Sam Forster

Personal profile

Biography

Sam leads the Microbiota and Systems Biology Laboratory at the Hudson Institute of Medical Research. His team's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.

Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into why we get sick and how to maintain health. Sam’s research seeks to understand the relationship between our immune system, the microbiota community and susceptibility to diseases. His research is focused on:

Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
Wide scale metagenomic sequence based analysis to understand microbiota community structure
Computational modeling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease

This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health

Research area keywords

Microbiota
Metagenomics
Systems Biology
Innate Immunity
microRNA
Interferon
Bioinformatics

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

3 Finished
8 Active

Innate mucosal sensing & shaping of the human-microbiome

Hertzog, P., Wells, C., Hartland, E. & Forster, S.

National Health & Medical Research Council (NHMRC)

1/01/20 → 31/12/24

Project: Research

Microbiome derived candidates to revolutionise treatment of inflammatory bowel disease

Forster, S. & Giles, E.

1/01/20 → 31/12/23

Project: Research

Novel bacteria as therapeutic candidates in Inflammatory Bowel Disease

Giles, E., Forster, S. & Abud, H.

1/10/19 → 30/09/20

Project: Research

Bacterial communities in metropolitan, rural and indigenous Australians

Forster, S. & Gibney, K. B.

12/06/19 → 11/06/23

Project: Research

Unravelling the role of type I Interferon family in human infectious and inflammatory diseases

Hertzog, P., Casanova, J., Netea, M. G., Turner, S., Creek, D., Gearing, J., Croft, N., Forster, S. & Polo, J.

National Health & Medical Research Council (NHMRC)

1/01/19 → 31/12/23

Project: Research

Research Output

25 Article
4 Comment / Debate
3 Review Article
1 Short Survey

Distinct microbial and immune niches of the human colon

James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M. D., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., Polański, K., Forster, S. C., Jarvis, L. B., Suchanek, O., Howlett, S., James, L. K., Jones, J. L., Meyer, K. B., Clatworthy, M. R., Saeb-Parsy, K. & 2 others, Lawley, T. D. & Teichmann, S. A., 1 Mar 2020, In : Nature Immunology. 21, 3, p. 343-353 11 p.