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Research Output 1997 2019

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Review Article
Review Article
12 Citations (Scopus)

Atherogenic factors and their epigenetic relationships

Fernandez, A. Z., Siebel, A. L. & El-Osta, A., 2010, In : International Journal of Vascular Medicine. 2010, 437809.

Research output: Contribution to journalReview ArticleResearchpeer-review

32 Citations (Scopus)

Chromatin modifications and DNA double-strand breaks: The current state of play

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 2, p. 195-200 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

26 Citations (Scopus)

Chromatin modifying agents - The cutting edge of anticancer therapy

Kwa, F. A. A., Balcerczyk, A., Licciardi, P., El-Osta, A. & Karagiannis, T. C., Jul 2011, In : Drug Discovery Today. 16, 13-14, p. 543-547 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer

Karagiannis, T. C. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 121-126 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Coordination of epigenetic events

El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2135-2136 2 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

DNA damage detection and repair, and the involvement of epigenetic states

Bassal, S. & El-Osta, A., 21 Feb 2005, In : Human Mutation. 25, 2, p. 101-109 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

101 Citations (Scopus)

DNA methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease

El-Osta, A. & Wolffe, A. P., 7 Dec 2000, In : Gene Expression. 9, 1-2, p. 63-75 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

69 Citations (Scopus)

DNMT cooperativity - The developing links between methylation, chromatin structure and cancer

El-Osta, A., 1 Nov 2003, In : BioEssays. 25, 11, p. 1071-1084 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

62 Citations (Scopus)

Double-strand breaks: Signaling pathways and repair mechanisms

Karagiannis, T. C. & El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2137-2147 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Double-strand breaks and the concept of short- and long-term epigenetic memory

Orlowski, C., Mah, L-J., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., Apr 2011, In : Chromosoma. 120, 2, p. 129-149 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Epidemic T2DM, early development and epigenetics: implications of the Chinese Famine

Zimmet, P., Shi, Z., El-Osta, A. & Ji, L., 1 Dec 2018, In : Nature Reviews Endocrinology. 14, 12, p. 738-746 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Epigenetic changes activate widespread signals in response to double-strand breaks

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 7, p. 617-623 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

42 Citations (Scopus)

Epigenetic changes in diabetes and cardiovascular risk

Keating, S. T., Plutzky, J. & El-Osta, A., 27 May 2016, In : Circulation Research. 118, 11, p. 1706-1722 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Epigenetic Contribution to the Development and Progression of Vascular Diabetic Complications

Rodriguez, H. & El-Osta, A., 10 Oct 2018, In : Antioxidants and Redox Signaling. 29, 11, p. 1074-1091 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Epigenetic-Mediated Reprogramming of Pancreatic Endocrine Cells

Mathiyalagan, P., Keating, S. T., Al-Hasani, K. & El-Osta, A., 1 Jun 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1483-1495 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

133 Citations (Scopus)

Epigenetic phenomena linked to diabetic complications

Pirola, L., Balcerczyk, A., Okabe, J. & El-Osta, A., Dec 2010, In : Nature Reviews Endocrinology. 6, 12, p. 665-675 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

30 Citations (Scopus)

Epigenetic programming, early life nutrition and the risk of metabolic disease

Block, T. & El-Osta, A., 1 Nov 2017, In : Atherosclerosis. 266, p. 31-40 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

91 Citations (Scopus)

Epigenetic regulation and fetal programming

Gicquel, C., El-Osta, A. & Le Bouc, Y., 1 Feb 2008, In : Best Practice and Research in Clinical Endocrinology and Metabolism. 22, 1, p. 1-16 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

130 Citations (Scopus)

Epigenetics: Mechanisms and implications for diabetic complications

Cooper, M. E. & El-Osta, A., 10 Dec 2010, In : Circulation Research. 107, 12, p. 1403-1413 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Epigenetics, cardiovascular disease, and cellular reprogramming

Al-Hasani, K., Mathiyalagan, P. & El-Osta, A., 1 Mar 2019, In : Journal of Molecular and Cellular Cardiology. 128, p. 129-133 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

109 Citations (Scopus)

Epigenetics and metabolism

Keating, S. T. & El-Osta, A., 13 Feb 2015, In : Circulation Research. 116, 4, p. 715-736 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Epigenetics in diabetic nephropathy, immunity and metabolism

Keating, S. T., van Diepen, J. A., Riksen, N. P. & El-Osta, A., 1 Jan 2018, In : Diabetologia. 61, 1, p. 6-20 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Epigenomic changes associated with impaired norepinephrine transporter function in postural tachycardia syndrome

Khan, A. W., Corcoran, S. J., Esler, M. & El-Osta, A., 1 Mar 2017, In : Neuroscience and Biobehavioral Reviews. 74, p. 342-355 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

Mah, L-J., Orlowski, C., Ververis, K., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., 25 Jan 2011, In : Genome Integrity. 2, 11 p., 3.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
25 Citations (Scopus)

Functional links between transcription, DNA repair and apoptosis

Berardi, P., Russell, M., El-Osta, A. & Riabowol, K., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2173-2180 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

59 Citations (Scopus)

Glycemic memory associated epigenetic changes

Siebel, A. L., Fernandez, A. Z. & El-Osta, A., 15 Dec 2010, In : Biochemical Pharmacology. 80, 12, p. 1853-1859 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Improving understanding of chromatin regulatory proteins and potential implications for drug discovery

Rafehi, H., Khan, A. W. & El-Osta, A., 2 Apr 2016, In : Expert Review of Proteomics. 13, 4, p. 435-445 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

44 Citations (Scopus)

MDR1, chemotherapy and chromatin remodeling

Baker, E. K. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 819-824 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Mechanisms of abnormal gene expression in tumor cells.

El-Osta, A., 1 Jan 2006, In : EXS. 96, p. 351-361 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

70 Citations (Scopus)

Modulation of cellular radiation responses by histone deacetylase inhibitors

Karagiannis, T. C. & El-Osta, A., 29 Jun 2006, In : Oncogene. 25, 28, p. 3885-3893 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2 Citations (Scopus)

Pharmacological histone deacetylation distinguishes transcriptional regulators

Rafehi, H., Karagiannis, T. C. & El-Osta, A., 1 May 2017, In : Current Topics in Medicinal Chemistry. 17, 14, p. 1611 - 1622 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Regulation of MDR1 gene expression: Emerging concepts

Kantharidis, P., El-Osta, S., De Silva, M., Lee, G., Hu, X. F. & Zalcberg, J., Apr 2000, In : Drug Resistance Updates. 3, 2, p. 99-108 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

107 Citations (Scopus)

RNA interference and potential therapeutic applications of short interfering RNAs

Karagiannis, T. C. & El-Osta, A., 1 Oct 2005, In : Cancer Gene Therapy. 12, 10, p. 787-795 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

24 Citations (Scopus)

siRNAs: Mechanism of RNA interference, in vivo and potential clinical applications

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 11

Research output: Contribution to journalReview ArticleResearchpeer-review

22 Citations (Scopus)

The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy

Lunke, S. & El-Osta, A., Jun 2009, In : Journal of Neurochemistry. 109, 6, p. 1557-1569 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

34 Citations (Scopus)

The methylation hypothesis of pharmacoresistance in epilepsy

Kobow, K., El-Osta, A. & Blumcke, I., May 2013, In : Epilepsia. 54, Suppl 2, p. 41-47 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation

Karagiannis, T. C. & El-Osta, A., 1 Feb 2006, In : Cell Cycle. 5, 3, p. 288-295 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer

Baker, E. K. & El-Osta, A., 1 Nov 2003, In : Experimental Cell Research. 290, 2, p. 177-194 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

41 Citations (Scopus)

Transcriptional regulation by the Set7 lysine methyltransferase

Keating, S. T. & El-Osta, A., 1 Apr 2013, In : Epigenetics. 8, 4, p. 361-372 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Understanding the consequences of epigenetic mechanisms and their effect on transcription in health and disease

El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 816-818 3 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

11 Citations (Scopus)
87 Citations (Scopus)

Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 1, p. 61-65 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

63 Citations (Scopus)

γH2AX as a molecular marker of aging and disease

Mah, L. J., El-Osta, A. & Karagiannis, T. C., 2010, In : Epigenetics. 5, 2, p. 129-136 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review