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Research Output 1997 2019

2007

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments

Karagiannis, T. C., Kn, H. & El-Osta, A., 7 Jun 2007, In : Oncogene. 26, 27, p. 3963-3971 9 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA double-strand breaks repair pathways in the framework of chromatin

Karagiannis, T. C. & El-Osta, A., 1 Dec 2007, New Research on DNA Repair. Nova Science Publishers, p. 295-324 30 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Will broad-spectrum histone deacetylase inhibitors be superseded by more specific compounds?

Karagiannis, T. C. & El-Osta, A., 1 Jan 2007, In : Leukemia. 21, 1, p. 61-65 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2006

Clinical potential of histone deacetylase inhibitors as stand alone therapeutics and in combination with other chemotherapeutics or radiotherapy for cancer

Karagiannis, T. C. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 121-126 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Harikrishnan et al. reply [3]

Harikrishnan, K. N., Pal, S., Yarski, M., Baker, E. K., Chow, M. Z., De Silva, M. G., Okabe, J., Wang, L., Jones, P. L., Sif, S. & El-Osta, A., 4 Sep 2006, In : Nature Genetics. 38, 9, p. 964-967 4 p.

Research output: Contribution to journalLetterOtherpeer-review

Mechanisms of abnormal gene expression in tumor cells.

El-Osta, A., 1 Jan 2006, In : EXS. 96, p. 351-361 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Modulation of cellular radiation responses by histone deacetylase inhibitors

Karagiannis, T. C. & El-Osta, A., 29 Jun 2006, In : Oncogene. 25, 28, p. 3885-3893 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The epigenetic modifier, valproic acid, enhances radiation sensitivity

Karagiannis, T. C., Kn, H. & El-Osta, A., 1 Jan 2006, In : Epigenetics. 1, 3, p. 131-137 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The neuronal noradrenaline transporter, anxiety and cardiovascular disease

Esler, M. D., Alvarenga, M., Pier, C., Richards, J. C., El-Osta, A., Barton, D. A., Haikerwal, D., Kaye, D., Schlaich, M., Guo, L., Jennings, G., Socratous, F. & Lambert, G. W., 2006, In : Journal of Psychopharmacology. 20, 4, p. 60 - 66 7 p.

Research output: Contribution to journalArticleResearchpeer-review

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation

Karagiannis, T. C. & El-Osta, A., 1 Feb 2006, In : Cell Cycle. 5, 3, p. 288-295 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2005

Brahma links the SWI/SNF chromatin-remodeling complex with MeCP2-dependent transcriptional silencing

Harikrishnan, K. N., Chow, M. Z., Baker, E. K., Pal, S., Bassal, S., Brasacchio, D., Wang, L., Craig, J. M., Jones, P. L., Sif, S. & El-Osta, A., 2005, In : Nature Genetics. 37, 3, p. 254-264 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Demethylation using the epigenetic modifier, 5-azacytidine, increases the efficiency of transient transfection of macrophages

Escher, G., Hoang, A., Georges, S., Tchoua, U., El-Osta, A., Krozowski, Z. & Sviridov, D., 1 Feb 2005, In : Journal of Lipid Research. 46, 2, p. 356-365 10 p.

Research output: Contribution to journalArticleResearchpeer-review

DNA damage detection and repair, and the involvement of epigenetic states

Bassal, S. & El-Osta, A., 21 Feb 2005, In : Human Mutation. 25, 2, p. 101-109 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic changes to the MDR1 locus in response to chemotherapeutic drugs

Baker, E. K., Johnstone, R. W., Zalcberg, J. R. & El-Osta, A., 1 Dec 2005, In : Oncogene. 24, 54, p. 8061-8075 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy

Forbes, J. M., Thorpe, S. R., Thallas-Bonke, V., Pete, J., Thomas, M. C., Deemer, E. R., Bassal, S., El-Osta, A., Long, D. M., Panagiotopoulos, S., Jerums, G., Osicka, T. M. & Cooper, M. E., 12 Dec 2005, In : Journal of the American Society of Nephrology. 16, 8, p. 2363-2372 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Review on epigenetics in cancer gene therapy: Series I

El-Osta, A., 1 Aug 2005, In : Cancer Gene Therapy. 12, 8, p. 663-664 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access

RNA interference and potential therapeutic applications of short interfering RNAs

Karagiannis, T. C. & El-Osta, A., 1 Oct 2005, In : Cancer Gene Therapy. 12, 10, p. 787-795 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

The histone deacetylase inhibitor, trichostatin A, enhances radiation sensitivity and accumulation of γH2A.X

Karagiannis, T. C., Harikrishnan, K. N. & El-Osta, A., 1 Jan 2005, In : Cancer Biology and Therapy. 4, 7, p. 787-793 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Coordination of epigenetic events

El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2135-2136 2 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Double-strand breaks: Signaling pathways and repair mechanisms

Karagiannis, T. C. & El-Osta, A., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2137-2147 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic changes activate widespread signals in response to double-strand breaks

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 7, p. 617-623 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Expression analysis of the epigenetic methyltransferases and methyl-CpG binding protein families in the normal B-cell and B-cell chronic lymphocytic leukemia (CLL)

Harikrishnan, K. N., Bassal, S., Tikellis, C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 10, p. 989-994 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Functional links between transcription, DNA repair and apoptosis

Berardi, P., Russell, M., El-Osta, A. & Riabowol, K., 1 Sep 2004, In : Cellular and Molecular Life Sciences. 61, 17, p. 2173-2180 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

MDR1, chemotherapy and chromatin remodeling

Baker, E. K. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 819-824 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Radio- and chemo-sensitization of human erythroleukemic K562 cells by the histone deacetylase inhibitor Trichostatin A

Karagiannis, T. C., Smith, A. J. & El'Osta, A., 1 Sep 2004, In : Medicine, Science and the Law. 7, 3, p. 184-191 8 p.

Research output: Contribution to journalArticleResearchpeer-review

siRNAs: Mechanism of RNA interference, in vivo and potential clinical applications

Karagiannis, T. C. & El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 11

Research output: Contribution to journalReview ArticleResearchpeer-review

The rise and fall of genomic methylation in cancer

El-Osta, A., 1 Jan 2004, In : Leukemia. 18, 2, p. 233-237 5 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

Understanding the consequences of epigenetic mechanisms and their effect on transcription in health and disease

El-Osta, A., 1 Jan 2004, In : Cancer Biology and Therapy. 3, 9, p. 816-818 3 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2003

DNMT cooperativity - The developing links between methylation, chromatin structure and cancer

El-Osta, A., 1 Nov 2003, In : BioEssays. 25, 11, p. 1071-1084 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

On the use of DNA methylation inhibitors and the reversal of transcriptional silencing [4] (multiple letters)

El-Osta, A., Lübbert, M., Wijermans, P. W., Licht, T. & Jones, P. A., 15 Feb 2003, In : Blood. 101, 4, p. 1656-1658 3 p.

Research output: Contribution to journalLetterOtherpeer-review

The rise of DNA methylation and the importance of chromatin on multidrug resistance in cancer

Baker, E. K. & El-Osta, A., 1 Nov 2003, In : Experimental Cell Research. 290, 2, p. 177-194 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2002

FMR1 silencing and the signals to chromatin: A unified model of transcriptional regulation

El-Osta, A., 1 Jan 2002, In : Biochemical and Biophysical Research Communications. 295, 3, p. 575-581 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Profiling methyl-CpG specific determinants on transcriptionally silent chromatin

El-Osta, A., Baker, E. K. & Wolffe, A. P., 15 Jul 2002, In : Molecular Biology Reports. 28, 4, p. 209-215 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

Analysis of chromatin-immunopurified MeCP2-associated fragments

El-Osta, A. & Wolffe, A. P., 7 Dec 2001, In : Biochemical and Biophysical Research Communications. 289, 3, p. 733-737 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

DNA methylation and histone deacetylation in the control of gene expression: Basic biochemistry to human development and disease

El-Osta, A. & Wolffe, A. P., 7 Dec 2000, In : Gene Expression. 9, 1-2, p. 63-75 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

MRP1 not MDR1 gene expression is the predominant mechanism of acquired multidrug resistance in two prostate carcinoma cell lines

Zalcberg, J., Hu, X. F., Slater, A., Parisot, J., El-Osta, S., Kantharidis, P., Chou, S. T. & Parkin, J. D., 2000, In : Prostate Cancer and Prostatic Diseases. 3, 2, p. 66-75 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Regulation of MDR1 gene expression: Emerging concepts

Kantharidis, P., El-Osta, S., De Silva, M., Lee, G., Hu, X. F. & Zalcberg, J., Apr 2000, In : Drug Resistance Updates. 3, 2, p. 99-108 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1999

Absolute quantitation of MDR1 transcripts using heterologous DNA standards - Validation of the competitive RT-PCR (CRT-PCR) approach

El-Osta, A., Kantharidis, P. & Zalcberg, J., 1999, In : BioTechniques. 26, 6, p. 1114-1124 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

Altered methylation of the human MDR1 promoter is associated with acquired multidrug resistance

Kantharidis, P., El-Osta, A., DeSilva, M., Wall, D. M. P., Hu, X. F., Slater, A., Nadalin, G., Parkin, J. D. & Zalcberg, J. R., Nov 1997, In : Clinical Cancer Research. 3, 11, p. 2025-2032 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Expression of mdr1 and mrp in the normal B-cell homologue of B-cell chronic lymphocytic leukaemia

Wall, D. M. P., El-Osta, S., Tzelepis, D., Bertoncello, I., Kantharidis, P., Chou, S. T., Zalcberg, J. R. & Parkin, J. D., 1997, In : British Journal of Haematology. 96, 4, p. 697-707 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequential extraction of DNA and DNA-binding proteins from low cell numbers

El-Osta, S., Kantharidis, P. & Zalcberg, J. R., Apr 1997, In : BioTechniques. 22, 4, p. 645-648 4 p.

Research output: Contribution to journalArticleResearchpeer-review