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Research Output 1997 2019

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2019

Dysregulation of the cohesin subunit RAD21 by Hepatitis C virus mediates host-virus interactions

Perez, S., Gevor, M., Davidovich, A., Kaspi, A., Yamin, K., Domovich, T., Meirson, T., Matityahu, A., Brody, Y., Stemmer, S. M., El-Osta, A., Haviv, I., Onn, I. & Gal-Tanamy, M., 18 Mar 2019, In : Nucleic Acids Research. 47, 5, p. 2455-2471 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Galectin-3 deficiency ameliorates fibrosis and remodeling in dilated cardiomyopathy mice with enhanced Mst1 signaling

Nguyen, M-N., Ziemann, M., Kiriazis, H., Su, Y., Thomas, Z., Lu, Q., Donner, D. G., Zhao, W-B., Rafehi, H., Sadoshima, J., McMullen, J. R., El-Osta, A. & Du, X-J., Jan 2019, In : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H45-H60 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Age-related differential structural and transcriptomic responses in the hypertensive heart

Marques, F. Z., Chu, P. Y., Ziemann, M., Kaspi, A., Kiriazis, H., Du, X. J., El-Osta, A. & Kaye, D. M., 9 Jul 2018, In : Frontiers in Physiology. 9, JUL, 13 p., 817.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring

Kaspi, A., Khurana, I., Ziemann, M., Connor, T., Spolding, B., Zimmet, P., Walder, K. & El-Osta, A., 1 Jul 2018, In : Molecular Nutrition and Food Research. 62, 14, 10 p., 1800134.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetics and precision medicine in cardiovascular patients: from basic concepts to the clinical arena

Costantino, S., Libby, P., Kishore, R., Tardif, J. C., El-Osta, A. & Paneni, F., 14 Dec 2018, In : European Heart Journal. 39, 47, p. 4150-4158 9 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Lipoxins regulate the early growth response-1 network and reverse diabetic kidney disease

Brennan, E. P., Mohan, M., McClelland, A., Tikellis, C., Ziemann, M., Kaspi, A., Gray, S. P., Pickering, R., Tan, S. M., Tasadaque Ali-Shah, S., Guiry, P. J., El-Osta, A., Jandeleit-Dahm, K., Cooper, M. E., Godson, C. & Kantharidis, P., 1 May 2018, In : Journal of the American Society of Nephrology. 29, 5, p. 1437-1448 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolic karma-the atherogenic legacy of diabetes: The 2017 edwin bierman award lecture

Cooper, M. E., El-Osta, A., Allen, T. J., Watson, A. M. D., Thomas, M. C. & Jandeleit-Dahm, K., 1 May 2018, In : Diabetes. 67, 5, p. 785-790 6 p.

Research output: Contribution to journalArticleOther

RAGE deletion confers renoprotection by reducing responsiveness to transforming growth factor-β and increasing resistance to apoptosis

Hagiwara, S., Sourris, K., Ziemann, M., Tieqiao, W., Mohan, M., McClelland, A. D., Brennan, E., Forbes, J., Coughlan, M., Harcourt, B., Penfold, S., Wang, B., Higgins, G., Pickering, R., El-Osta, A., Thomas, M. C., Cooper, M. E. & Kantharidis, P., 1 May 2018, In : Diabetes. 67, 5, p. 960-973 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Transcription factors Tp73, Cebpd, Pax6, and Spi1 rather than DNA methylation regulate chronic transcriptomics changes after experimental traumatic brain injury

Lipponen, A., El-Osta, A., Kaspi, A., Ziemann, M., Khurana, I., Kn, H., Navarro-Ferrandis, V., Puhakka, N., Paananen, J. & Pitkänen, A., 27 Feb 2018, In : Acta neuropathologica communications. 6, 1, 16 p., 17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

MeCP2 interacts with chromosomal microRNAs in brain

Khan, A. W., Ziemann, M., Rafehi, H., Maxwell, S., Ciccotosto, G. D. & El-Osta, A., 2 Dec 2017, In : Epigenetics. 12, 12, p. 1028-1037 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Metabolism and chromatin dynamics in health and disease

Rodriguez, H., Rafehi, H., Bhave, M. & El-Osta, A., Apr 2017, In : Molecular Aspects of Medicine. 54, p. 1-15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Multi-Cellular Transcriptional Analysis of Mammalian Heart Regeneration

Quaife-Ryan, G. A., Sim, C. B., Ziemann, M., Kaspi, A., Rafehi, H., Ramialison, M., El-Osta, A., Hudson, J. E. & Porrello, E. R., 19 Sep 2017, In : Circulation. 136, 12, p. 1123-1139 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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NET silencing by let-7i in postural tachycardia syndrome

Khan, A. W., Ziemann, M., Corcoran, S. J., K N, H., Okabe, J., Rafehi, H., Maxwell, S. S., Esler, M. D. & El-Osta, A., 23 Mar 2017, In : JCI Insight. 2, 6, 11 p., e90183.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Rafehi, H., Kaspi, A., Ziemann, M., Okabe, J., Karagiannis, T. C. & El-Osta, A., 2 Nov 2017, In : Epigenetics. 12, 11, p. 991-1003 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Current perspectives in Set7 mediated stem cell differentiation

Karimnia, N., Rafehi, H., Tuano, N. K., Ziemann, M., K.N., H., Okabe, J. & El-Osta, A., 4 Dec 2016, In : Non-Coding RNA. 2, 4, 8 p., 2040014.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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DNA methylation regulates hypothalamic gene expression linking parental diet during pregnancy to the offspring's risk of obesity in Psammomys obesus

Khurana, I., Kaspi, A., Ziemann, M., Block, T., Connor, T., Spolding, B., Cooper, A., Zimmet, P., El-Osta, A. & Walder, K., 1 Jul 2016, In : International Journal of Obesity. 40, 7, p. 1079-1088 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Etiology matters-Genomic DNA Methylation Patterns in Three Rat Models of Acquired Epilepsy

Debski, K. J., Pitkanen, A., Puhakka, N., Bot, A. M., Khurana, I., Harikrishnan, K. N., Ziemann, M., Kaspi, A., El-Osta, A., Lukasiuk, K. & Kobow, K., 9 May 2016, In : Scientific Reports. 6, 14 p., 25668.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Evaluation of microRNA alignment techniques

Ziemann, M., Kaspi, A. & El-Osta, A., 1 Aug 2016, In : Rna-A Publication of the Rna Society. 22, 8, p. 1120-1138 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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HDAC inhibition in vascular endothelial cells regulates the expression of ncRNAs

Rafehi, H. & El-Osta, A., 25 May 2016, In : Non-Coding RNA. 2, 2, 10 p., 4.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Pharmacological inhibition of arginine and lysine methyltransferases induces nuclear abnormalities and suppresses angiogenesis in human endothelial cells

Balcerczyk, A., Rybaczek, D., Wojtala, M., Pirola, L., Okabe, J. & El-Osta, A., 1 Dec 2016, In : Biochemical Pharmacology. 121, p. 18-32 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species can provide atheroprotection via NOX4-dependent inhibition of inflammation and vascular remodeling

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W. & Jandeleit-Dahm, K. A. M., 1 Feb 2016, In : Arteriosclerosis, Thrombosis and Vascular Biology. 36, 2, p. 295-307 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Set7 mediated interactions regulate transcriptional networks in embryonic stem cells

Tuano, N. K., Okabe, J., Ziemann, M. D., Cooper, M. E. & El-Osta, A., 2016, In : Nucleic Acids Research. 44, 19, p. 9206-9217 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Clinical applicability of methylome sequencing in a pilot study of ischemic stroke individuals

Ziemann, M., Kaipananickal, H., Khurana, I., Kaspi, A., Keating, S. T., De Silva, D. A., Moe, K. T. & El-Osta, A., Jan 2015, In : Methods in Next Generation Sequencing. 2, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Current advances in noncoding RNA relevant to epigenetic mechanisms

Mathiyalagan, P., Khan, W., Du, X-J. & El-Osta, A., Mar 2015, In : Current Molecular Biology Reports. 1, 1, p. 29 - 38 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Current Epigenetic Perspective on Diabetes: Who Regulates the Regulators?

Keating, S. T. & El-Osta, A., 18 Dec 2015, In : Cellular & Molecular Medicine: Open access. 1, p. 1-4 4 p., 7.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Development of novel activin-targeted therapeutics

Chen, J., Walton, K., Al-Musawi, S., Kelly, E. M., Qian, H., La, M., Lu, L., Lovrecz, G. O., Ziemann, M., Lazarus, R., El-Osta, A., Gregorevic, P. & Harrison, C. A., 2015, In : Molecular Therapy. 23, 3, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic changes in the cardiac methylome during postnatal development

Sim, C. B., Ziemann, M., Kaspi, A., Harikrishnan, K. N., Ooi, J., Khurana, I., Chang, L., Hudson, J. E., El-Osta, A. & Porrello, E. R., 1 Apr 2015, In : FASEB Journal. 29, 4, p. 1329-1343 15 p.

Research output: Contribution to journalArticleResearchpeer-review

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Ooi, J., Tuano, N. K., Rafehi, H., Gao, X-M., Ziemann, M., Du, X-J. & El-Osta, A., 2015, In : Epigenetics. 10, 5, p. 418-430 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathological hypertrophy reverses β2-adrenergic receptorinduced angiogenesis in mouse heart

Xu, Q., Jennings, N. L., Sim, K., Chang, L., Gao, X. M., Kiriazis, H., Lee, Y. Y., Nguyen, M-N., Woodcock, E. A., Zhang, Y. Y., Osta, A. E., Dart, A. M. & Du, X. J., 2015, In : Physiological Reports. 3, 3, 16 p., e12340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells

Rodd, A. L., Ververis, K., Sayakkarage, D., Khan, A. W., Rafehi, H., Ziemann, M., Loveridge, S. J., Lazarus, R., Kerr, C. A., Lockett, T., El-Osta, A., Karagiannis, T. C. & Bennett, L. E., 2015, In : Food & Function: linking the chemistry and physics of food with health and nutrition. 6, 8, p. 2507-2524 18 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Chromatin modifications remodel cardiac gene expression

Mathiyalagan, P., Keating, S. T., Du, X-J. & El-Osta, A., 2014, In : Cardiovascular Research. 103, 1, p. 7-16 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Deep sequencing reveals novel Set7 networks

Keating, S. T., Ziemann, M., Okabe, J., Khan, A. W., Balcerczyk, A. & El-Osta, A., 2014, In : Cellular and Molecular Life Sciences. 71, 22, p. 4471-4486 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial transcriptome in response to pharmacological methyltransferase inhibition

Okabe, J., Fernandez, A. Z., Ziemann, M., Keating, S. T., Balcerczyk, A. & El-Osta, A., 2014, In : ChemMedChem. 9, 8, p. 1755 - 1762 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in longterm diabetic nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic variants within the second intron of the KCNQ1 gene affect CTCF binding and confer a risk of Beckwith-Wiedemann syndrome upon maternal transmission

Demars, J., Shmela, M. E., Khan, A. W., Lee, K. S., Azzi, S., Dehais, P., Netchine, I., Rossignol, S., Le Bouc, Y., El-Osta, A. & Gicquel, C., 2014, In : Journal of Medical Genetics. 51, 8, p. 502-511 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interplay of chromatin modifications and non-coding RNAs in the heart

Mathiyalagan, P., Keating, S. T., Du, X. & El-Osta, A., 2014, In : Epigenetics. 9, 1, p. 101 - 112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring

Latouche, C., Heywood, S. E., Henry, S., Ziemann, M., Lazarus, R., El-Osta, A., Armitage, J. A. & Kingwell, B. A., 2014, In : Journal of Nutrition. 144, 3, p. 237-244 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-referenced genome assembly from epigenomic short-read data

Kaspi, A., Ziemann, M., Keating, S. T., Khurana, I., Connor, T., Spolding, B., Cooper, A., Lazarus, R., Walder, K. R., Zimmet, P. & El-Osta, A., 2014, In : Epigenetics. 9, 10, p. 1329-1338 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat)

Spolding, B., Connor, T., Wittmer, C., Abreu, L. L. F., Kaspi, A., Ziemann, M., Kaur, G., Cooper, A., Morrison, S., Lee, S., Sinclair, A., Gibert, Y., Trevaskis, J. L., Roth, J. D., El-Osta, A., Standish, R. & Walder, K., 20 Mar 2014, In : PLoS ONE. 9, 3, 7 p., e92656.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

Mathiyalagan, P., Okabe, J., Chang, L. H. C., Su, Y., Du, X-J. & El-Osta, A., 2014, In : Nucleic Acids Research. 42, 2, p. 790-803 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Vascular histone deacetylation by pharmacological HDAC inhibition

Rafehi, H., Balcerczyk, A., Lunke, S., Kaspi, A., Ziemann, M., Harikrishnan, K. N., Okabe, J., Khurana, I., Ooi, J., Khan, A. W., Du, X-J., Chang, L. H. C., Haviv, I., Keating, S. T., Karagiannis, T. & El-Osta, A., 2014, In : Genome Research. 24, 8, p. 1271-1284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Analysis of the barley leaf transcriptome under salinity stress using mRNA-Seq

Ziemann, M., Kamboj, A., Hove, R. M., Loveridge, S., El-Osta, A. & Bhave, M., Jun 2013, In : Acta Physiologiae Plantarum. 35, 6, p. 1915-1924 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy

Lunke, S. & El-Osta, A., 2013, In : Neurotherapeutics. 10, 4, p. 677 - 687 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Chromatin context and ncRNA highlight targets of MeCP2 in brain

Maxwell, S. S., Pelka, G. J., Tam, P. P. L. & El-Osta, A., Nov 2013, In : RNA Biology. 10, 11, p. 1741-1757 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

Kobow, K., Kaspi, A., Harikrishnan, KN., Kiese, K., Ziemann, M., Khurana, I., Fritzsche, I., Hauke, J., Hahnen, E. T., Coras, R., Muhlebner, A., El-Osta, A. & Blumcke, I., 2013, In : Acta Neuropathologica. 126, 5, p. 741-756 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic changes in diabetes

Keating, S. T. & El-Osta, A., 2013, In : Clinical Genetics. 84, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycemic memories and the epigenetic component of diabetic nephropathy

Keating, S. T. & El-Osta, A., 2013, In : Current Diabetes Reports. 13, 4, p. 574-581 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunomodulatory effects of histone deacetylase inhibitors

Licciardi, P. V., Ververis, K., Tang, M. L., El-Osta, A. & Karagiannis, T. C., 2013, In : Current Molecular Medicine. 13, 4, p. 640-647 8 p.

Research output: Contribution to journalArticleResearchpeer-review