20092022
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Personal profile

Biography

Sam's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.

Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into health and disease. Sam's research seeks to understand the relationship between host state, microbiota community and the susceptibility to diseases including infections by opportunistic pathogens such as Clostridium difficile and Inflammatory Bowel Disease. His research is focused on:

  • Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
  • Wide scale 16S profiling and metagenomic sequence based analysis to understand microbiota community structure
  • Computational modeling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease

This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health

Keywords

  • Microbiota
  • Metagenomics
  • Systems Biology
  • Innate Immunity
  • microRNA
  • Interferon
  • Bioinformatics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2012 2022

Research Output 2009 2018

A new piece in the microbiome puzzle

Pike, L. J. & Forster, S. C. 1 Apr 2018 In : Nature Reviews Microbiology. 16, 4, 1 p.

Research output: Contribution to journalComment / DebateResearchpeer-review

Commensal Koch's postulates: establishing causation in human microbiota research

Neville, B. A., Forster, S. C. & Lawley, T. D. 1 Apr 2018 In : Current Opinion in Microbiology. 42, p. 47-52 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File

Concurrent host-pathogen transcriptional responses in a clostridium perfringens murine myonecrosis infection

Low, L-Y., Harrison, P. F., Gould, J., Powell, D. R., Choo, J. M., Forster, S. C., Chapman, R., Gearing, L. J., Cheung, J. K., Hertzog, P. & Rood, J. I. 1 Mar 2018 In : mBio. 9, 2, 15 p., e00473-18

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Culturing of female bladder bacteria reveals an interconnected urogenital microbiota

Thomas-White, K., Forster, S. C., Kumar, N., Van Kuiken, M., Putonti, C., Stares, M. D., Hilt, E. E., Price, T. K., Wolfe, A. J. & Lawley, T. D. 1 Dec 2018 In : Nature Communications. 9, 1, 7 p., 1557

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Zoonotic transfer of Clostridium difficile harboring antimicrobial resistance between farm animals and humans

Knetsch, C. W. , Kumar, N. , Forster, S. C. , Connor, T. R. , Browne, H. P. , Harmanus, C. , Sanders, I. M. , Harris, S. R. , Turner, L. , Morris, T. , Perry, M. , Miyajima, F. , Roberts, P. , Pirmohamed, M. , Songer, J. G. , Weese, J. S. , Indra, A. , Corver, J. , Rupnik, M. , Wren, B. W. & 3 others Riley, T. V., Kuijper, E. J. & Lawley, T. D. 1 Mar 2018 In : Journal of Clinical Microbiology. 56, 3, 8 p., e01384-17

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Activities 2015 2015

  • 2 External research organisation, centre or institute

NHMRC CJ Martin Overseas Biomedical Fellowship

Forster, S. (Visitor)
1 Jan 201531 Dec 2018

Activity: External research organisation, centre or institute

NHMRC CJ Martin Overseas Biomedical Fellowship

Forster, S. (Visitor)
1 Jan 201531 Dec 2018

Activity: External research organisation, centre or institute