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Research Output 1997 2019

2009

Erratum: FOXO1 regulates the expression of 4E-BP1 and inhibits mTOR signalling in mammalian skeletal muscle (Journal of Biological Chemistry (2007) vol. 282 (21176-21186))

Southgate, R. J., Neill, B. A., Prelovsek, O., El-Osta, A., Kamei, Y., Miura, S., Ezaki, O., McLoughlin, T. J., Zhang, W., Unterman, T. G. & Febbraio, M. A., 24 Jul 2009, In : Journal of Biological Chemistry. 284, 30, p. 20440 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Hyperglycemia induces a dynamic cooperativity of histone methylase and demethylase enzymes associated with gene-activating epigenetic marks that coexist on the lysine tail

Brasacchio, D., Okabe, J., Tikellis, C., Balcerczyk, A., George, P., Baker, E. K., Calkin, A. C., Brownlee, M., Cooper, M. E. & El-Osta, A., May 2009, In : Diabetes. 58, 5, p. 1229-1236 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Survival motor neuron gene 2 silencing by DNA methylation correlates with spinal muscular atrophy disease severity and can be bypassed by histone deacetylase inhibition

Hauke, J., Riessland, M., Lunke, S., Eyüpoglu, I. Y., Blümcke, I., El-osta, A., Wirth, B. & Hahnen, E. T., 2009, In : Human Molecular Genetics. 18, 2, p. 304-317 14 p.

Research output: Contribution to journalArticleResearchpeer-review

The emerging role of epigenetic modifications and chromatin remodeling in spinal muscular atrophy

Lunke, S. & El-Osta, A., Jun 2009, In : Journal of Neurochemistry. 109, 6, p. 1557-1569 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2010

Alleviating transcriptional inhibition of the norepinephrine Slc6a2 transporter gene in depolarized neurons

Harikrishnan, K. N., Bayles, R., Ciccotosto, G. D., Maxwell, S., Cappai, R., Pelka, G. J., Tam, P. P. L., Christodoulou, J. & El-Osta, A., 27 Jan 2010, In : Journal of Neuroscience. 30, 4, p. 1494-1501 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Analysis of the IGF2/H19 imprinting control region uncovers new genetic defects, including mutations of OCT-binding sequences, in patients with 11p15 fetal growth disorders

Demars, J., Shmela, M. E., Rossignol, S., Okabe, J., Netchine, I., Azzi, S., Cabrol, S., le Caignec, C., David, A., Le Bouc, Y., El-Osta, A. & Gicquel, C., Mar 2010, In : Human Molecular Genetics. 19, 5, p. 803-814 12 p., ddp549.

Research output: Contribution to journalArticleResearchpeer-review

Atherogenic factors and their epigenetic relationships

Fernandez, A. Z., Siebel, A. L. & El-Osta, A., 2010, In : International Journal of Vascular Medicine. 2010, 437809.

Research output: Contribution to journalReview ArticleResearchpeer-review

Cardiac ventricular chambers are epigenetically distinguishable

Mathiyalagan, P., Chang, L., Du, X. J. & El-Osta, A., 1 Feb 2010, In : Cell Cycle. 9, 3, p. 612-617 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Downstream targets of methyl CpG binding protein 2 and their abnormal expression in the frontal cortex of the human Rett syndrome brain

Gibson, J. H., Slobedman, B., KN, H., Williamson, S. L., Minchenko, D., El-Osta, A., Stern, J. L. & Christodoulou, J., 26 Apr 2010, In : BMC Neuroscience. 11, 53.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic phenomena linked to diabetic complications

Pirola, L., Balcerczyk, A., Okabe, J. & El-Osta, A., Dec 2010, In : Nature Reviews Endocrinology. 6, 12, p. 665-675 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic regulation of multidrug resistance 1 gene expression: profiling CpG methylation status using bisulphite sequencing.

Baker, E. K. & El-Osta, A., 2010, In : Methods in Molecular Biology. 596, p. 183-198 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetics: Mechanisms and implications for diabetic complications

Cooper, M. E. & El-Osta, A., 10 Dec 2010, In : Circulation Research. 107, 12, p. 1403-1413 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Evaluation of the spatial distribution of γH2AX following ionizing radiation

Vasireddy, R. S., Tang, M. M., Mah, L-J., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C., Aug 2010, In : Journal of Visualized Experiments. 42, e2203.

Research output: Contribution to journalArticleResearchpeer-review

Glycemic memory associated epigenetic changes

Siebel, A. L., Fernandez, A. Z. & El-Osta, A., 15 Dec 2010, In : Biochemical Pharmacology. 80, 12, p. 1853-1859 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Histone modifications regulate the norepinephrine transporter gene

Bayles, R., Baker, E. K., Eikelis, N., El-Osta, A. & Lambert, G., 15 Nov 2010, In : Cell Cycle. 9, 22, p. 4600-4601 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Metabolic memory and diabetic nephropathy: Potential role for epigenetic mechanisms

Tonna, S., El-Osta, A., Cooper, M. E. & Tikellis, C., 2010, In : Nature Reviews Nephrology. 6, 6, p. 332-341 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantification of γH2AX foci in response to Ionising radiation

Mah, L. J., Vasireddy, R. S., Tang, M. M., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C., Apr 2010, In : Journal of Visualized Experiments. 38, e1957.

Research output: Contribution to journalArticleResearchpeer-review

Quantitation of gammaH2AX Foci in Tissue Samples

Tang, M. M., Mah, L-J., Vasireddy, R. S., Georgiadis, G. T., El-Osta, A., Royce, S. G. & Karagiannis, T., 2010, In : Journal of Visualized Experiments. 2010, 40, p. 1 - 3 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes

Karagiannis, T. C., Lin, A. J. E., Ververis, K., Chang, L., Tang, M. M., Okabe, J. & El-Osta, A., Oct 2010, In : Aging. 2, 10, p. 659-668 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

γH2AX as a molecular marker of aging and disease

Mah, L. J., El-Osta, A. & Karagiannis, T. C., 2010, In : Epigenetics. 5, 2, p. 129-136 8 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

γ-radiation-induced γh2AX formation occurs preferentially in actively transcribing euchromatic loci

Vasireddy, R. S., Karagiannis, T. C. & El-Osta, A., Jan 2010, In : Cellular and Molecular Life Sciences. 67, 2, p. 291-294 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Cardiac genes show contextual SWI/SNF interactions with distinguishable gene activities

Chang, L., Kiriazis, H., Gao, X. M., Du, X. J. & El-Osta, A., 2011, In : Epigenetics. 6, 6, p. 760-768 9 p.

Research output: Contribution to journalArticleResearchpeer-review

ChIP sequencing

Lunke, S. & El-Osta, A., 2011, Epigenetics: A Reference Manual. Craig, J. M. & Wong, N. C. (eds.). Norfolk UK: Caister Academic Press, p. 357 - 370 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Chromatin modifications and radiotherapy

Mah, L-J., Ververis, K., El-Osta, A. & Karagiannis, T., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Kerala, India: Transworld Research Network, p. 101-124 24 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Chromatin modifying agents - The cutting edge of anticancer therapy

Kwa, F. A. A., Balcerczyk, A., Licciardi, P., El-Osta, A. & Karagiannis, T. C., Jul 2011, In : Drug Discovery Today. 16, 13-14, p. 543-547 5 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Clonogenic assay: Adherent cells

Rafehi, H., Orlowski, C., Georgiadis, G. T., Ververis, K., El-Osta, A. & Karagiannis, T. C., Mar 2011, In : Journal of Visualized Experiments. 49, 4 p., e2573.

Research output: Contribution to journalArticleOtherpeer-review

Developmental origins of disease: Effects of parental diet on asthma

Royce, S. G., Dang, W., Tang, M. L. K., El-Osta, A. & Karagiannis, T. C., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Kerala India: Transworld Research Network, p. 77 - 91 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Double-strand breaks and the concept of short- and long-term epigenetic memory

Orlowski, C., Mah, L-J., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., Apr 2011, In : Chromosoma. 120, 2, p. 129-149 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Epigenetic and genetic mechanisms of abnormal 11p15 genomic imprinting in Silver-Russell and Beckwith-Wiedemann syndromes

Demars, J., Le Bouc, Y., El-Osta, A. & Gicquel, C., Apr 2011, In : Current Medicinal Chemistry. 18, 12, p. 1740-1750 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Epigenetic basis of disease

Venables, G., Tuano, N. K., El-Osta, A. & Karagiannis, T. C., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Kerala, India: Transworld Research Network, p. 31-43 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Epigenetic reprogramming of stem cells

Orlowski, C., Karagiannis, T. & El-Osta, A., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Kerala, India: Transworld Research Network, p. 11-30 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Research

Epigenetics and diabetic complications

Rafehi, H., El-Osta, A. & Karagiannis, T. C., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Kerala, India: Transworld Research Network, p. 45-61 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks

Mah, L-J., Orlowski, C., Ververis, K., Vasireddy, R. S., El-Osta, A. & Karagiannis, T. C., 25 Jan 2011, In : Genome Integrity. 2, 11 p., 3.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Genetic and epigenetic events in diabetic wound healing

Rafehi, H., El-Osta, A. & Karagiannis, T. C., 2011, In : International Wound Journal. 8, 1, p. 12 - 21 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes

Syreeni, A., El-Osta, A., Forsblom, C., Sandholm, N., Parkkonen, M., Tarnow, L., Parving, H. H., McKnight, A. J., Maxwell, A. P., Cooper, M. E., Groop, P. H. & the FinnDiane Study Group, Nov 2011, In : Diabetes. 60, 11, p. 3073-3080 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

Pirola, L., Balcerczyk, A., Tothill, R. W., Haviv, I., Kaspi, A., Lunke, S., Ziemann, M., Karagiannis, T., Tonna, S., Kowalczyk, A., Beresford-Smith, B., Macintyre, G., Kelong, M., Hongyu, Z., Zhu, J. & El-Osta, A., Oct 2011, In : Genome Research. 21, 10, p. 1601-1615 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Glycemic memory and epigenetic changes

Siebel, A. L., Fernandez, A. Z. & El-Osta, A., 2011, Nutrition, Epigenetic Mechanisms, and Human Disease. Maulik, N. & Maulik, G. (eds.). Boca Raton FL USA: CRC Press, p. 215-227 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Histone deacetylase inhibitors augment doxorubicin-induced DNA damage in cardiomyocytes

Ververis, K., Rodd, A. L., Tang, M. M., El-Osta, A. & Karagiannis, T. C., Dec 2011, In : Cellular and Molecular Life Sciences. 68, 24, p. 4101-4114 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Maternal diet, epigenetics and diabetes

Rafehi, H., Georgiadis, G. T., El-Osta, A. & Karagiannis, T. C., 2011, Epigenomic Medicine. Karagiannis, T. C. (ed.). Transworld Research Network, p. 63-75 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

New insights into the pathogenesis of beckwith-wiedemann and silver-russell syndromes: Contribution of small copy number variations to 11p15 imprinting defects

Demars, J., Rossignol, S., Netchine, I., Lee, K. S., Shmela, M., Faivre, L., Weill, J., Odent, S., Azzi, S., Callier, P., Lucas, J., Dubourg, C., Andrieux, J., Le Bouc, Y., El-Osta, A. & Gicquel, C., Oct 2011, In : Human Mutation. 32, 10, p. 1171-1182 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

Fröjdö, S., Durand, C., Molin, L., Carey, A. L., El-Osta, A., Kingwell, B. A., Febbraio, M. A., Solari, F., Vidal, H. & Pirola, L., 30 Mar 2011, In : Molecular and Cellular Endocrinology. 335, 2, p. 166-176 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Protective effects of valproic acid against airway hyperresponsiveness and airway remodeling in a mouse model of allergic airways disease

Royce, S. G., Dang, W., Ververis, K., De Sampayo, N., El-Osta, A., Tang, M. L. K. & Karagiannis, T. C., Dec 2011, In : Epigenetics. 6, 12, p. 1463 - 1470 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Remodeling is at the heart of chromatin: The heartaches of chromatin

El-Osta, A., 2011, In : Epigenetics. 6, 7, p. 884-887 4 p.

Research output: Contribution to journalArticleOtherpeer-review

Resveratrol has protective effects against airway remodeling and airway hyperreactivity in a murine model of allergic airways disease

Royce, S. G., Dang, W., Yuan, G. Y., Tran, J., El-Osta, A., Karagiannis, T. & Tang, M. LK., 2011, In : Pathobiology of Aging & Age-related Diseases. 1, 10 p., 7134.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2012

A pipeline for the identification and characterization of chromatin modifications derived from ChIP-Seq datasets

Kaspi, A., Ziemann, M., Rafehi, H., Lazarus, R. & El-Osta, A., 2012, In : Biochimie. 94, 11, p. 2353-2359 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Chromatin modifications associated with diabetes

Keating, S. T. & El-Osta, A., 2012, In : Journal of Cardiovascular Translational Research. 5, 4, p. 399-412 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Contraction-induced interleukin-6 gene transcription in skeletal muscle is regulated by c-Jun terminal kinase/activator protein-1

Whitham, M., Chan, M. H. S., Pal, M., Matthews, V. B., Prelovsek, O., Lunke, S., El-Osta, A., Broenneke, H., Alber, J., Bruning, J. C., Wunderlich, F. T., Lancaster, G. I. & Febbraio, M. A., 30 Mar 2012, In : Journal of Biological Chemistry. 287, 14, p. 10771-10779 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Distinguishing hyperglycemic changes by set7 in vascular endothelial cells

Okabe, J., Orlowski, C., Balcerczyk, A., Tikellis, C., Thomas, M. C., Cooper, M. E. & El-Osta, A., 2012, In : Circulation Research. 110, 8, p. 1067 - 1076 10 p.

Research output: Contribution to journalArticleResearchpeer-review