martin Overseas Biomedical Fellowship

Sam Forster (Visitor)
1 Jan 201531 Dec 2018

Activity: External Academic EngagementExternal research organisation, centre or institute

NHMRC CJ Martin Overseas Biomedical Fellowship

Sam Forster (Visitor)
1 Jan 201531 Dec 2018

Activity: External Academic EngagementExternal research organisation, centre or institute