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Research Output 1997 2019

2012

Effects of the histone deacetylase inhibitor, trichostatin A, in a chronic allergic airways disease model in mice

Royce, S. G., Dang, W., Yuan, G. Y., Tran, J., El-Osta, A., Karagiannis, T. & Tang, M. L. K., Aug 2012, In : Archivum Immunologiae et Therapiae Experimentalis. 60, 4, p. 295-306 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

Rafehi, H., El-Osta, A. & Karagiannis, T. C., 2012, In : Journal of Diabetes and its Complications. 26, 6, p. 554-561 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic modification of the norepinephrine transporter gene in postural tachycardia syndrome

Bayles, R., Harikrishnan, K. N., Lambert, E., Baker, E. K., Agrotis, A., Guo, L., Jowett, J. B., Esler, M. D., Lambert, G. & El-Osta, A., 2012, In : Arteriosclerosis, Thrombosis and Vascular Biology. 32, 8, p. 1910 - 1916 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycemic memory

El-Osta, A., 2012, In : Current Opinion in Lipidology. 23, 1, p. 24 - 29 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Influence of natural and synthetic histone deacetylase inhibitors on chromatin

Licciardi, P. V., Kwa, F., Ververis, K., Di Costanzo, N., Balcerczyk, A., Tang, M. L., El-Osta, A. & Karagiannis, T. C., 2012, In : Antioxidants and Redox Signaling. 17, 2, p. 340-354 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

Rafehi, H., Smith, A. J., Balcerczyk, A., Ziemann, M., Ooi, J., Loveridge, S. J., Baker, E. K., El-Osta, A. & Karagiannis, T. C., 2012, In : Genes and Nutrition. 7, 2, p. 343-355 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

Rafehi, H., Ververis, K., Balcerczyk, A., Ziemann, M., Ooi, J., Hu, S., Kwa, F., Loveridge, S. J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T., 2012, In : Pathobiology of Aging & Age-related Diseases. 2, 1, 14 p., 11905.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Microparticles: major transport vehicles for distinct microRNAs in circulation

Diehl, P., Fricke, A., Sander, L., Stamm, J., Bassler, N., Htun, N., Ziemann, M., Helbing, T., El-Osta, A., Jowett, J. B. & Peter, K., 2012, In : Cardiovascular Research. 93, 4, p. 633-644 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular model of naphthalene-induced DNA damage in the murine lung

Karagiannis, T. C., Li, X., Tang, M. M., Orlowski, C., El-Osta, A., Tang, M. L. K. & Royce, S. G., 2012, In : Human and Experimental Toxicology. 31, 1, p. 42-50 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Redox mediating epigenetic changes confer metabolic memories

El-Osta, A., 20 Jul 2012, In : Circulation Research. 111, 3, p. 262-264 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

Role of histone acetylation in the stimulatory effect of valproic acid on vascular endothelial tissue-type plasminogen activator expression

Larsson, P., Ulfhammer, E., Magnusson, M., Bergh, N., Lunke, S., El-Osta, A., Medcalf, R. L., Svensson, P. A., Karlsson, L. & Jern, S., Feb 2012, In : PLoS ONE. 7, 2 , 9 p., e31573.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Système IGF et croissance foetale

Demars, J., Rossignol, S., Shmela, M., Netchine, I., Azzi, S., El-Osta, A., Le Bouc, Y. & Gicquel, C., 2012, Aspects biologiques, moléculaires et cliniques de l’axe GH/IGF-I. Le Bouc, Y. & Tauber, M. (eds.). Paris France: Springer-Verlag London Ltd., p. 97 - 108 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2013

Analysis of the barley leaf transcriptome under salinity stress using mRNA-Seq

Ziemann, M., Kamboj, A., Hove, R. M., Loveridge, S., El-Osta, A. & Bhave, M., Jun 2013, In : Acta Physiologiae Plantarum. 35, 6, p. 1915-1924 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Applicability of histone deacetylase inhibition for the treatment of spinal muscular atrophy

Lunke, S. & El-Osta, A., 2013, In : Neurotherapeutics. 10, 4, p. 677 - 687 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Chromatin context and ncRNA highlight targets of MeCP2 in brain

Maxwell, S. S., Pelka, G. J., Tam, P. P. L. & El-Osta, A., Nov 2013, In : RNA Biology. 10, 11, p. 1741-1757 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

Kobow, K., Kaspi, A., Harikrishnan, KN., Kiese, K., Ziemann, M., Khurana, I., Fritzsche, I., Hauke, J., Hahnen, E. T., Coras, R., Muhlebner, A., El-Osta, A. & Blumcke, I., 2013, In : Acta Neuropathologica. 126, 5, p. 741-756 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic changes in diabetes

Keating, S. T. & El-Osta, A., 2013, In : Clinical Genetics. 84, 1, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycemic memories and the epigenetic component of diabetic nephropathy

Keating, S. T. & El-Osta, A., 2013, In : Current Diabetes Reports. 13, 4, p. 574-581 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Immunomodulatory effects of histone deacetylase inhibitors

Licciardi, P. V., Ververis, K., Tang, M. L., El-Osta, A. & Karagiannis, T. C., 2013, In : Current Molecular Medicine. 13, 4, p. 640-647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Methylation of the SLC6a2 gene promoter in major depression and panic disorder

Bayles, R., Baker, E. K., Jowett, J. B. M., Barton, D., Esler, M., El-Osta, A. & Lambert, G., 2 Dec 2013, In : PLoS ONE. 8, 12, 12 p., e83223.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Motif analysis in DNAse hypersensitivity regions uncovers distal cis elements associated with gene expression

Ziemann, M., Kaspi, A., Lazarus, R. & El-Osta, A., 2013, In : Bioinformation. 9, 4, p. 212-215 4 p.

Research output: Contribution to journalArticleOtherpeer-review

NADPH oxidase 1 plays a key role in diabetes mellitus-accelerated atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., De Haan-Klein, J. B., Koulis, C., El-Osta, A., Andrews, K. L., Chin-Dusting, J. PF., Touyz, R. M., Wingler, K., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2013, In : Circulation. 127, 18, p. 1888 - 1902 15 p.

Research output: Contribution to journalArticleResearchpeer-review

The methylation hypothesis of pharmacoresistance in epilepsy

Kobow, K., El-Osta, A. & Blumcke, I., May 2013, In : Epilepsia. 54, Suppl 2, p. 41-47 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Transcriptional regulation by the Set7 lysine methyltransferase

Keating, S. T. & El-Osta, A., 1 Apr 2013, In : Epigenetics. 8, 4, p. 361-372 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation

Kitamura, H., Kimura, S., Shimamoto, Y., Okabe, J., Ito, M., Miyamoto, T., Naoe, Y., Kikuguchi, C., Meek, B., Toda, C., Okamoto, S., Kanehira, K., Hase, K., Watarai, H., Ishizuka, M., El-Osta, A., Ohara, O. & Miyoshi, I., 2013, In : FASEB Journal. 27, 12, p. 4940 - 4953 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Chromatin modifications remodel cardiac gene expression

Mathiyalagan, P., Keating, S. T., Du, X-J. & El-Osta, A., 2014, In : Cardiovascular Research. 103, 1, p. 7-16 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Deep sequencing reveals novel Set7 networks

Keating, S. T., Ziemann, M., Okabe, J., Khan, A. W., Balcerczyk, A. & El-Osta, A., 2014, In : Cellular and Molecular Life Sciences. 71, 22, p. 4471-4486 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelial transcriptome in response to pharmacological methyltransferase inhibition

Okabe, J., Fernandez, A. Z., Ziemann, M., Keating, S. T., Balcerczyk, A. & El-Osta, A., 2014, In : ChemMedChem. 9, 8, p. 1755 - 1762 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic targeting or pharmacologic inhibition of NADPH oxidase Nox4 provides renoprotection in longterm diabetic nephropathy

Jha, J. C., Gray, S. P., Barit, D., Okabe, J., El-Osta, A., Namikoshi, T., Thallas-Bonke, V., Wingler, K., Szyndralewiez, C., Heitz, F., Touyz, R. M., Cooper, M. E., Schmidt, H. & Jandeleit-Dahm, K. A. M., 2014, In : Journal of the American Society of Nephrology. 25, 6, p. 1237-1254 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic variants within the second intron of the KCNQ1 gene affect CTCF binding and confer a risk of Beckwith-Wiedemann syndrome upon maternal transmission

Demars, J., Shmela, M. E., Khan, A. W., Lee, K. S., Azzi, S., Dehais, P., Netchine, I., Rossignol, S., Le Bouc, Y., El-Osta, A. & Gicquel, C., 2014, In : Journal of Medical Genetics. 51, 8, p. 502-511 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome-wide DNA Methylation Analysis Reveals Dynamic Changes in the Cardiac Methylome During Post-natal Heart Development

Sim, C. B., Ziemann, M., Kaipananickal, H., Kaspi, A. D., Ooi, J. Y. Y., Chang, L. H. C., Khurana, I., Olson, E. N., El-Osta, A. & Porrello, E. R., 18 Jul 2014, p. 92. 1 p.

Research output: Contribution to conferenceAbstractOther

Open Access

Glycemic memory and epigenetic persistence

El-Osta, A., Jul 2014, p. 83-84. 2 p.

Research output: Contribution to conferenceAbstractOther

Interplay of chromatin modifications and non-coding RNAs in the heart

Mathiyalagan, P., Keating, S. T., Du, X. & El-Osta, A., 2014, In : Epigenetics. 9, 1, p. 101 - 112 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal overnutrition programs changes in the expression of skeletal muscle genes that are associated with insulin resistance and defects of oxidative phosphorylation in adult male rat offspring

Latouche, C., Heywood, S. E., Henry, S., Ziemann, M., Lazarus, R., El-Osta, A., Armitage, J. A. & Kingwell, B. A., 2014, In : Journal of Nutrition. 144, 3, p. 237-244 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-referenced genome assembly from epigenomic short-read data

Kaspi, A., Ziemann, M., Keating, S. T., Khurana, I., Connor, T., Spolding, B., Cooper, A., Lazarus, R., Walder, K. R., Zimmet, P. & El-Osta, A., 2014, In : Epigenetics. 9, 10, p. 1329-1338 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Rapid development of non-alcoholic steatohepatitis in Psammomys obesus (Israeli sand rat)

Spolding, B., Connor, T., Wittmer, C., Abreu, L. L. F., Kaspi, A., Ziemann, M., Kaur, G., Cooper, A., Morrison, S., Lee, S., Sinclair, A., Gibert, Y., Trevaskis, J. L., Roth, J. D., El-Osta, A., Standish, R. & Walder, K., 20 Mar 2014, In : PLoS ONE. 9, 3, 7 p., e92656.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart

Mathiyalagan, P., Okabe, J., Chang, L. H. C., Su, Y., Du, X-J. & El-Osta, A., 2014, In : Nucleic Acids Research. 42, 2, p. 790-803 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Vascular histone deacetylation by pharmacological HDAC inhibition

Rafehi, H., Balcerczyk, A., Lunke, S., Kaspi, A., Ziemann, M., Harikrishnan, K. N., Okabe, J., Khurana, I., Ooi, J., Khan, A. W., Du, X-J., Chang, L. H. C., Haviv, I., Keating, S. T., Karagiannis, T. & El-Osta, A., 2014, In : Genome Research. 24, 8, p. 1271-1284 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Clinical applicability of methylome sequencing in a pilot study of ischemic stroke individuals

Ziemann, M., Kaipananickal, H., Khurana, I., Kaspi, A., Keating, S. T., De Silva, D. A., Moe, K. T. & El-Osta, A., Jan 2015, In : Methods in Next Generation Sequencing. 2, 1, p. 11-22 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Current advances in noncoding RNA relevant to epigenetic mechanisms

Mathiyalagan, P., Khan, W., Du, X-J. & El-Osta, A., Mar 2015, In : Current Molecular Biology Reports. 1, 1, p. 29 - 38 10 p.

Research output: Contribution to journalArticleOtherpeer-review

Current Epigenetic Perspective on Diabetes: Who Regulates the Regulators?

Keating, S. T. & El-Osta, A., 18 Dec 2015, In : Cellular & Molecular Medicine: Open access. 1, p. 1-4 4 p., 7.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Development of novel activin-targeted therapeutics

Chen, J., Walton, K., Al-Musawi, S., Kelly, E. M., Qian, H., La, M., Lu, L., Lovrecz, G. O., Ziemann, M., Lazarus, R., El-Osta, A., Gregorevic, P. & Harrison, C. A., 2015, In : Molecular Therapy. 23, 3, p. 434-444 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Dynamic changes in the cardiac methylome during postnatal development

Sim, C. B., Ziemann, M., Kaspi, A., Harikrishnan, K. N., Ooi, J., Khurana, I., Chang, L., Hudson, J. E., El-Osta, A. & Porrello, E. R., 1 Apr 2015, In : FASEB Journal. 29, 4, p. 1329-1343 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic-Mediated Reprogramming of Pancreatic Endocrine Cells

Mathiyalagan, P., Keating, S. T., Al-Hasani, K. & El-Osta, A., 1 Jun 2015, In : Antioxidants and Redox Signaling. 22, 16, p. 1483-1495 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetics and metabolism

Keating, S. T. & El-Osta, A., 13 Feb 2015, In : Circulation Research. 116, 4, p. 715-736 22 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

HDAC inhibition attenuates cardiac hypertrophy by acetylation and deacetylation of target genes

Ooi, J., Tuano, N. K., Rafehi, H., Gao, X-M., Ziemann, M., Du, X-J. & El-Osta, A., 2015, In : Epigenetics. 10, 5, p. 418-430 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathological hypertrophy reverses β2-adrenergic receptorinduced angiogenesis in mouse heart

Xu, Q., Jennings, N. L., Sim, K., Chang, L., Gao, X. M., Kiriazis, H., Lee, Y. Y., Nguyen, M-N., Woodcock, E. A., Zhang, Y. Y., Osta, A. E., Dart, A. M. & Du, X. J., 2015, In : Physiological Reports. 3, 3, 16 p., e12340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Regulation of inflammatory gene expression by histone acetylation and HDAC inhibition in human aortic endothelial cells

Rafehi, H., Balcerczyk, A., Lunke, S., Kaspi, A. D., Ziemann, M., Kaipananickal, H., Okabe, J., Khurana, I., Ooi, J., Khan, A. W., Du, X-J., Chang, L., Haviv, I., Keating, S. T., Karagiannis, T. & El-Osta, S., 2015, In : Atherosclerosis. 241, 1, p. e6 1 p.

Research output: Contribution to journalMeeting AbstractOtherpeer-review

Open Access

RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells

Rodd, A. L., Ververis, K., Sayakkarage, D., Khan, A. W., Rafehi, H., Ziemann, M., Loveridge, S. J., Lazarus, R., Kerr, C. A., Lockett, T., El-Osta, A., Karagiannis, T. C. & Bennett, L. E., 2015, In : Food & Function: linking the chemistry and physics of food with health and nutrition. 6, 8, p. 2507-2524 18 p.

Research output: Contribution to journalArticleResearchpeer-review