Projects per year
Personal profile
Biography
Sam leads the Microbiota and Systems Biology Laboratory at the Hudson Institute of Medical Research. His team's work combines microbiology, immunology and computational analysis to understand the functional role and community dynamics of the human microbiota in health and disease.
Understanding how our microbiota is acquired and the forces that cause it to change provides important insights into why we get sick and how to maintain health. Sam’s research seeks to understand the relationship between our immune system, the microbiota community and susceptibility to diseases. His research is focused on:
- Analysis of the diversity of host cellular and transcriptional responses using in-vitro and in-vivo models of human microbiota communities
- Wide scale metagenomic sequence based analysis to understand microbiota community structure
- Computational modeling and machine learning based approaches to understand microbiota community dynamics in health and dysbiotic disease
This work ultimately seeks to provide novel bacteriotherapies and identify other therapeutic interventions to improve human health
Research area keywords
- Microbiota
- Metagenomics
- Systems Biology
- Innate Immunity
- microRNA
- Interferon
- Bioinformatics
Network
Projects
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Should you be eating that? Food-derived bacteria and their role in treating disease
Forster, S., Kellow, N. & Iacovou, M.
1/01/21 → 31/12/25
Project: Research
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Microbiome derived candidates to revolutionise treatment of inflammatory bowel disease
1/01/20 → 31/12/23
Project: Research
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Innate mucosal sensing & shaping of the human-microbiome
Hertzog, P., Wells, C., Hartland, E. & Forster, S.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/20 → 31/12/24
Project: Research
-
Novel bacteria as therapeutic candidates in Inflammatory Bowel Disease
Giles, E., Forster, S. & Abud, H.
1/10/19 → 31/03/21
Project: Research
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Bacterial communities in metropolitan, rural and indigenous Australians
Forster, S. & Gibney, K. B.
12/06/19 → 11/06/23
Project: Research
Research output
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Distinct microbial and immune niches of the human colon
James, K. R., Gomes, T., Elmentaite, R., Kumar, N., Gulliver, E. L., King, H. W., Stares, M. D., Bareham, B. R., Ferdinand, J. R., Petrova, V. N., Polański, K., Forster, S. C., Jarvis, L. B., Suchanek, O., Howlett, S., James, L. K., Jones, J. L., Meyer, K. B., Clatworthy, M. R., Saeb-Parsy, K. & 2 others, , 1 Mar 2020, In : Nature Immunology. 21, 3, p. 343-353 11 p.Research output: Contribution to journal › Article › Research › peer-review
22 Citations (Scopus) -
Adaptation of host transmission cycle during Clostridium difficile speciation
Kumar, N., Browne, H. P., Viciani, E., Forster, S. C., Clare, S., Harcourt, K., Stares, M. D., Dougan, G., Fairley, D. J., Roberts, P., Pirmohamed, M., Clokie, M. R. J., Jensen, M. B. F., Hargreaves, K. R., Ip, M., Wieler, L. H., Seyboldt, C., Norén, T., Riley, T. V., Kuijper, E. J. & 2 others, , 1 Sep 2019, In : Nature Genetics. 51, 9, p. 1315-1320 6 p.Research output: Contribution to journal › Article › Research › peer-review
13 Citations (Scopus) -
A human gut bacterial genome and culture collection for improved metagenomic analyses
Forster, S. C., Kumar, N., Anonye, B. O., Almeida, A., Viciani, E., Stares, M. D., Dunn, M., Mkandawire, T. T., Zhu, A., Shao, Y., Pike, L. J., Louie, T., Browne, H. P., Mitchell, A. L., Neville, B. A., Finn, R. D. & Lawley, T. D., 1 Feb 2019, In : Nature Biotechnology. 37, 2, p. 186-192 7 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile89 Citations (Scopus) -
A new genomic blueprint of the human gut microbiota
Almeida, A., Mitchell, A. L., Boland, M., Forster, S. C., Gloor, G. B., Tarkowska, A., Lawley, T. D. & Finn, R. D., 25 Apr 2019, In : Nature. 568, 7753, p. 499-504 6 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile209 Citations (Scopus) -
CiIIder: A tool for predicting and analysing transcription factor binding sites
Gearing, L. J., Cumming, H. E., Chapman, R., Finkel, A. M., Woodhouse, I. B., Luu, K., Gould, J. A., Forster, S. C. & Hertzog, P. J., 4 Sep 2019, In : PLoS ONE. 14, 9, 12 p., e0215495.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile15 Citations (Scopus)
Activities
- 2 External research organisation, centre or institute
-
NHMRC CJ Martin Overseas Biomedical Fellowship
Sam Forster (Visitor)
1 Jan 2015 → 31 Dec 2018Activity: External Academic Engagement › External research organisation, centre or institute
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NHMRC CJ Martin Overseas Biomedical Fellowship
Sam Forster (Visitor)
1 Jan 2015 → 31 Dec 2018Activity: External Academic Engagement › External research organisation, centre or institute