Projects per year
Personal profile
Biography
Sam leads the Microbiota and Systems Biology Laboratory at the Hudson Institute of Medical Research. His team's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.
Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into why we get sick and how to maintain health. Sam’s research seeks to understand the relationship between our immune system, the microbiota community and susceptibility to diseases. His research is focused on:
- Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
- Wide scale metagenomic sequence based analysis to understand microbiota community structure
- Computational modeling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease
This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Microbiota
- Metagenomics
- Systems Biology
- Innate Immunity
- microRNA
- Interferon
- Bioinformatics
Collaborations and top research areas from the last five years
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Rational microbiome restructuring for improve management of ulcerative colitis
1/01/23 → 31/12/27
Project: Research
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CALIPSO: Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study (CALIPSO): multicentre, adaptive, double-blind, three-arm, placebo-controlled, non-inferiority trial examining antimicrobial prophylaxis duration in cardiac surgery
Peel, T. (Primary Chief Investigator (PCI)), Myles, P. (Chief Investigator (CI)), McGiffin, D. (Chief Investigator (CI)), Smith, J. (Chief Investigator (CI)), Forbes, A. (Chief Investigator (CI)), Marasco, S. (Chief Investigator (CI)), Pilcher, D. (Chief Investigator (CI)), Stewardson, A. (Chief Investigator (CI)), Petrie, D. (Chief Investigator (CI)), Peleg, A. (Chief Investigator (CI)), Wisniewski, J. (Associate Investigator (AI)), Russo, P. (Associate Investigator (AI)) & Forster, S. (Associate Investigator (AI))
Department of Health and Aged Care (Australia)
1/02/22 → 31/05/27
Project: Research
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Should you be eating that? Food-derived bacteria and their role in treating disease
Forster, S. (Primary Chief Investigator (PCI)), Kellow, N. (Chief Investigator (CI)) & Iacovou, M. (Chief Investigator (CI))
1/01/21 → 31/12/25
Project: Research
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Targeting Innate Immune Inflammasomes as Key Drivers of Microbial-Associated Pancreatic Cancer and Therapy Resistance
Jenkins, B. (Primary Chief Investigator (PCI)), Croagh, D. (Chief Investigator (CI)), Forster, S. (Chief Investigator (CI)), Pajic, M. (Chief Investigator (CI)), Zavros, Y. (Chief Investigator (CI)), Kumar, B. (Chief Investigator (CI)) & Schmidt, F. (Chief Investigator (CI))
1/09/22 → 24/02/24
Project: Research
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Discovery of Novel Bacteriophage with the Capacity to Modulate Gut Bacteria
Barr, J. (Primary Chief Investigator (PCI)) & Forster, S. (Chief Investigator (CI))
25/03/21 → 31/12/24
Project: Research
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Bacterial clade-specific analysis identifies distinct epithelial responses in inflammatory bowel disease
D'Adamo, G. L., Chonwerawong, M., Gearing, L. J., Marcelino, V. R., Gould, J. A., Rutten, E. L., Solari, S. M., Khoo, P. W. R., Wilson, T. J., Thomason, T., Gulliver, E. L., Hertzog, P. J., Giles, E. M. & Forster, S. C., 18 Jul 2023, In: Cell Reports Medicine. 4, 7, 14 p., 101124.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Disease-specific loss of microbial cross-feeding interactions in the human gut
Marcelino, V. R., Welsh, C., Diener, C., Gulliver, E. L., Rutten, E. L., Young, R. B., Giles, E. M., Gibbons, S. M., Greening, C. & Forster, S. C., 20 Oct 2023, In: Nature Communications. 14, 1, 11 p., 6546.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Extensive genome analysis identifies novel plasmid families in Clostridium perfringens
Gulliver, E. L., Adams, V., Marcelino, V. R., Gould, J., Rutten, E. L., Powell, D. R., Young, R. B., D'Adamo, G. L., Hemphill, J., Solari, S. M., Revitt-Mills, S. A., Munn, S., Jirapanjawat, T., Greening, C., Boer, J. C., Flanagan, K. L., Kaldhusdal, M., Plebanski, M., Gibney, K. B. & Moore, R. J. & 2 others, , 1 Apr 2023, In: Microbial Genomics. 9, 4, 16 p., 000995.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Citations (Scopus) -
Temperate gut phages are prevalent, diverse, and predominantly inactive
Dahlman, S., Avellaneda Franco, L., Kett, C., Subedi, D., Young, R. B., Gould, J., Rutten, E. L., Gulliver, E. L., Turkington, C., Nezam-Abadi, N., Grasis, J., Lyras, D., Edwards, R. A., Forster, S. & Barr, J. J., 18 Aug 2023, 19 p. bioRxiv.Research output: Other contribution › Research
Open Access -
The broccoli-derived antioxidant sulforaphane changes the growth of gastrointestinal microbiota, allowing for the production of anti-inflammatory metabolites
Marshall, S. A. (Leading Author), Young, R. B., Lewis, J. M., Rutten, E. L., Gould, J., Barlow, C. K., Giogha, C., Marcelino, V. R., Fields, N., Schittenhelm, R. B., Hartland, E. L., Scott, N. E., Forster, S. C. & Gulliver, E. L. (Leading Author), Aug 2023, In: Journal of Functional Foods. 107, 105645.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Activities
- 2 External research organisation, centre or institute
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NHMRC CJ Martin Overseas Biomedical Fellowship
Sam Forster (Visitor)
1 Jan 2015 → 31 Dec 2018Activity: External Academic Engagement › External research organisation, centre or institute
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NHMRC CJ Martin Overseas Biomedical Fellowship
Sam Forster (Visitor)
1 Jan 2015 → 31 Dec 2018Activity: External Academic Engagement › External research organisation, centre or institute